HUMAN:DNLI4

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	LIG4
Protein Name(s)	DNA ligase 4 DNA ligase IV Polydeoxyribonucleotide synthase [ATP] 4
External Links
UniProt	P49917
EMBL	X83441 AF479264 AL157762 BC037491
CCDS	CCDS9508.1
PIR	I37079
RefSeq	NP_001091738.1 NP_002303.2 NP_996820.1 XP_005254113.1 XP_005254114.1 XP_005254115.1 XP_006720013.1 XP_006720014.1 XP_006720015.1
UniGene	Hs.166091
PDB	1IK9 2E2W 3II6 3VNN 3W1B 3W1G 3W5O 4HTO 4HTP
PDBsum	1IK9 2E2W 3II6 3VNN 3W1B 3W1G 3W5O 4HTO 4HTP
ProteinModelPortal	P49917
SMR	P49917
BioGrid	110169
DIP	DIP-37958N
IntAct	P49917
MINT	MINT-3018022
STRING	9606.ENSP00000349393
PhosphoSite	P49917
DMDM	88911290
MaxQB	P49917
PaxDb	P49917
PRIDE	P49917
DNASU	3981
Ensembl	ENST00000356922 ENST00000405925 ENST00000442234 ENST00000611712 ENST00000614526
GeneID	3981
KEGG	hsa:3981
UCSC	uc001vqn.3
CTD	3981
GeneCards	GC13M108859
HGNC	HGNC:6601
HPA	HPA001334
MIM	601837 602450 606593
neXtProt	NX_P49917
Orphanet	235 99812 39041
PharmGKB	PA30375
eggNOG	COG1793
GeneTree	ENSGT00750000117695
HOGENOM	HOG000007831
HOVERGEN	HBG005516
InParanoid	P49917
KO	K10777
OMA	LQEENQY
OrthoDB	EOG7BKCT2
PhylomeDB	P49917
TreeFam	TF312980
BRENDA	6.5.1.1
Reactome	REACT_1022 REACT_9058
SignaLink	P49917
ChiTaRS	LIG4
EvolutionaryTrace	P49917
GeneWiki	LIG4
GenomeRNAi	3981
NextBio	15604
PRO	PR:P49917
Proteomes	UP000005640
Bgee	P49917
CleanEx	HS_LIG4
ExpressionAtlas	P49917
Genevestigator	P49917
GO	GO:0000793 GO:0005737 GO:0032807 GO:0005958 GO:0005925 GO:0070419 GO:0005654 GO:0005634 GO:0005886 GO:0005524 GO:0003677 GO:0003910 GO:0003909 GO:0016874 GO:0046872 GO:0008022 GO:0007049 GO:0051301 GO:0008283 GO:0007417 GO:0051276 GO:0071897 GO:0006266 GO:0051102 GO:0051103 GO:0006281 GO:0006302 GO:0006303 GO:0075713 GO:0001701 GO:0045190 GO:0006273 GO:0043524 GO:0051402 GO:0006297 GO:0048146 GO:0050769 GO:0002328 GO:0010332 GO:0010165 GO:0000012 GO:0035019 GO:0033077 GO:0033153 GO:0033151 GO:0016032
Gene3D	1.10.3260.10 2.40.50.140 3.40.50.10190
InterPro	IPR001357 IPR000977 IPR012309 IPR012310 IPR016059 IPR012308 IPR021536 IPR029710 IPR012340
PANTHER	PTHR10459:SF7
Pfam	PF00533 PF04679 PF01068 PF04675 PF11411
SMART	SM00292
SUPFAM	SSF117018 SSF50249 SSF52113
TIGRFAMs	TIGR00574
PROSITE	PS50172 PS00697 PS00333 PS50160

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0006260	DNA replication	PMID:7760816^[1]	ECO:0000314			P		Figure 8 shows DNA ligase 4 added to different human cells. It appears to be more active in cell that replicate frequently.	complete CACAO 6346
involved_in	GO:0071479	cellular response to ionizing radiation	PMID:29463814^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:G5EGA3	P		Seeded From UniProt	complete
	GO:0003910	DNA ligase (ATP) activity	PMID:22192310^[3]	ECO:0000314			F		Fig. 4.	complete CACAO 9374
part_of	GO:0070419	nonhomologous end joining complex	PMID:25941166^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
	GO:0003909	DNA ligase activity	PMID:23523427^[5]	ECO:0000314			F		The SDS-PAGE gel of fractions eluted from a heparin column and from a Superdex column led to protein bands forming next to the same molecular weight markers.	complete CACAO 9406
part_of	GO:0000784	nuclear chromosome, telomeric region	PMID:23275564^[6]	ECO:0000305	curator inference used in manual assertion	GO:0006303	C		Seeded From UniProt	complete
involved_in	GO:0006303	double-strand break repair via nonhomologous end joining	PMID:23275564^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q15554	P	occurs_at:(GO:0000781)	Seeded From UniProt	complete
involved_in	GO:0006303	double-strand break repair via nonhomologous end joining	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BTF7	P	occurs_at:(GO:0000781)	Seeded From UniProt	complete
involved_in	GO:2001252	positive regulation of chromosome organization	PMID:23275564^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097680	double-strand break repair via classical nonhomologous end joining	PMID:24837021^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003910	DNA ligase (ATP) activity	PMID:22192310^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006302	double-strand break repair	PMID:19589734^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0070419	nonhomologous end joining complex	PMID:20383123^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051402	neuron apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BTF7	P		Seeded From UniProt	complete
involved_in	GO:0051276	chromosome organization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BTF7	P		Seeded From UniProt	complete
involved_in	GO:0051103	DNA ligation involved in DNA repair	PMID:12517771^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051103	DNA ligation involved in DNA repair	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BTF7	P		Seeded From UniProt	complete
involved_in	GO:0051102	DNA ligation involved in DNA recombination	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BTF7	P		Seeded From UniProt	complete
involved_in	GO:0050769	positive regulation of neurogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BTF7	P		Seeded From UniProt	complete
involved_in	GO:0048146	positive regulation of fibroblast proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BTF7	P		Seeded From UniProt	complete
involved_in	GO:0045190	isotype switching	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BTF7	P		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BTF7	P		Seeded From UniProt	complete
involved_in	GO:0035019	somatic stem cell population maintenance	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BTF7	P		Seeded From UniProt	complete
involved_in	GO:0033153	T cell receptor V(D)J recombination	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BTF7	P		Seeded From UniProt	complete
involved_in	GO:0033151	V(D)J recombination	PMID:9809069^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033077	T cell differentiation in thymus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BTF7	P		Seeded From UniProt	complete
part_of	GO:0032807	DNA ligase IV complex	PMID:9809069^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0016874	ligase activity	PMID:9242410^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0010332	response to gamma radiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BTF7	P		Seeded From UniProt	complete
involved_in	GO:0010165	response to X-ray	PMID:9809069^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BTF7	P		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	PMID:12589063^[13]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O95347	F		Seeded From UniProt	complete
involved_in	GO:0007417	central nervous system development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BTF7	P		Seeded From UniProt	complete
involved_in	GO:0006303	double-strand break repair via nonhomologous end joining	PMID:9809069^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006303	double-strand break repair via nonhomologous end joining	PMID:12517771^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006302	double-strand break repair	PMID:9242410^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006302	double-strand break repair	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BTF7	P		Seeded From UniProt	complete
involved_in	GO:0006297	nucleotide-excision repair, DNA gap filling	PMID:12517771^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006266	DNA ligation	PMID:12517771^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BTF7	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12589063^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:8798671^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003910	DNA ligase (ATP) activity	PMID:8798671^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003909	DNA ligase activity	PMID:12517771^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:8798671^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0002328	pro-B cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BTF7	P		Seeded From UniProt	complete
involved_in	GO:0001701	in utero embryonic development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BTF7	P		Seeded From UniProt	complete
part_of	GO:0000793	condensed chromosome	PMID:12589063^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000012	single strand break repair	PMID:8798671^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033152	immunoglobulin V(D)J recombination	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1335098 PANTHER:PTN000048705	P		Seeded From UniProt	complete
part_of	GO:0032807	DNA ligase IV complex	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000048698 PomBase:SPCC1183.05c SGD:S000005531 UniProtKB:P49917	C		Seeded From UniProt	complete
involved_in	GO:0006303	double-strand break repair via nonhomologous end joining	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0030506 MGI:MGI:1335098 PANTHER:PTN000048698 SGD:S000005531 TAIR:locus:2175544 UniProtKB:P49917	P		Seeded From UniProt	complete
involved_in	GO:0006297	nucleotide-excision repair, DNA gap filling	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000048698 UniProtKB:P49917	P		Seeded From UniProt	complete
part_of	GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1335098 PANTHER:PTN000825456 UniProtKB:P49917	C		Seeded From UniProt	complete
part_of	GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex	PMID:15194694^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0036464	cytoplasmic ribonucleoprotein granule	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0071285	cellular response to lithium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A0U6 ensembl:ENSRNOP00000019615	P		Seeded From UniProt	complete
involved_in	GO:0006266	DNA ligation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A0U6 ensembl:ENSRNOP00000019615	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A0U6 ensembl:ENSRNOP00000019615	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A0U6 ensembl:ENSRNOP00000019615	F		Seeded From UniProt	complete
enables	GO:0003910	DNA ligase (ATP) activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A0U6 ensembl:ENSRNOP00000019615	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A0U6 ensembl:ENSRNOP00000019615	F		Seeded From UniProt	complete
involved_in	GO:0051402	neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BTF7 ensembl:ENSMUSP00000093130	P		Seeded From UniProt	complete
involved_in	GO:0051276	chromosome organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BTF7 ensembl:ENSMUSP00000093130	P		Seeded From UniProt	complete
involved_in	GO:0051103	DNA ligation involved in DNA repair	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BTF7 ensembl:ENSMUSP00000093130	P		Seeded From UniProt	complete
involved_in	GO:0051102	DNA ligation involved in DNA recombination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BTF7 ensembl:ENSMUSP00000093130	P		Seeded From UniProt	complete
involved_in	GO:0050769	positive regulation of neurogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BTF7 ensembl:ENSMUSP00000093130	P		Seeded From UniProt	complete
involved_in	GO:0048146	positive regulation of fibroblast proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BTF7 ensembl:ENSMUSP00000093130	P		Seeded From UniProt	complete
involved_in	GO:0045190	isotype switching	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BTF7 ensembl:ENSMUSP00000093130	P		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BTF7 ensembl:ENSMUSP00000093130	P		Seeded From UniProt	complete
involved_in	GO:0035019	somatic stem cell population maintenance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BTF7 ensembl:ENSMUSP00000093130	P		Seeded From UniProt	complete
involved_in	GO:0033153	T cell receptor V(D)J recombination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BTF7 ensembl:ENSMUSP00000093130	P		Seeded From UniProt	complete
involved_in	GO:0033152	immunoglobulin V(D)J recombination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BTF7 ensembl:ENSMUSP00000093130	P		Seeded From UniProt	complete
involved_in	GO:0033151	V(D)J recombination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BTF7 ensembl:ENSMUSP00000093130	P		Seeded From UniProt	complete
involved_in	GO:0033077	T cell differentiation in thymus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BTF7 ensembl:ENSMUSP00000093130	P		Seeded From UniProt	complete
involved_in	GO:0010332	response to gamma radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BTF7 ensembl:ENSMUSP00000093130	P		Seeded From UniProt	complete
involved_in	GO:0010212	response to ionizing radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BTF7 ensembl:ENSMUSP00000093130	P		Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BTF7 ensembl:ENSMUSP00000093130	P		Seeded From UniProt	complete
involved_in	GO:0007417	central nervous system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BTF7 ensembl:ENSMUSP00000093130	P		Seeded From UniProt	complete
involved_in	GO:0006303	double-strand break repair via nonhomologous end joining	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BTF7 ensembl:ENSMUSP00000093130	P		Seeded From UniProt	complete
involved_in	GO:0006302	double-strand break repair	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BTF7 ensembl:ENSMUSP00000093130	P		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BTF7 ensembl:ENSMUSP00000093130	P		Seeded From UniProt	complete
involved_in	GO:0006266	DNA ligation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BTF7 ensembl:ENSMUSP00000093130	P		Seeded From UniProt	complete
part_of	GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BTF7 ensembl:ENSMUSP00000093130	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BTF7 ensembl:ENSMUSP00000093130	F		Seeded From UniProt	complete
enables	GO:0003910	DNA ligase (ATP) activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BTF7 ensembl:ENSMUSP00000093130	F		Seeded From UniProt	complete
involved_in	GO:0002328	pro-B cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BTF7 ensembl:ENSMUSP00000093130	P		Seeded From UniProt	complete
involved_in	GO:0001701	in utero embryonic development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BTF7 ensembl:ENSMUSP00000093130	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012308 InterPro:IPR029710 InterPro:IPR036599	F		Seeded From UniProt	complete
enables	GO:0003909	DNA ligase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016059	F		Seeded From UniProt	complete
enables	GO:0003910	DNA ligase (ATP) activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000977 InterPro:IPR012308 InterPro:IPR012309 InterPro:IPR012310 InterPro:IPR021536 InterPro:IPR029710 InterPro:IPR036599	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000977 InterPro:IPR012310 InterPro:IPR029710	F		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000977 InterPro:IPR012308 InterPro:IPR012309 InterPro:IPR012310 InterPro:IPR029710 InterPro:IPR036599	P		Seeded From UniProt	complete
involved_in	GO:0006310	DNA recombination	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000977 InterPro:IPR012308 InterPro:IPR012309 InterPro:IPR012310 InterPro:IPR036599	P		Seeded From UniProt	complete
involved_in	GO:0051103	DNA ligation involved in DNA repair	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016059 InterPro:IPR029710	P		Seeded From UniProt	complete
involved_in	GO:0071897	DNA biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000977	P		Seeded From UniProt	complete
enables	GO:0003910	DNA ligase (ATP) activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:6.5.1.1	F		Seeded From UniProt	complete
involved_in	GO:0075713	establishment of integrated proviral latency	Reactome:R-HSA-162592	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006303	double-strand break repair via nonhomologous end joining	Reactome:R-HSA-5693571	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-5693604 Reactome:R-HSA-5693574 Reactome:R-HSA-5687360 Reactome:R-HSA-175258 Reactome:R-HSA-175177	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003909	DNA ligase activity	Reactome:R-HSA-5693604 Reactome:R-HSA-175258 Reactome:R-GGA-353298	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0006310	DNA recombination	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0233	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0051301	cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0132	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0006260	DNA replication	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0235	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P		Seeded From UniProt	complete
enables	GO:0016874	ligase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0436	F		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Wei, YF et al. (1995) Molecular cloning and expression of human cDNAs encoding a novel DNA ligase IV and DNA ligase III, an enzyme active in DNA repair and recombination. Mol. Cell. Biol. 15 3206-16 PubMed GONUTS page
↑ Hong, Y et al. (2018) LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during late mitosis. Nat Commun 9 728 PubMed GONUTS page
↑ ^3.0 ^3.1 Tseng, HM et al. (2012) A high-throughput scintillation proximity-based assay for human DNA ligase IV. Assay Drug Dev Technol 10 235-49 PubMed GONUTS page
↑ Craxton, A et al. (2015) XLS (c9orf142) is a new component of mammalian DNA double-stranded break repair. Cell Death Differ. 22 890-7 PubMed GONUTS page
↑ Ochi, T et al. (2013) Structure of the catalytic region of DNA ligase IV in complex with an Artemis fragment sheds light on double-strand break repair. Structure 21 672-9 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Oh, S et al. (2013) Human LIGIV is synthetically lethal with the loss of Rad54B-dependent recombination and is required for certain chromosome fusion events induced by telomere dysfunction. Nucleic Acids Res. 41 1734-49 PubMed GONUTS page
↑ Oh, S et al. (2014) DNA ligase III and DNA ligase IV carry out genetically distinct forms of end joining in human somatic cells. DNA Repair (Amst.) 21 97-110 PubMed GONUTS page
↑ Chen, X et al. (2009) Distinct kinetics of human DNA ligases I, IIIalpha, IIIbeta, and IV reveal direct DNA sensing ability and differential physiological functions in DNA repair. DNA Repair (Amst.) 8 961-8 PubMed GONUTS page
↑ Roberts, SA et al. (2010) Ku is a 5'-dRP/AP lyase that excises nucleotide damage near broken ends. Nature 464 1214-7 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 Lee, JW et al. (2003) Requirement for XRCC4 and DNA ligase IV in alignment-based gap filling for nonhomologous DNA end joining in vitro. Cancer Res. 63 22-4 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Grawunder, U et al. (1998) DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes. Mol. Cell 2 477-84 PubMed GONUTS page
↑ ^12.0 ^12.1 Grawunder, U et al. (1997) Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells. Nature 388 492-5 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Przewloka, MR et al. (2003) In vitro and in vivo interactions of DNA ligase IV with a subunit of the condensin complex. Mol. Biol. Cell 14 685-97 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 Robins, P & Lindahl, T (1996) DNA ligase IV from HeLa cell nuclei. J. Biol. Chem. 271 24257-61 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Wang, YG et al. (2004) Phosphorylation and regulation of DNA ligase IV stability by DNA-dependent protein kinase. J. Biol. Chem. 279 37282-90 PubMed GONUTS page

[PMID:7760816-1] Wei, YF et al. (1995) Molecular cloning and expression of human cDNAs encoding a novel DNA ligase IV and DNA ligase III, an enzyme active in DNA repair and recombination. Mol. Cell. Biol. 15 3206-16 PubMed GONUTS page

[PMID:29463814-2] Hong, Y et al. (2018) LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during late mitosis. Nat Commun 9 728 PubMed GONUTS page

[PMID:22192310-3] 3.0 ^3.1 Tseng, HM et al. (2012) A high-throughput scintillation proximity-based assay for human DNA ligase IV. Assay Drug Dev Technol 10 235-49 PubMed GONUTS page

[PMID:25941166-4] Craxton, A et al. (2015) XLS (c9orf142) is a new component of mammalian DNA double-stranded break repair. Cell Death Differ. 22 890-7 PubMed GONUTS page

[PMID:23523427-5] Ochi, T et al. (2013) Structure of the catalytic region of DNA ligase IV in complex with an Artemis fragment sheds light on double-strand break repair. Structure 21 672-9 PubMed GONUTS page

[PMID:23275564-6] 6.0 ^6.1 ^6.2 Oh, S et al. (2013) Human LIGIV is synthetically lethal with the loss of Rad54B-dependent recombination and is required for certain chromosome fusion events induced by telomere dysfunction. Nucleic Acids Res. 41 1734-49 PubMed GONUTS page

[PMID:24837021-7] Oh, S et al. (2014) DNA ligase III and DNA ligase IV carry out genetically distinct forms of end joining in human somatic cells. DNA Repair (Amst.) 21 97-110 PubMed GONUTS page

[PMID:19589734-8] Chen, X et al. (2009) Distinct kinetics of human DNA ligases I, IIIalpha, IIIbeta, and IV reveal direct DNA sensing ability and differential physiological functions in DNA repair. DNA Repair (Amst.) 8 961-8 PubMed GONUTS page

[PMID:20383123-9] Roberts, SA et al. (2010) Ku is a 5'-dRP/AP lyase that excises nucleotide damage near broken ends. Nature 464 1214-7 PubMed GONUTS page

[PMID:12517771-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 Lee, JW et al. (2003) Requirement for XRCC4 and DNA ligase IV in alignment-based gap filling for nonhomologous DNA end joining in vitro. Cancer Res. 63 22-4 PubMed GONUTS page

[PMID:9809069-11] 11.0 ^11.1 ^11.2 ^11.3 Grawunder, U et al. (1998) DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes. Mol. Cell 2 477-84 PubMed GONUTS page

[PMID:9242410-12] 12.0 ^12.1 Grawunder, U et al. (1997) Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells. Nature 388 492-5 PubMed GONUTS page

[PMID:12589063-13] 13.0 ^13.1 ^13.2 Przewloka, MR et al. (2003) In vitro and in vivo interactions of DNA ligase IV with a subunit of the condensin complex. Mol. Biol. Cell 14 685-97 PubMed GONUTS page

[PMID:8798671-14] 14.0 ^14.1 ^14.2 ^14.3 Robins, P & Lindahl, T (1996) DNA ligase IV from HeLa cell nuclei. J. Biol. Chem. 271 24257-61 PubMed GONUTS page

[PMID:21873635-15] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:15194694-16] Wang, YG et al. (2004) Phosphorylation and regulation of DNA ligase IV stability by DNA-dependent protein kinase. J. Biol. Chem. 279 37282-90 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

HUMAN:DNLI4

Contents

Annotations

Notes

References

a

c

d

e

h

i

l

m

n

o

p

r

s

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools