HUMAN:DNLI3

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	LIG3
Protein Name(s)	DNA ligase 3 DNA ligase III Polydeoxyribonucleotide synthase [ATP] 3
External Links
UniProt	P49916
EMBL	X84740 U40671 AF491645 AC004223 AC022903 CH471147 BC068005
CCDS	CCDS11284.2 CCDS11285.2
PIR	I37292
RefSeq	NP_002302.2 NP_039269.2 XP_005258028.1
UniGene	Hs.100299
PDB	1IMO 1IN1 1UW0 3L2P 3PC7 3PC8 3QVG
PDBsum	1IMO 1IN1 1UW0 3L2P 3PC7 3PC8 3QVG
ProteinModelPortal	P49916
SMR	P49916
BioGrid	110168
IntAct	P49916
MINT	MINT-4531178
STRING	9606.ENSP00000367787
DrugBank	DB00290
PhosphoSite	P49916
DMDM	251757259
MaxQB	P49916
PaxDb	P49916
PRIDE	P49916
DNASU	3980
Ensembl	ENST00000262327 ENST00000378526
GeneID	3980
KEGG	hsa:3980
UCSC	uc002hik.2
CTD	3980
GeneCards	GC17P033307
HGNC	HGNC:6600
HPA	HPA006723
MIM	600940
neXtProt	NX_P49916
PharmGKB	PA30374
eggNOG	COG1793
GeneTree	ENSGT00750000117695
HOGENOM	HOG000007653
HOVERGEN	HBG005515
InParanoid	P49916
KO	K10776
OMA	LFSEMKH
OrthoDB	EOG7BKCT2
PhylomeDB	P49916
TreeFam	TF316220
BRENDA	6.5.1.1
Reactome	REACT_933
ChiTaRS	LIG3
EvolutionaryTrace	P49916
GeneWiki	LIG3
GenomeRNAi	3980
NextBio	15598
PRO	PR:P49916
Proteomes	UP000005640
Bgee	P49916
CleanEx	HS_LIG3
ExpressionAtlas	P49916
Genevestigator	P49916
GO	GO:0005694 GO:0005654 GO:0005634 GO:0000795 GO:0005524 GO:0003677 GO:0003910 GO:0003909 GO:0008270 GO:0006284 GO:0006288 GO:0071897 GO:0006281 GO:0006303 GO:0006273 GO:0043504 GO:0045910 GO:0006289 GO:0007131 GO:0007283
Gene3D	1.10.3260.10 2.40.50.140 3.30.1740.10 3.40.50.10190
InterPro	IPR001357 IPR000977 IPR012309 IPR012310 IPR016059 IPR012308 IPR012340 IPR001510
Pfam	PF04679 PF01068 PF04675 PF00645
SMART	SM00292
SUPFAM	SSF117018 SSF50249 SSF52113
TIGRFAMs	TIGR00574
PROSITE	PS50172 PS00697 PS00333 PS50160 PS00347 PS50064

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0090298	negative regulation of mitochondrial DNA replication	PMID:21878356^[1]	ECO:0000315			P		Fig. 1 B,C. DNA ligase III levels in cell lysates prepared from cells treated with scramble (Sc) dsRNA or DNA ligase III-specific (LIII) dsRNA.	complete CACAO 9375
involved_in	GO:0090298	negative regulation of mitochondrial DNA replication	PMID:21878356^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006302	double-strand break repair	PMID:19589734^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006288	base-excision repair, DNA ligation	PMID:19589734^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
NOT\|involved_in	GO:0033151	V(D)J recombination	PMID:9809069^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003909	DNA ligase activity	PMID:9809069^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0097681	double-strand break repair via alternative nonhomologous end joining	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109152 PANTHER:PTN000048765 UniProtKB:P49916 ZFIN:ZDB-GENE-030131-8453	P		Seeded From UniProt	complete
involved_in	GO:0043504	mitochondrial DNA repair	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109152 PANTHER:PTN000048765 UniProtKB:P49916	P		Seeded From UniProt	complete
involved_in	GO:0006288	base-excision repair, DNA ligation	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000048765 RGD:1309875 UniProtKB:P49916	P		Seeded From UniProt	complete
involved_in	GO:0006273	lagging strand elongation	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000048695 SGD:S000002323	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000048763 PomBase:SPAC20G8.01 SGD:S000002323 TAIR:locus:2199953 UniProtKB:P49916	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0262619 PANTHER:PTN000048695	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101789 PANTHER:PTN000048763 PomBase:SPAC20G8.01 RGD:1309875 RGD:621424 SGD:S000002323 TAIR:locus:2199953 UniProtKB:P49916	C		Seeded From UniProt	complete
enables	GO:0003910	DNA ligase (ATP) activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0262619 PANTHER:PTN000048695 PomBase:SPAC20G8.01 SGD:S000002323 UniProtKB:P49916 UniProtKB:P9WNV5 UniProtKB:Q8IES4	F		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006288	base-excision repair, DNA ligation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5U2M4 ensembl:ENSRNOP00000052836	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5U2M4 ensembl:ENSRNOP00000052836	C		Seeded From UniProt	complete
enables	GO:0003909	DNA ligase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5U2M4 ensembl:ENSRNOP00000052836	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001510 InterPro:IPR012308 InterPro:IPR036599 InterPro:IPR036957	F		Seeded From UniProt	complete
enables	GO:0003909	DNA ligase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016059	F		Seeded From UniProt	complete
enables	GO:0003910	DNA ligase (ATP) activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000977 InterPro:IPR012308 InterPro:IPR012309 InterPro:IPR012310 InterPro:IPR036599	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000977 InterPro:IPR012310	F		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000977 InterPro:IPR012308 InterPro:IPR012309 InterPro:IPR012310 InterPro:IPR036599	P		Seeded From UniProt	complete
involved_in	GO:0006310	DNA recombination	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000977 InterPro:IPR012308 InterPro:IPR012309 InterPro:IPR012310 InterPro:IPR036599	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001510 InterPro:IPR036957	F		Seeded From UniProt	complete
involved_in	GO:0051103	DNA ligation involved in DNA repair	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016059	P		Seeded From UniProt	complete
involved_in	GO:0071897	DNA biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000977	P		Seeded From UniProt	complete
enables	GO:0003910	DNA ligase (ATP) activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:6.5.1.1	F		Seeded From UniProt	complete
involved_in	GO:0043504	mitochondrial DNA repair	PMID:21390132^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007005	mitochondrion organization	PMID:24837021^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:24837021^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003909	DNA ligase activity	PMID:24674627^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(GO:0005739)	Seeded From UniProt	complete
involved_in	GO:0006288	base-excision repair, DNA ligation	PMID:24674627^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(GO:0005739)	Seeded From UniProt	complete
enables	GO:0003910	DNA ligase (ATP) activity	PMID:10207110^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_in:(GO:0005739)	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:10207110^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0097681	double-strand break repair via alternative nonhomologous end joining	PMID:24837021^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P13010	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:24837021^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070421	DNA ligase III-XRCC1 complex	PMID:8532526^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:10207110^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003910	DNA ligase (ATP) activity	PMID:7565692^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006266	DNA ligation	PMID:7565692^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006297	nucleotide-excision repair, DNA gap filling	Reactome:R-HSA-5696397	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006288	base-excision repair, DNA ligation	Reactome:R-HSA-73931	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006283	transcription-coupled nucleotide-excision repair	Reactome:R-HSA-6781827	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-73932 Reactome:R-HSA-73931 Reactome:R-HSA-6782227 Reactome:R-HSA-5690997 Reactome:R-HSA-5687675 Reactome:R-HSA-5687673 Reactome:R-HSA-5649734 Reactome:R-HSA-5649726 Reactome:R-HSA-5649724 Reactome:R-HSA-5649723 Reactome:R-HSA-5649705 Reactome:R-HSA-110380 Reactome:R-HSA-110376	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003909	DNA ligase activity	Reactome:R-HSA-73931 Reactome:R-HSA-5687675 Reactome:R-HSA-5649734	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000724	double-strand break repair via homologous recombination	Reactome:R-HSA-5693538	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0016874	ligase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0436	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0051301	cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0132	P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496 UniProtKB-SubCell:SL-0173	C		Seeded From UniProt	complete
involved_in	GO:0006310	DNA recombination	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0233	P		Seeded From UniProt	complete
involved_in	GO:0006260	DNA replication	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0235	P		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Ruhanen, H et al. (2011) Involvement of DNA ligase III and ribonuclease H1 in mitochondrial DNA replication in cultured human cells. Biochim. Biophys. Acta 1813 2000-7 PubMed GONUTS page
↑ ^2.0 ^2.1 Chen, X et al. (2009) Distinct kinetics of human DNA ligases I, IIIalpha, IIIbeta, and IV reveal direct DNA sensing ability and differential physiological functions in DNA repair. DNA Repair (Amst.) 8 961-8 PubMed GONUTS page
↑ ^3.0 ^3.1 Grawunder, U et al. (1998) DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes. Mol. Cell 2 477-84 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Simsek, D et al. (2011) Crucial role for DNA ligase III in mitochondria but not in Xrcc1-dependent repair. Nature 471 245-8 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Oh, S et al. (2014) DNA ligase III and DNA ligase IV carry out genetically distinct forms of end joining in human somatic cells. DNA Repair (Amst.) 21 97-110 PubMed GONUTS page
↑ ^7.0 ^7.1 Akbari, M et al. (2014) Overexpression of DNA ligase III in mitochondria protects cells against oxidative stress and improves mitochondrial DNA base excision repair. DNA Repair (Amst.) 16 44-53 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Lakshmipathy, U & Campbell, C (1999) The human DNA ligase III gene encodes nuclear and mitochondrial proteins. Mol. Cell. Biol. 19 3869-76 PubMed GONUTS page
↑ Caldecott, KW et al. (1995) Characterization of the XRCC1-DNA ligase III complex in vitro and its absence from mutant hamster cells. Nucleic Acids Res. 23 4836-43 PubMed GONUTS page
↑ ^10.0 ^10.1 Chen, J et al. (1995) Mammalian DNA ligase III: molecular cloning, chromosomal localization, and expression in spermatocytes undergoing meiotic recombination. Mol. Cell. Biol. 15 5412-22 PubMed GONUTS page

[PMID:21878356-1] 1.0 ^1.1 Ruhanen, H et al. (2011) Involvement of DNA ligase III and ribonuclease H1 in mitochondrial DNA replication in cultured human cells. Biochim. Biophys. Acta 1813 2000-7 PubMed GONUTS page

[PMID:19589734-2] 2.0 ^2.1 Chen, X et al. (2009) Distinct kinetics of human DNA ligases I, IIIalpha, IIIbeta, and IV reveal direct DNA sensing ability and differential physiological functions in DNA repair. DNA Repair (Amst.) 8 961-8 PubMed GONUTS page

[PMID:9809069-3] 3.0 ^3.1 Grawunder, U et al. (1998) DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes. Mol. Cell 2 477-84 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21390132-5] Simsek, D et al. (2011) Crucial role for DNA ligase III in mitochondria but not in Xrcc1-dependent repair. Nature 471 245-8 PubMed GONUTS page

[PMID:24837021-6] 6.0 ^6.1 ^6.2 ^6.3 Oh, S et al. (2014) DNA ligase III and DNA ligase IV carry out genetically distinct forms of end joining in human somatic cells. DNA Repair (Amst.) 21 97-110 PubMed GONUTS page

[PMID:24674627-7] 7.0 ^7.1 Akbari, M et al. (2014) Overexpression of DNA ligase III in mitochondria protects cells against oxidative stress and improves mitochondrial DNA base excision repair. DNA Repair (Amst.) 16 44-53 PubMed GONUTS page

[PMID:10207110-8] 8.0 ^8.1 ^8.2 Lakshmipathy, U & Campbell, C (1999) The human DNA ligase III gene encodes nuclear and mitochondrial proteins. Mol. Cell. Biol. 19 3869-76 PubMed GONUTS page

[PMID:8532526-9] Caldecott, KW et al. (1995) Characterization of the XRCC1-DNA ligase III complex in vitro and its absence from mutant hamster cells. Nucleic Acids Res. 23 4836-43 PubMed GONUTS page

[PMID:7565692-10] 10.0 ^10.1 Chen, J et al. (1995) Mammalian DNA ligase III: molecular cloning, chromosomal localization, and expression in spermatocytes undergoing meiotic recombination. Mol. Cell. Biol. 15 5412-22 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

HUMAN:DNLI3

Contents

Annotations

Notes

References

a

c

d

e

h

l

m

n

o

p

t

v

z

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools