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HUMAN:DNJC2

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) DNAJC2 (synonyms: MPHOSPH11, MPP11, ZRF1)
Protein Name(s) DnaJ homolog subfamily C member 2

M-phase phosphoprotein 11 Zuotin-related factor 1 DnaJ homolog subfamily C member 2, N-terminally processed

External Links
UniProt Q99543
EMBL X98260
AC004668
BC000859
BC139751
CCDS CCDS43628.1
CCDS47679.1
RefSeq NP_001123359.1
NP_055192.1
UniGene Hs.558476
PDB 2M2E
PDBsum 2M2E
ProteinModelPortal Q99543
SMR Q99543
BioGrid 117946
DIP DIP-60462N
IntAct Q99543
STRING 9606.ENSP00000368565
iPTMnet Q99543
PhosphoSitePlus Q99543
BioMuta DNAJC2
DMDM 296439472
EPD Q99543
MaxQB Q99543
PaxDb Q99543
PeptideAtlas Q99543
PRIDE Q99543
DNASU 27000
Ensembl ENST00000249270
ENST00000379263
GeneID 27000
KEGG hsa:27000
UCSC uc003vbo.4
CTD 27000
DisGeNET 27000
GeneCards DNAJC2
HGNC HGNC:13192
HPA HPA020454
MIM 605502
neXtProt NX_Q99543
OpenTargets ENSG00000105821
PharmGKB PA162383835
eggNOG KOG0724
COG5269
GeneTree ENSGT00530000063419
HOGENOM HOG000006900
HOVERGEN HBG008782
InParanoid Q99543
KO K09522
OMA LTSCTKE
OrthoDB EOG091G04S8
PhylomeDB Q99543
TreeFam TF105834
Reactome [www.reactome.org/content/detail/R-HSA-3371453 R-HSA-3371453]
GeneWiki ZRF1
GenomeRNAi 27000
PRO PR:Q99543
Proteomes UP000005640
Bgee ENSG00000105821
CleanEx HS_DNAJC2
ExpressionAtlas Q99543
Genevisible Q99543
GO GO:0005737
GO:0005829
GO:0031965
GO:0005654
GO:0005634
GO:0001671
GO:0003682
GO:0003677
GO:0042393
GO:0030544
GO:0003723
GO:0043130
GO:0051083
GO:0016569
GO:0006260
GO:2000279
GO:0045893
GO:1900034
GO:0006351
CDD cd06257
Gene3D 1.10.10.60
1.10.287.110
InterPro IPR001623
IPR018253
IPR009057
IPR032003
IPR001005
IPR017884
Pfam PF00226
PF00249
PF16717
SMART SM00271
SM00717
SUPFAM SSF46565
SSF46689
PROSITE PS00636
PS50076
PS51293

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049[1]

ECO:0000255

match to sequence model evidence used in manual assertion

InterPro:IPR001005
InterPro:IPR009057

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

GO_REF:0000113

ECO:0005556

multiple sequence alignment evidence used in manual assertion

UniProtKB:P06876

F

Seeded From UniProt

complete

GO:0005730

nucleolus

PMID:28416769[2]

ECO:0000314

C

Paper’s Protein Name: H2A-ubiquitin binding protein ZRF1. UniProt’s Protein Name: DnaJ homolog subfamily C member 2 or alternatively Zuotin-related factor 1. Organism: Homo sapiens. Notes: Figure 5A is used. While “investigating the nuclear distribution of ZRF1 after pre-extraction of U2OS cells, [the researchers] detected ZRF1 in the nucleolus as seen by simultaneous Nucleophosmin (NPM) staining.” This can indeed be seen in the cell visualization for Figure 5A. This protein was present even prior to UV irradiation, so the relationship between the protein and nucleolus is not transient, and the Colocalizes With qualifier is not necessary. U2OS cells are human cells, so the protein is human as well.

complete
CACAO 12680

part_of

GO:0005634

nucleus

PMID:8885239[3]

ECO:0000314

direct assay evidence used in manual assertion

C

exists_during:(GO:0000087)

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:8885239[3]

ECO:0000314

direct assay evidence used in manual assertion

C

exists_during:(GO:0000087)

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:21179169[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22658674[5]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0061649

ubiquitin modification-dependent histone binding

PMID:21179169[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0042393

histone binding

PMID:21179169[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0030544

Hsp70 protein binding

PMID:16002468[6]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q0VDF9

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:16002468[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21179169[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21179169[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003682

chromatin binding

PMID:21179169[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0031965

nuclear membrane

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006357

regulation of transcription by RNA polymerase II

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0000981

P

Seeded From UniProt

complete

involved_in

GO:0006357

regulation of transcription by RNA polymerase II

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0000981

P

Seeded From UniProt

complete

involved_in

GO:2000279

negative regulation of DNA biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P54103
ensembl:ENSMUSP00000030771

P

Seeded From UniProt

complete

involved_in

GO:0006260

DNA replication

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P54103
ensembl:ENSMUSP00000030771

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR009057

F

Seeded From UniProt

complete

involved_in

GO:0051083

'de novo' cotranslational protein folding

PMID:16002468[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1900034

regulation of cellular response to heat

Reactome:R-HSA-3371453

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-5251959

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-5251955

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006325

chromatin organization

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0156

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0091

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
  2. ↑ Chitale, S & Richly, H (2017) Nuclear organization of nucleotide excision repair is mediated by RING1B dependent H2A-ubiquitylation. Oncotarget PubMed GONUTS page
  3. ↑ 3.0 3.1 Matsumoto-Taniura, N et al. (1996) Identification of novel M phase phosphoproteins by expression cloning. Mol. Biol. Cell 7 1455-69 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Richly, H et al. (2010) Transcriptional activation of polycomb-repressed genes by ZRF1. Nature 468 1124-8 PubMed GONUTS page
  5. ↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 Otto, H et al. (2005) The chaperones MPP11 and Hsp70L1 form the mammalian ribosome-associated complex. Proc. Natl. Acad. Sci. U.S.A. 102 10064-9 PubMed GONUTS page
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