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HUMAN:DNAS1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) DNASE1 (synonyms: DNL1, DRNI)
Protein Name(s) Deoxyribonuclease-1

Deoxyribonuclease I DNase I

External Links
UniProt P24855
EMBL M55983
D83195
AJ298844
AB188151
AB188152
AK300914
AC005203
AC006111
CH471112
BC029437
CCDS CCDS10507.1
PIR A38417
RefSeq NP_005214.2
XP_006720915.1
XP_006720916.1
UniGene Hs.629638
Hs.733045
PDB 4AWN
PDBsum 4AWN
ProteinModelPortal P24855
SMR P24855
BioGrid 108112
MINT MINT-4722539
STRING 9606.ENSP00000246949
PhosphoSite P24855
DMDM 118919
PaxDb P24855
PRIDE P24855
DNASU 1773
Ensembl ENST00000246949
ENST00000407479
GeneID 1773
KEGG hsa:1773
UCSC uc002cvr.3
CTD 1773
GeneCards GC16P003663
HGNC HGNC:2956
HPA HPA010703
MIM 125505
152700
neXtProt NX_P24855
Orphanet 536
PharmGKB PA27427
eggNOG NOG46375
GeneTree ENSGT00390000013146
HOGENOM HOG000059570
HOVERGEN HBG051368
InParanoid P24855
KO K11994
OMA TSTHCAY
PhylomeDB P24855
TreeFam TF329541
BRENDA 3.1.21.1
ChiTaRS DNASE1
GeneWiki Deoxyribonuclease_I
GenomeRNAi 1773
NextBio 35475345
PRO PR:P24855
Proteomes UP000005640
Bgee P24855
CleanEx HS_DNASE1
ExpressionAtlas P24855
Genevestigator P24855
GO GO:0005576
GO:0070062
GO:0005635
GO:0004530
GO:0006915
Gene3D 3.60.10.10
InterPro IPR018057
IPR016202
IPR005135
PANTHER PTHR11371
Pfam PF03372
PIRSF PIRSF000988
PRINTS PR00130
SMART SM00476
SUPFAM SSF56219
PROSITE PS00919
PS00918

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0051179

localization

PMID:28185850[1]

ECO:0000316

P

In figure 3, detection of DDB2 or XPC protein together with PCNA was significantly enhanced after DNase I digestion, by more than 4 and 5 times, respectively.

Missing: with/from
CACAO 12768

involved_in

GO:0070948

regulation of neutrophil mediated cytotoxicity

PMID:29191910[2]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P49183

P

Seeded From UniProt

complete

involved_in

GO:0002673

regulation of acute inflammatory response

PMID:29191910[2]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P49183

P

Seeded From UniProt

complete

involved_in

GO:0002283

neutrophil activation involved in immune response

PMID:29191910[2]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P49183

P

Seeded From UniProt

complete

involved_in

GO:0000737

DNA catabolic process, endonucleolytic

PMID:29191910[2]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P49183

P

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:23533145[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006308

DNA catabolic process

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1913955
PANTHER:PTN002260967
UniProtKB:Q9HXA4

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1314633
PANTHER:PTN000889801
RGD:620669
UniProtKB:Q13609

C

Seeded From UniProt

complete

enables

GO:0004536

deoxyribonuclease activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002260967
RGD:2510
UniProtKB:Q9HXA4

F

Seeded From UniProt

complete

enables

GO:0004530

deoxyribonuclease I activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103157
PANTHER:PTN002260967
RGD:2510

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002260967
RGD:620669

F

Seeded From UniProt

complete

involved_in

GO:0000737

DNA catabolic process, endonucleolytic

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103157
MGI:MGI:1314633
PANTHER:PTN000889801

P

Seeded From UniProt

complete

enables

GO:0004536

deoxyribonuclease activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21704
ensembl:ENSRNOP00000009283

F

Seeded From UniProt

complete

enables

GO:0004530

deoxyribonuclease I activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21704
ensembl:ENSRNOP00000009283

F

Seeded From UniProt

complete

involved_in

GO:0070948

regulation of neutrophil mediated cytotoxicity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P49183
ensembl:ENSMUSP00000006136

P

Seeded From UniProt

complete

enables

GO:0004530

deoxyribonuclease I activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P49183
ensembl:ENSMUSP00000006136

F

Seeded From UniProt

complete

involved_in

GO:0002673

regulation of acute inflammatory response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P49183
ensembl:ENSMUSP00000006136

P

Seeded From UniProt

complete

involved_in

GO:0002283

neutrophil activation involved in immune response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P49183
ensembl:ENSMUSP00000006136

P

Seeded From UniProt

complete

involved_in

GO:0000737

DNA catabolic process, endonucleolytic

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P49183
ensembl:ENSMUSP00000006136

P

Seeded From UniProt

complete

enables

GO:0004536

deoxyribonuclease activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016202

F

Seeded From UniProt

complete

involved_in

GO:0006308

DNA catabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016202

P

Seeded From UniProt

complete

enables

GO:0004530

deoxyribonuclease I activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.1.21.1

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

PMID:2349940[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0053

P

Seeded From UniProt

complete

enables

GO:0003779

actin binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0009

F

Seeded From UniProt

complete

enables

GO:0004518

nuclease activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0540

F

Seeded From UniProt

complete

enables

GO:0004519

endonuclease activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0255

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

part_of

GO:0005635

nuclear envelope

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0178

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Dutto, I et al. (2017) An improved method for the detection of nucleotide excision repair factors at local UV DNA damage sites. DNA Repair (Amst.) 51 79-84 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 Jiménez-Alcázar, M et al. (2017) Host DNases prevent vascular occlusion by neutrophil extracellular traps. Science 358 1202-1206 PubMed GONUTS page
  3. ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  5. ↑ Kishi, K et al. (1990) Human serum deoxyribonuclease I (DNase I) polymorphism: pattern similarities among isozymes from serum, urine, kidney, liver, and pancreas. Am. J. Hum. Genet. 47 121-6 PubMed GONUTS page
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