HUMAN:DNA2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	DNA2 (synonyms: DNA2L, KIAA0083)
Protein Name(s)	DNA replication ATP-dependent helicase/nuclease DNA2 hDNA2 DNA replication ATP-dependent helicase-like homolog DNA replication nuclease DNA2 DNA replication ATP-dependent helicase DNA2
External Links
UniProt	P51530
EMBL	D42046 AL136233 AL136233 BC041115 BC053574 BC063664 BC111740 BC028188
CCDS	CCDS44415.2
PIR	T50697
RefSeq	NP_001073918.2
UniGene	Hs.532446
ProteinModelPortal	P51530
SMR	P51530
BioGrid	108103
STRING	9606.ENSP00000382133
PhosphoSite	P51530
MaxQB	P51530
PaxDb	P51530
PRIDE	P51530
Ensembl	ENST00000358410 ENST00000399179 ENST00000399180
GeneID	1763
KEGG	hsa:1763
UCSC	uc031pvh.1
CTD	1763
GeneCards	GC10M070173
HGNC	HGNC:2939
HPA	HPA037487
MIM	601810 615156 615807
neXtProt	NX_P51530
Orphanet	352470
eggNOG	COG1112
GeneTree	ENSGT00770000120532
HOGENOM	HOG000168456
HOVERGEN	HBG081456
InParanoid	P51530
KO	K10742
PhylomeDB	P51530
Reactome	REACT_70 REACT_7999
ChiTaRS	DNA2
GeneWiki	DNA2L
GenomeRNAi	1763
NextBio	7187
PRO	PR:P51530
Proteomes	UP000005640
Bgee	P51530
CleanEx	HS_DNA2
ExpressionAtlas	P51530
Genevestigator	P51530
GO	GO:0042645 GO:0005654 GO:0005634 GO:0051539 GO:0043139 GO:0017108 GO:0005524 GO:0016887 GO:0003677 GO:0003678 GO:0004386 GO:0046872 GO:0004518 GO:0043142 GO:0016890 GO:0006200 GO:0006284 GO:0000737 GO:0000729 GO:0032508 GO:0006260 GO:0000076 GO:0033567 GO:0043137 GO:0006271 GO:0043504 GO:0006264 GO:0000278 GO:0045740 GO:0000723 GO:0000722 GO:0032201
Gene3D	3.40.50.300
InterPro	IPR014808 IPR027417
Pfam	PF08696
SUPFAM	SSF52540

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0006260	DNA replication	PMID:7788527^[1]	ECO:0000314			P		Figure 2 shows the expression patterns of representative clones.	complete CACAO 9455
part_of	GO:0000784	nuclear chromosome, telomeric region	PMID:23604072^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6ZQJ5	C		Seeded From UniProt	complete
involved_in	GO:1902990	mitotic telomere maintenance via semi-conservative replication	PMID:23604072^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6ZQJ5	P		Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	PMID:23604072^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6ZQJ5	P	part_of:(GO:1902990)	Seeded From UniProt	complete
involved_in	GO:0000723	telomere maintenance	PMID:23604072^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6ZQJ5	P		Seeded From UniProt	complete
involved_in	GO:0045740	positive regulation of DNA replication	PMID:18995831^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043504	mitochondrial DNA repair	PMID:19487465^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043142	single-stranded DNA-dependent ATPase activity	PMID:16595800^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043142	single-stranded DNA-dependent ATPase activity	PMID:16595799^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043139	5'-3' DNA helicase activity	PMID:20019387^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043137	DNA replication, removal of RNA primer	PMID:18995831^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0042645	mitochondrial nucleoid	PMID:19487465^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0033567	DNA replication, Okazaki fragment processing	PMID:22570407^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0017108	5'-flap endonuclease activity	PMID:20019387^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0017108	5'-flap endonuclease activity	PMID:16595800^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0017108	5'-flap endonuclease activity	PMID:16595799^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0017108	5'-flap endonuclease activity	PMID:22570407^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0017108	5'-flap endonuclease activity	PMID:18995831^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0016890	site-specific endodeoxyribonuclease activity, specific for altered base	PMID:18995831^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006284	base-excision repair	PMID:18995831^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006264	mitochondrial DNA replication	PMID:19487465^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006264	mitochondrial DNA replication	PMID:18995831^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006260	DNA replication	PMID:22570476^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
colocalizes_with	GO:0005760	gamma DNA polymerase complex	PMID:18995831^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19487465^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004518	nuclease activity	PMID:21325134^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003678	DNA helicase activity	PMID:16595800^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
NOT\|enables	GO:0003678	DNA helicase activity	PMID:16595799^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:20019387^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:22570407^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000729	DNA double-strand break processing	PMID:21325134^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000076	DNA replication checkpoint	PMID:22570476^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071932	replication fork reversal	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000094675 PomBase:SPBC16D10.04c	P		Seeded From UniProt	complete
enables	GO:0017108	5'-flap endonuclease activity	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2443732 PANTHER:PTN000094675 SGD:S000001207 UniProtKB:P51530	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000094675 PomBase:SPBC16D10.04c SGD:S000001207	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000094675 SGD:S000001207 UniProtKB:A0A1P8ASY1 UniProtKB:P51530	C		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000094509 UniProtKB:Q92900 UniProtKB:Q9HCE1	F		Seeded From UniProt	complete
part_of	GO:0000784	nuclear chromosome, telomeric region	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2443732 PANTHER:PTN000094675 PomBase:SPBC16D10.04c SGD:S000001207	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0032508	DNA duplex unwinding	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0003678	P		Seeded From UniProt	complete
involved_in	GO:0032508	DNA duplex unwinding	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0003678	P		Seeded From UniProt	complete
involved_in	GO:0032508	DNA duplex unwinding	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0043139	P		Seeded From UniProt	complete
involved_in	GO:1902990	mitotic telomere maintenance via semi-conservative replication	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6ZQJ5 ensembl:ENSMUSP00000115750	P		Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6ZQJ5 ensembl:ENSMUSP00000115750	P		Seeded From UniProt	complete
enables	GO:0017108	5'-flap endonuclease activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6ZQJ5 ensembl:ENSMUSP00000115750	F		Seeded From UniProt	complete
part_of	GO:0000784	nuclear chromosome, telomeric region	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6ZQJ5 ensembl:ENSMUSP00000115750	C		Seeded From UniProt	complete
involved_in	GO:0000723	telomere maintenance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6ZQJ5 ensembl:ENSMUSP00000115750	P		Seeded From UniProt	complete
enables	GO:0017108	5'-flap endonuclease activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026851	F		Seeded From UniProt	complete
involved_in	GO:0033567	DNA replication, Okazaki fragment processing	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026851	P		Seeded From UniProt	complete
enables	GO:0043142	single-stranded DNA-dependent ATPase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026851	F		Seeded From UniProt	complete
involved_in	GO:0044806	G-quadruplex DNA unwinding	PMID:27918544^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090656	t-circle formation	PMID:27918544^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	PMID:18995831^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004386	helicase activity	PMID:18995831^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1901796	regulation of signal transduction by p53 class mediator	Reactome:R-HSA-5633007	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032201	telomere maintenance via semi-conservative replication	Reactome:R-HSA-174451 Reactome:R-HSA-174441	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006260	DNA replication	Reactome:R-HSA-5684887 Reactome:R-HSA-5684875	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-69144 Reactome:R-HSA-69142 Reactome:R-HSA-6799332 Reactome:R-HSA-5693620 Reactome:R-HSA-5693593 Reactome:R-HSA-5693589 Reactome:R-HSA-5693584 Reactome:R-HSA-5693580 Reactome:R-HSA-5693564 Reactome:R-HSA-5693561 Reactome:R-HSA-5693542 Reactome:R-HSA-5693539 Reactome:R-HSA-5686657 Reactome:R-HSA-5686642 Reactome:R-HSA-5686483 Reactome:R-HSA-5686469 Reactome:R-HSA-5686440 Reactome:R-HSA-5686410 Reactome:R-HSA-5685994 Reactome:R-HSA-5685985 Reactome:R-HSA-5685838 Reactome:R-HSA-5685341 Reactome:R-HSA-5685156 Reactome:R-HSA-5685011 Reactome:R-HSA-5684887 Reactome:R-HSA-5684882 Reactome:R-HSA-5684875 Reactome:R-HSA-174451 Reactome:R-HSA-174441	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0511	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
involved_in	GO:0008152	metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0511	P		Seeded From UniProt	complete
involved_in	GO:0006260	DNA replication	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0235	P		Seeded From UniProt	complete
enables	GO:0051539	4 iron, 4 sulfur cluster binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0004	F		Seeded From UniProt	complete
enables	GO:0004386	helicase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0347	F		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P		Seeded From UniProt	complete
enables	GO:0051536	iron-sulfur cluster binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0411	F		Seeded From UniProt	complete
enables	GO:0004518	nuclease activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0540	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496 UniProtKB-SubCell:SL-0173	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
enables	GO:0004519	endonuclease activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0255	F		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Nagase, T et al. (1995) Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. DNA Res. 2 37-43 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Lin, W et al. (2013) Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity. EMBO J. 32 1425-39 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 ^3.8 Zheng, L et al. (2008) Human DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediates. Mol. Cell 32 325-36 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Duxin, JP et al. (2009) Human Dna2 is a nuclear and mitochondrial DNA maintenance protein. Mol. Cell. Biol. 29 4274-82 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Masuda-Sasa, T et al. (2006) Biochemical analysis of human Dna2. Nucleic Acids Res. 34 1865-75 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Kim, JH et al. (2006) Isolation of human Dna2 endonuclease and characterization of its enzymatic properties. Nucleic Acids Res. 34 1854-64 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Balakrishnan, L et al. (2010) Acetylation of Dna2 endonuclease/helicase and flap endonuclease 1 by p300 promotes DNA stability by creating long flap intermediates. J. Biol. Chem. 285 4398-404 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Gloor, JW et al. (2012) Biochemical analyses indicate that binding and cleavage specificities define the ordered processing of human Okazaki fragments by Dna2 and FEN1. Nucleic Acids Res. 40 6774-86 PubMed GONUTS page
↑ ^9.0 ^9.1 Duxin, JP et al. (2012) Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication. J. Biol. Chem. 287 21980-91 PubMed GONUTS page
↑ ^10.0 ^10.1 Nimonkar, AV et al. (2011) BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair. Genes Dev. 25 350-62 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^12.0 ^12.1 Rivera, T et al. (2017) A balance between elongation and trimming regulates telomere stability in stem cells. Nat. Struct. Mol. Biol. 24 30-39 PubMed GONUTS page

[PMID:7788527-1] Nagase, T et al. (1995) Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. DNA Res. 2 37-43 PubMed GONUTS page

[PMID:23604072-2] 2.0 ^2.1 ^2.2 ^2.3 Lin, W et al. (2013) Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity. EMBO J. 32 1425-39 PubMed GONUTS page

[PMID:18995831-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 ^3.8 Zheng, L et al. (2008) Human DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediates. Mol. Cell 32 325-36 PubMed GONUTS page

[PMID:19487465-4] 4.0 ^4.1 ^4.2 ^4.3 Duxin, JP et al. (2009) Human Dna2 is a nuclear and mitochondrial DNA maintenance protein. Mol. Cell. Biol. 29 4274-82 PubMed GONUTS page

[PMID:16595800-5] 5.0 ^5.1 ^5.2 Masuda-Sasa, T et al. (2006) Biochemical analysis of human Dna2. Nucleic Acids Res. 34 1865-75 PubMed GONUTS page

[PMID:16595799-6] 6.0 ^6.1 ^6.2 Kim, JH et al. (2006) Isolation of human Dna2 endonuclease and characterization of its enzymatic properties. Nucleic Acids Res. 34 1854-64 PubMed GONUTS page

[PMID:20019387-7] 7.0 ^7.1 ^7.2 Balakrishnan, L et al. (2010) Acetylation of Dna2 endonuclease/helicase and flap endonuclease 1 by p300 promotes DNA stability by creating long flap intermediates. J. Biol. Chem. 285 4398-404 PubMed GONUTS page

[PMID:22570407-8] 8.0 ^8.1 ^8.2 Gloor, JW et al. (2012) Biochemical analyses indicate that binding and cleavage specificities define the ordered processing of human Okazaki fragments by Dna2 and FEN1. Nucleic Acids Res. 40 6774-86 PubMed GONUTS page

[PMID:22570476-9] 9.0 ^9.1 Duxin, JP et al. (2012) Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication. J. Biol. Chem. 287 21980-91 PubMed GONUTS page

[PMID:21325134-10] 10.0 ^10.1 Nimonkar, AV et al. (2011) BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair. Genes Dev. 25 350-62 PubMed GONUTS page

[PMID:21873635-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:27918544-12] 12.0 ^12.1 Rivera, T et al. (2017) A balance between elongation and trimming regulates telomere stability in stem cells. Nat. Struct. Mol. Biol. 24 30-39 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

HUMAN:DNA2

Contents

Annotations

Notes

References

4

5

a

b

c

d

e

g

h

i

m

n

o

p

r

s

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools