HUMAN:DKK1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	DKK1
Protein Name(s)	Dickkopf-related protein 1 Dickkopf-1 Dkk-1 hDkk-1 SK
External Links
UniProt	O94907
EMBL	AF127563 AF177394 AB020315 AF261158 AF261157 AY359005 AK314902 CH471083 BC001539
CCDS	CCDS7246.1
RefSeq	NP_036374.1
UniGene	Hs.40499
PDB	3S2K 3S8V
PDBsum	3S2K 3S8V
ProteinModelPortal	O94907
SMR	O94907
BioGrid	116599
DIP	DIP-46461N
IntAct	O94907
MINT	MINT-1196808
STRING	9606.ENSP00000363081
BindingDB	O94907
ChEMBL	CHEMBL6024
MaxQB	O94907
PaxDb	O94907
PRIDE	O94907
DNASU	22943
Ensembl	ENST00000373970
GeneID	22943
KEGG	hsa:22943
UCSC	uc001jjr.3
CTD	22943
GeneCards	GC10P054074
HGNC	HGNC:2891
HPA	CAB009726 HPA018995
MIM	605189
neXtProt	NX_O94907
Orphanet	85193
PharmGKB	PA27345
eggNOG	NOG289067
GeneTree	ENSGT00390000007000
HOGENOM	HOG000246998
HOVERGEN	HBG000441
InParanoid	O94907
KO	K02165
OMA	RSSDCAT
OrthoDB	EOG7K3TMT
PhylomeDB	O94907
TreeFam	TF330916
Reactome	REACT_200643 REACT_200777 REACT_228096
SignaLink	O94907
ChiTaRS	DKK1
GeneWiki	DKK1
GenomeRNAi	22943
NextBio	43697
PMAP-CutDB	O94907
PRO	PR:O94907
Proteomes	UP000005640
Bgee	O94907
CleanEx	HS_DKK1
ExpressionAtlas	O94907
Genevestigator	O94907
GO	GO:0005615 GO:0005886 GO:0008083 GO:0050750 GO:0048019 GO:0004871 GO:0000904 GO:0030326 GO:0001706 GO:1900116 GO:0060325 GO:0030900 GO:0001942 GO:0001707 GO:0030514 GO:0090090 GO:1901296 GO:2000726 GO:0042662 GO:0060394 GO:0033137 GO:0031333 GO:0048642 GO:0000122 GO:0030178 GO:0090082 GO:0042663 GO:0002090 GO:0032526 GO:0090244
InterPro	IPR006796
Pfam	PF04706

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0032091	negative regulation of protein binding	PMID:20723538^[1]	ECO:0000314			P		Figure 2A:DKK1 blocked both Wnt3a and Wnt3a/sFRP2 leading to increased phosphorylation of LRP6	complete
involved_in	GO:0030178	negative regulation of Wnt signaling pathway	PMID:15020244^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:23164821^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	ComplexPortal:CPX-1120 ComplexPortal:CPX-1134 UniProtKB:P08592:PRO_0000000166 UniProtKB:P08592:PRO_0000000167	P	regulates_o_occurs_in:(CL:0002609) regulates_expression_of:(ENSEMBL:ENSG00000166886)\|regulates_o_occurs_in(CL:0002609) regulates_expression_of:(ENSEMBL:ENSG00000155090)\|regulates_o_occurs_in(CL:0002609) regulates_expression_of:(ENSEMBL:ENSG00000110092)\|regulates_o_occurs_in(CL:0002609) regulates_expression_of:(ENSEMBL:ENSG00000170345)\|regulates_o_occurs_in(CL:0002609) regulates_expression_of:(ENSEMBL:ENSG00000120738)	Seeded From UniProt	complete
involved_in	GO:1902949	positive regulation of tau-protein kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O54908	P	occurs_in:(UBERON:0002421) happens_during:(UBERON:0007222) causally_upstream_of:(GO:0007611)	Seeded From UniProt	complete
involved_in	GO:0090647	modulation of age-related behavioral decline	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O54908	P	happens_during:(UBERON:0007222) causally_upstream_of:(GO:0007611)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O54908	P	occurs_in:(UBERON:0016538) regulates_expression_of:(ENSEMBL:ENSG00000120738)\|occurs_in(UBERON:0016538) regulates_expression_of:(ENSEMBL:ENSG00000170345)\|occurs_in(UBERON:0016538) regulates_expression_of:(ENSEMBL:ENSG00000110092)\|occurs_in(UBERON:0016538) regulates_expression_of:(ENSEMBL:ENSG00000155090)\|occurs_in(UBERON:0016538) regulates_expression_of:(ENSEMBL:ENSG00000166886)	Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O54908	P	happens_during:(UBERON:0007222)	Seeded From UniProt	complete
involved_in	GO:1901216	positive regulation of neuron death	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:D3Z9J1	P	regulates_o_occurs_in:(CL:0002609)	Seeded From UniProt	complete
involved_in	GO:0043507	positive regulation of JUN kinase activity	PMID:23164821^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0002609)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:23164821^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	ComplexPortal:CPX-1120 ComplexPortal:CPX-1134 UniProtKB:P05067:PRO_0000000092 UniProtKB:P05067:PRO_0000000093	P	regulates_o_occurs_in:(CL:0002609) regulates_expression_of:(ENSEMBL:ENSG00000166886)\|regulates_o_occurs_in(CL:0002609) regulates_expression_of:(ENSEMBL:ENSG00000155090)\|regulates_o_occurs_in(CL:0002609) regulates_expression_of:(ENSEMBL:ENSG00000110092)\|regulates_o_occurs_in(CL:0002609) regulates_expression_of:(ENSEMBL:ENSG00000170345)\|regulates_o_occurs_in(CL:0002609) regulates_expression_of:(ENSEMBL:ENSG00000120738)	Seeded From UniProt	complete
involved_in	GO:0060173	limb development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O54908	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O54908	P		Seeded From UniProt	complete
involved_in	GO:0030279	negative regulation of ossification	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O54908	P		Seeded From UniProt	complete
involved_in	GO:1904723	negative regulation of Wnt-Frizzled-LRP5/6 complex assembly	PMID:11433302^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O75581	P	part_of:(GO:0090090)	Seeded From UniProt	complete
enables	GO:0039706	co-receptor binding	PMID:11433302^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O75197	F		Seeded From UniProt	complete
enables	GO:0039706	co-receptor binding	PMID:11433302^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O75581	F		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:11433302^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:22902902^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:24431302^[6]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032091	negative regulation of protein binding	PMID:20093360^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:O75581)\|has_regulation_target:(UniProtKB:O14905)\|has_regulation_target:(UniProtKB:P56704)\|part_of(GO:1904723)	Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:20093360^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904723	negative regulation of Wnt-Frizzled-LRP5/6 complex assembly	PMID:20093360^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	part_of:(GO:0090090)	Seeded From UniProt	complete
enables	GO:0039706	co-receptor binding	PMID:20093360^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O75581	F		Seeded From UniProt	complete
involved_in	GO:0030178	negative regulation of Wnt signaling pathway	PMID:22615920^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000726	negative regulation of cardiac muscle cell differentiation	PMID:20559569^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901296	negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment	PMID:20559569^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:17804805^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:11742004^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:11448771^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:20039315^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:18044981^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:12857724^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090082	positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O54908	P		Seeded From UniProt	complete
involved_in	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation	PMID:20559569^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q15797)	Seeded From UniProt	complete
enables	GO:0048019	receptor antagonist activity	PMID:20723538^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0042663	regulation of endodermal cell fate specification	PMID:20559569^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042662	negative regulation of mesodermal cell fate specification	PMID:20559569^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033137	negative regulation of peptidyl-serine phosphorylation	PMID:20723538^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904723	negative regulation of Wnt-Frizzled-LRP5/6 complex assembly	PMID:11448771^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:11742004^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:11448771^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0002090	regulation of receptor internalization	PMID:17804805^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:20723538^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O54908	P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1329040 PANTHER:PTN001383489 UniProtKB:O94907 UniProtKB:Q9UBP4 UniProtKB:Q9UBU2 ZFIN:ZDB-GENE-990708-5	P		Seeded From UniProt	complete
enables	GO:0048019	receptor antagonist activity	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001383489 UniProtKB:O94907	F		Seeded From UniProt	complete
enables	GO:0039706	co-receptor binding	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1890663 PANTHER:PTN001383489 UniProtKB:O94907	F		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001383489 RGD:1307313 UniProtKB:O94907 UniProtKB:Q9UBU2	C		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:18166153^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P27467	P		Seeded From UniProt	complete
enables	GO:0050750	low-density lipoprotein particle receptor binding	PMID:16263759^[18]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:16263759^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:2000272	negative regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0048019	P		Seeded From UniProt	complete
involved_in	GO:2000272	negative regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0048019	P		Seeded From UniProt	complete
involved_in	GO:1905607	negative regulation of presynapse assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54908 ensembl:ENSMUSP00000025803	P		Seeded From UniProt	complete
involved_in	GO:1904958	positive regulation of midbrain dopaminergic neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54908 ensembl:ENSMUSP00000025803	P		Seeded From UniProt	complete
involved_in	GO:1902949	positive regulation of tau-protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54908 ensembl:ENSMUSP00000025803	P		Seeded From UniProt	complete
involved_in	GO:0090647	modulation of age-related behavioral decline	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54908 ensembl:ENSMUSP00000025803	P		Seeded From UniProt	complete
involved_in	GO:0090244	Wnt signaling pathway involved in somitogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54908 ensembl:ENSMUSP00000025803	P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54908 ensembl:ENSMUSP00000025803	P		Seeded From UniProt	complete
involved_in	GO:0090082	positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54908 ensembl:ENSMUSP00000025803	P		Seeded From UniProt	complete
involved_in	GO:0061743	motor learning	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54908 ensembl:ENSMUSP00000025803	P		Seeded From UniProt	complete
involved_in	GO:0060325	face morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54908 ensembl:ENSMUSP00000025803	P		Seeded From UniProt	complete
involved_in	GO:0060323	head morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54908 ensembl:ENSMUSP00000025803	P		Seeded From UniProt	complete
involved_in	GO:0060173	limb development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54908 ensembl:ENSMUSP00000025803	P		Seeded From UniProt	complete
involved_in	GO:0051966	regulation of synaptic transmission, glutamatergic	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54908 ensembl:ENSMUSP00000025803	P		Seeded From UniProt	complete
involved_in	GO:0050807	regulation of synapse organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54908 ensembl:ENSMUSP00000025803	P		Seeded From UniProt	complete
involved_in	GO:0048642	negative regulation of skeletal muscle tissue development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54908 ensembl:ENSMUSP00000025803	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54908 ensembl:ENSMUSP00000025803	P		Seeded From UniProt	complete
involved_in	GO:0032526	response to retinoic acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54908 ensembl:ENSMUSP00000025803	P		Seeded From UniProt	complete
involved_in	GO:0030900	forebrain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54908 ensembl:ENSMUSP00000025803	P		Seeded From UniProt	complete
involved_in	GO:0030514	negative regulation of BMP signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54908 ensembl:ENSMUSP00000025803	P		Seeded From UniProt	complete
involved_in	GO:0030326	embryonic limb morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54908 ensembl:ENSMUSP00000025803	P		Seeded From UniProt	complete
involved_in	GO:0030279	negative regulation of ossification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54908 ensembl:ENSMUSP00000025803	P		Seeded From UniProt	complete
involved_in	GO:0030178	negative regulation of Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54908 ensembl:ENSMUSP00000025803	P		Seeded From UniProt	complete
involved_in	GO:0030111	regulation of Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54908 ensembl:ENSMUSP00000025803	P		Seeded From UniProt	complete
involved_in	GO:0010977	negative regulation of neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54908 ensembl:ENSMUSP00000025803	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54908 ensembl:ENSMUSP00000025803	P		Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54908 ensembl:ENSMUSP00000025803	P		Seeded From UniProt	complete
involved_in	GO:0007492	endoderm development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54908 ensembl:ENSMUSP00000025803	P		Seeded From UniProt	complete
involved_in	GO:0001942	hair follicle development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54908 ensembl:ENSMUSP00000025803	P		Seeded From UniProt	complete
involved_in	GO:0001707	mesoderm formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54908 ensembl:ENSMUSP00000025803	P		Seeded From UniProt	complete
involved_in	GO:0001706	endoderm formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54908 ensembl:ENSMUSP00000025803	P		Seeded From UniProt	complete
involved_in	GO:0000904	cell morphogenesis involved in differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54908 ensembl:ENSMUSP00000025803	P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54908 ensembl:ENSMUSP00000025803	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006796	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006796	P		Seeded From UniProt	complete
involved_in	GO:0030178	negative regulation of Wnt signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006796	P		Seeded From UniProt	complete
involved_in	GO:0010942	positive regulation of cell death	PMID:23164821^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	negatively_regulates:(GO:0016055) happens_during:(GO:1904646)	Seeded From UniProt	complete
involved_in	GO:0045813	positive regulation of Wnt signaling pathway, calcium modulating pathway	PMID:23164821^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000096	positive regulation of Wnt signaling pathway, planar cell polarity pathway	PMID:23164821^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:23164821^[3] PMID:24449494^[19] Reactome:R-HSA-3772470	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904723	negative regulation of Wnt-Frizzled-LRP5/6 complex assembly	PMID:23164821^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0098883	synapse pruning	PMID:24449494^[19]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904338	regulation of dopaminergic neuron differentiation	PMID:24431302^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0039706	co-receptor binding	PMID:22988876^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	part_of:(GO:0090090) has_direct_input:(UniProtKB:O75581) occurs_at:(GO:0005886)	Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	PMID:10383463^[21]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0031901	early endosome membrane	Reactome:R-HSA-5368586	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-5368586 Reactome:R-HSA-5339711 Reactome:R-HSA-3769401	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
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References

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↑ ^1.0 ^1.1 ^1.2 ^1.3 von Marschall, Z & Fisher, LW (2010) Secreted Frizzled-related protein-2 (sFRP2) augments canonical Wnt3a-induced signaling. Biochem. Biophys. Res. Commun. 400 299-304 PubMed GONUTS page
↑ Yanagita, M et al. (2004) USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney. Biochem. Biophys. Res. Commun. 316 490-500 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Killick, R et al. (2014) Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway. Mol. Psychiatry 19 88-98 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Bafico, A et al. (2001) Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow. Nat. Cell Biol. 3 683-6 PubMed GONUTS page
↑ Dun, Y et al. (2012) Inhibition of the canonical Wnt pathway by Dickkopf-1 contributes to the neurodegeneration in 6-OHDA-lesioned rats. Neurosci. Lett. 525 83-8 PubMed GONUTS page
↑ ^6.0 ^6.1 Arenas, E (2014) Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease. J Mol Cell Biol 6 42-53 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Bourhis, E et al. (2010) Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6. J. Biol. Chem. 285 9172-9 PubMed GONUTS page
↑ Gong, X et al. (2012) LGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressor. PLoS ONE 7 e37137 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 Paige, SL et al. (2010) Endogenous Wnt/beta-catenin signaling is required for cardiac differentiation in human embryonic stem cells. PLoS ONE 5 e11134 PubMed GONUTS page
↑ ^10.0 ^10.1 Binnerts, ME et al. (2007) R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6. Proc. Natl. Acad. Sci. U.S.A. 104 14700-5 PubMed GONUTS page
↑ ^11.0 ^11.1 Li, L et al. (2002) Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled. J. Biol. Chem. 277 5977-81 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Semënov, MV et al. (2001) Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6. Curr. Biol. 11 951-61 PubMed GONUTS page
↑ Bhat, RA et al. (2010) Wnt3-frizzled 1 chimera as a model to study canonical Wnt signaling. J. Cell. Biochem. 109 876-84 PubMed GONUTS page
↑ Björklund, P et al. (2007) An LRP5 receptor with internal deletion in hyperparathyroid tumors with implications for deregulated WNT/beta-catenin signaling. PLoS Med. 4 e328 PubMed GONUTS page
↑ Caricasole, A et al. (2003) Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins. J. Biol. Chem. 278 37024-31 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Cho, SW et al. (2008) Differential effects of secreted frizzled-related proteins (sFRPs) on osteoblastic differentiation of mouse mesenchymal cells and apoptosis of osteoblasts. Biochem. Biophys. Res. Commun. 367 399-405 PubMed GONUTS page
↑ ^18.0 ^18.1 Li, Y et al. (2005) Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding. J. Cell. Sci. 118 5305-14 PubMed GONUTS page
↑ ^19.0 ^19.1 Purro, SA et al. (2014) Dysfunction of Wnt signaling and synaptic disassembly in neurodegenerative diseases. J Mol Cell Biol 6 75-80 PubMed GONUTS page
↑ Berwick, DC & Harvey, K (2012) The importance of Wnt signalling for neurodegeneration in Parkinson's disease. Biochem. Soc. Trans. 40 1123-8 PubMed GONUTS page
↑ Fedi, P et al. (1999) Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling. J. Biol. Chem. 274 19465-72 PubMed GONUTS page

[PMID:20723538-1] 1.0 ^1.1 ^1.2 ^1.3 von Marschall, Z & Fisher, LW (2010) Secreted Frizzled-related protein-2 (sFRP2) augments canonical Wnt3a-induced signaling. Biochem. Biophys. Res. Commun. 400 299-304 PubMed GONUTS page

[PMID:15020244-2] Yanagita, M et al. (2004) USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney. Biochem. Biophys. Res. Commun. 316 490-500 PubMed GONUTS page

[PMID:23164821-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Killick, R et al. (2014) Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway. Mol. Psychiatry 19 88-98 PubMed GONUTS page

[PMID:11433302-4] 4.0 ^4.1 ^4.2 ^4.3 Bafico, A et al. (2001) Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow. Nat. Cell Biol. 3 683-6 PubMed GONUTS page

[PMID:22902902-5] Dun, Y et al. (2012) Inhibition of the canonical Wnt pathway by Dickkopf-1 contributes to the neurodegeneration in 6-OHDA-lesioned rats. Neurosci. Lett. 525 83-8 PubMed GONUTS page

[PMID:24431302-6] 6.0 ^6.1 Arenas, E (2014) Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease. J Mol Cell Biol 6 42-53 PubMed GONUTS page

[PMID:20093360-7] 7.0 ^7.1 ^7.2 ^7.3 Bourhis, E et al. (2010) Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6. J. Biol. Chem. 285 9172-9 PubMed GONUTS page

[PMID:22615920-8] Gong, X et al. (2012) LGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressor. PLoS ONE 7 e37137 PubMed GONUTS page

[PMID:20559569-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 Paige, SL et al. (2010) Endogenous Wnt/beta-catenin signaling is required for cardiac differentiation in human embryonic stem cells. PLoS ONE 5 e11134 PubMed GONUTS page

[PMID:17804805-10] 10.0 ^10.1 Binnerts, ME et al. (2007) R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6. Proc. Natl. Acad. Sci. U.S.A. 104 14700-5 PubMed GONUTS page

[PMID:11742004-11] 11.0 ^11.1 Li, L et al. (2002) Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled. J. Biol. Chem. 277 5977-81 PubMed GONUTS page

[PMID:11448771-12] 12.0 ^12.1 ^12.2 Semënov, MV et al. (2001) Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6. Curr. Biol. 11 951-61 PubMed GONUTS page

[PMID:20039315-13] Bhat, RA et al. (2010) Wnt3-frizzled 1 chimera as a model to study canonical Wnt signaling. J. Cell. Biochem. 109 876-84 PubMed GONUTS page

[PMID:18044981-14] Björklund, P et al. (2007) An LRP5 receptor with internal deletion in hyperparathyroid tumors with implications for deregulated WNT/beta-catenin signaling. PLoS Med. 4 e328 PubMed GONUTS page

[PMID:12857724-15] Caricasole, A et al. (2003) Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins. J. Biol. Chem. 278 37024-31 PubMed GONUTS page

[PMID:21873635-16] 16.0 ^16.1 ^16.2 ^16.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:18166153-17] Cho, SW et al. (2008) Differential effects of secreted frizzled-related proteins (sFRPs) on osteoblastic differentiation of mouse mesenchymal cells and apoptosis of osteoblasts. Biochem. Biophys. Res. Commun. 367 399-405 PubMed GONUTS page

[PMID:16263759-18] 18.0 ^18.1 Li, Y et al. (2005) Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding. J. Cell. Sci. 118 5305-14 PubMed GONUTS page

[PMID:24449494-19] 19.0 ^19.1 Purro, SA et al. (2014) Dysfunction of Wnt signaling and synaptic disassembly in neurodegenerative diseases. J Mol Cell Biol 6 75-80 PubMed GONUTS page

[PMID:22988876-20] Berwick, DC & Harvey, K (2012) The importance of Wnt signalling for neurodegeneration in Parkinson's disease. Biochem. Soc. Trans. 40 1123-8 PubMed GONUTS page

[PMID:10383463-21] Fedi, P et al. (1999) Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling. J. Biol. Chem. 274 19465-72 PubMed GONUTS page

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