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HUMAN:DHX29
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | DHX29 (ECO:0000255 with HAMAP-Rule:MF_03068) (synonyms: DDX29) | |
| Protein Name(s) | ATP-dependent RNA helicase DHX29 (ECO:0000255 with HAMAP-Rule:MF_03068)
DEAH box protein 29 (ECO:0000255 with HAMAP-Rule:MF_03068) Nucleic acid helicase DDXx | |
| External Links | ||
| UniProt | Q7Z478 | |
| EMBL | AY036974 BC056219 AL834496 BX648101 BX648269 AL079292 AF070639 | |
| CCDS | CCDS34158.1 | |
| RefSeq | NP_061903.2 | |
| UniGene | Hs.593268 | |
| ProteinModelPortal | Q7Z478 | |
| SMR | Q7Z478 | |
| BioGrid | 120001 | |
| IntAct | Q7Z478 | |
| MINT | MINT-1376685 | |
| STRING | 9606.ENSP00000251636 | |
| iPTMnet | Q7Z478 | |
| PhosphoSitePlus | Q7Z478 | |
| BioMuta | DHX29 | |
| DMDM | 110278938 | |
| EPD | Q7Z478 | |
| MaxQB | Q7Z478 | |
| PaxDb | Q7Z478 | |
| PeptideAtlas | Q7Z478 | |
| PRIDE | Q7Z478 | |
| Ensembl | ENST00000251636 | |
| GeneID | 54505 | |
| KEGG | hsa:54505 | |
| UCSC | uc003jpx.4 | |
| CTD | 54505 | |
| GeneCards | DHX29 | |
| H-InvDB | HIX0004866 | |
| HGNC | HGNC:15815 | |
| HPA | HPA038317 HPA038318 | |
| MIM | 612720 | |
| neXtProt | NX_Q7Z478 | |
| OpenTargets | ENSG00000067248 | |
| PharmGKB | PA27215 | |
| eggNOG | KOG0920 COG1643 | |
| GeneTree | ENSGT00760000119189 | |
| HOGENOM | HOG000247063 | |
| HOVERGEN | HBG081436 | |
| InParanoid | Q7Z478 | |
| KO | K18995 | |
| PhylomeDB | Q7Z478 | |
| TreeFam | TF324744 | |
| ChiTaRS | DHX29 | |
| GenomeRNAi | 54505 | |
| PRO | PR:Q7Z478 | |
| Proteomes | UP000005640 | |
| Bgee | ENSG00000067248 | |
| CleanEx | HS_DHX29 | |
| ExpressionAtlas | Q7Z478 | |
| Genevisible | Q7Z478 | |
| GO | GO:0005913 GO:0016282 GO:0005739 GO:0005634 GO:0005524 GO:0004004 GO:0098641 GO:0044822 GO:0043024 GO:0003743 GO:0006396 | |
| Gene3D | 3.40.50.300 | |
| HAMAP | MF_03068 | |
| InterPro | IPR011545 IPR002464 IPR011709 IPR007502 IPR014001 IPR001650 IPR027417 | |
| Pfam | PF00270 PF04408 PF00271 PF07717 | |
| SMART | SM00487 SM00847 SM00490 | |
| SUPFAM | SSF52540 | |
| PROSITE | PS00690 PS51192 PS51194 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0001731 |
formation of translation preinitiation complex |
ECO:0000315 |
P |
Fig. 2E: Lane 2 shows non-canonical toeprints without DHX29, and 2e lane 3 shows canonical toeprints of formation of preinitiation complex with DHX29 in the presence of all other necessary translation initiation components. Lanes 4, 5, and 6 of the same figure show non-canonical toeprints with truncated forms of DHX29 Human DHX29 transfected into E. coli |
complete | |||||
| GO:0017111 |
nucleoside-triphosphatase activity |
ECO:0000315 |
F |
Fig. 7C shows NTPase activity for human DHX29. Within the paper, the protein is called DHX29 of mammalian DHX29. From fig. 1 and methods, it is said to be human DHX29 |
complete | |||||
| GO:0009615 |
detection of virus |
ECO:0000315 |
P |
Fig. 2I, and J show that knockdown DHX29 expression shows a reduced production of immune response peptides IFN-β and IL-6 upon viral stimulation. The protein is referred to as DHX29 in the paper and is specifically mentioned to be human DHX29. |
complete | |||||
| GO:0022627 |
cytosolic small ribosomal subunit |
ECO:0000314 |
C |
Human DHX29. Figure 1: Immunofluorescence shows DHX29 was enriched in 40S fractions. A low level of DHX29 was associated with 60S and 80S ribosomes. |
complete | |||||
| GO:0042255 |
ribosome assembly |
ECO:0000315 |
P |
Human DHX29. In cells with silenced DHX using shRNA, polysome profiles showed a reduction in polysomes with concomitant increases in 40S, 60S, and 80S ribosome fractions (Fig. 3B). |
complete | |||||
| GO:0008494 |
translation activator activity |
ECO:0000315 |
F |
Human DHX29. In control cells, Cdc25C mRNA sedimented predominantly with heavy polysomes, whereas in DHX29-silenced cells, it was shifted to light polysomes, indicating decreased translation initiation of this mRNA (Fig. 4A). In agreement with these findings, Cdc25C protein levels decreased by more than 3-fold on DHX29 silencing (Fig. 4B). |
complete | |||||
| GO:0008284 |
positive regulation of cell proliferation |
ECO:0000315 |
P |
Human DHX29. HeLa cell proliferation was inhibited by almost 3-fold in DHX29 siRNA-silenced cells (Fig. 5A). Cell proliferation also was significantly (3-fold) inhibited by shRNA-mediated silencing of DHX29 after 4 days, compared with a nontargeting shRNA control (Fig. 5B). These results demonstrate that DHX29 is associated for cell proliferation. |
complete | |||||
|
enables |
GO:0045296 |
cadherin binding |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0043024 |
ribosomal small subunit binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016282 |
eukaryotic 43S preinitiation complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0034459 |
ATP-dependent 3'-5' RNA helicase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001449167 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0002774 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003676 |
nucleic acid binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004004 |
ATP-dependent RNA helicase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004386 |
helicase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006413 |
translational initiation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000369429 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016818 |
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000369429 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003724 |
RNA helicase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000369429 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045948 |
positive regulation of translational initiation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000369429 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006412 |
translation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006413 |
translational initiation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003743 |
translation initiation factor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004386 |
helicase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Dhote, V et al. (2012) Roles of individual domains in the function of DHX29, an essential factor required for translation of structured mammalian mRNAs. Proc. Natl. Acad. Sci. U.S.A. 109 E3150-9 PubMed GONUTS page
- ↑ Sugimoto, N et al. (2014) Helicase proteins DHX29 and RIG-I cosense cytosolic nucleic acids in the human airway system. Proc. Natl. Acad. Sci. U.S.A. 111 7747-52 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Parsyan, A et al. (2009) The helicase protein DHX29 promotes translation initiation, cell proliferation, and tumorigenesis. Proc. Natl. Acad. Sci. U.S.A. 106 22217-22 PubMed GONUTS page
- ↑ Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page
- ↑ Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
- ↑ 6.0 6.1 Hashem, Y et al. (2013) Structure of the mammalian ribosomal 43S preinitiation complex bound to the scanning factor DHX29. Cell 153 1108-19 PubMed GONUTS page
- ↑ 7.0 7.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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