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HUMAN:DGCR8

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) DGCR8 (synonyms: C22orf12, DGCRK6)
Protein Name(s) Microprocessor complex subunit DGCR8

DiGeorge syndrome critical region 8

External Links
UniProt Q8WYQ5
EMBL AB050770
CR456356
AK025539
AK025780
AK313357
AC006547
BC009323
BC009984
BC078147
AF165527
BX649187
AY189282
CCDS CCDS13773.1
CCDS54501.1
RefSeq NP_001177255.1
NP_073557.3
UniGene Hs.643452
Hs.713579
PDB 1X47
2YT4
3LE4
PDBsum 1X47
2YT4
3LE4
ProteinModelPortal Q8WYQ5
SMR Q8WYQ5
BioGrid 119986
DIP DIP-29261N
IntAct Q8WYQ5
MINT MINT-3048369
PhosphoSite Q8WYQ5
DMDM 23813990
MaxQB Q8WYQ5
PaxDb Q8WYQ5
PRIDE Q8WYQ5
DNASU 54487
Ensembl ENST00000351989
ENST00000383024
ENST00000407755
GeneID 54487
KEGG hsa:54487
UCSC uc002zri.3
uc010grz.3
CTD 54487
GeneCards GC22P020070
GeneReviews DGCR8
HGNC HGNC:2847
HPA HPA019965
MIM 609030
neXtProt NX_Q8WYQ5
PharmGKB PA27309
eggNOG NOG300512
GeneTree ENSGT00390000015977
HOVERGEN HBG051344
InParanoid Q8WYQ5
KO K18419
OMA METYESP
OrthoDB EOG75J0MG
PhylomeDB Q8WYQ5
TreeFam TF324256
Reactome REACT_12417
ChiTaRS DGCR8
EvolutionaryTrace Q8WYQ5
GeneWiki DGCR8_(gene)
GenomeRNAi 54487
NextBio 56807
PRO PR:Q8WYQ5
Proteomes UP000005640
Bgee Q8WYQ5
ExpressionAtlas Q8WYQ5
Genevestigator Q8WYQ5
GO GO:0005737
GO:0015630
GO:0005654
GO:0005634
GO:0003725
GO:0046872
GO:0010467
GO:0031053
Gene3D 3.30.160.20
InterPro IPR014720
IPR001202
Pfam PF00035
SMART SM00358
SM00456
SUPFAM SSF51045
PROSITE PS50137
PS50020

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0042803

protein homodimerization activity

PMID:15574589[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:25670082[2]

ECO:0000314

C

Figure 1. Comprehensive analysis of 77 FHWTs indicates that tumors with SIX1/2 and/or miRNAPG mutations show a pre-induction metanephric mesenchyme gene expression pattern and are significantly associated with both perilobar nephrogenic rests and 11p15 imprinting aberrations. Figure 2. The combination of SIX and miRNAPG mutations in the same tumor is associated with evidence of RAS activation and a higher rate of relapse and death.

complete
CACAO 10694

part_of

GO:0070877

microprocessor complex

PMID:15574589[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

contributes_to

GO:0004525

ribonuclease III activity

PMID:15574589[1]

ECO:0000314

direct assay evidence used in manual assertion

F

part_of:(GO:0031053)

Seeded From UniProt

complete

enables

GO:0020037

heme binding

PMID:24449907[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0031053

primary miRNA processing

PMID:24449907[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0020037

heme binding

PMID:24910438[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0031053

primary miRNA processing

PMID:24910438[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0070878

primary miRNA binding

PMID:24910438[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000054

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003725

double-stranded RNA binding

PMID:17704815[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0070878

primary miRNA binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002668854
UniProtKB:Q8WYQ5

F

Seeded From UniProt

complete

part_of

GO:0070877

microprocessor complex

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002668854
UniProtKB:Q8WYQ5

C

Seeded From UniProt

complete

involved_in

GO:0031053

primary miRNA processing

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0039861
PANTHER:PTN002668854
UniProtKB:Q8WYQ5
WB:WBGene00011908

P

Seeded From UniProt

complete

enables

GO:0020037

heme binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002668854
UniProtKB:Q8WYQ5

F

Seeded From UniProt

complete

contributes_to

GO:0004525

ribonuclease III activity

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002668854
UniProtKB:Q8WYQ5

F

Seeded From UniProt

complete

enables

GO:0003725

double-stranded RNA binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002668854
UniProtKB:Q8WYQ5

F

Seeded From UniProt

complete

involved_in

GO:0031053

primary miRNA processing

PMID:15574589[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031053

primary miRNA processing

PMID:15531877[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:15574589[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:17159994[8]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q8WYQ5

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:15574589[1]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q8WYQ5

F

Seeded From UniProt

complete

involved_in

GO:0090501

RNA phosphodiester bond hydrolysis

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004525

P

Seeded From UniProt

complete

involved_in

GO:0090501

RNA phosphodiester bond hydrolysis

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004525

P

Seeded From UniProt

complete

involved_in

GO:0090502

RNA phosphodiester bond hydrolysis, endonucleolytic

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004525

P

Seeded From UniProt

complete

involved_in

GO:0090502

RNA phosphodiester bond hydrolysis, endonucleolytic

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004525

P

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR040375

F

Seeded From UniProt

complete

enables

GO:0020037

heme binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR040375

F

Seeded From UniProt

complete

involved_in

GO:0031053

primary miRNA processing

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR040375

P

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR040375

F

Seeded From UniProt

complete

part_of

GO:0070877

microprocessor complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR040375

C

Seeded From UniProt

complete

involved_in

GO:0010586

miRNA metabolic process

Reactome:R-HSA-203927

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-203893

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0694

F

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0188

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Han, J et al. (2004) The Drosha-DGCR8 complex in primary microRNA processing. Genes Dev. 18 3016-27 PubMed GONUTS page
  2. ↑ Walz, AL et al. (2015) Recurrent DGCR8, DROSHA, and SIX homeodomain mutations in favorable histology Wilms tumors. Cancer Cell 27 286-97 PubMed GONUTS page
  3. ↑ 3.0 3.1 Weitz, SH et al. (2014) Processing of microRNA primary transcripts requires heme in mammalian cells. Proc. Natl. Acad. Sci. U.S.A. 111 1861-6 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Quick-Cleveland, J et al. (2014) The DGCR8 RNA-binding heme domain recognizes primary microRNAs by clamping the hairpin. Cell Rep 7 1994-2005 PubMed GONUTS page
  5. ↑ Sohn, SY et al. (2007) Crystal structure of human DGCR8 core. Nat. Struct. Mol. Biol. 14 847-53 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  7. ↑ Gregory, RI et al. (2004) The Microprocessor complex mediates the genesis of microRNAs. Nature 432 235-40 PubMed GONUTS page
  8. ↑ Faller, M et al. (2007) Heme is involved in microRNA processing. Nat. Struct. Mol. Biol. 14 23-9 PubMed GONUTS page
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