GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

Category:GO:0070877 ! microprocessor complex

From GONUTS
Jump to: navigation, search

DAG for GO:0070877id: GO:0070877

name: microprocessor complex
namespace: cellular_component
def: "A protein complex that binds to heme and to pri-miRNAs, and is required for the formation of a pre-microRNA (pre-miRNA), the initial step of microRNA (miRNA) biogenesis. The complex is composed of the double-stranded-RNA-specific RNase Drosha (also called RNASEN) and the RNA-binding protein DGCR8 (heme-free or heme-bound forms). Within the complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs RNASEN/Drosha to cleave the 3' and 5' strands of a stem-loop to release hairpin-shaped pre-miRNAs." [PMID:16963499, PMID:17159994]
is_a: GO:0140513 ! nuclear protein-containing complex
is_a: GO:1903095 ! ribonuclease III complex

AmiGO <GOterm>GO:0070877</GOterm>
Gene Ontology Home


The contents of this box are automatically generated. You can help by adding information to the "Notes"

Usage Notes

References

See Help:References for how to manage references in GONUTS.

Pages in category "GO:0070877 ! microprocessor complex"

The following 2 pages are in this category, out of 2 total.


Jump to pages starting with: H P