GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

HUMAN:DFFB

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) DFFB (synonyms: CAD, DFF2, DFF40)
Protein Name(s) DNA fragmentation factor subunit beta

Caspase-activated deoxyribonuclease CAD Caspase-activated DNase Caspase-activated nuclease CPAN DNA fragmentation factor 40 kDa subunit DFF-40

External Links
UniProt O76075
EMBL AF064019
AB013918
AF039210
AB028911
AB028912
AB028913
AK290877
AL691523
BC048797
CCDS CCDS52.1
RefSeq NP_004393.1
UniGene Hs.133089
PDB 1IBX
PDBsum 1IBX
ProteinModelPortal O76075
SMR O76075
BioGrid 108041
IntAct O76075
MINT MINT-365482
STRING 9606.ENSP00000367454
PhosphoSite O76075
MaxQB O76075
PaxDb O76075
PRIDE O76075
Ensembl ENST00000339350
ENST00000378209
ENST00000491998
GeneID 1677
KEGG hsa:1677
UCSC uc001alc.3
uc009vlo.1
CTD 1677
GeneCards GC01P003797
HGNC HGNC:2773
HPA CAB004328
MIM 601883
neXtProt NX_O76075
PharmGKB PA27255
eggNOG NOG68641
GeneTree ENSGT00390000014490
HOGENOM HOG000006502
HOVERGEN HBG003828
InParanoid O76075
KO K02311
OMA CQGPFDV
OrthoDB EOG712TW8
PhylomeDB O76075
TreeFam TF102022
Reactome REACT_13462
SignaLink O76075
EvolutionaryTrace O76075
GeneWiki DFFB
GenomeRNAi 1677
NextBio 6902
PRO PR:O76075
Proteomes UP000005640
Bgee O76075
CleanEx HS_CAD
HS_DFFB
ExpressionAtlas O76075
Genevestigator O76075
GO GO:0005829
GO:0000790
GO:0005654
GO:0005634
GO:0004536
GO:0003677
GO:0019899
GO:0030263
GO:0006309
GO:0006915
GO:0007420
GO:0006921
InterPro IPR015311
IPR003508
Pfam PF02017
PF09230
PROSITE PS51135

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0004536

deoxyribonuclease activity

PMID:19944011[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006308

DNA catabolic process

PMID:19944011[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0019904

protein domain specific binding

PMID:19944011[1]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O00273

F

Seeded From UniProt

complete

involved_in

GO:0006309

apoptotic DNA fragmentation

PMID:22253444[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:22253444[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:22253444[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

colocalizes_with

GO:0000790

nuclear chromatin

PMID:22253444[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:11371636[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0051260

protein homooligomerization

PMID:11371636[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0097718

disordered domain specific binding

PMID:11371636[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O00273

F

Seeded From UniProt

complete

involved_in

GO:0030263

apoptotic chromosome condensation

PMID:10959840[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0019899

enzyme binding

PMID:10959840[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P11388

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:9108473[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:10959840[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000790

nuclear chromatin

PMID:19882353[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006309

apoptotic DNA fragmentation

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000990874
RGD:620335
UniProtKB:O76075

P

Seeded From UniProt

complete

enables

GO:0004536

deoxyribonuclease activity

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000990874
RGD:620335
UniProtKB:O76075

F

Seeded From UniProt

complete

part_of

GO:0000790

nuclear chromatin

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000990874
UniProtKB:O76075

C

Seeded From UniProt

complete

involved_in

GO:0006309

apoptotic DNA fragmentation

PMID:15572351[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:15572351[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004536

deoxyribonuclease activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR039729

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR015311

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR015311

C

Seeded From UniProt

complete

involved_in

GO:0006309

apoptotic DNA fragmentation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR015311
InterPro:IPR039729

P

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003508

P

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR015311

F

Seeded From UniProt

complete

enables

GO:0004536

deoxyribonuclease activity

PMID:9671700[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006309

apoptotic DNA fragmentation

Reactome:R-HSA-140342

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-211224
Reactome:R-HSA-211206
Reactome:R-HSA-211191

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-9029667
Reactome:R-HSA-211247
Reactome:R-HSA-211239
Reactome:R-HSA-211207
Reactome:R-HSA-211206
Reactome:R-HSA-211193
Reactome:R-HSA-211190
Reactome:R-HSA-211186

ECO:0000304

author statement supported by traceable reference used in manual assertion








C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0004518

nuclease activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0540

F

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0053

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 Park, HH (2009) Fifty C-terminal amino acid residues are necessary for the chaperone activity of DFF45 but not for the inhibition of DFF40. BMB Rep 42 713-8 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 Iglesias-Guimarais, V et al. (2012) Apoptotic DNA degradation into oligonucleosomal fragments, but not apoptotic nuclear morphology, relies on a cytosolic pool of DFF40/CAD endonuclease. J. Biol. Chem. 287 7766-79 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Zhou, P et al. (2001) Solution structure of DFF40 and DFF45 N-terminal domain complex and mutual chaperone activity of DFF40 and DFF45. Proc. Natl. Acad. Sci. U.S.A. 98 6051-5 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Durrieu, F et al. () DNA topoisomerase IIalpha interacts with CAD nuclease and is involved in chromatin condensation during apoptotic execution. Curr. Biol. 10 923-6 PubMed GONUTS page
  5. ↑ Liu, X et al. (1997) DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. Cell 89 175-84 PubMed GONUTS page
  6. ↑ Ninios, YP et al. (2010) Histone H1 subtype preferences of DFF40 and possible nuclear localization of DFF40/45 in normal and trichostatin A-treated NB4 leukemic cells. Apoptosis 15 128-38 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  8. ↑ 8.0 8.1 Korn, C et al. (2005) Interaction of DNA fragmentation factor (DFF) with DNA reveals an unprecedented mechanism for nuclease inhibition and suggests that DFF can be activated in a DNA-bound state. J. Biol. Chem. 280 6005-15 PubMed GONUTS page
  9. ↑ Liu, X et al. (1998) The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis. Proc. Natl. Acad. Sci. U.S.A. 95 8461-6 PubMed GONUTS page
Retrieved from "https://gowiki.tamu.edu/wiki/index.php?title=HUMAN:DFFB&oldid=5955014"