HUMAN:D103A

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	DEFB103B (synonyms: BD3, DEFB103, DEFB3)
Protein Name(s)	Beta-defensin 103 Beta-defensin 3 BD-3 DEFB-3 HBD3 hBD-3 Defensin, beta 103 Defensin-like protein
External Links
UniProt	P81534
EMBL	AJ237673 AF295370 AF217245 AB037972 AF301470 AF516673
CCDS	CCDS34810.1 CCDS43701.1
RefSeq	NP_001075020.1 NP_061131.1 XP_016885681.1
UniGene	Hs.283082 Hs.637221
PDB	1KJ6
PDBsum	1KJ6
ProteinModelPortal	P81534
SMR	P81534
BioGrid	120984
IntAct	P81534
STRING	9606.ENSP00000324633
TCDB	1.C.85.1.3
BioMuta	DEFB103A
DMDM	17372441
PaxDb	P81534
PRIDE	P81534
DNASU	414325 55894
Ensembl	ENST00000314357 ENST00000318124 ENST00000613448
GeneID	414325 55894
KEGG	hsa:414325 hsa:55894
UCSC	uc003wrf.4
CTD	414325 55894
DisGeNET	414325 55894
GeneCards	DEFB103A DEFB103B
HGNC	HGNC:15967 HGNC:31702
MIM	606611
neXtProt	NX_P81534
OpenTargets	ENSG00000176797
PharmGKB	PA134933952
eggNOG	ENOG410JFYR ENOG411134U
GeneTree	ENSGT00530000064280
HOGENOM	HOG000015465
HOVERGEN	HBG004834
InParanoid	P81534
OMA	IRGGRCA
OrthoDB	EOG093719AW
PhylomeDB	P81534
Reactome	[www.reactome.org/content/detail/R-HSA-1461957 R-HSA-1461957] [www.reactome.org/content/detail/R-HSA-1461973 R-HSA-1461973]
EvolutionaryTrace	P81534
GeneWiki	DEFB103A
PRO	PR:P81534
Proteomes	UP000005640
Bgee	ENSG00000176797
CleanEx	HS_DEFB103A HS_DEFB103B
Genevisible	P81534
GO	GO:0005576 GO:0005615 GO:0005796 GO:0019730 GO:0042742 GO:0006965
InterPro	IPR001855
Pfam	PF00711

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0042742	defense response to bacterium	PMID:16436752^[1]	ECO:0000314			P	The bactericidal activity of hBD-3, an abbreviation of human beta-defensin 3 which is an alternative name for human beta-defensin 103, against various clinical isolates was evaluated by a liquid microdilution assay as shown in Figure 1. The results showed that hBD-3 used at a concentration of 4 μg/ml was bactericidal against A. baumannii (strain 3) after 3 min of incubation. hBD-3 used at a concentration of 8 μg/ml caused a bactericidal effect within 20 min of incubation against S. aureus (strain 3), E. faecium (strain 3), and P. aeruginosa (strain 3) and within 1 min against S. maltophilia (strain 4) and A. baumannii. At a concentration of 16 μg/ml, the peptide produced a bactericidal effect against S. aureus, E. faecium, P. aeruginosa, and S. maltophilia within 10, 20, 5, and 1 min, respectively.	complete CACAO 12386
	GO:0051873	killing by host of symbiont cells	PMID:16436752^[1]	ECO:0000314			P	Human Beta-defensin 103, also known as human beta-defensin 3 (hBD-3), has the ability to kill cells of other organisms. The bactericidal activity of hBD-3 against various clinical isolates was evaluated by a liquid microdilution assay as shown in Figure 1. The results of that assay showed that hBD-3 used at a concentration of 4 μg/ml was bactericidal against A. baumannii (strain 3) after 3 min of incubation. hBD-3 used at a concentration of 8 μg/ml caused a bactericidal effect within 20 min of incubation against S. aureus (strain 3), E. faecium (strain 3), and P. aeruginosa (strain 3) and within 1 min against S. maltophilia (strain 4) and A. baumannii. At a concentration of 16 μg/ml, the peptide produced a bactericidal effect against S. aureus, E. faecium, P. aeruginosa, and S. maltophilia within 10, 20, 5, and 1 min, respectively.	complete CACAO 12520
	GO:0002376	immune system process	PMID:16436752^[1]	ECO:0000314			P	Human Beta-defensin 103, also known as human beta-defensin 3 (hBD-3), plays a role in immune system processes. The bactericidal immune activity of hBD-3 against various clinical isolates was evaluated by a liquid microdilution assay as shown in Figure 1. The results of that assay showed that hBD-3 used at a concentration of 4 μg/ml was bactericidal against A. baumannii (strain 3) after 3 min of incubation. hBD-3 used at a concentration of 8 μg/ml caused a bactericidal effect within 20 min of incubation against S. aureus (strain 3), E. faecium (strain 3), and P. aeruginosa (strain 3) and within 1 min against S. maltophilia (strain 4) and A. baumannii. At a concentration of 16 μg/ml, the peptide produced a bactericidal effect against S. aureus, E. faecium, P. aeruginosa, and S. maltophilia within 10, 20, 5, and 1 min, respectively.	complete CACAO 12523
	GO:0016045	detection of bacterium	PMID:16436752^[1]	ECO:0000314			P	Human Beta-defensin 103, also known as human beta-defensin 3 (hBD-3), has the ability to detect bacterial cells and express bactericidal activity against them. The bactericidal activity of hBD-3 against various clinical isolates was evaluated by a liquid microdilution assay as shown in Figure 1. The results of that assay showed that hBD-3 used at a concentration of 4 μg/ml was bactericidal against A. baumannii (strain 3) after 3 min of incubation. hBD-3 used at a concentration of 8 μg/ml caused a bactericidal effect within 20 min of incubation against S. aureus (strain 3), E. faecium (strain 3), and P. aeruginosa (strain 3) and within 1 min against S. maltophilia (strain 4) and A. baumannii. At a concentration of 16 μg/ml, the peptide produced a bactericidal effect against S. aureus, E. faecium, P. aeruginosa, and S. maltophilia within 10, 20, 5, and 1 min, respectively.	complete CACAO 12524
involved_in	GO:0050830	defense response to Gram-positive bacterium	PMID:15625724^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050829	defense response to Gram-negative bacterium	PMID:15625724^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031640	killing of cells of other organism	PMID:15625724^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031640	killing of cells of other organism	PMID:15625724^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031640	killing of cells of other organism	PMID:15625724^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031640	killing of cells of other organism	PMID:15625724^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031640	killing of cells of other organism	PMID:15625724^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060326	cell chemotaxis	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2675345 PANTHER:PTN000464032	P	Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1351612 MGI:MGI:1927667 MGI:MGI:2654206 MGI:MGI:2675345 PANTHER:PTN000464032 UniProtKB:O15263	P	Seeded From UniProt	complete
enables	GO:0042056	chemoattractant activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2675345 PANTHER:PTN000464032	F	Seeded From UniProt	complete
enables	GO:0031731	CCR6 chemokine receptor binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1927667 PANTHER:PTN000464032 UniProtKB:O15263	F	Seeded From UniProt	complete
involved_in	GO:0006935	chemotaxis	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1927667 PANTHER:PTN000464032 UniProtKB:O15263	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000464032 UniProtKB:O15263 UniProtKB:Q6QLR1	C	Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	PMID:21115716^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21115716^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0050918	positive chemotaxis	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0042056	P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001855	C	Seeded From UniProt	complete
involved_in	GO:0006952	defense response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001855	P	Seeded From UniProt	complete
involved_in	GO:0050830	defense response to Gram-positive bacterium	PMID:11085990^[5]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050829	defense response to Gram-negative bacterium	PMID:11085990^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	PMID:11085990^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031640	killing of cells of other organism	PMID:11085990^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031640	killing of cells of other organism	PMID:11085990^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031640	killing of cells of other organism	PMID:11085990^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031640	killing of cells of other organism	PMID:11085990^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031640	killing of cells of other organism	PMID:11085990^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031640	killing of cells of other organism	PMID:11085990^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0019730	antimicrobial humoral response	Reactome:R-HSA-6803157	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005796	Golgi lumen	Reactome:R-HSA-1471322 Reactome:R-HSA-1462023	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-1974676 Reactome:R-HSA-1973968 Reactome:R-HSA-1471338 Reactome:R-HSA-1471322 Reactome:R-HSA-1467269 Reactome:R-HSA-1467209	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0044	P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
involved_in	GO:0006952	defense response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0211	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Maisetta, G et al. (2006) In vitro bactericidal activity of human beta-defensin 3 against multidrug-resistant nosocomial strains. Antimicrob. Agents Chemother. 50 806-9 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Schulz, A et al. (2005) Engineering disulfide bonds of the novel human beta-defensins hBD-27 and hBD-28: differences in disulfide formation and biological activity among human beta-defensins. Biopolymers 80 34-49 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^4.0 ^4.1 Augustin, DK et al. (2011) Role of defensins in corneal epithelial barrier function against Pseudomonas aeruginosa traversal. Infect. Immun. 79 595-605 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 Harder, J et al. (2001) Isolation and characterization of human beta -defensin-3, a novel human inducible peptide antibiotic. J. Biol. Chem. 276 5707-13 PubMed GONUTS page

[PMID:16436752-1] 1.0 ^1.1 ^1.2 ^1.3 Maisetta, G et al. (2006) In vitro bactericidal activity of human beta-defensin 3 against multidrug-resistant nosocomial strains. Antimicrob. Agents Chemother. 50 806-9 PubMed GONUTS page

[PMID:15625724-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Schulz, A et al. (2005) Engineering disulfide bonds of the novel human beta-defensins hBD-27 and hBD-28: differences in disulfide formation and biological activity among human beta-defensins. Biopolymers 80 34-49 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21115716-4] 4.0 ^4.1 Augustin, DK et al. (2011) Role of defensins in corneal epithelial barrier function against Pseudomonas aeruginosa traversal. Infect. Immun. 79 595-605 PubMed GONUTS page

[PMID:11085990-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 Harder, J et al. (2001) Isolation and characterization of human beta -defensin-3, a novel human inducible peptide antibiotic. J. Biol. Chem. 276 5707-13 PubMed GONUTS page

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HUMAN:D103A

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