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HUMAN:CSKP

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) CASK (synonyms: LIN2)
Protein Name(s) Peripheral plasma membrane protein CASK

hCASK Calcium/calmodulin-dependent serine protein kinase Protein lin-2 homolog

External Links
UniProt O14936
EMBL AF032119
AF035582
AB039327
AY705392
AL627402
AL158144
AL353691
AL445239
AL603754
AL627402
AL158144
AL353691
AL445239
AL603754
AL627402
AL158144
AL353691
AL445239
AL603754
AL627402
AL158144
AL353691
AL445239
AL603754
AL445239
AL158144
AL353691
AL603754
AL627402
AL445239
AL158144
AL353691
AL603754
AL627402
AL445239
AL158144
AL353691
AL603754
AL627402
AL445239
AL158144
AL353691
AL603754
AL627402
AL603754
AL158144
AL353691
AL445239
AL627402
AL603754
AL158144
AL353691
AL445239
AL627402
AL603754
AL158144
AL353691
AL445239
AL627402
AL603754
AL158144
AL353691
AL445239
AL627402
AL353691
AL158144
AL445239
AL603754
AL627402
AL353691
AL158144
AL445239
AL603754
AL627402
AL353691
AL158144
AL445239
AL603754
AL627402
AL353691
AL158144
AL445239
AL603754
AL627402
AL158144
AL353691
AL445239
AL603754
AL627402
AL158144
AL353691
AL445239
AL603754
AL627402
AL158144
AL353691
AL445239
AL603754
AL627402
AL158144
AL353691
AL445239
AL603754
AL627402
BC117311
BC143454
AB208859
AF262404
AF262405
CCDS CCDS14257.1
CCDS48094.1
CCDS48095.1
RefSeq NP_001119526.1
NP_001119527.1
NP_003679.2
UniGene Hs.495984
PDB 1KGD
1KWA
1ZL8
3C0G
3C0H
3C0I
3MFR
3MFS
3MFT
3MFU
3TAC
PDBsum 1KGD
1KWA
1ZL8
3C0G
3C0H
3C0I
3MFR
3MFS
3MFT
3MFU
3TAC
ProteinModelPortal O14936
SMR O14936
BioGrid 114141
DIP DIP-38727N
IntAct O14936
MINT MINT-102444
BindingDB O14936
ChEMBL CHEMBL1908381
GuidetoPHARMACOLOGY 1959
PhosphoSite O14936
MaxQB O14936
PaxDb O14936
PRIDE O14936
DNASU 8573
Ensembl ENST00000378158
ENST00000378163
ENST00000378166
ENST00000421587
ENST00000442742
GeneID 8573
KEGG hsa:8573
UCSC uc004dfk.4
uc004dfl.4
uc004dfm.4
uc004dfn.4
CTD 8573
GeneCards GC0XM041374
GeneReviews CASK
HGNC HGNC:1497
HPA CAB001949
HPA023857
MIM 300172
300422
300749
neXtProt NX_O14936
Orphanet 1934
323
163937
PharmGKB PA26081
eggNOG COG0515
GeneTree ENSGT00760000118866
HOVERGEN HBG001858
InParanoid O14936
KO K06103
OMA RCINRET
OrthoDB EOG79CXZ5
PhylomeDB O14936
TreeFam TF314263
BRENDA 2.7.11.1
Reactome REACT_163942
REACT_23832
SignaLink O14936
ChiTaRS CASK
EvolutionaryTrace O14936
GeneWiki CASK
GenomeRNAi 8573
NextBio 32157
PRO PR:O14936
Proteomes UP000005640
Bgee O14936
CleanEx HS_CASK
ExpressionAtlas O14936
Genevestigator O14936
GO GO:0015629
GO:0005604
GO:0016323
GO:0005911
GO:0060170
GO:0005737
GO:0005829
GO:0005925
GO:0005652
GO:0016363
GO:0005730
GO:0005886
GO:0042734
GO:0005524
GO:0004385
GO:0004674
GO:0070509
GO:0007155
GO:0030198
GO:0001953
GO:0090288
GO:0010839
GO:0061045
GO:0046939
GO:0090280
GO:0045944
Gene3D 2.30.42.10
3.40.50.300
InterPro IPR008145
IPR008144
IPR020590
IPR011009
IPR004172
IPR014775
IPR027417
IPR001478
IPR000719
IPR002290
IPR011511
IPR001452
Pfam PF00625
PF02828
PF00595
PF00069
PF07653
SMART SM00072
SM00569
SM00228
SM00220
SM00326
SUPFAM SSF50044
SSF50156
SSF52540
SSF56112
PROSITE PS00856
PS50052
PS51022
PS50106
PS50011
PS50002

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0005604

basement membrane

PMID:18664494[1]

ECO:0000314

C

Figure 1D immunofluorescence shows in adult human Cask localizes to cell borders of cells of the basal layer of the epidermis. Dashed line indicate basement membrane zone.

complete
CACAO 2748

GO:0005730

nucleolus

PMID:18664494[1]

ECO:0000314

C

Figure 5D, CASK protein retained in nucleoli, from nuclear matrix extraction.

complete
CACAO 2751

GO:0005652

nuclear lamina

PMID:18664494[1]

ECO:0000314

C

Figure 5CD, CASK retained in nuclear lamina, nuclear matrix extraction.

complete
CACAO 2752

GO:0010839

negative regulation of keratinocyte proliferation

PMID:18664494[1]

ECO:0000314

P

Figure 6B, knockout CASK in human keratinocyte cell line HaCaT, showed increase in HaCaT cell number compared to control. Therefore knockout CASK mice increased in growth rate of cells compared to control, figure 6C.

complete
CACAO 2753

GO:0090288

negative regulation of cellular response to growth factor stimulus

PMID:18664494[1]

ECO:0000315

P

Figure 7B, show knockout CASK increased response to growth factors when treated with KGF and TGFalpha compared to control by increase in cell proliferation.

complete
CACAO 2754

GO:0061045

negative regulation of wound healing

PMID:18664494[1]

ECO:0000315

P

Figure 9B, knockout human CASK protein showed accelerated keratinocyte cell matrix adhesion during wound healing. More spreading of cells and formation focal adhesion sites of attached cells, figure 9C

complete
CACAO 2755

involved_in

GO:0061045

negative regulation of wound healing

PMID:18664494[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0090288

negative regulation of cellular response to growth factor stimulus

PMID:18664494[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010839

negative regulation of keratinocyte proliferation

PMID:18664494[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005652

nuclear lamina

PMID:18664494[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

PMID:18664494[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005604

basement membrane

PMID:18664494[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005925

focal adhesion

PMID:21423176[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000057)

Seeded From UniProt

complete

involved_in

GO:0090288

negative regulation of cellular response to growth factor stimulus

PMID:18664494[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0061045

negative regulation of wound healing

PMID:18664494[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0060170

ciliary membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62915

C

Seeded From UniProt

complete

part_of

GO:0042734

presynaptic membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62915

C

Seeded From UniProt

complete

part_of

GO:0016363

nuclear matrix

PMID:18664494[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0010839

negative regulation of keratinocyte proliferation

PMID:18664494[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005911

cell-cell junction

PMID:18664494[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:18664494[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

PMID:18664494[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005652

nuclear lamina

PMID:18664494[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

colocalizes_with

GO:0005604

basement membrane

PMID:18664494[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0001953

negative regulation of cell-matrix adhesion

PMID:18664494[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046037

GMP metabolic process

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004385

P

Seeded From UniProt

complete

involved_in

GO:0046710

GDP metabolic process

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004385

P

Seeded From UniProt

complete

involved_in

GO:2000300

regulation of synaptic vesicle exocytosis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O70589
ensembl:ENSMUSP00000111098

P

Seeded From UniProt

complete

part_of

GO:0098685

Schaffer collateral - CA1 synapse

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O70589
ensembl:ENSMUSP00000111098

C

Seeded From UniProt

complete

involved_in

GO:0090280

positive regulation of calcium ion import

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O70589
ensembl:ENSMUSP00000111098

P

Seeded From UniProt

complete

involved_in

GO:0070509

calcium ion import

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O70589
ensembl:ENSMUSP00000111098

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O70589
ensembl:ENSMUSP00000111098

P

Seeded From UniProt

complete

part_of

GO:0045202

synapse

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O70589
ensembl:ENSMUSP00000111098

C

Seeded From UniProt

complete

enables

GO:0042043

neurexin family protein binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O70589
ensembl:ENSMUSP00000111098

F

Seeded From UniProt

complete

part_of

GO:0031982

vesicle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O70589
ensembl:ENSMUSP00000111098

C

Seeded From UniProt

complete

part_of

GO:0016323

basolateral plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O70589
ensembl:ENSMUSP00000111098

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O70589
ensembl:ENSMUSP00000111098

C

Seeded From UniProt

complete

part_of

GO:0005911

cell-cell junction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O70589
ensembl:ENSMUSP00000111098

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O70589
ensembl:ENSMUSP00000111098

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O70589
ensembl:ENSMUSP00000111098

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O70589
ensembl:ENSMUSP00000111098

C

Seeded From UniProt

complete

part_of

GO:0005604

basement membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O70589
ensembl:ENSMUSP00000111098

C

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719

F

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719

P

Seeded From UniProt

complete

part_of

GO:0015629

actin cytoskeleton

PMID:9660868[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007155

cell adhesion

PMID:9660868[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:9660868[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004385

guanylate kinase activity

PMID:9660868[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0007269

neurotransmitter secretion

Reactome:R-HSA-112310

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-6797568
Reactome:R-HSA-6797553
Reactome:R-HSA-5336443

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0723

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

enables

GO:0005516

calmodulin binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0112

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 1.15 1.16 1.17 1.18 1.19 1.20 1.21 Ojeh, N et al. (2008) The MAGUK-family protein CASK is targeted to nuclei of the basal epidermis and controls keratinocyte proliferation. J. Cell. Sci. 121 2705-17 PubMed GONUTS page
  2. ↑ Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 Cohen, AR et al. (1998) Human CASK/LIN-2 binds syndecan-2 and protein 4.1 and localizes to the basolateral membrane of epithelial cells. J. Cell Biol. 142 129-38 PubMed GONUTS page
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