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HUMAN:CPT1A

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) CPT1A (synonyms: CPT1)
Protein Name(s) Carnitine O-palmitoyltransferase 1, liver isoform

CPT1-L Carnitine O-palmitoyltransferase I, liver isoform CPT I CPTI-L Carnitine palmitoyltransferase 1A

External Links
UniProt P50416
EMBL L39211
AJ420747
AJ420748
BT009791
BC000185
CCDS CCDS31624.1
CCDS8185.1
PIR I59351
RefSeq NP_001027017.1
NP_001867.2
UniGene Hs.503043
PDB 2LE3
PDBsum 2LE3
ProteinModelPortal P50416
SMR P50416
BioGrid 107765
IntAct P50416
MINT MINT-3018357
STRING 9606.ENSP00000265641
BindingDB P50416
ChEMBL CHEMBL1293194
DrugBank DB01016
DB00583
DB01074
PhosphoSite P50416
DMDM 56405343
MaxQB P50416
PaxDb P50416
PeptideAtlas P50416
PRIDE P50416
DNASU 1374
Ensembl ENST00000265641
ENST00000376618
ENST00000539743
ENST00000540367
GeneID 1374
KEGG hsa:1374
UCSC uc001oof.4
uc001oog.4
CTD 1374
GeneCards GC11M068524
GeneReviews CPT1A
HGNC HGNC:2328
HPA HPA008835
MIM 255120
600528
neXtProt NX_P50416
Orphanet 156
PharmGKB PA26847
eggNOG NOG70127
GeneTree ENSGT00760000119220
HOGENOM HOG000233542
HOVERGEN HBG003458
InParanoid P50416
KO K08765
OMA IASEKHQ
OrthoDB EOG7J17ZQ
PhylomeDB P50416
TreeFam TF313836
BioCyc MetaCyc:HS03286-MONOMER
BRENDA 2.3.1.21
Reactome REACT_11082
REACT_116145
REACT_118659
SABIO-RK P50416
UniPathway UPA00659
ChiTaRS CPT1A
GenomeRNAi 1374
NextBio 5569
PRO PR:P50416
Proteomes UP000005640
Bgee P50416
CleanEx HS_CPT1A
ExpressionAtlas P50416
Genevestigator P50416
GO GO:0031307
GO:0016020
GO:0005743
GO:0005741
GO:0005739
GO:0004095
GO:0009437
GO:0006853
GO:0044255
GO:0071398
GO:0042755
GO:0030855
GO:0006635
GO:0006006
GO:0001676
GO:0032000
GO:0051260
GO:0050796
GO:0042493
GO:0014070
GO:0044281
GO:0006641
InterPro IPR000542
PANTHER PTHR22589
Pfam PF00755
PROSITE PS00439
PS00440

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0004095

carnitine O-palmitoyltransferase activity

PMID:7892212[1]

ECO:0000314

F

Data in the text

complete
CACAO 9921

enables

GO:0004095

carnitine O-palmitoyltransferase activity

PMID:7892212[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:19946888[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0030855

epithelial cell differentiation

PMID:21492153[3]

ECO:0000270

expression pattern evidence used in manual assertion

P

results_in_acquisition_of_features_of:(CL:1000334)

Seeded From UniProt

complete

part_of

GO:0031307

integral component of mitochondrial outer membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P32198

C

Seeded From UniProt

complete

involved_in

GO:0009437

carnitine metabolic process

PMID:11350182[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:11350182[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004095

carnitine O-palmitoyltransferase activity

PMID:11350182[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0001676

long-chain fatty acid metabolic process

PMID:11350182[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009437

carnitine metabolic process

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001097100
RGD:1305384
RGD:2396
UniProtKB:P50416

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001097100
RGD:2396
RGD:2397
UniProtKB:P50416

C

Seeded From UniProt

complete

enables

GO:0004095

carnitine O-palmitoyltransferase activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001097100
RGD:1305384
RGD:2396
RGD:2397
UniProtKB:P50416

F

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0071398

cellular response to fatty acid

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P32198
ensembl:ENSRNOP00000019652

P

Seeded From UniProt

complete

involved_in

GO:0051260

protein homooligomerization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P32198
ensembl:ENSRNOP00000019652

P

Seeded From UniProt

complete

involved_in

GO:0050796

regulation of insulin secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P32198
ensembl:ENSRNOP00000019652

P

Seeded From UniProt

complete

involved_in

GO:0046320

regulation of fatty acid oxidation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P32198
ensembl:ENSRNOP00000019652

P

Seeded From UniProt

complete

part_of

GO:0043231

intracellular membrane-bounded organelle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P32198
ensembl:ENSRNOP00000019652

C

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P32198
ensembl:ENSRNOP00000019652

F

Seeded From UniProt

complete

involved_in

GO:0042755

eating behavior

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P32198
ensembl:ENSRNOP00000019652

P

Seeded From UniProt

complete

involved_in

GO:0042493

response to drug

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P32198
ensembl:ENSRNOP00000019652

P

Seeded From UniProt

complete

involved_in

GO:0032000

positive regulation of fatty acid beta-oxidation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P32198
ensembl:ENSRNOP00000019652

P

Seeded From UniProt

complete

part_of

GO:0031307

integral component of mitochondrial outer membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P32198
ensembl:ENSRNOP00000019652

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P32198
ensembl:ENSRNOP00000019652

C

Seeded From UniProt

complete

involved_in

GO:0014070

response to organic cyclic compound

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P32198
ensembl:ENSRNOP00000019652

P

Seeded From UniProt

complete

involved_in

GO:0009437

carnitine metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P32198
ensembl:ENSRNOP00000019652

P

Seeded From UniProt

complete

involved_in

GO:0006641

triglyceride metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P32198
ensembl:ENSRNOP00000019652

P

Seeded From UniProt

complete

involved_in

GO:0006006

glucose metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P32198
ensembl:ENSRNOP00000019652

P

Seeded From UniProt

complete

part_of

GO:0005741

mitochondrial outer membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P32198
ensembl:ENSRNOP00000019652

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P32198
ensembl:ENSRNOP00000019652

C

Seeded From UniProt

complete

enables

GO:0004095

carnitine O-palmitoyltransferase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P32198
ensembl:ENSRNOP00000019652

F

Seeded From UniProt

complete

involved_in

GO:0001676

long-chain fatty acid metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P32198
ensembl:ENSRNOP00000019652

P

Seeded From UniProt

complete

enables

GO:1990698

palmitoleoyltransferase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97742
ensembl:ENSMUSP00000025835

F

Seeded From UniProt

complete

enables

GO:0016746

transferase activity, transferring acyl groups

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000542

F

Seeded From UniProt

complete

enables

GO:0004095

carnitine O-palmitoyltransferase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.3.1.21

F

Seeded From UniProt

complete

involved_in

GO:0006635

fatty acid beta-oxidation

PMID:7892212[1]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:7892212[1]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004095

carnitine O-palmitoyltransferase activity

PMID:7892212[1]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0019216

regulation of lipid metabolic process

Reactome:R-HSA-400206

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007623

circadian rhythm

Reactome:R-HSA-400253

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006853

carnitine shuttle

Reactome:R-HSA-200425

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005741

mitochondrial outer membrane

Reactome:R-HSA-200406
Reactome:R-HSA-1801587

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

part_of

GO:0005741

mitochondrial outer membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1000
UniProtKB-SubCell:SL-0172

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496

C

Seeded From UniProt

complete

involved_in

GO:0006629

lipid metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0443

P

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

involved_in

GO:0006631

fatty acid metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0276

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

enables

GO:0016746

transferase activity, transferring acyl groups

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0012

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0006635

fatty acid beta-oxidation

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00659

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Britton, CH et al. (1995) Human liver mitochondrial carnitine palmitoyltransferase I: characterization of its cDNA and chromosomal localization and partial analysis of the gene. Proc. Natl. Acad. Sci. U.S.A. 92 1984-8 PubMed GONUTS page
  2. ↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
  3. ↑ Buhrke, T et al. (2011) Analysis of proteomic changes induced upon cellular differentiation of the human intestinal cell line Caco-2. Dev. Growth Differ. 53 411-26 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 Prip-Buus, C et al. (2001) Molecular and enzymatic characterization of a unique carnitine palmitoyltransferase 1A mutation in the Hutterite community. Mol. Genet. Metab. 73 46-54 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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