HUMAN:CKAP5

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	CKAP5 (synonyms: KIAA0097)
Protein Name(s)	Cytoskeleton-associated protein 5 Colonic and hepatic tumor overexpressed gene protein Ch-TOG
External Links
UniProt	Q14008
EMBL	X92474 D43948 AC115088 BC017856 BC070136 BC111043 BC120869 BC120870
CCDS	CCDS31477.1 CCDS7924.1
PIR	S68176
RefSeq	NP_001008938.1 NP_055571.2
UniGene	Hs.201253 Hs.737795
PDB	4QMI 4QMJ
PDBsum	4QMI 4QMJ
ProteinModelPortal	Q14008
SMR	Q14008
BioGrid	115137
IntAct	Q14008
MINT	MINT-5002817
STRING	9606.ENSP00000432768
PhosphoSite	Q14008
BioMuta	CKAP5
DMDM	212276513
MaxQB	Q14008
PaxDb	Q14008
PRIDE	Q14008
Ensembl	ENST00000312055 ENST00000354558 ENST00000529230
GeneID	9793
KEGG	hsa:9793
UCSC	uc001ndi.2 uc001ndj.2 uc009ylg.1
CTD	9793
GeneCards	GC11M047086
H-InvDB	HIX0022364
HGNC	HGNC:28959
HPA	HPA039377 HPA040375
MIM	611142
neXtProt	NX_Q14008
PharmGKB	PA142672107
eggNOG	NOG253097
GeneTree	ENSGT00390000014757
HOVERGEN	HBG050955
InParanoid	Q14008
KO	K16803
OMA	EPAEMSL
OrthoDB	EOG751NDM
PhylomeDB	Q14008
TreeFam	TF105639
Reactome	R-HSA-2467813 R-HSA-2500257 R-HSA-2565942 R-HSA-380259 R-HSA-380270 R-HSA-380284 R-HSA-5620912 R-HSA-5663220 R-HSA-68877
ChiTaRS	CKAP5
GeneWiki	CKAP5
GenomeRNAi	9793
NextBio	36878
PRO	PR:Q14008
Proteomes	UP000005640
Bgee	Q14008
CleanEx	HS_CKAP5
ExpressionAtlas	Q14008
Genevisible	Q14008
GO	GO:0005813 GO:0005829 GO:0016020 GO:0043234 GO:0000922 GO:0051301 GO:0051297 GO:0030951 GO:0000086 GO:0000278 GO:0007067 GO:0006996 GO:0050658 GO:0007264 GO:0007051
Gene3D	1.25.10.10
InterPro	IPR011989 IPR016024 IPR024395 IPR021133
Pfam	PF12348
SUPFAM	SSF48371
PROSITE	PS50077

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
part_of	GO:0000776	kinetochore	PMID:25596274^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	PMID:25468996^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19946888^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0007098	centrosome cycle	PMID:14718566^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050658	RNA transport	PMID:15703215^[5]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q32Q01	P	Seeded From UniProt	complete
involved_in	GO:0030951	establishment or maintenance of microtubule cytoskeleton polarity	PMID:14718566^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
colocalizes_with	GO:0015630	microtubule cytoskeleton	PMID:15703215^[5]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q32Q01	C	Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:14718566^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
colocalizes_with	GO:0000930	gamma-tubulin complex	PMID:14718566^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
colocalizes_with	GO:0035371	microtubule plus-end	PMID:21646404^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0007051	spindle organization	PMID:14718566^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:21646404^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:21399614^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0000922	spindle pole	PMID:21646404^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0051298	centrosome duplication	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000288762 dictyBase:DDB_G0268616	P	Seeded From UniProt	complete
enables	GO:0051010	microtubule plus-end binding	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000288762 UniProtKB:Q5B1Q9	F	Seeded From UniProt	complete
	GO:0090063	positive regulation of microtubule nucleation	PMID:26414402^[9]	ECO:0000314			P	Figure 6b&c	complete CACAO 11009
involved_in	GO:0046785	microtubule polymerization	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000288762 UniProtKB:Q5B1Q9 dictyBase:DDB_G0268616	P	Seeded From UniProt	complete
colocalizes_with	GO:0035371	microtubule plus-end	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0027948 PANTHER:PTN000288762 UniProtKB:Q14008	C	Seeded From UniProt	complete
involved_in	GO:0030951	establishment or maintenance of microtubule cytoskeleton polarity	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000288762 UniProtKB:Q14008	P	Seeded From UniProt	complete
involved_in	GO:0007051	spindle organization	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000288762 UniProtKB:Q14008 WB:WBGene00006994	P	Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000288762 UniProtKB:Q14008 WB:WBGene00006994 dictyBase:DDB_G0268616	C	Seeded From UniProt	complete
part_of	GO:0000922	spindle pole	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000288762 UniProtKB:Q14008 WB:WBGene00006994 dictyBase:DDB_G0268616	C	Seeded From UniProt	complete
part_of	GO:0000776	kinetochore	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000288762 SGD:S000004035 UniProtKB:Q14008 WB:WBGene00006994 dictyBase:DDB_G0268616	C	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:18468998^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0007019	microtubule depolymerization	PMID:26323690^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046785	microtubule polymerization	PMID:26323690^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0097711	ciliary basal body-plasma membrane docking	Reactome:R-HSA-5620912	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010389	regulation of G2/M transition of mitotic cell cycle	Reactome:R-HSA-8854518	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-8853419 Reactome:R-HSA-8853405 Reactome:R-HSA-5666169 Reactome:R-HSA-5666160 Reactome:R-HSA-5666129 Reactome:R-HSA-5638009 Reactome:R-HSA-5626699 Reactome:R-HSA-5626681 Reactome:R-HSA-5626228 Reactome:R-HSA-5626227 Reactome:R-HSA-5626223 Reactome:R-HSA-5626220 Reactome:R-HSA-5617816 Reactome:R-HSA-380508 Reactome:R-HSA-380455 Reactome:R-HSA-380316 Reactome:R-HSA-380311 Reactome:R-HSA-380303 Reactome:R-HSA-380294 Reactome:R-HSA-380283 Reactome:R-HSA-380272 Reactome:R-HSA-375302 Reactome:R-HSA-3000319 Reactome:R-HSA-3000310 Reactome:R-HSA-2574845 Reactome:R-HSA-2574840 Reactome:R-HSA-2484822 Reactome:R-HSA-2468287 Reactome:R-HSA-2467811 Reactome:R-HSA-2467809 Reactome:R-HSA-1638821 Reactome:R-HSA-1638803 Reactome:R-HSA-141439 Reactome:R-HSA-141431 Reactome:R-HSA-141422 Reactome:R-HSA-141409	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0000086	G2/M transition of mitotic cell cycle	Reactome:R-HSA-69275	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C	Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206	C	Seeded From UniProt	complete
involved_in	GO:0051301	cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0132	P	Seeded From UniProt	complete
part_of	GO:0000776	kinetochore	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0995	C	Seeded From UniProt	complete
part_of	GO:0000775	chromosome, centromeric region	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0137	C	Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P	Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0048	C	Seeded From UniProt	complete
part_of	GO:0000777	condensed chromosome kinetochore	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0149	C	Seeded From UniProt	complete
part_of	GO:0005819	spindle	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0251	C	Seeded From UniProt	complete
part_of	GO:0000922	spindle pole	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0448	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Gutiérrez-Caballero, C et al. (2015) TACC3-ch-TOG track the growing tips of microtubules independently of clathrin and Aurora-A phosphorylation. Biol Open 4 170-9 PubMed GONUTS page
↑ Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page
↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Cassimeris, L & Morabito, J (2004) TOGp, the human homolog of XMAP215/Dis1, is required for centrosome integrity, spindle pole organization, and bipolar spindle assembly. Mol. Biol. Cell 15 1580-90 PubMed GONUTS page
↑ ^5.0 ^5.1 Kosturko, LD et al. (2005) The microtubule-associated protein tumor overexpressed gene binds to the RNA trafficking protein heterogeneous nuclear ribonucleoprotein A2. Mol. Biol. Cell 16 1938-47 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 van der Vaart, B et al. (2011) SLAIN2 links microtubule plus end-tracking proteins and controls microtubule growth in interphase. J. Cell Biol. 193 1083-99 PubMed GONUTS page
↑ Jakobsen, L et al. (2011) Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. EMBO J. 30 1520-35 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 ^8.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Roostalu, J et al. (2015) Complementary activities of TPX2 and chTOG constitute an efficient importin-regulated microtubule nucleation module. Nat. Cell Biol. 17 1422-34 PubMed GONUTS page
↑ Lyssand, JS et al. (2008) Blood pressure is regulated by an alpha1D-adrenergic receptor/dystrophin signalosome. J. Biol. Chem. 283 18792-800 PubMed GONUTS page
↑ ^11.0 ^11.1 Watanabe, T et al. (2015) TTBK2 with EB1/3 regulates microtubule dynamics in migrating cells through KIF2A phosphorylation. J. Cell Biol. 210 737-51 PubMed GONUTS page

[PMID:25596274-1] Gutiérrez-Caballero, C et al. (2015) TACC3-ch-TOG track the growing tips of microtubules independently of clathrin and Aurora-A phosphorylation. Biol Open 4 170-9 PubMed GONUTS page

[PMID:25468996-2] Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page

[PMID:19946888-3] Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page

[PMID:14718566-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Cassimeris, L & Morabito, J (2004) TOGp, the human homolog of XMAP215/Dis1, is required for centrosome integrity, spindle pole organization, and bipolar spindle assembly. Mol. Biol. Cell 15 1580-90 PubMed GONUTS page

[PMID:15703215-5] 5.0 ^5.1 Kosturko, LD et al. (2005) The microtubule-associated protein tumor overexpressed gene binds to the RNA trafficking protein heterogeneous nuclear ribonucleoprotein A2. Mol. Biol. Cell 16 1938-47 PubMed GONUTS page

[PMID:21646404-6] 6.0 ^6.1 ^6.2 van der Vaart, B et al. (2011) SLAIN2 links microtubule plus end-tracking proteins and controls microtubule growth in interphase. J. Cell Biol. 193 1083-99 PubMed GONUTS page

[PMID:21399614-7] Jakobsen, L et al. (2011) Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. EMBO J. 30 1520-35 PubMed GONUTS page

[PMID:21873635-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 ^8.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:26414402-9] Roostalu, J et al. (2015) Complementary activities of TPX2 and chTOG constitute an efficient importin-regulated microtubule nucleation module. Nat. Cell Biol. 17 1422-34 PubMed GONUTS page

[PMID:18468998-10] Lyssand, JS et al. (2008) Blood pressure is regulated by an alpha1D-adrenergic receptor/dystrophin signalosome. J. Biol. Chem. 283 18792-800 PubMed GONUTS page

[PMID:26323690-11] 11.0 ^11.1 Watanabe, T et al. (2015) TTBK2 with EB1/3 regulates microtubule dynamics in migrating cells through KIF2A phosphorylation. J. Cell Biol. 210 737-51 PubMed GONUTS page

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HUMAN:CKAP5

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References

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