HUMAN:CIDEA

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	CIDEA
Protein Name(s)	Cell death activator CIDE-A Cell death-inducing DFFA-like effector A
External Links
UniProt	O60543
EMBL	AF041378 AY364639 EF444967
CCDS	CCDS11856.1
RefSeq	NP_001270.1
UniGene	Hs.249129
PDB	2EEL
PDBsum	2EEL
ProteinModelPortal	O60543
SMR	O60543
BioGrid	107570
IntAct	O60543
MINT	MINT-7002607
STRING	9606.ENSP00000320209
PhosphoSite	O60543
BioMuta	CIDEA
PaxDb	O60543
PRIDE	O60543
Ensembl	ENST00000320477
GeneID	1149
KEGG	hsa:1149
UCSC	uc002kqt.5
CTD	1149
GeneCards	CIDEA
HGNC	HGNC:1976
MIM	604440
neXtProt	NX_O60543
PharmGKB	PA26514
eggNOG	ENOG410IVIC ENOG4111SUV
GeneTree	ENSGT00390000018596
HOGENOM	HOG000029211
HOVERGEN	HBG050961
InParanoid	O60543
OMA	IRPLTFM
OrthoDB	EOG7K3TN6
PhylomeDB	O60543
TreeFam	TF334321
EvolutionaryTrace	O60543
GeneWiki	CIDEA
GenomeRNAi	1149
NextBio	4776
PRO	PR:O60543
Proteomes	UP000005640
Bgee	O60543
CleanEx	HS_CIDEA
ExpressionAtlas	O60543
Genevisible	O60543
GO	GO:0005737 GO:0005811 GO:0005740 GO:0005739 GO:0005634 GO:0042803 GO:0006915 GO:0008219 GO:0006629 GO:0019915 GO:0050710 GO:1900118 GO:0050995 GO:0030512 GO:0032720 GO:0010890 GO:1902510 GO:0042981 GO:0006355 GO:0035634 GO:0001659 GO:0006351
InterPro	IPR032936 IPR003508
PANTHER	PTHR12306:SF8
Pfam	PF02017
SMART	SM00266
PROSITE	PS51135

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0120163	negative regulation of cold-induced thermogenesis	PMID:12910269^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O70302	P		Seeded From UniProt	complete
involved_in	GO:1902510	regulation of apoptotic DNA fragmentation	PMID:9564035^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O70302	P		Seeded From UniProt	complete
involved_in	GO:1900118	negative regulation of execution phase of apoptosis	PMID:17080483^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O70302	P		Seeded From UniProt	complete
involved_in	GO:0050995	negative regulation of lipid catabolic process	PMID:15919794^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050995	negative regulation of lipid catabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O70302	P		Seeded From UniProt	complete
involved_in	GO:0050710	negative regulation of cytokine secretion	PMID:15919794^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:17080483^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O70302	F		Seeded From UniProt	complete
involved_in	GO:0032720	negative regulation of tumor necrosis factor production	PMID:15919794^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	PMID:17080483^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O70302	P		Seeded From UniProt	complete
involved_in	GO:0019915	lipid storage	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O70302	P		Seeded From UniProt	complete
involved_in	GO:0010890	positive regulation of sequestering of triglyceride	PMID:18509062^[5]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O70302	P	occurs_in:(CL:0000449)	Seeded From UniProt	complete
involved_in	GO:0008219	cell death	PMID:17080483^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O70302	P		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O70302	P		Seeded From UniProt	complete
colocalizes_with	GO:0005811	lipid droplet	PMID:18509062^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005740	mitochondrial envelope	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O70302	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O70302	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:17080483^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O70302	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17080483^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O70302	C		Seeded From UniProt	complete
involved_in	GO:0001659	temperature homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O70302	P		Seeded From UniProt	complete
part_of	GO:0005811	lipid droplet	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1270845 PANTHER:PTN000959606 UniProtKB:O60543	C		Seeded From UniProt	complete
involved_in	GO:1902510	regulation of apoptotic DNA fragmentation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70302 ensembl:ENSMUSP00000025404	P		Seeded From UniProt	complete
involved_in	GO:1900118	negative regulation of execution phase of apoptosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70302 ensembl:ENSMUSP00000025404	P		Seeded From UniProt	complete
involved_in	GO:0120163	negative regulation of cold-induced thermogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70302 ensembl:ENSMUSP00000025404	P		Seeded From UniProt	complete
involved_in	GO:0050995	negative regulation of lipid catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70302 ensembl:ENSMUSP00000025404	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70302 ensembl:ENSMUSP00000025404	F		Seeded From UniProt	complete
involved_in	GO:0035634	response to stilbenoid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70302 ensembl:ENSMUSP00000025404	P		Seeded From UniProt	complete
involved_in	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70302 ensembl:ENSMUSP00000025404	P		Seeded From UniProt	complete
involved_in	GO:0019915	lipid storage	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70302 ensembl:ENSMUSP00000025404	P		Seeded From UniProt	complete
involved_in	GO:0010890	positive regulation of sequestering of triglyceride	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70302 ensembl:ENSMUSP00000025404	P		Seeded From UniProt	complete
involved_in	GO:0008219	cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70302 ensembl:ENSMUSP00000025404	P		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70302 ensembl:ENSMUSP00000025404	P		Seeded From UniProt	complete
part_of	GO:0005811	lipid droplet	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70302 ensembl:ENSMUSP00000025404	C		Seeded From UniProt	complete
part_of	GO:0005740	mitochondrial envelope	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70302 ensembl:ENSMUSP00000025404	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70302 ensembl:ENSMUSP00000025404	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70302 ensembl:ENSMUSP00000025404	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70302 ensembl:ENSMUSP00000025404	C		Seeded From UniProt	complete
involved_in	GO:0001659	temperature homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70302 ensembl:ENSMUSP00000025404	P		Seeded From UniProt	complete
part_of	GO:0005811	lipid droplet	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032936	C		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003508	P		Seeded From UniProt	complete
involved_in	GO:0019915	lipid storage	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032936	P		Seeded From UniProt	complete
involved_in	GO:0034389	lipid droplet organization	Reactome:R-HSA-8964572	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-8856630	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
part_of	GO:0005811	lipid droplet	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0551 UniProtKB-SubCell:SL-0154	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Zhou, Z et al. (2003) Cidea-deficient mice have lean phenotype and are resistant to obesity. Nat. Genet. 35 49-56 PubMed GONUTS page
↑ Inohara, N et al. (1998) CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor. EMBO J. 17 2526-33 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Iwahana, H et al. (2006) Glycoproteome profiling of transforming growth factor-beta (TGFbeta) signaling: nonglycosylated cell death-inducing DFF-like effector A inhibits TGFbeta1-dependent apoptosis. Proteomics 6 6168-80 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Nordström, EA et al. (2005) A human-specific role of cell death-inducing DFFA (DNA fragmentation factor-alpha)-like effector A (CIDEA) in adipocyte lipolysis and obesity. Diabetes 54 1726-34 PubMed GONUTS page
↑ ^5.0 ^5.1 Puri, V et al. (2008) Cidea is associated with lipid droplets and insulin sensitivity in humans. Proc. Natl. Acad. Sci. U.S.A. 105 7833-8 PubMed GONUTS page
↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12910269-1] Zhou, Z et al. (2003) Cidea-deficient mice have lean phenotype and are resistant to obesity. Nat. Genet. 35 49-56 PubMed GONUTS page

[PMID:9564035-2] Inohara, N et al. (1998) CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor. EMBO J. 17 2526-33 PubMed GONUTS page

[PMID:17080483-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Iwahana, H et al. (2006) Glycoproteome profiling of transforming growth factor-beta (TGFbeta) signaling: nonglycosylated cell death-inducing DFF-like effector A inhibits TGFbeta1-dependent apoptosis. Proteomics 6 6168-80 PubMed GONUTS page

[PMID:15919794-4] 4.0 ^4.1 ^4.2 Nordström, EA et al. (2005) A human-specific role of cell death-inducing DFFA (DNA fragmentation factor-alpha)-like effector A (CIDEA) in adipocyte lipolysis and obesity. Diabetes 54 1726-34 PubMed GONUTS page

[PMID:18509062-5] 5.0 ^5.1 Puri, V et al. (2008) Cidea is associated with lipid droplets and insulin sensitivity in humans. Proc. Natl. Acad. Sci. U.S.A. 105 7833-8 PubMed GONUTS page

[PMID:21873635-6] Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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HUMAN:CIDEA

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