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HUMAN:CHD1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) CHD1
Protein Name(s) Chromodomain-helicase-DNA-binding protein 1

CHD-1 ATP-dependent helicase CHD1

External Links
UniProt O14646
EMBL AF006513
AC022121
BC117134
CCDS CCDS34204.1
RefSeq NP_001261.2
XP_005271924.1
UniGene Hs.643465
PDB 2B2T
2B2U
2B2V
2B2W
2B2Y
4B4C
4NW2
4O42
PDBsum 2B2T
2B2U
2B2V
2B2W
2B2Y
4B4C
4NW2
4O42
ProteinModelPortal O14646
SMR O14646
BioGrid 107530
DIP DIP-38922N
IntAct O14646
STRING 9606.ENSP00000284049
DrugBank DB00445
PhosphoSite O14646
MaxQB O14646
PaxDb O14646
PRIDE O14646
Ensembl ENST00000284049
ENST00000614616
GeneID 1105
KEGG hsa:1105
UCSC uc003knf.3
CTD 1105
GeneCards GC05M098190
H-InvDB HIX0005061
HGNC HGNC:1915
HPA HPA022236
MIM 602118
neXtProt NX_O14646
PharmGKB PA26451
eggNOG COG0553
GeneTree ENSGT00760000119067
HOGENOM HOG000207917
HOVERGEN HBG005325
InParanoid O14646
KO K11367
OMA MDHRASS
OrthoDB EOG7NPFSB
PhylomeDB O14646
TreeFam TF313461
ChiTaRS CHD1
EvolutionaryTrace O14646
GeneWiki CHD1
GenomeRNAi 1105
NextBio 4580
PRO PR:O14646
Proteomes UP000005640
Bgee O14646
CleanEx HS_CHD1
ExpressionAtlas O14646
Genevestigator O14646
GO GO:0005737
GO:0005634
GO:0005524
GO:0004003
GO:0003677
GO:0035064
GO:0016568
GO:0032508
GO:0006357
GO:0006351
Gene3D 3.40.50.300
InterPro IPR023780
IPR000953
IPR016197
IPR023779
IPR025260
IPR014001
IPR001650
IPR027417
IPR000330
Pfam PF00385
PF13907
PF00271
PF00176
SMART SM00298
SM00487
SM00490
SUPFAM SSF52540
SSF54160
PROSITE PS00598
PS50013
PS51192
PS51194

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0005634

nucleus

PMID:22046413[1]

ECO:0000314

C

Fig. 5A

complete
CACAO 2702

GO:0005737

cytoplasm

PMID:22046413[1]

ECO:0000314

C

Fig. 5A

complete
CACAO 2703

GO:0043923

positive regulation by host of viral transcription

PMID:25297984[2]

ECO:0000315

P

Figure 4 panel C shows a decrease in HIV-1 transcripts in cells that underwent siRNA-mediated knockdown of CHD1 compared to the control. Figure 4 panel C shows an increase in transcripts in cells transfected with plasmids encoding tagged CHD1.

complete
CACAO 10408

enables

GO:0035064

methylated histone binding

PMID:28866611[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:22046413[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:22046413[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0043923

positive regulation by host of viral transcription

PMID:25297984[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0035064

methylated histone binding

PMID:21029866[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0016569

covalent chromatin modification

PMID:28866611[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0001650

fibrillar center

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0032508

DNA duplex unwinding

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004003

P

Seeded From UniProt

complete

involved_in

GO:0006338

chromatin remodeling

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P40201
ensembl:ENSMUSP00000024627

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000330

F

Seeded From UniProt

complete

involved_in

GO:0006357

regulation of transcription by RNA polymerase II

PMID:9326634[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004003

ATP-dependent DNA helicase activity

PMID:9326634[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-9012186

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0004386

helicase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0347

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

involved_in

GO:0006325

chromatin organization

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0156

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Dey, P et al. (2011) Human RNA polymerase II-association factor 1 (hPaf1/PD2) regulates histone methylation and chromatin remodeling in pancreatic cancer. PLoS ONE 6 e26926 PubMed GONUTS page
  2. 2.0 2.1 Rodgers, MJ et al. (2014) CHD1 and CHD2 are positive regulators of HIV-1 gene expression. Virol. J. 11 180 PubMed GONUTS page
  3. 3.0 3.1 Pilarowski, GO et al. (2018) Missense variants in the chromatin remodeler are associated with neurodevelopmental disability. J. Med. Genet. 55 561-566 PubMed GONUTS page
  4. Bartke, T et al. (2010) Nucleosome-interacting proteins regulated by DNA and histone methylation. Cell 143 470-84 PubMed GONUTS page
  5. 5.0 5.1 Woodage, T et al. (1997) Characterization of the CHD family of proteins. Proc. Natl. Acad. Sci. U.S.A. 94 11472-7 PubMed GONUTS page