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HUMAN:CHD1
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | CHD1 | |
| Protein Name(s) | Chromodomain-helicase-DNA-binding protein 1
CHD-1 ATP-dependent helicase CHD1 | |
| External Links | ||
| UniProt | O14646 | |
| EMBL | AF006513 AC022121 BC117134 | |
| CCDS | CCDS34204.1 | |
| RefSeq | NP_001261.2 XP_005271924.1 | |
| UniGene | Hs.643465 | |
| PDB | 2B2T 2B2U 2B2V 2B2W 2B2Y 4B4C 4NW2 4O42 | |
| PDBsum | 2B2T 2B2U 2B2V 2B2W 2B2Y 4B4C 4NW2 4O42 | |
| ProteinModelPortal | O14646 | |
| SMR | O14646 | |
| BioGrid | 107530 | |
| DIP | DIP-38922N | |
| IntAct | O14646 | |
| STRING | 9606.ENSP00000284049 | |
| DrugBank | DB00445 | |
| PhosphoSite | O14646 | |
| MaxQB | O14646 | |
| PaxDb | O14646 | |
| PRIDE | O14646 | |
| Ensembl | ENST00000284049 ENST00000614616 | |
| GeneID | 1105 | |
| KEGG | hsa:1105 | |
| UCSC | uc003knf.3 | |
| CTD | 1105 | |
| GeneCards | GC05M098190 | |
| H-InvDB | HIX0005061 | |
| HGNC | HGNC:1915 | |
| HPA | HPA022236 | |
| MIM | 602118 | |
| neXtProt | NX_O14646 | |
| PharmGKB | PA26451 | |
| eggNOG | COG0553 | |
| GeneTree | ENSGT00760000119067 | |
| HOGENOM | HOG000207917 | |
| HOVERGEN | HBG005325 | |
| InParanoid | O14646 | |
| KO | K11367 | |
| OMA | MDHRASS | |
| OrthoDB | EOG7NPFSB | |
| PhylomeDB | O14646 | |
| TreeFam | TF313461 | |
| ChiTaRS | CHD1 | |
| EvolutionaryTrace | O14646 | |
| GeneWiki | CHD1 | |
| GenomeRNAi | 1105 | |
| NextBio | 4580 | |
| PRO | PR:O14646 | |
| Proteomes | UP000005640 | |
| Bgee | O14646 | |
| CleanEx | HS_CHD1 | |
| ExpressionAtlas | O14646 | |
| Genevestigator | O14646 | |
| GO | GO:0005737 GO:0005634 GO:0005524 GO:0004003 GO:0003677 GO:0035064 GO:0016568 GO:0032508 GO:0006357 GO:0006351 | |
| Gene3D | 3.40.50.300 | |
| InterPro | IPR023780 IPR000953 IPR016197 IPR023779 IPR025260 IPR014001 IPR001650 IPR027417 IPR000330 | |
| Pfam | PF00385 PF13907 PF00271 PF00176 | |
| SMART | SM00298 SM00487 SM00490 | |
| SUPFAM | SSF52540 SSF54160 | |
| PROSITE | PS00598 PS50013 PS51192 PS51194 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0005634 |
nucleus |
ECO:0000314 |
C |
Fig. 5A |
complete | |||||
| GO:0005737 |
cytoplasm |
ECO:0000314 |
C |
Fig. 5A |
complete | |||||
| GO:0043923 |
positive regulation by host of viral transcription |
ECO:0000315 |
P |
Figure 4 panel C shows a decrease in HIV-1 transcripts in cells that underwent siRNA-mediated knockdown of CHD1 compared to the control. Figure 4 panel C shows an increase in transcripts in cells transfected with plasmids encoding tagged CHD1. |
complete | |||||
|
enables |
GO:0035064 |
methylated histone binding |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043923 |
positive regulation by host of viral transcription |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0035064 |
methylated histone binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016569 |
covalent chromatin modification |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0001650 |
fibrillar center |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032508 |
DNA duplex unwinding |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004003 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006338 |
chromatin remodeling |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P40201 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006357 |
regulation of transcription by RNA polymerase II |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004003 |
ATP-dependent DNA helicase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-HSA-9012186 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004386 |
helicase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006325 |
chromatin organization |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Dey, P et al. (2011) Human RNA polymerase II-association factor 1 (hPaf1/PD2) regulates histone methylation and chromatin remodeling in pancreatic cancer. PLoS ONE 6 e26926 PubMed GONUTS page
- ↑ 2.0 2.1 Rodgers, MJ et al. (2014) CHD1 and CHD2 are positive regulators of HIV-1 gene expression. Virol. J. 11 180 PubMed GONUTS page
- ↑ 3.0 3.1 Pilarowski, GO et al. (2018) Missense variants in the chromatin remodeler are associated with neurodevelopmental disability. J. Med. Genet. 55 561-566 PubMed GONUTS page
- ↑ Bartke, T et al. (2010) Nucleosome-interacting proteins regulated by DNA and histone methylation. Cell 143 470-84 PubMed GONUTS page
- ↑ 5.0 5.1 Woodage, T et al. (1997) Characterization of the CHD family of proteins. Proc. Natl. Acad. Sci. U.S.A. 94 11472-7 PubMed GONUTS page
