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HUMAN:CHAC1
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | CHAC1 (ECO:0000303 with PMID:19109178[1], ECO:0000312 with HGNC:HGNC:28680) (synonyms: BOTCH (ECO:0000303 with PMID:22445366[2])) | |
| Protein Name(s) | Glutathione-specific gamma-glutamylcyclotransferase 1 (ECO:0000305 with PMID:23070364[3])
Gamma-GCG 1 (ECO:0000303 with PMID:23070364[3]) Blocks Notch protein (ECO:0000303 with PMID:22445366[2]) Botch (ECO:0000303 with PMID:22445366[2]) Cation transport regulator-like protein 1 (ECO:0000303 with PMID:19109178[1]) | |
| External Links | ||
| UniProt | Q9BUX1 | |
| EMBL | AC020661 BC001683 BC001847 BC019625 AY702027 | |
| CCDS | CCDS10070.2 CCDS45233.1 | |
| RefSeq | NP_001136248.1 NP_077016.2 | |
| UniGene | Hs.155569 | |
| ProteinModelPortal | Q9BUX1 | |
| BioGrid | 122541 | |
| IntAct | Q9BUX1 | |
| MINT | MINT-1451921 | |
| PhosphoSite | Q9BUX1 | |
| DMDM | 294862423 | |
| MaxQB | Q9BUX1 | |
| PaxDb | Q9BUX1 | |
| PRIDE | Q9BUX1 | |
| DNASU | 79094 | |
| Ensembl | ENST00000444189 ENST00000446533 ENST00000617768 ENST00000617961 | |
| GeneID | 79094 | |
| KEGG | hsa:79094 | |
| UCSC | uc001znh.2 uc010uct.1 | |
| CTD | 79094 | |
| GeneCards | GC15P041245 | |
| H-InvDB | HIX0012144 | |
| HGNC | HGNC:28680 | |
| HPA | HPA042708 HPA043505 | |
| MIM | 614587 | |
| neXtProt | NX_Q9BUX1 | |
| PharmGKB | PA142672119 | |
| eggNOG | COG3703 | |
| GeneTree | ENSGT00390000003855 | |
| HOGENOM | HOG000264264 | |
| HOVERGEN | HBG056733 | |
| InParanoid | Q9BUX1 | |
| KO | K07232 | |
| OMA | PQALWIF | |
| OrthoDB | EOG7F7W9F | |
| PhylomeDB | Q9BUX1 | |
| TreeFam | TF313048 | |
| ChiTaRS | CHAC1 | |
| GenomeRNAi | 79094 | |
| NextBio | 67939 | |
| PRO | PR:Q9BUX1 | |
| Proteomes | UP000005640 | |
| Bgee | Q9BUX1 | |
| CleanEx | HS_CHAC1 | |
| ExpressionAtlas | Q9BUX1 | |
| Genevestigator | Q9BUX1 | |
| GO | GO:0005829 GO:0005802 GO:0005112 GO:0070059 GO:0045746 GO:0010955 GO:0022008 GO:0007219 GO:0006986 | |
| Gene3D | 3.10.490.10 | |
| InterPro | IPR013024 IPR006840 | |
| PANTHER | PTHR12192 | |
| Pfam | PF04752 | |
| SUPFAM | SSF110857 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0070059 |
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045746 |
negative regulation of Notch signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0022008 |
neurogenesis |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010955 |
negative regulation of protein processing |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005802 |
trans-Golgi network |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005112 |
Notch binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006751 |
glutathione catabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG12403 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001742855 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003839 |
gamma-glutamylcyclotransferase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG12403 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003839 |
gamma-glutamylcyclotransferase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006751 |
glutathione catabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0061928 |
glutathione specific gamma-glutamylcyclotransferase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006750 |
glutathione biosynthetic process |
Reactome:R-HSA-174403 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-6785928 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016829 |
lyase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007399 |
nervous system development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006915 |
apoptotic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005794 |
Golgi apparatus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006986 |
response to unfolded protein |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007219 |
Notch signaling pathway |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Mungrue, IN et al. (2009) CHAC1/MGC4504 is a novel proapoptotic component of the unfolded protein response, downstream of the ATF4-ATF3-CHOP cascade. J. Immunol. 182 466-76 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Chi, Z et al. (2012) Botch promotes neurogenesis by antagonizing Notch. Dev. Cell 22 707-20 PubMed GONUTS page
- ↑ 3.0 3.1 Kumar, A et al. (2012) Mammalian proapoptotic factor ChaC1 and its homologues function as γ-glutamyl cyclotransferases acting specifically on glutathione. EMBO Rep. 13 1095-101 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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