HUMAN:CDT1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	CDT1 (ECO:0000312 with EMBL:AAG45181.1)
Protein Name(s)	DNA replication factor Cdt1 Double parked homolog DUP
External Links
UniProt	Q9H211
EMBL	AF321125 AB053172 AC092384 BC000137 BC008676 BC008860 BC009410 BC014202 BC049205 AF070552
CCDS	CCDS32510.1
RefSeq	NP_112190.2
UniGene	Hs.122908
PDB	2LE8 2WVR
PDBsum	2LE8 2WVR
ProteinModelPortal	Q9H211
SMR	Q9H211
BioGrid	123555
DIP	DIP-31089N
IntAct	Q9H211
MINT	MINT-1202336
STRING	9606.ENSP00000301019
PhosphoSite	Q9H211
DMDM	308153620
MaxQB	Q9H211
PaxDb	Q9H211
PRIDE	Q9H211
Ensembl	ENST00000301019
GeneID	81620
KEGG	hsa:81620
UCSC	uc002flu.3
CTD	81620
GeneCards	GC16P088870
H-InvDB	HIX0013345
HGNC	HGNC:24576
HPA	HPA017224
MIM	605525 613804
neXtProt	NX_Q9H211
Orphanet	2554
PharmGKB	PA145008572
eggNOG	NOG312810
GeneTree	ENSGT00390000012337
HOVERGEN	HBG050872
InParanoid	Q9H211
KO	K10727
OMA	GMLHNRS
OrthoDB	EOG7V49Z6
PhylomeDB	Q9H211
TreeFam	TF101159
Reactome	REACT_1095 REACT_1156 REACT_1181 REACT_1949 REACT_207 REACT_2243 REACT_471 REACT_683
EvolutionaryTrace	Q9H211
GeneWiki	DNA_replication_factor_CDT1
GenomeRNAi	81620
NextBio	71980
PRO	PR:Q9H211
Proteomes	UP000005640
Bgee	Q9H211
CleanEx	HS_CDT1
Genevestigator	Q9H211
GO	GO:0005829 GO:0005654 GO:0005634 GO:0003677 GO:0006260 GO:0000076 GO:0000082 GO:0000278 GO:0030174 GO:0033262 GO:0000083
InterPro	IPR014939
Pfam	PF08839
SMART	SM01075

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005730	nucleolus	PMID:11555648^[1]	ECO:0000314			C		Figure 2.	complete
involved_in	GO:0031334	positive regulation of protein complex assembly	PMID:22581055^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(GO:0031262)	Seeded From UniProt	complete
involved_in	GO:0071163	DNA replication preinitiation complex assembly	PMID:11125146^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000105	positive regulation of DNA-dependent DNA replication	PMID:11125146^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2001178	positive regulation of mediator complex assembly	PMID:11125146^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035563	positive regulation of chromatin binding	PMID:11125146^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P30664) has_regulation_target:(UniProtKB:Q5XK83) has_regulation_target:(UniProtKB:Q91628)	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:11125146^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007059	chromosome segregation	PMID:22581055^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051315	attachment of mitotic spindle microtubules to kinetochore	PMID:22581055^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902426	deactivation of mitotic spindle assembly checkpoint	PMID:22581055^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q9Y6D9)	Seeded From UniProt	complete
involved_in	GO:1905341	negative regulation of protein localization to kinetochore	PMID:22581055^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q9Y6D9) part_of:(GO:1902426)	Seeded From UniProt	complete
involved_in	GO:1902595	regulation of DNA replication origin binding	PMID:21856198^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	happens_during:(GO:0072708) has_regulation_target:(UniProtKB:O95251)	Seeded From UniProt	complete
involved_in	GO:0072708	response to sorbitol	PMID:21856198^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051383	kinetochore organization	PMID:22581055^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000278	mitotic cell cycle	PMID:22581055^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0000776	kinetochore	PMID:22581055^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0000236)	Seeded From UniProt	complete
involved_in	GO:0051301	cell division	PMID:22581055^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033044	regulation of chromosome organization	PMID:22581055^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1905342	positive regulation of protein localization to kinetochore	PMID:22581055^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q9Y5N6)	Seeded From UniProt	complete
involved_in	GO:0045740	positive regulation of DNA replication	PMID:26842564^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:26842564^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030174	regulation of DNA-dependent DNA replication initiation	PMID:11125146^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11125146^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8R4E9	F		Seeded From UniProt	complete
involved_in	GO:0000076	DNA replication checkpoint	PMID:14672932^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071163	DNA replication preinitiation complex assembly	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002008627 UniProtKB:Q9H211	P		Seeded From UniProt	complete
enables	GO:0070182	DNA polymerase binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002008627 TAIR:locus:2042541 TAIR:locus:2102460	F		Seeded From UniProt	complete
involved_in	GO:0051315	attachment of mitotic spindle microtubules to kinetochore	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002008627 UniProtKB:Q9H211	P		Seeded From UniProt	complete
involved_in	GO:0006260	DNA replication	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000996 PANTHER:PTN002008627 TAIR:locus:2042541 TAIR:locus:2102460	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000996 MGI:MGI:1914427 PANTHER:PTN002008627 TAIR:locus:2042541 UniProtKB:Q9H211 WB:WBGene00000413	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1914427 PANTHER:PTN002008627	F		Seeded From UniProt	complete
colocalizes_with	GO:0000776	kinetochore	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002008627 UniProtKB:Q9H211	C		Seeded From UniProt	complete
involved_in	GO:0000281	mitotic cytokinesis	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000996 PANTHER:PTN002008627	P		Seeded From UniProt	complete
involved_in	GO:0000278	mitotic cell cycle	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002008627 UniProtKB:Q9H211 ZFIN:ZDB-GENE-070111-1	P		Seeded From UniProt	complete
involved_in	GO:0000076	DNA replication checkpoint	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000996 MGI:MGI:1914427 PANTHER:PTN002008627 UniProtKB:Q9H211	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:24217620^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0033262	regulation of nuclear cell cycle DNA replication	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8R4E9 ensembl:ENSMUSP00000006760	P		Seeded From UniProt	complete
involved_in	GO:0030174	regulation of DNA-dependent DNA replication initiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8R4E9 ensembl:ENSMUSP00000006760	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8R4E9 ensembl:ENSMUSP00000006760	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8R4E9 ensembl:ENSMUSP00000006760	F		Seeded From UniProt	complete
involved_in	GO:0000076	DNA replication checkpoint	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8R4E9 ensembl:ENSMUSP00000006760	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-68712	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-8961952 Reactome:R-HSA-69299 Reactome:R-HSA-68944 Reactome:R-HSA-68940 Reactome:R-HSA-68919 Reactome:R-HSA-68849 Reactome:R-HSA-68826	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle	Reactome:R-HSA-69205	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000082	G1/S transition of mitotic cell cycle	Reactome:R-HSA-69206	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0000775	chromosome, centromeric region	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0137	C		Seeded From UniProt	complete
part_of	GO:0000776	kinetochore	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0995	C		Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158	C		Seeded From UniProt	complete
involved_in	GO:0006260	DNA replication	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0235	P		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0051301	cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0132	P		Seeded From UniProt	complete
part_of	GO:0000777	condensed chromosome kinetochore	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0149	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Nishitani, H et al. (2001) The human licensing factor for DNA replication Cdt1 accumulates in G1 and is destabilized after initiation of S-phase. J. Biol. Chem. 276 44905-11 PubMed GONUTS page
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 Varma, D et al. (2012) Recruitment of the human Cdt1 replication licensing protein by the loop domain of Hec1 is required for stable kinetochore-microtubule attachment. Nat. Cell Biol. 14 593-603 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Wohlschlegel, JA et al. (2000) Inhibition of eukaryotic DNA replication by geminin binding to Cdt1. Science 290 2309-12 PubMed GONUTS page
↑ ^4.0 ^4.1 Miotto, B & Struhl, K (2011) JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress. Mol. Cell 44 62-71 PubMed GONUTS page
↑ ^5.0 ^5.1 Franz, A et al. (2016) Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression. Nat Commun 7 10612 PubMed GONUTS page
↑ Cook, JG et al. (2004) The regulated association of Cdt1 with minichromosome maintenance proteins and Cdc6 in mammalian cells. J. Biol. Chem. 279 9625-33 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 ^7.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Mosammaparast, N et al. (2013) The histone demethylase LSD1/KDM1A promotes the DNA damage response. J. Cell Biol. 203 457-70 PubMed GONUTS page

[PMID:11555648-1] Nishitani, H et al. (2001) The human licensing factor for DNA replication Cdt1 accumulates in G1 and is destabilized after initiation of S-phase. J. Biol. Chem. 276 44905-11 PubMed GONUTS page

[PMID:22581055-2] 2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 Varma, D et al. (2012) Recruitment of the human Cdt1 replication licensing protein by the loop domain of Hec1 is required for stable kinetochore-microtubule attachment. Nat. Cell Biol. 14 593-603 PubMed GONUTS page

[PMID:11125146-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Wohlschlegel, JA et al. (2000) Inhibition of eukaryotic DNA replication by geminin binding to Cdt1. Science 290 2309-12 PubMed GONUTS page

[PMID:21856198-4] 4.0 ^4.1 Miotto, B & Struhl, K (2011) JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress. Mol. Cell 44 62-71 PubMed GONUTS page

[PMID:26842564-5] 5.0 ^5.1 Franz, A et al. (2016) Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression. Nat Commun 7 10612 PubMed GONUTS page

[PMID:14672932-6] Cook, JG et al. (2004) The regulated association of Cdt1 with minichromosome maintenance proteins and Cdc6 in mammalian cells. J. Biol. Chem. 279 9625-33 PubMed GONUTS page

[PMID:21873635-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 ^7.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:24217620-8] Mosammaparast, N et al. (2013) The histone demethylase LSD1/KDM1A promotes the DNA damage response. J. Cell Biol. 203 457-70 PubMed GONUTS page

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HUMAN:CDT1

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