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HUMAN:CDN2A
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | CDKN2A (ECO:0000312 with HGNC:HGNC:1787) (synonyms: CDKN2, MTS1) | |
| Protein Name(s) | Cyclin-dependent kinase inhibitor 2A (ECO:0000312 with HGNC:HGNC:1787)
Cyclin-dependent kinase 4 inhibitor A CDK4I Multiple tumor suppressor 1 MTS-1 p16-INK4a p16-INK4 p16INK4A | |
| External Links | ||
| UniProt | P42771 | |
| EMBL | L27211 AF115544 AB060808 AF527803 DQ318021 AL449423 CH471071 CH471071 CH471071 X94154 AH007355 S69804 U12820 U12818 U12819 | |
| CCDS | CCDS56565.1 CCDS6510.1 CCDS87644.1 | |
| PIR | JE0141 | |
| RefSeq | NP_000068.1 NP_001182061.1 NP_478104.2 XP_005251400.1 XP_011515981.1 | |
| UniGene | Hs.512599 | |
| PDB | 1A5E 1BI7 1DC2 2A5E | |
| PDBsum | 1A5E 1BI7 1DC2 2A5E | |
| ProteinModelPortal | P42771 | |
| SMR | P42771 | |
| BioGrid | 107463 | |
| CORUM | P42771 | |
| DIP | DIP-6108N | |
| IntAct | P42771 | |
| MINT | P42771 | |
| STRING | 9606.ENSP00000394932 | |
| iPTMnet | P42771 | |
| PhosphoSitePlus | P42771 | |
| BioMuta | MTAP | |
| DMDM | 3041660 | |
| EPD | P42771 | |
| PaxDb | P42771 | |
| PeptideAtlas | P42771 | |
| PRIDE | P42771 | |
| ProteomicsDB | 55551 55552 55553 55554 | |
| TopDownProteomics | P42771-1 | |
| DNASU | 1029 | |
| Ensembl | ENST00000304494 ENST00000380151 ENST00000494262 ENST00000498124 ENST00000498628 ENST00000578845 | |
| GeneID | 1029 | |
| KEGG | hsa:1029 | |
| UCSC | uc003zpk.4 | |
| CTD | 1029 | |
| DisGeNET | 1029 | |
| EuPathDB | HostDB:ENSG00000147889.16 | |
| GeneCards | CDKN2A | |
| HGNC | HGNC:1787 | |
| HPA | CAB000093 CAB000445 CAB018232 | |
| MalaCards | CDKN2A | |
| MIM | 155601 155755 600160 606719 | |
| neXtProt | NX_P42771 | |
| OpenTargets | ENSG00000147889 | |
| Orphanet | 404560 618 1333 252206 51013 99860 99861 | |
| PharmGKB | PA106 | |
| eggNOG | KOG0504 COG0666 | |
| GeneTree | ENSGT00390000004527 | |
| HOGENOM | HOG000290191 | |
| HOVERGEN | HBG050870 | |
| InParanoid | P42771 | |
| KO | K06621 | |
| OMA | MMMGSSE | |
| TreeFam | TF352389 | |
| Reactome | R-HSA-2559580 R-HSA-2559582 R-HSA-2559585 R-HSA-69231 | |
| SIGNOR | P42771 | |
| ChiTaRS | CDKN2A | |
| EvolutionaryTrace | P42771 | |
| GeneWiki | P16_(gene) | |
| GenomeRNAi | 1029 | |
| Proteomes | UP000005640 | |
| Bgee | ENSG00000147889 | |
| CleanEx | HS_CDKN2A | |
| ExpressionAtlas | P42771 | |
| Genevisible | P42771 | |
| GO | GO:0005737 GO:0005829 GO:0005634 GO:0035985 GO:0004861 GO:0016301 GO:0051059 GO:0019901 GO:0003723 GO:0007050 GO:0090398 GO:0000082 GO:0030308 GO:0008285 GO:0001953 GO:0045736 GO:0031658 GO:0032088 GO:0042326 GO:0045892 GO:2000774 GO:2000111 GO:0034393 GO:0007265 GO:0090399 GO:0035986 | |
| CDD | cd00204 | |
| Gene3D | 1.25.40.20 | |
| InterPro | IPR020683 IPR036770 | |
| SUPFAM | SSF48403 | |
| PROSITE | PS50297 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:2000111 |
positive regulation of macrophage apoptotic process |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0090399 |
replicative senescence |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0051059 |
NF-kappaB binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045736 |
negative regulation of cyclin-dependent protein serine/threonine kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042326 |
negative regulation of phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042326 |
negative regulation of phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0034393 |
positive regulation of smooth muscle cell apoptotic process |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032088 |
negative regulation of NF-kappaB transcription factor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030308 |
negative regulation of cell growth |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019901 |
protein kinase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008285 |
negative regulation of cell population proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008285 |
negative regulation of cell population proliferation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007265 |
Ras protein signal transduction |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007050 |
cell cycle arrest |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004861 |
cyclin-dependent protein serine/threonine kinase inhibitor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001953 |
negative regulation of cell-matrix adhesion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000082 |
G1/S transition of mitotic cell cycle |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008285 |
negative regulation of cell population proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007050 |
cell cycle arrest |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0090398 |
cellular senescence |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000774 |
positive regulation of cellular senescence |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0035986 |
senescence-associated heterochromatin focus assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0035985 |
senescence-associated heterochromatin focus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008285 |
negative regulation of cell population proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001948826 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004861 |
cyclin-dependent protein serine/threonine kinase inhibitor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001948826 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045736 |
negative regulation of cyclin-dependent protein serine/threonine kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004861 |
cyclin-dependent protein serine/threonine kinase inhibitor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000134 |
negative regulation of G1/S transition of mitotic cell cycle |
Reactome:R-HSA-182594 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-3209114 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007049 |
cell cycle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 González-Navarro, H et al. (2010) p19(ARF) deficiency reduces macrophage and vascular smooth muscle cell apoptosis and aggravates atherosclerosis. J. Am. Coll. Cardiol. 55 2258-68 PubMed GONUTS page
- ↑ Bond, J et al. (2004) Direct evidence from siRNA-directed "knock down" that p16(INK4a) is required for human fibroblast senescence and for limiting ras-induced epithelial cell proliferation. Exp. Cell Res. 292 151-6 PubMed GONUTS page
- ↑ 3.0 3.1 Wolff, B & Naumann, M (1999) INK4 cell cycle inhibitors direct transcriptional inactivation of NF-kappaB. Oncogene 18 2663-6 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Serrano, M et al. (1993) A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 366 704-7 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Schreiber, M et al. (1999) Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity. Oncogene 18 1663-76 PubMed GONUTS page
- ↑ Medema, RH et al. (1995) Growth suppression by p16ink4 requires functional retinoblastoma protein. Proc. Natl. Acad. Sci. U.S.A. 92 6289-93 PubMed GONUTS page
- ↑ 7.0 7.1 Herbig, U et al. (2004) Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol. Cell 14 501-13 PubMed GONUTS page
- ↑ Serrano, M et al. (1997) Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88 593-602 PubMed GONUTS page
- ↑ Fåhraeus, R & Lane, DP (1999) The p16(INK4a) tumour suppressor protein inhibits alphavbeta3 integrin-mediated cell spreading on vitronectin by blocking PKC-dependent localization of alphavbeta3 to focal contacts. EMBO J. 18 2106-18 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 10.3 10.4 Chen, J et al. (2006) Contribution of p16INK4a and p21CIP1 pathways to induction of premature senescence of human endothelial cells: permissive role of p53. Am. J. Physiol. Heart Circ. Physiol. 290 H1575-86 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 11.3 11.4 Narita, M et al. (2006) A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation. Cell 126 503-14 PubMed GONUTS page
- ↑ Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
- ↑ 13.0 13.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 14.0 14.1 Hirai, H et al. (1995) Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6. Mol. Cell. Biol. 15 2672-81 PubMed GONUTS page
c
n
- GO:0045892 ! negative regulation of DNA-templated transcription
- GO:0001953 ! negative regulation of cell-matrix adhesion
- GO:0008285 ! negative regulation of cell population proliferation
- GO:2000134 ! negative regulation of G1/S transition of mitotic cell cycle
- GO:0030308 ! negative regulation of cell growth
- GO:0032088 ! negative regulation of NF-kappaB transcription factor activity
- GO:0042326 ! negative regulation of phosphorylation
- GO:0045736 ! negative regulation of cyclin-dependent protein serine/threonine kinase activity
- GO:0051059 ! NF-kappaB binding
- GO:0005634 ! nucleus
p
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