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HUMAN:CDK13

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) CDK13 (synonyms: CDC2L, CDC2L5, CHED, KIAA1791)
Protein Name(s) Cyclin-dependent kinase 13

CDC2-related protein kinase 5 Cell division cycle 2-like protein kinase 5 Cell division protein kinase 13 hCDK13 Cholinesterase-related cell division controller

External Links
UniProt Q14004
EMBL AJ297709
AJ297710
AY679523
AC072061
AC072061
AC006023
M80629
AK223053
AB058694
CCDS CCDS5461.1
CCDS5462.1
PIR A38197
RefSeq NP_003709.3
NP_112557.2
UniGene Hs.233552
ProteinModelPortal Q14004
SMR Q14004
BioGrid 114176
IntAct Q14004
MINT MINT-1197921
STRING 9606.ENSP00000181839
BindingDB Q14004
ChEMBL CHEMBL1795192
GuidetoPHARMACOLOGY 1966
PhosphoSite Q14004
DMDM 66774048
MaxQB Q14004
PaxDb Q14004
PRIDE Q14004
DNASU 8621
Ensembl ENST00000181839
ENST00000340829
GeneID 8621
KEGG hsa:8621
UCSC uc003thh.4
uc003thi.4
CTD 8621
GeneCards GC07P039957
HGNC HGNC:1733
HPA HPA059241
MIM 603309
neXtProt NX_Q14004
PharmGKB PA26264
eggNOG COG0515
GeneTree ENSGT00770000120511
HOVERGEN HBG050851
InParanoid Q14004
KO K08819
OMA KERHREH
OrthoDB EOG76DTSM
PhylomeDB Q14004
TreeFam TF101060
SignaLink Q14004
ChiTaRS CDK13
GeneWiki CDC2L5
GenomeRNAi 8621
NextBio 32303
PMAP-CutDB Q14004
PRO PR:Q14004
Proteomes UP000005640
Bgee Q14004
CleanEx HS_CDC2L5
ExpressionAtlas Q14004
Genevestigator Q14004
GO GO:0002945
GO:0005615
GO:0019908
GO:0016607
GO:0005524
GO:0030332
GO:0004693
GO:0044822
GO:0004672
GO:0008353
GO:0000380
GO:0030097
GO:0007275
GO:0070816
GO:0008284
GO:0007088
GO:0016032
InterPro IPR011009
IPR000719
IPR017441
IPR002290
IPR008271
Pfam PF00069
SMART SM00220
SUPFAM SSF56112
PROSITE PS00107
PS50011
PS00108

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0005615

extracellular space

PMID:22664934[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001827)

Seeded From UniProt

complete

involved_in

GO:0070816

phosphorylation of RNA polymerase II C-terminal domain

PMID:20952539[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22681889[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0030097

hemopoiesis

PMID:1731328[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0019908

nuclear cyclin-dependent protein kinase holoenzyme complex

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q69ZA1

C

Seeded From UniProt

complete

part_of

GO:0016607

nuclear speck

PMID:16721827[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0008353

RNA polymerase II CTD heptapeptide repeat kinase activity

PMID:20952539[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0000380

alternative mRNA splicing, via spliceosome

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q69ZA1

P

Seeded From UniProt

complete

involved_in

GO:0070816

phosphorylation of RNA polymerase II C-terminal domain

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0037093
PANTHER:PTN001936021
SGD:S000001622
SGD:S000006365
UniProtKB:Q14004
UniProtKB:Q9NYV4

P

Seeded From UniProt

complete

involved_in

GO:0070816

phosphorylation of RNA polymerase II C-terminal domain

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0037093
PANTHER:PTN000623455
SGD:S000001622
SGD:S000006365
UniProtKB:Q14004
UniProtKB:Q9NYV4

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0019949
PANTHER:PTN000623455
UniProtKB:P50750

P

Seeded From UniProt

complete

enables

GO:0044212

transcription regulatory region DNA binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1328368
PANTHER:PTN000623455

F

Seeded From UniProt

complete

involved_in

GO:0032968

positive regulation of transcription elongation from RNA polymerase II promoter

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001936021
SGD:S000006365

P

Seeded From UniProt

complete

enables

GO:0030332

cyclin binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0037093
MGI:MGI:1916812
PANTHER:PTN000623455
RGD:621111
UniProtKB:Q14004
UniProtKB:Q9NYV4

F

Seeded From UniProt

complete

enables

GO:0008353

RNA polymerase II CTD heptapeptide repeat kinase activity

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0019949
FB:FBgn0037093
MGI:MGI:1328368
PANTHER:PTN001936021
PomBase:SPAC2F3.15
PomBase:SPBC32H8.10
SGD:S000006365
UniProtKB:P50750
UniProtKB:Q14004
UniProtKB:Q9NYV4

F

Seeded From UniProt

complete

enables

GO:0008353

RNA polymerase II CTD heptapeptide repeat kinase activity

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0019949
FB:FBgn0037093
MGI:MGI:1328368
PANTHER:PTN000623455
PomBase:SPAC2F3.15
PomBase:SPBC32H8.10
SGD:S000006365
UniProtKB:P50750
UniProtKB:Q14004
UniProtKB:Q9NYV4

F

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000623455
RGD:1359638

F

Seeded From UniProt

complete

part_of

GO:0008024

cyclin/CDK positive transcription elongation factor complex

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1328368
PANTHER:PTN000623455
UniProtKB:P50750

C

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0004106
FB:FBgn0005640
FB:FBgn0013435
FB:FBgn0013762
FB:FBgn0015618
FB:FBgn0263237
MGI:MGI:101765
MGI:MGI:104772
MGI:MGI:88351
MGI:MGI:88357
PANTHER:PTN000623091
RGD:621124
RGD:70514
SGD:S000001622
SGD:S000001865
SGD:S000005488
SGD:S000005952
SGD:S000005963
SGD:S000006365
TAIR:locus:2119961
UniProtKB:P06493
UniProtKB:P11802
UniProtKB:P21127
UniProtKB:P24941
UniProtKB:P50750
UniProtKB:Q00534
UniProtKB:Q00646
UniProtKB:Q9UQ88
WB:WBGene00000405
WB:WBGene00000407
WB:WBGene00019362
ZFIN:ZDB-GENE-040808-34
dictyBase:DDB_G0267442
dictyBase:DDB_G0272813
dictyBase:DDB_G0288677

P

Seeded From UniProt

complete

involved_in

GO:0006368

transcription elongation from RNA polymerase II promoter

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0019949
PANTHER:PTN000623455

P

Seeded From UniProt

complete

part_of

GO:0005694

chromosome

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000623455
WB:WBGene00000410
WB:WBGene00007135

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0015618
FB:FBgn0019949
FB:FBgn0263237
MGI:MGI:101765
MGI:MGI:102956
MGI:MGI:104772
MGI:MGI:1328368
MGI:MGI:88353
MGI:MGI:88357
MGI:MGI:894318
PANTHER:PTN000623091
PomBase:SPAC2F3.15
PomBase:SPBC11B10.09
PomBase:SPBC32H8.10
RGD:1305435
RGD:1359638
RGD:2319
RGD:619874
RGD:621120
RGD:621124
RGD:70486
RGD:70514
SGD:S000000364
SGD:S000001622
SGD:S000002266
SGD:S000005952
TAIR:locus:2008595
TAIR:locus:2027819
TAIR:locus:2033349
TAIR:locus:2080290
TAIR:locus:2084086
TAIR:locus:2099478
TAIR:locus:2119961
TAIR:locus:2158554
TAIR:locus:2194045
UniProtKB:O76039
UniProtKB:O94921
UniProtKB:P06493
UniProtKB:P11802
UniProtKB:P21127
UniProtKB:P24941
UniProtKB:P49336
UniProtKB:P50613
UniProtKB:P61075
UniProtKB:P79432
UniProtKB:Q00534
UniProtKB:Q00535
UniProtKB:Q00646
UniProtKB:Q5B3E4
UniProtKB:Q8IDW1
UniProtKB:Q8IIL5
UniProtKB:Q8IJQ1
UniProtKB:Q8RWN3
UniProtKB:Q8W4P1
UniProtKB:Q92772
UniProtKB:Q96VK3
UniProtKB:Q9NYV4
UniProtKB:Q9UQ88
WB:WBGene00000405
dictyBase:DDB_G0267442
dictyBase:DDB_G0288677

C

Seeded From UniProt

complete

enables

GO:0004693

cyclin-dependent protein serine/threonine kinase activity

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0004106
FB:FBgn0005640
FB:FBgn0013762
FB:FBgn0019949
FB:FBgn0263237
MGI:MGI:104772
MGI:MGI:88351
MGI:MGI:88357
PANTHER:PTN000623091
PomBase:SPAC23H4.17c
PomBase:SPAC2F3.15
PomBase:SPBC11B10.09
PomBase:SPBC19F8.07
PomBase:SPBC32H8.10
RGD:2319
RGD:621120
RGD:621124
RGD:70486
RGD:70514
SGD:S000000364
SGD:S000001622
SGD:S000005952
SGD:S000005963
SGD:S000006365
TAIR:locus:2011761
UniProtKB:A0A1D8PDA6
UniProtKB:C9K505
UniProtKB:O94921
UniProtKB:P06493
UniProtKB:P11802
UniProtKB:P24941
UniProtKB:P50750
UniProtKB:P61075
UniProtKB:Q00534
UniProtKB:Q00646
UniProtKB:Q8IJQ1
WB:WBGene00000405
ZFIN:ZDB-GENE-010131-2
dictyBase:DDB_G0272813
dictyBase:DDB_G0288677

F

Seeded From UniProt

complete

part_of

GO:0000790

nuclear chromatin

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001936021
PomBase:SPAC2F3.15
PomBase:SPBC32H8.10

C

Seeded From UniProt

complete

part_of

GO:0000307

cyclin-dependent protein kinase holoenzyme complex

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001936021
PomBase:SPBC32H8.10
SGD:S000006365

C

Seeded From UniProt

complete

enables

GO:0030332

cyclin binding

PMID:22012619[7]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O75909

F

Seeded From UniProt

complete

part_of

GO:0002945

cyclin K-CDK13 complex

PMID:22012619[7]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O75909

C

Seeded From UniProt

complete

part_of

GO:0016607

nuclear speck

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:2000737

negative regulation of stem cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q69ZA1
ensembl:ENSMUSP00000036013

P

Seeded From UniProt

complete

enables

GO:0030332

cyclin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q69ZA1
ensembl:ENSMUSP00000036013

F

Seeded From UniProt

complete

part_of

GO:0019908

nuclear cyclin-dependent protein kinase holoenzyme complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q69ZA1
ensembl:ENSMUSP00000036013

C

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q69ZA1
ensembl:ENSMUSP00000036013

F

Seeded From UniProt

complete

involved_in

GO:0000380

alternative mRNA splicing, via spliceosome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q69ZA1
ensembl:ENSMUSP00000036013

P

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR008271

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR017441

F

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR008271

P

Seeded From UniProt

complete

enables

GO:0004693

cyclin-dependent protein serine/threonine kinase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.7.11.22

F

Seeded From UniProt

complete

enables

GO:0008353

RNA polymerase II CTD heptapeptide repeat kinase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.7.11.23

F

Seeded From UniProt

complete

involved_in

GO:0008284

positive regulation of cell population proliferation

PMID:1731328[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

PMID:1731328[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007088

regulation of mitotic nuclear division

PMID:1731328[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

PMID:1731328[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0000380

alternative mRNA splicing, via spliceosome

PMID:16721827[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:1904813

ficolin-1-rich granule lumen

Reactome:R-HSA-6800434

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0043312

neutrophil degranulation

Reactome:R-HSA-6798695

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-6797100

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-HSA-6800434

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0723

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

involved_in

GO:0016032

viral process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0945

P

Seeded From UniProt

complete

involved_in

GO:0006397

mRNA processing

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0507

P

Seeded From UniProt

complete

involved_in

GO:0008380

RNA splicing

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0508

P

Seeded From UniProt

complete

part_of

GO:0016607

nuclear speck

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0186

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Böhm, D et al. (2012) Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Oncol. Rep. 28 429-38 PubMed GONUTS page
  2. ↑ 2.0 2.1 Bartkowiak, B et al. (2010) CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1. Genes Dev. 24 2303-16 PubMed GONUTS page
  3. ↑ Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 Lapidot-Lifson, Y et al. (1992) Cloning and antisense oligodeoxynucleotide inhibition of a human homolog of cdc2 required in hematopoiesis. Proc. Natl. Acad. Sci. U.S.A. 89 579-83 PubMed GONUTS page
  5. ↑ 5.0 5.1 Even, Y et al. (2006) CDC2L5, a Cdk-like kinase with RS domain, interacts with the ASF/SF2-associated protein p32 and affects splicing in vivo. J. Cell. Biochem. 99 890-904 PubMed GONUTS page
  6. ↑ 6.00 6.01 6.02 6.03 6.04 6.05 6.06 6.07 6.08 6.09 6.10 6.11 6.12 6.13 6.14 6.15 6.16 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  7. ↑ 7.0 7.1 Blazek, D et al. (2011) The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes. Genes Dev. 25 2158-72 PubMed GONUTS page
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