HUMAN:CD4

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	CD4
Protein Name(s)	T-cell surface glycoprotein CD4 T-cell surface antigen T4/Leu-3
External Links
UniProt	P01730
EMBL	M12807 U47924 M35160 BT019791 BT019811 DQ012936 AK312828 CH471116 CH471116 BC025782
CCDS	CCDS8562.1
PIR	A90872
RefSeq	NP_000607.1
UniGene	Hs.631659
PDB	1CDH 1CDI 1CDJ 1CDU 1CDY 1G9M 1G9N 1GC1 1JL4 1OPN 1OPT 1OPW 1Q68 1RZJ 1RZK 1WBR 1WIO 1WIP 1WIQ 2B4C 2JKR 2JKT 2KLU 2NXY 2NXZ 2NY0 2NY1 2NY2 2NY3 2NY4 2NY5 2NY6 2QAD 3B71 3CD4 3JWD 3JWO 3LQA 3O2D 3S4S 3S5L 3T0E 4H8W 4JM2 4P9H 4Q6I 4R2G 4R4H
PDBsum	1CDH 1CDI 1CDJ 1CDU 1CDY 1G9M 1G9N 1GC1 1JL4 1OPN 1OPT 1OPW 1Q68 1RZJ 1RZK 1WBR 1WIO 1WIP 1WIQ 2B4C 2JKR 2JKT 2KLU 2NXY 2NXZ 2NY0 2NY1 2NY2 2NY3 2NY4 2NY5 2NY6 2QAD 3B71 3CD4 3JWD 3JWO 3LQA 3O2D 3S4S 3S5L 3T0E 4H8W 4JM2 4P9H 4Q6I 4R2G 4R4H
DisProt	DP00123
ProteinModelPortal	P01730
SMR	P01730
BioGrid	107358
DIP	DIP-617N
IntAct	P01730
MINT	MINT-1130311
STRING	9606.ENSP00000011653
BindingDB	P01730
ChEMBL	CHEMBL2754
DrugBank	DB00098
PhosphoSite	P01730
UniCarbKB	P01730
DMDM	116013
MaxQB	P01730
PaxDb	P01730
PeptideAtlas	P01730
PRIDE	P01730
DNASU	920
Ensembl	ENST00000011653
GeneID	920
KEGG	hsa:920
UCSC	uc001qqv.2
CTD	920
GeneCards	GC12P006899
HGNC	HGNC:1678
HPA	CAB000011 HPA004252 HPA004472
MIM	186940 613949
neXtProt	NX_P01730
PharmGKB	PA26220
eggNOG	NOG47205
GeneTree	ENSGT00390000001745
HOGENOM	HOG000008696
HOVERGEN	HBG005281
InParanoid	P01730
KO	K06454
OMA	PEAGMWQ
PhylomeDB	P01730
TreeFam	TF335974
Reactome	REACT_11166 REACT_115574 REACT_12555 REACT_12582 REACT_12596 REACT_12623 REACT_19324 REACT_6903 REACT_9031
SignaLink	P01730
ChiTaRS	CD4
EvolutionaryTrace	P01730
GeneWiki	CD4
GenomeRNAi	920
NextBio	3806
PRO	PR:P01730
Proteomes	UP000005640
Bgee	P01730
CleanEx	HS_CD4
ExpressionAtlas	P01730
Genevestigator	P01730
GO	GO:0005769 GO:0005788 GO:0005789 GO:0009897 GO:0016021 GO:0045121 GO:0005886 GO:0042101 GO:0015026 GO:0019899 GO:0005201 GO:0001948 GO:0042289 GO:0042803 GO:0019901 GO:0004872 GO:0004888 GO:0008270 GO:0007155 GO:0007166 GO:0001816 GO:0050829 GO:0030260 GO:0007167 GO:0006955 GO:0006948 GO:0045087 GO:0032507 GO:0050850 GO:0045086 GO:0050731 GO:0045860 GO:0045234 GO:0050690 GO:0050863 GO:0007165 GO:0031295 GO:0030217 GO:0050852 GO:0045058 GO:0007169 GO:0016032
Gene3D	2.60.40.10
InterPro	IPR000973 IPR015274 IPR007110 IPR013783 IPR008424 IPR003599 IPR013106 IPR003596 IPR021963
Pfam	PF05790 PF09191 PF12104 PF07686
PRINTS	PR00692
SMART	SM00409 SM00406
PROSITE	PS50835

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0030225	macrophage differentiation	PMID:24942581^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:24942581^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0035723	interleukin-15-mediated signaling pathway	PMID:24942581^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus	PMID:24942581^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045657	positive regulation of monocyte differentiation	PMID:24942581^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0042289	MHC class II protein binding	PMID:24942581^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04233,UniProtKB:P13760	F	Seeded From UniProt	complete
enables	GO:1990782	protein tyrosine kinase binding	PMID:3262426^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P06240	F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:2823150^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0042289	MHC class II protein binding	PMID:11535811^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0042289	MHC class II protein binding	PMID:2823150^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:9168119^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:9168119^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0046598	positive regulation of viral entry into host cell	PMID:24942581^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:24942581^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0033674	positive regulation of kinase activity	PMID:24942581^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PMID:24942581^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	PMID:24942581^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	PMID:24942581^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0042011	interleukin-16 binding	PMID:24942581^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q14005	F	Seeded From UniProt	complete
involved_in	GO:0051924	regulation of calcium ion transport	PMID:24942581^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0042012	interleukin-16 receptor activity	PMID:24942581^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:24942581^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050863	regulation of T cell activation	PMID:1533274^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045860	positive regulation of protein kinase activity	PMID:2118992^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045086	positive regulation of interleukin-2 biosynthetic process	PMID:1901411^[8]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045058	T cell selection	PMID:9551897^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:12444132^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0042289	MHC class II protein binding	PMID:8512039^[11]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0042101	T cell receptor complex	PMID:8512039^[11]	ECO:0000303	author statement without traceable support used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0030217	T cell differentiation	PMID:1533274^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:7486703^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P06239	F	Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:19333378^[13]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O15162	F	Seeded From UniProt	complete
enables	GO:0015026	coreceptor activity	PMID:8512039^[11]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	PMID:9668045^[14]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	PMID:8512039^[11]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006955	immune response	PMID:8512039^[11]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006948	induction by virus of host cell-cell fusion	PMID:9166430^[15]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:19333378^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:8124721^[16]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005201	extracellular matrix structural constituent	PMID:12444132^[10]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
enables	GO:1990782	protein tyrosine kinase binding	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002605579 RGD:2306 UniProtKB:P01730	F	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002605579 UniProtKB:P01730	P	Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88335 PANTHER:PTN002605579 UniProtKB:P01730	C	Seeded From UniProt	complete
enables	GO:0042289	MHC class II protein binding	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002605579 UniProtKB:P01730	F	Seeded From UniProt	complete
involved_in	GO:0042110	T cell activation	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002605579 RGD:2306	P	Seeded From UniProt	complete
involved_in	GO:0035723	interleukin-15-mediated signaling pathway	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002605579 UniProtKB:P01730	P	Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88335 PANTHER:PTN002605579 RGD:2306 UniProtKB:P01730	C	Seeded From UniProt	complete
involved_in	GO:0032507	maintenance of protein location in cell	PMID:15128768^[18]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:17213291^[19]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:11390434^[20]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:9168119^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P01730	F	Seeded From UniProt	complete
enables	GO:1990782	protein tyrosine kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05540 ensembl:ENSRNOP00000021915	F	Seeded From UniProt	complete
involved_in	GO:0042110	T cell activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05540 ensembl:ENSRNOP00000021915	P	Seeded From UniProt	complete
involved_in	GO:0042102	positive regulation of T cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05540 ensembl:ENSRNOP00000021915	P	Seeded From UniProt	complete
involved_in	GO:0033280	response to vitamin D	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05540 ensembl:ENSRNOP00000021915	P	Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05540 ensembl:ENSRNOP00000021915	P	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05540 ensembl:ENSRNOP00000021915	F	Seeded From UniProt	complete
enables	GO:0019865	immunoglobulin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05540 ensembl:ENSRNOP00000021915	F	Seeded From UniProt	complete
involved_in	GO:0010524	positive regulation of calcium ion transport into cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05540 ensembl:ENSRNOP00000021915	P	Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05540 ensembl:ENSRNOP00000021915	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05540 ensembl:ENSRNOP00000021915	C	Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05540 ensembl:ENSRNOP00000021915	F	Seeded From UniProt	complete
involved_in	GO:0050870	positive regulation of T cell activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06332 ensembl:ENSMUSP00000024044	P	Seeded From UniProt	complete
involved_in	GO:0050850	positive regulation of calcium-mediated signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06332 ensembl:ENSMUSP00000024044	P	Seeded From UniProt	complete
involved_in	GO:0050829	defense response to Gram-negative bacterium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06332 ensembl:ENSMUSP00000024044	P	Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06332 ensembl:ENSMUSP00000024044	P	Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06332 ensembl:ENSMUSP00000024044	C	Seeded From UniProt	complete
involved_in	GO:0035397	helper T cell enhancement of adaptive immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06332 ensembl:ENSMUSP00000024044	P	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06332 ensembl:ENSMUSP00000024044	C	Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06332 ensembl:ENSMUSP00000024044	C	Seeded From UniProt	complete
involved_in	GO:0007166	cell surface receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06332 ensembl:ENSMUSP00000024044	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06332 ensembl:ENSMUSP00000024044	C	Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06332 ensembl:ENSMUSP00000024044	C	Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06332 ensembl:ENSMUSP00000024044	C	Seeded From UniProt	complete
involved_in	GO:0001816	cytokine production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06332 ensembl:ENSMUSP00000024044	P	Seeded From UniProt	complete
involved_in	GO:0006955	immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000973	P	Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008424	P	Seeded From UniProt	complete
enables	GO:0015026	coreceptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000973	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000973	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008424	C	Seeded From UniProt	complete
enables	GO:0015026	coreceptor activity	PMID:8674120^[21]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0007167	enzyme linked receptor protein signaling pathway	PMID:10358157^[22]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007166	cell surface receptor signaling pathway	PMID:9780207^[23]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:9558100^[24] PMID:10358157^[22]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0004888	transmembrane signaling receptor activity	PMID:10358157^[22]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	PMID:10413516^[25]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0061024	membrane organization	Reactome:R-HSA-199991	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050852	T cell receptor signaling pathway	Reactome:R-HSA-202403	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050690	regulation of defense response to virus by virus	Reactome:R-HSA-167590	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0030665	clathrin-coated vesicle membrane	Reactome:R-HSA-8871194 Reactome:R-HSA-8871193 Reactome:R-HSA-8869438 Reactome:R-HSA-8868661 Reactome:R-HSA-8868660 Reactome:R-HSA-8868659 Reactome:R-HSA-8868658	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0030260	entry into host cell	Reactome:R-HSA-173107	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	Reactome:R-HSA-449836	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0019064	fusion of virus membrane with host plasma membrane	Reactome:R-HSA-164524	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-8868661 Reactome:R-HSA-8868651 Reactome:R-HSA-8868648 Reactome:R-HSA-8868236 Reactome:R-HSA-8868230 Reactome:R-HSA-8868072 Reactome:R-HSA-8868071 Reactome:R-HSA-8867756 Reactome:R-HSA-8867754 Reactome:R-HSA-8866277 Reactome:R-HSA-8855381 Reactome:R-HSA-8852200 Reactome:R-HSA-449087 Reactome:R-HSA-389758 Reactome:R-HSA-202344 Reactome:R-HSA-202307 Reactome:R-HSA-202291 Reactome:R-HSA-202248 Reactome:R-HSA-202245 Reactome:R-HSA-202233 Reactome:R-HSA-202216 Reactome:R-HSA-202214 Reactome:R-HSA-202174 Reactome:R-HSA-202168 Reactome:R-HSA-202165 Reactome:R-HSA-200879 Reactome:R-HSA-167597 Reactome:R-HSA-167566 Reactome:R-HSA-167537 Reactome:R-HSA-164524 Reactome:R-HSA-164521 Reactome:R-HSA-164515 Reactome:R-HSA-164510 Reactome:R-HSA-164509 Reactome:R-HSA-164508 Reactome:R-HSA-164507 Reactome:R-HSA-164500 Reactome:R-HSA-1471314	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	Reactome:R-HSA-180606 Reactome:R-HSA-180599 Reactome:R-HSA-180597 Reactome:R-HSA-180591 Reactome:R-HSA-180573	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005769	early endosome	Reactome:R-HSA-200879 Reactome:R-HSA-167601 Reactome:R-HSA-167597	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
enables	GO:0001618	virus receptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1183	F	Seeded From UniProt	complete
involved_in	GO:0002250	adaptive immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1064	P	Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 ^1.15 Zhen, A et al. (2014) CD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infection. J. Virol. 88 9934-46 PubMed GONUTS page
↑ Veillette, A et al. (1988) The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck. Cell 55 301-8 PubMed GONUTS page
↑ ^3.0 ^3.1 Doyle, C & Strominger, JL () Interaction between CD4 and class II MHC molecules mediates cell adhesion. Nature 330 256-9 PubMed GONUTS page
↑ Wang, JH et al. (2001) Crystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC molecule. Proc. Natl. Acad. Sci. U.S.A. 98 10799-804 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Wu, H et al. (1997) Dimeric association and segmental variability in the structure of human CD4. Nature 387 527-30 PubMed GONUTS page
↑ ^6.0 ^6.1 Seong, RH et al. (1992) Signal for T-cell differentiation to a CD4 cell lineage is delivered by CD4 transmembrane region and/or cytoplasmic tail. Nature 356 718-20 PubMed GONUTS page
↑ Luo, KX & Sefton, BM (1990) Cross-linking of T-cell surface molecules CD4 and CD8 stimulates phosphorylation of the lck tyrosine protein kinase at the autophosphorylation site. Mol. Cell. Biol. 10 5305-13 PubMed GONUTS page
↑ Miceli, MC et al. (1991) Adhesion versus coreceptor function of CD4 and CD8: role of the cytoplasmic tail in coreceptor activity. Proc. Natl. Acad. Sci. U.S.A. 88 2623-7 PubMed GONUTS page
↑ Frank, GD & Parnes, JR (1998) The level of CD4 surface protein influences T cell selection in the thymus. J. Immunol. 160 634-42 PubMed GONUTS page
↑ ^10.0 ^10.1 Moldovan, MC et al. (2002) CD4 dimers constitute the functional component required for T cell activation. J. Immunol. 169 6261-8 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 Miceli, MC & Parnes, JR (1993) Role of CD4 and CD8 in T cell activation and differentiation. Adv. Immunol. 53 59-122 PubMed GONUTS page
↑ Campbell, KS et al. (1995) Interaction of p56lck with CD4 in the yeast two-hybrid system. Ann. N. Y. Acad. Sci. 766 89-92 PubMed GONUTS page
↑ ^13.0 ^13.1 Py, B et al. (2009) The phospholipid scramblases 1 and 4 are cellular receptors for the secretory leukocyte protease inhibitor and interact with CD4 at the plasma membrane. PLoS ONE 4 e5006 PubMed GONUTS page
↑ Huse, M et al. (1998) A Zn2+ ion links the cytoplasmic tail of CD4 and the N-terminal region of Lck. J. Biol. Chem. 273 18729-33 PubMed GONUTS page
↑ Liao, F et al. (1997) STRL33, A novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1. J. Exp. Med. 185 2015-23 PubMed GONUTS page
↑ Aiken, C et al. (1994) Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain. Cell 76 853-64 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 ^17.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Balamuth, F et al. (2004) CD4 raft association and signaling regulate molecular clustering at the immunological synapse site. J. Immunol. 172 5887-92 PubMed GONUTS page
↑ Wilson, TJ et al. (2007) FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection. Blood 109 3786-93 PubMed GONUTS page
↑ Kirchgessner, H et al. (2001) The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain. J. Exp. Med. 193 1269-84 PubMed GONUTS page
↑ Doranz, BJ et al. (1996) A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors. Cell 85 1149-58 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 Su, SB et al. (1999) Inhibition of tyrosine kinase activation blocks the down-regulation of CXC chemokine receptor 4 by HIV-1 gp120 in CD4+ T cells. J. Immunol. 162 7128-32 PubMed GONUTS page
↑ Wang, JM et al. (1998) HIV-1 envelope gp120 inhibits the monocyte response to chemokines through CD4 signal-dependent chemokine receptor down-regulation. J. Immunol. 161 4309-17 PubMed GONUTS page
↑ Rubbert, A et al. (1998) Dendritic cells express multiple chemokine receptors used as coreceptors for HIV entry. J. Immunol. 160 3933-41 PubMed GONUTS page
↑ Zhang, W et al. (1999) Conformational changes of gp120 in epitopes near the CCR5 binding site are induced by CD4 and a CD4 miniprotein mimetic. Biochemistry 38 9405-16 PubMed GONUTS page

[PMID:24942581-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 ^1.15 Zhen, A et al. (2014) CD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infection. J. Virol. 88 9934-46 PubMed GONUTS page

[PMID:3262426-2] Veillette, A et al. (1988) The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck. Cell 55 301-8 PubMed GONUTS page

[PMID:2823150-3] 3.0 ^3.1 Doyle, C & Strominger, JL () Interaction between CD4 and class II MHC molecules mediates cell adhesion. Nature 330 256-9 PubMed GONUTS page

[PMID:11535811-4] Wang, JH et al. (2001) Crystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC molecule. Proc. Natl. Acad. Sci. U.S.A. 98 10799-804 PubMed GONUTS page

[PMID:9168119-5] 5.0 ^5.1 ^5.2 Wu, H et al. (1997) Dimeric association and segmental variability in the structure of human CD4. Nature 387 527-30 PubMed GONUTS page

[PMID:1533274-6] 6.0 ^6.1 Seong, RH et al. (1992) Signal for T-cell differentiation to a CD4 cell lineage is delivered by CD4 transmembrane region and/or cytoplasmic tail. Nature 356 718-20 PubMed GONUTS page

[PMID:2118992-7] Luo, KX & Sefton, BM (1990) Cross-linking of T-cell surface molecules CD4 and CD8 stimulates phosphorylation of the lck tyrosine protein kinase at the autophosphorylation site. Mol. Cell. Biol. 10 5305-13 PubMed GONUTS page

[PMID:1901411-8] Miceli, MC et al. (1991) Adhesion versus coreceptor function of CD4 and CD8: role of the cytoplasmic tail in coreceptor activity. Proc. Natl. Acad. Sci. U.S.A. 88 2623-7 PubMed GONUTS page

[PMID:9551897-9] Frank, GD & Parnes, JR (1998) The level of CD4 surface protein influences T cell selection in the thymus. J. Immunol. 160 634-42 PubMed GONUTS page

[PMID:12444132-10] 10.0 ^10.1 Moldovan, MC et al. (2002) CD4 dimers constitute the functional component required for T cell activation. J. Immunol. 169 6261-8 PubMed GONUTS page

[PMID:8512039-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 Miceli, MC & Parnes, JR (1993) Role of CD4 and CD8 in T cell activation and differentiation. Adv. Immunol. 53 59-122 PubMed GONUTS page

[PMID:7486703-12] Campbell, KS et al. (1995) Interaction of p56lck with CD4 in the yeast two-hybrid system. Ann. N. Y. Acad. Sci. 766 89-92 PubMed GONUTS page

[PMID:19333378-13] 13.0 ^13.1 Py, B et al. (2009) The phospholipid scramblases 1 and 4 are cellular receptors for the secretory leukocyte protease inhibitor and interact with CD4 at the plasma membrane. PLoS ONE 4 e5006 PubMed GONUTS page

[PMID:9668045-14] Huse, M et al. (1998) A Zn2+ ion links the cytoplasmic tail of CD4 and the N-terminal region of Lck. J. Biol. Chem. 273 18729-33 PubMed GONUTS page

[PMID:9166430-15] Liao, F et al. (1997) STRL33, A novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1. J. Exp. Med. 185 2015-23 PubMed GONUTS page

[PMID:8124721-16] Aiken, C et al. (1994) Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain. Cell 76 853-64 PubMed GONUTS page

[PMID:21873635-17] 17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 ^17.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:15128768-18] Balamuth, F et al. (2004) CD4 raft association and signaling regulate molecular clustering at the immunological synapse site. J. Immunol. 172 5887-92 PubMed GONUTS page

[PMID:17213291-19] Wilson, TJ et al. (2007) FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection. Blood 109 3786-93 PubMed GONUTS page

[PMID:11390434-20] Kirchgessner, H et al. (2001) The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain. J. Exp. Med. 193 1269-84 PubMed GONUTS page

[PMID:8674120-21] Doranz, BJ et al. (1996) A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors. Cell 85 1149-58 PubMed GONUTS page

[PMID:10358157-22] 22.0 ^22.1 ^22.2 Su, SB et al. (1999) Inhibition of tyrosine kinase activation blocks the down-regulation of CXC chemokine receptor 4 by HIV-1 gp120 in CD4+ T cells. J. Immunol. 162 7128-32 PubMed GONUTS page

[PMID:9780207-23] Wang, JM et al. (1998) HIV-1 envelope gp120 inhibits the monocyte response to chemokines through CD4 signal-dependent chemokine receptor down-regulation. J. Immunol. 161 4309-17 PubMed GONUTS page

[PMID:9558100-24] Rubbert, A et al. (1998) Dendritic cells express multiple chemokine receptors used as coreceptors for HIV entry. J. Immunol. 160 3933-41 PubMed GONUTS page

[PMID:10413516-25] Zhang, W et al. (1999) Conformational changes of gp120 in epitopes near the CCR5 binding site are induced by CD4 and a CD4 miniprotein mimetic. Biochemistry 38 9405-16 PubMed GONUTS page

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