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HUMAN:CD166

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) ALCAM (synonyms: MEMD)
Protein Name(s) CD166 antigen

Activated leukocyte cell adhesion molecule

External Links
UniProt Q13740
EMBL L38608
AY644765
DQ486139
DQ486140
AK127617
AK300362
AK316113
AC023602
AC078806
AC133476
BC057809
BC137096
BC137097
Y10183
CCDS CCDS33810.1
CCDS58841.1
PIR I39428
RefSeq NP_001230209.1
NP_001230212.1
NP_001618.2
UniGene Hs.591293
Hs.740441
PDB 1KJC
PDBsum 1KJC
ProteinModelPortal Q13740
SMR Q13740
BioGrid 106716
IntAct Q13740
STRING 9606.ENSP00000305988
MEROPS I43.001
PhosphoSite Q13740
DMDM 118572629
MaxQB Q13740
PaxDb Q13740
PRIDE Q13740
Ensembl ENST00000306107
ENST00000472644
GeneID 214
KEGG hsa:214
UCSC uc003dvv.3
uc003dvw.2
uc003dvy.3
uc003dvz.3
CTD 214
GeneCards GC03P105085
HGNC HGNC:400
HPA CAB002148
HPA010926
MIM 601662
neXtProt NX_Q13740
PharmGKB PA24691
eggNOG NOG148902
GeneTree ENSGT00530000063457
HOGENOM HOG000070101
HOVERGEN HBG050847
InParanoid Q13740
KO K06547
OMA IQWTITG
OrthoDB EOG74J97B
PhylomeDB Q13740
TreeFam TF321859
Reactome REACT_22205
ChiTaRS ALCAM
GeneWiki ALCAM
GenomeRNAi 214
NextBio 866
PMAP-CutDB Q13740
PRO PR:Q13740
Proteomes UP000005640
Bgee Q13740
CleanEx HS_ALCAM
ExpressionAtlas Q13740
Genevestigator Q13740
GO GO:0030424
GO:0009897
GO:0070062
GO:0005925
GO:0016021
GO:0043025
GO:0005102
GO:0007411
GO:0007155
GO:0008045
GO:0007165
Gene3D 2.60.40.10
InterPro IPR013162
IPR007110
IPR013783
IPR003599
IPR013106
Pfam PF08205
PF07686
SMART SM00409
PROSITE PS50835

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0030424

axon

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P42292

C

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P42292

C

Seeded From UniProt

complete

involved_in

GO:1990138

neuron projection extension

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P42292

P

Seeded From UniProt

complete

involved_in

GO:0048846

axon extension involved in axon guidance

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P42292

P

Seeded From UniProt

complete

involved_in

GO:0031290

retinal ganglion cell axon guidance

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P42292

P

Seeded From UniProt

complete

involved_in

GO:0007155

cell adhesion

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P42292

P

Seeded From UniProt

complete

involved_in

GO:0007157

heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

PMID:16352806[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0001772

immunological synapse

PMID:15294938[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

colocalizes_with

GO:0042101

T cell receptor complex

PMID:15294938[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0031226

intrinsic component of plasma membrane

PMID:15294938[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005925

focal adhesion

PMID:21423176[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000057)

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:19056867[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001088)

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:20458337[5]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000639)

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:26146185[6]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q13740

F

Seeded From UniProt

complete

part_of

GO:0043025

neuronal cell body

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61490
ensembl:ENSMUSP00000023312

C

Seeded From UniProt

complete

part_of

GO:0030424

axon

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61490
ensembl:ENSMUSP00000023312

C

Seeded From UniProt

complete

part_of

GO:0009897

external side of plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61490
ensembl:ENSMUSP00000023312

C

Seeded From UniProt

complete

involved_in

GO:0008045

motor neuron axon guidance

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61490
ensembl:ENSMUSP00000023312

P

Seeded From UniProt

complete

involved_in

GO:0007411

axon guidance

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61490
ensembl:ENSMUSP00000023312

P

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

PMID:7760007[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007155

cell adhesion

PMID:7760007[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

PMID:7760007[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0042995

cell projection

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0966

C

Seeded From UniProt

complete

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

involved_in

GO:0007155

cell adhesion

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0130

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

involved_in

GO:0002250

adaptive immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1064

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0030424

axon

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0279

C

Seeded From UniProt

complete

part_of

GO:0030425

dendrite

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0283

C

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Zimmerman, AW et al. (2006) Long-term engagement of CD6 and ALCAM is essential for T-cell proliferation induced by dendritic cells. Blood 107 3212-20 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Gimferrer, I et al. (2004) Relevance of CD6-mediated interactions in T cell activation and proliferation. J. Immunol. 173 2262-70 PubMed GONUTS page
  3. ↑ Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page
  4. ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
  5. ↑ Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
  6. ↑ Chappell, PE et al. (2015) Structures of CD6 and Its Ligand CD166 Give Insight into Their Interaction. Structure 23 1426-1436 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 Bowen, MA et al. (1995) Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand. J. Exp. Med. 181 2213-20 PubMed GONUTS page
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