HUMAN:CD151

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	CD151 (synonyms: TSPAN24)
Protein Name(s)	CD151 antigen GP27 Membrane glycoprotein SFA-1 Platelet-endothelial tetraspan antigen 3 PETA-3 Tetraspanin-24 Tspan-24
External Links
UniProt	P48509
EMBL	U14650 D29963 AF315942 BT007397 BT020132 CR456826 CR542098 AK293073 DQ074789 AP006621 AP006623 CH471158 BC001374 BC013302
CCDS	CCDS7719.1
RefSeq	NP_001034579.1 NP_004348.2 NP_620598.1 NP_620599.1
UniGene	Hs.654379
ProteinModelPortal	P48509
BioGrid	107415
STRING	9606.ENSP00000324101
PhosphoSite	P48509
DMDM	85687560
MaxQB	P48509
PaxDb	P48509
PeptideAtlas	P48509
PRIDE	P48509
DNASU	977
Ensembl	ENST00000322008 ENST00000397420 ENST00000397421 ENST00000530726
GeneID	977
KEGG	hsa:977
UCSC	uc001lry.3
CTD	977
GeneCards	GC11P000835
HGNC	HGNC:1630
HPA	CAB002428 HPA011906
MIM	179620 602243 609057
neXtProt	NX_P48509
Orphanet	300333
PharmGKB	PA26189
eggNOG	NOG281510
GeneTree	ENSGT00760000118875
HOGENOM	HOG000230651
HOVERGEN	HBG107306
InParanoid	P48509
KO	K06537
OMA	CATFKEQ
OrthoDB	EOG7PGDRZ
PhylomeDB	P48509
TreeFam	TF352892
Reactome	REACT_150180 REACT_20537
GeneWiki	CD151
GenomeRNAi	977
NextBio	4102
PRO	PR:P48509
Proteomes	UP000005640
Bgee	P48509
CleanEx	HS_CD151
ExpressionAtlas	P48509
Genevestigator	P48509
GO	GO:0005829 GO:0005925 GO:0005887 GO:0016020 GO:0005886 GO:0005178 GO:0007155 GO:0034329 GO:0016477 GO:0030198 GO:0031581 GO:0042098
InterPro	IPR000301 IPR018499 IPR018503 IPR008952
Pfam	PF00335
PIRSF	PIRSF002419
PRINTS	PR00259
SUPFAM	SSF48652
PROSITE	PS00421

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005604	basement membrane	PMID:23302890^[1]	ECO:0000314			C		Figure 1 shows the distribution of CD151 in the basement membrane of human cervical mucosa through staining.	complete CACAO 10034
enables	GO:0005178	integrin binding	PMID:27993971^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005604	basement membrane	PMID:23302890^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	PMID:21423176^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
enables	GO:0005178	integrin binding	PMID:24220332^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P26006	F		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	PMID:9602068^[5]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:9602068^[5]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1096360 PANTHER:PTN002319281 UniProtKB:P48509	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1889818 PANTHER:PTN001060286 UniProtKB:P60033	C		Seeded From UniProt	complete
involved_in	GO:0045807	positive regulation of endocytosis	PMID:17716972^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045807	positive regulation of endocytosis	PMID:17716972^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0044319	wound healing, spreading of cells	PMID:17716972^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0044319	wound healing, spreading of cells	PMID:17716972^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:17716972^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:17716972^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:17716972^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005178	integrin binding	PMID:17716972^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0042098	T cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35566 ensembl:ENSMUSP00000101622	P		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35566 ensembl:ENSMUSP00000101622	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000301 InterPro:IPR008952 InterPro:IPR018499 InterPro:IPR018503	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:8627808^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:8627808^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0031581	hemidesmosome assembly	Reactome:R-HSA-446107	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-2213192	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-446083 Reactome:R-HSA-446077	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Scheffer, KD et al. (2013) Tetraspanin CD151 mediates papillomavirus type 16 endocytosis. J. Virol. 87 3435-46 PubMed GONUTS page
↑ Yu, J et al. (2017) The CD9, CD81, and CD151 EC2 domains bind to the classical RGD-binding site of integrin αvβ3. Biochem. J. 474 589-596 PubMed GONUTS page
↑ Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page
↑ Yamada, M & Sekiguchi, K (2013) Disease-associated single amino acid mutation in the calf-1 domain of integrin α3 leads to defects in its processing and cell surface expression. Biochem. Biophys. Res. Commun. 441 988-93 PubMed GONUTS page
↑ ^5.0 ^5.1 Fitter, S et al. (1998) Characterisation of the mouse homologue of CD151 (PETA-3/SFA-1); genomic structure, chromosomal localisation and identification of 2 novel splice forms. Biochim. Biophys. Acta 1398 75-85 PubMed GONUTS page
↑ ^6.0 ^6.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 Liu, L et al. (2007) Tetraspanin CD151 promotes cell migration by regulating integrin trafficking. J. Biol. Chem. 282 31631-42 PubMed GONUTS page
↑ ^8.0 ^8.1 Hasegawa, H et al. (1996) SFA-1, a novel cellular gene induced by human T-cell leukemia virus type 1, is a member of the transmembrane 4 superfamily. J. Virol. 70 3258-63 PubMed GONUTS page

[PMID:23302890-1] 1.0 ^1.1 Scheffer, KD et al. (2013) Tetraspanin CD151 mediates papillomavirus type 16 endocytosis. J. Virol. 87 3435-46 PubMed GONUTS page

[PMID:27993971-2] Yu, J et al. (2017) The CD9, CD81, and CD151 EC2 domains bind to the classical RGD-binding site of integrin αvβ3. Biochem. J. 474 589-596 PubMed GONUTS page

[PMID:21423176-3] Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page

[PMID:24220332-4] Yamada, M & Sekiguchi, K (2013) Disease-associated single amino acid mutation in the calf-1 domain of integrin α3 leads to defects in its processing and cell surface expression. Biochem. Biophys. Res. Commun. 441 988-93 PubMed GONUTS page

[PMID:9602068-5] 5.0 ^5.1 Fitter, S et al. (1998) Characterisation of the mouse homologue of CD151 (PETA-3/SFA-1); genomic structure, chromosomal localisation and identification of 2 novel splice forms. Biochim. Biophys. Acta 1398 75-85 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:17716972-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 Liu, L et al. (2007) Tetraspanin CD151 promotes cell migration by regulating integrin trafficking. J. Biol. Chem. 282 31631-42 PubMed GONUTS page

[PMID:8627808-8] 8.0 ^8.1 Hasegawa, H et al. (1996) SFA-1, a novel cellular gene induced by human T-cell leukemia virus type 1, is a member of the transmembrane 4 superfamily. J. Virol. 70 3258-63 PubMed GONUTS page

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HUMAN:CD151

Contents

Annotations

Notes

References

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