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HUMAN:CASPE
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | CASP14 | |
| Protein Name(s) | Caspase-14
CASP-14 Caspase-14 subunit p19 Caspase-14 subunit p10 | |
| External Links | ||
| UniProt | P31944 | |
| EMBL | AF097874 BC069541 BC103868 BC103869 | |
| CCDS | CCDS12323.1 | |
| PIR | JC7517 | |
| RefSeq | NP_036246.1 | |
| UniGene | Hs.466057 | |
| ProteinModelPortal | P31944 | |
| SMR | P31944 | |
| BioGrid | 117116 | |
| IntAct | P31944 | |
| STRING | 9606.ENSP00000221740 | |
| BindingDB | P31944 | |
| ChEMBL | CHEMBL5991 | |
| MEROPS | C14.018 | |
| DMDM | 12231007 | |
| MaxQB | P31944 | |
| PaxDb | P31944 | |
| PeptideAtlas | P31944 | |
| PRIDE | P31944 | |
| DNASU | 23581 | |
| Ensembl | ENST00000427043 | |
| GeneID | 23581 | |
| KEGG | hsa:23581 | |
| UCSC | uc010dzv.2 | |
| CTD | 23581 | |
| GeneCards | GC19P015160 | |
| HGNC | HGNC:1502 | |
| HPA | CAB010059 HPA027062 | |
| MIM | 605848 | |
| neXtProt | NX_P31944 | |
| PharmGKB | PA26085 | |
| eggNOG | NOG327631 | |
| GeneTree | ENSGT00760000118912 | |
| HOGENOM | HOG000231878 | |
| HOVERGEN | HBG050804 | |
| InParanoid | P31944 | |
| KO | K04401 | |
| OMA | CVTKARE | |
| OrthoDB | EOG7VQJDT | |
| PhylomeDB | P31944 | |
| TreeFam | TF102023 | |
| ChiTaRS | CASP14 | |
| GeneWiki | Caspase_14 | |
| GenomeRNAi | 23581 | |
| NextBio | 46186 | |
| PMAP-CutDB | P31944 | |
| PRO | PR:P31944 | |
| Proteomes | UP000005640 | |
| Bgee | P31944 | |
| CleanEx | HS_CASP14 | |
| ExpressionAtlas | P31944 | |
| Genevestigator | P31944 | |
| GO | GO:0005737 GO:0070062 GO:0045095 GO:0005634 GO:0004197 GO:0070268 GO:0008544 GO:0097192 GO:0008630 GO:0031424 | |
| Gene3D | 3.40.50.1460 | |
| InterPro | IPR029030 IPR011600 IPR001309 IPR016129 IPR002138 IPR015917 | |
| Pfam | PF00656 | |
| PRINTS | PR00376 | |
| SMART | SM00115 | |
| PROSITE | PS01122 PS50207 PS50208 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0005634 |
nucleus |
ECO:0000314 |
C |
Fig. 1a Through immunohistochemical staining, the protein was found to be expressed in the nucleus in the first trimester. |
complete | |||||
| GO:0005737 |
cytoplasm |
ECO:0000314 |
C |
Fig. 1B and 1C Through immunohistochemical staining, the protein was found to be expressed in the cytoplasm in the second and third trimester. |
complete | |||||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0097153 |
cysteine-type endopeptidase activity involved in apoptotic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0019972 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0008630 |
intrinsic apoptotic signaling pathway in response to DNA damage |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000048016 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006915 |
apoptotic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0010501 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0019972 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0045095 |
keratin filament |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:D3ZZ65 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:D3ZZ65 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004197 |
cysteine-type endopeptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001309 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008234 |
cysteine-type peptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070268 |
cornification |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008544 |
epidermis development |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004197 |
cysteine-type endopeptidase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070268 |
cornification |
PMID:18309324[4] |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
P |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0031424 |
keratinization |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-8934819 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008234 |
cysteine-type peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030154 |
cell differentiation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008233 |
peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Gkegkes, ID et al. (2013) Expression of caspase-14 and keratin-19 in the human epidermis and appendages during fetal skin development. Arch. Dermatol. Res. 305 379-87 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 3.0 3.1 Van de Craen, M et al. (1998) Identification of a new caspase homologue: caspase-14. Cell Death Differ. 5 838-46 PubMed GONUTS page
- ↑ 4.0 4.1 Galluzzi, L et al. (2008) No death without life: vital functions of apoptotic effectors. Cell Death Differ. 15 1113-23 PubMed GONUTS page
