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HUMAN:BUB1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) BUB1 (synonyms: BUB1L)
Protein Name(s) Mitotic checkpoint serine/threonine-protein kinase BUB1

hBUB1 BUB1A

External Links
UniProt O43683
EMBL AF046078
AF043294
AF053305
AF047471
AF139363
AF139349
AF139350
AF139351
AF139352
AF139353
AF139354
AF139355
AF139356
AF139357
AF139358
AF139359
AF139360
AF139361
AF139362
AC114776
AC226101
CH471237
BC028201
AF011387
CCDS CCDS33273.1
CCDS62984.1
CCDS62985.1
RefSeq NP_001265546.1
NP_004327.1
UniGene Hs.469649
PDB 2LAH
3E7E
4A1G
4QPM
4R8Q
PDBsum 2LAH
3E7E
4A1G
4QPM
4R8Q
ProteinModelPortal O43683
SMR O43683
BioGrid 107164
DIP DIP-24206N
IntAct O43683
MINT MINT-1460788
STRING 9606.ENSP00000302530
BindingDB O43683
ChEMBL CHEMBL1772932
PhosphoSite O43683
MaxQB O43683
PaxDb O43683
PRIDE O43683
DNASU 699
Ensembl ENST00000302759
ENST00000409311
ENST00000535254
GeneID 699
KEGG hsa:699
UCSC uc002tgc.3
CTD 699
GeneCards GC02M111395
HGNC HGNC:1148
HPA HPA006123
MIM 602452
neXtProt NX_O43683
Orphanet 1052
PharmGKB PA81
eggNOG NOG317001
GeneTree ENSGT00520000055622
HOGENOM HOG000231751
HOVERGEN HBG003709
InParanoid O43683
KO K02178
OMA DPLDVYD
PhylomeDB O43683
TreeFam TF105455
BRENDA 2.7.11.1
Reactome REACT_150425
REACT_150471
REACT_682
SignaLink O43683
ChiTaRS BUB1
EvolutionaryTrace O43683
GeneWiki BUB1
GenomeRNAi 699
NextBio 2860
PRO PR:O43683
Proteomes UP000005640
Bgee O43683
CleanEx HS_BUB1
ExpressionAtlas O43683
Genevestigator O43683
GO GO:0000777
GO:0000780
GO:0005737
GO:0005829
GO:0000776
GO:0016020
GO:0005634
GO:0005524
GO:0004672
GO:0004674
GO:0006915
GO:0008283
GO:0007059
GO:0000278
GO:0007093
GO:0007067
GO:0007094
GO:2001244
GO:0051983
GO:0007063
GO:0071173
GO:0016032
InterPro IPR015661
IPR011009
IPR013212
IPR000719
IPR017441
IPR008271
PANTHER PTHR14030
Pfam PF08311
PF00069
SMART SM00777
SUPFAM SSF56112
PROSITE PS51489
PS00107
PS50011
PS00108

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0000942

condensed nuclear chromosome outer kinetochore

PMID:24055156[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:19946888[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0051983

regulation of chromosome segregation

PMID:19487456[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007063

regulation of sister chromatid cohesion

PMID:15723797[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0000777

condensed chromosome kinetochore

PMID:19465021[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000776

kinetochore

PMID:16760428[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000776

kinetochore

PMID:15020684[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0051754

meiotic sister chromatid cohesion, centromeric

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0263855
PANTHER:PTN000361607
PomBase:SPCC1322.12c

P

Seeded From UniProt

complete

involved_in

GO:0007094

mitotic spindle assembly checkpoint

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0031696
FB:FBgn0263855
PANTHER:PTN000361607
PomBase:SPCC1322.12c
PomBase:SPCC1795.01c
SGD:S000003420
SGD:S000003550
TAIR:locus:2050977
WB:WBGene00004721

P

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000361607
SGD:S000003420

F

Seeded From UniProt

complete

part_of

GO:0000778

condensed nuclear chromosome kinetochore

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1333889
PANTHER:PTN000361607
PomBase:SPCC1322.12c
PomBase:SPCC1795.01c
SGD:S000003420
UniProtKB:G5EAT8

C

Seeded From UniProt

complete

part_of

GO:0000776

kinetochore

PMID:22331848[9]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000776

kinetochore

PMID:17227893[10]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0008283

cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D4A5D3
ensembl:ENSRNOP00000042114

P

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR008271

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR017441

F

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR008271

P

Seeded From UniProt

complete

involved_in

GO:0007094

mitotic spindle assembly checkpoint

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR015661

P

Seeded From UniProt

complete

involved_in

GO:0007094

mitotic spindle assembly checkpoint

PMID:9790499[11]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007093

mitotic cell cycle checkpoint

PMID:9521327[12]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

PMID:10198256[13]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-5666169
Reactome:R-HSA-5666160
Reactome:R-HSA-5666129
Reactome:R-HSA-375302
Reactome:R-HSA-2484822
Reactome:R-HSA-2468287
Reactome:R-HSA-2467811
Reactome:R-HSA-2467809
Reactome:R-HSA-1638821
Reactome:R-HSA-1638803
Reactome:R-HSA-141439
Reactome:R-HSA-141431
Reactome:R-HSA-141422
Reactome:R-HSA-141409

ECO:0000304

author statement supported by traceable reference used in manual assertion














C

Seeded From UniProt

complete

part_of

GO:0000776

kinetochore

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0995

C

Seeded From UniProt

complete

involved_in

GO:0051301

cell division

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0132

P

Seeded From UniProt

complete

part_of

GO:0005694

chromosome

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0158

C

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

involved_in

GO:0016032

viral process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0945

P

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

part_of

GO:0000775

chromosome, centromeric region

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0137

C

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0053

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

involved_in

GO:0007059

chromosome segregation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0159

P

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0723

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0000777

condensed chromosome kinetochore

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0149

C

Seeded From UniProt

complete

GO:0000942

condensed nuclear chromosome outer kinetochore

PMID:24055156[1]

ECO:0000314

C

Figure S1A. The authors state that "Sgo1 and Bub1 localized to inner centromeres and outer kinetochores, respectively.

complete
CACAO 8644

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Liu, H et al. (2013) Phospho-H2A and cohesin specify distinct tension-regulated Sgo1 pools at kinetochores and inner centromeres. Curr. Biol. 23 1927-33 PubMed GONUTS page
  2. ↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
  3. ↑ Klebig, C et al. (2009) Bub1 regulates chromosome segregation in a kinetochore-independent manner. J. Cell Biol. 185 841-58 PubMed GONUTS page
  4. ↑ Kitajima, TS et al. (2005) Human Bub1 defines the persistent cohesion site along the mitotic chromosome by affecting Shugoshin localization. Curr. Biol. 15 353-9 PubMed GONUTS page
  5. ↑ Gambe, AE et al. (2009) A nucleolar protein RRS1 contributes to chromosome congression. FEBS Lett. 583 1951-6 PubMed GONUTS page
  6. ↑ Qi, W et al. (2006) Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1. Mol. Biol. Cell 17 3705-16 PubMed GONUTS page
  7. ↑ Johnson, VL et al. (2004) Bub1 is required for kinetochore localization of BubR1, Cenp-E, Cenp-F and Mad2, and chromosome congression. J. Cell. Sci. 117 1577-89 PubMed GONUTS page
  8. ↑ 8.0 8.1 8.2 8.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  9. ↑ Krenn, V et al. (2012) Structural analysis reveals features of the spindle checkpoint kinase Bub1-kinetochore subunit Knl1 interaction. J. Cell Biol. 196 451-67 PubMed GONUTS page
  10. ↑ Dikovskaya, D et al. (2007) Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis. J. Cell Biol. 176 183-95 PubMed GONUTS page
  11. ↑ Ouyang, B et al. (1998) Human Bub1: a putative spindle checkpoint kinase closely linked to cell proliferation. Cell Growth Differ. 9 877-85 PubMed GONUTS page
  12. ↑ Cahill, DP et al. (1998) Mutations of mitotic checkpoint genes in human cancers. Nature 392 300-3 PubMed GONUTS page
  13. ↑ Seeley, TW et al. (1999) Phosphorylation of human MAD1 by the BUB1 kinase in vitro. Biochem. Biophys. Res. Commun. 257 589-95 PubMed GONUTS page
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