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HUMAN:BIRC1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) NAIP (synonyms: BIRC1)
Protein Name(s) Baculoviral IAP repeat-containing protein 1

Neuronal apoptosis inhibitory protein

External Links
UniProt Q13075
EMBL U19251
U80017
AC005031
AC044797
BC136273
AB048534
AH003063
AB209123
CCDS CCDS4009.1
CCDS43327.1
RefSeq NP_004527.2
NP_075043.1
UniGene Hs.646951
Hs.654500
Hs.710305
PDB 2VM5
PDBsum 2VM5
ProteinModelPortal Q13075
SMR Q13075
BioGrid 110752
DIP DIP-59150N
IntAct Q13075
STRING 9606.ENSP00000428657
MEROPS I32.001
PhosphoSite Q13075
BioMuta NAIP
DMDM 109940027
PaxDb Q13075
PRIDE Q13075
Ensembl ENST00000194097
ENST00000503719
ENST00000517649
ENST00000523981
ENST00000612328
ENST00000620988
GeneID 4671
KEGG hsa:4671
UCSC uc003jyj.1
uc003kas.1
CTD 4671
GeneCards NAIP
H-InvDB HIX0164257
HGNC HGNC:7634
HPA HPA042438
MalaCards NAIP
MIM 600355
neXtProt NX_Q13075
Orphanet 83330
83418
83419
PharmGKB PA162396805
eggNOG KOG1101
ENOG410YPNM
GeneTree ENSGT00500000044782
HOGENOM HOG000236326
HOVERGEN HBG050689
InParanoid Q13075
KO K12807
OMA DISRHIP
PhylomeDB Q13075
TreeFam TF105356
SignaLink Q13075
ChiTaRS NAIP
EvolutionaryTrace Q13075
GeneWiki NAIP_(gene)
GenomeRNAi 4671
NextBio 18000
PRO PR:Q13075
Proteomes UP000005640
Bgee Q13075
CleanEx HS_NAIP
ExpressionAtlas Q13075
Genevisible Q13075
GO GO:0016323
GO:0005737
GO:0070062
GO:0043005
GO:0005634
GO:0043204
GO:0005524
GO:0043027
GO:0046872
GO:0004842
GO:0006954
GO:1990001
GO:0045087
GO:0043066
GO:0043154
GO:0043524
GO:0007399
GO:0016567
GO:0009966
GO:0043200
GO:0048678
Gene3D 1.10.1170.10
3.40.50.300
3.80.10.10
InterPro IPR003593
IPR001370
IPR032675
IPR007111
IPR027417
Pfam PF00653
SMART SM00382
SM00238
SUPFAM SSF52540
PROSITE PS01282
PS50143
PS50837

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0043154

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

PMID:11896143[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

GO:0006954

inflammatory response

PMID:21874021[2]

ECO:0000315

P

Figure 2. (NAIP)

complete
CACAO 11237

involved_in

GO:0043066

negative regulation of apoptotic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9QWK5

P

Seeded From UniProt

complete

GO:1900118

negative regulation of execution phase of apoptosis

PMID:9564035[3]

ECO:0000250

UniProtKB:O60543


P

Figure 1. The human homolog of CIDE-A. Analysis of the nucleotide sequence of both human and mouse CIDE-A cDNAs revealed two potential in-frame translation initi- ation sites separated by 51 nucleotides. These two potential initiation codons produce a protein of 217 amino acids (designated CIDE-A*) and a protein identical to CIDE-A* but lacking its 17 most N-terminal amino acids (designated CIDE-A)

complete
CACAO 11416

part_of

GO:0016323

basolateral plasma membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9QWK5

C

Seeded From UniProt

complete

GO:0009405

pathogenesis

other:GO_REF:0000037

P

pathogenesis (IEA)

Missing: evidence
CACAO 11238

part_of

GO:0005737

cytoplasm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9QWK5

C

Seeded From UniProt

complete

GO:0043154

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

PMID:11896143[1]

ECO:0000314

P

The neuronal apoptosis inhibitory protein (NAIP) was identified as a candidate gene for the inherited neurodegenerative disorder spinal muscular atrophy.

complete
CACAO 11239

enables

GO:0005524

ATP binding

PMID:21371431[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

GO:0043281

regulation of cysteine-type endopeptidase activity involved in apoptotic process

PMID:15190255[5]

ECO:0000315

P

Specific adaptors regulate the activation of initiator caspases; for example, FADD and Apaf-1 engage caspases 8 and 9, respectively. The adaptors ASC, Ipaf and RIP2 have each been proposed to regulate caspase-1 (also called interleukin (IL)-1 converting enzyme), which is activated within the 'inflammasome', a complex comprising several adaptors.

complete
CACAO 11240

enables

GO:0043027

cysteine-type endopeptidase inhibitor activity involved in apoptotic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR028789

F

Seeded From UniProt

complete

GO:0016020

membrane

other:GO_REF:0000002

C

InterPro:IPR008104 - IEA: Inferred from Electronic Annotation

Missing: evidence
CACAO 11241

involved_in

GO:0043066

negative regulation of apoptotic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR028789

P

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:21371431[4]

F

IPI: Inferred from Physical Interaction - UniProtKB:O14727

Missing: evidence
CACAO 11244

involved_in

GO:0043066

negative regulation of apoptotic process

PMID:8552191[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

GO:0070062

extracellular exosome

PMID:23376485[7]

ECO:0000314

C

Figure 1. study was the identification of podocyte exosome proteins based on urine immunoabsorption using podocyte-specific CR1-immunocoated beads followed by proteomic analysis using LC MS/MS techniques.

complete
CACAO 11291

involved_in

GO:0007399

nervous system development

PMID:7813013[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

GO:1900118

negative regulation of execution phase of apoptosis

PMID:9564035[3]

ECO:0000314

P

Figure1. The homology of CIDE-A, CIDE-B and FSP27 with DFF45 was restricted to an N-terminal region designated here as CIDE-N domain which showed 39, 29 and 38% amino acid identity respectively with DFF45. Another region of CIDE-A and CIDE-B, termed CIDE-C domain, located in their C-termini shared amino acid homology (54 and 53% identity, respectively) with FSP27 but not with DFF45

complete
CACAO 11417

involved_in

GO:0043524

negative regulation of neuron apoptotic process

PMID:18414036[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

involved_in

GO:0010466

negative regulation of peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0646

P

Seeded From UniProt

complete

involved_in

GO:0006954

inflammatory response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0395

P

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0004869

cysteine-type endopeptidase inhibitor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0789

F

Seeded From UniProt

complete

involved_in

GO:0045087

innate immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0399

P

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0053

P

Seeded From UniProt

complete

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

enables

GO:0030414

peptidase inhibitor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0646

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Maier, JK et al. (2002) The neuronal apoptosis inhibitory protein is a direct inhibitor of caspases 3 and 7. J. Neurosci. 22 2035-43 PubMed GONUTS page
  2. ↑ Kofoed, EM & Vance, RE (2011) Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity. Nature 477 592-5 PubMed GONUTS page
  3. ↑ 3.0 3.1 Inohara, N et al. (1998) CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor. EMBO J. 17 2526-33 PubMed GONUTS page
  4. ↑ 4.0 4.1 Karimpour, S et al. (2011) Integrity of ATP binding site is essential for effective inhibition of the intrinsic apoptosis pathway by NAIP. Biochem. Biophys. Res. Commun. 407 158-62 PubMed GONUTS page
  5. ↑ Mariathasan, S et al. (2004) Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature 430 213-8 PubMed GONUTS page
  6. ↑ Liston, P et al. (1996) Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes. Nature 379 349-53 PubMed GONUTS page
  7. ↑ Prunotto, M et al. (2013) Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. J Proteomics 82 193-229 PubMed GONUTS page
  8. ↑ Roy, N et al. (1995) The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy. Cell 80 167-78 PubMed GONUTS page
  9. ↑ Dubrez-Daloz, L et al. (2008) IAPs: more than just inhibitors of apoptosis proteins. Cell Cycle 7 1036-46 PubMed GONUTS page
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