HUMAN:BCAM

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	BCAM (synonyms: LU, MSK19)
Protein Name(s)	Basal cell adhesion molecule Auberger B antigen B-CAM cell surface glycoprotein F8/G253 antigen Lutheran antigen Lutheran blood group glycoprotein
External Links
UniProt	P50895
EMBL	X83425 AY845133 AC092306 CH471126 BC050450 X80026 EU307108 EU307109
CCDS	CCDS12644.1
PIR	I37202 I38000
RefSeq	NP_001013275.1 NP_005572.2
UniGene	Hs.625725
PDB	2PET 2PF6
PDBsum	2PET 2PF6
ProteinModelPortal	P50895
SMR	P50895
BioGrid	110237
MINT	MINT-5004331
STRING	9606.ENSP00000270233
PhosphoSite	P50895
DMDM	92058724
MaxQB	P50895
PaxDb	P50895
PRIDE	P50895
Ensembl	ENST00000270233
GeneID	4059
KEGG	hsa:4059
UCSC	uc002ozt.2
CTD	4059
GeneCards	GC19P045312
HGNC	HGNC:6722
HPA	HPA005654
MIM	111200 247420 612773
neXtProt	NX_P50895
PharmGKB	PA30484
eggNOG	NOG150030
GeneTree	ENSGT00530000063457
HOGENOM	HOG000113409
InParanoid	P50895
KO	K06578
OMA	HYPTEHV
OrthoDB	EOG7GBFWH
PhylomeDB	P50895
TreeFam	TF330534
ChiTaRS	BCAM
EvolutionaryTrace	P50895
GeneWiki	BCAM
GenomeRNAi	4059
NextBio	15906
PRO	PR:P50895
Proteomes	UP000005640
Bgee	P50895
CleanEx	HS_BCAM
ExpressionAtlas	P50895
Genevestigator	P50895
GO	GO:0009897 GO:0070062 GO:0005887 GO:0005886 GO:0043236 GO:0005055 GO:0004888 GO:0007155 GO:0007160 GO:0007165
Gene3D	2.60.40.10
InterPro	IPR013162 IPR007110 IPR013783 IPR003599 IPR003598
Pfam	PF08205
SMART	SM00409 SM00408
PROSITE	PS50835

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0008022	protein C-terminus binding	PMID:24453976^[1]	ECO:0000314			F		Cells not expressing Lu/BCAM did not respond to CNF1 toxin. The data indicated that the toxin (CNF1) specifically binds to Lu/BCAM (figure 4). MALDI-TOF analysis of the precipitate identified Lu/BCAM as an interaction partner for CNF1. It was suggested that there are two interaction sites in CNF1: The N-terminus binding to 37LRP/67LR and the C-terminus binding with high affinity to Lu/BCAM. The interaction of CNF1 Lu/BCAM was verified using several methods: Western blotting, immunofluorescence, MALDI-TOF analysis, and fluorescence activated cell sorting (FACS) analysis.	complete CACAO 9225
	GO:0019534	toxin transporter activity	PMID:24453976^[1]	ECO:0000314			F		Figure 3. Lu/BCAM is crucial for binding and uptake of CNF1.	complete
part_of	GO:0005576	extracellular region	PMID:27068509^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0007318)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:27559042^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0006618) part_of:(UBERON:0002302)	Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	PMID:24453976^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
enables	GO:0043236	laminin binding	PMID:16236823^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:16236823^[5]	ECO:0000305	curator inference used in manual assertion	GO:0005055	C		Seeded From UniProt	complete
involved_in	GO:0007160	cell-matrix adhesion	PMID:16236823^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005055	laminin receptor activity	PMID:16236823^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R069 ensembl:ENSMUSP00000003061	C		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R069 ensembl:ENSMUSP00000003061	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R069 ensembl:ENSMUSP00000003061	C		Seeded From UniProt	complete
enables	GO:0005055	laminin receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R069 ensembl:ENSMUSP00000003061	F		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:7777537^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	PMID:7954395^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:7777537^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:9166867^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004888	transmembrane signaling receptor activity	PMID:7777537^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Piteau, M et al. (2014) Lu/BCAM adhesion glycoprotein is a receptor for Escherichia coli Cytotoxic Necrotizing Factor 1 (CNF1). PLoS Pathog. 10 e1003884 PubMed GONUTS page
↑ Barallobre-Barreiro, J et al. (2016) Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc. Res. 110 419-30 PubMed GONUTS page
↑ Barallobre-Barreiro, J et al. (2016) Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation. Circulation 134 817-32 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Vainionpää, N et al. (2006) Laminin-10 and Lutheran blood group glycoproteins in adhesion of human endothelial cells. Am. J. Physiol., Cell Physiol. 290 C764-75 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Parsons, SF et al. (1995) The Lutheran blood group glycoprotein, another member of the immunoglobulin superfamily, is widely expressed in human tissues and is developmentally regulated in human liver. Proc. Natl. Acad. Sci. U.S.A. 92 5496-500 PubMed GONUTS page
↑ Campbell, IG et al. (1994) Molecular cloning of the B-CAM cell surface glycoprotein of epithelial cancers: a novel member of the immunoglobulin superfamily. Cancer Res. 54 5761-5 PubMed GONUTS page
↑ Parsons, SF et al. (1997) Use of domain-deletion mutants to locate Lutheran blood group antigens to each of the five immunoglobulin superfamily domains of the Lutheran glycoprotein: elucidation of the molecular basis of the Lu(a)/Lu(b) and the Au(a)/Au(b) polymorphisms. Blood 89 4219-25 PubMed GONUTS page

[PMID:24453976-1] 1.0 ^1.1 ^1.2 Piteau, M et al. (2014) Lu/BCAM adhesion glycoprotein is a receptor for Escherichia coli Cytotoxic Necrotizing Factor 1 (CNF1). PLoS Pathog. 10 e1003884 PubMed GONUTS page

[PMID:27068509-2] Barallobre-Barreiro, J et al. (2016) Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc. Res. 110 419-30 PubMed GONUTS page

[PMID:27559042-3] Barallobre-Barreiro, J et al. (2016) Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation. Circulation 134 817-32 PubMed GONUTS page

[PMID:19056867-4] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:16236823-5] 5.0 ^5.1 ^5.2 ^5.3 Vainionpää, N et al. (2006) Laminin-10 and Lutheran blood group glycoproteins in adhesion of human endothelial cells. Am. J. Physiol., Cell Physiol. 290 C764-75 PubMed GONUTS page

[PMID:7777537-6] 6.0 ^6.1 ^6.2 Parsons, SF et al. (1995) The Lutheran blood group glycoprotein, another member of the immunoglobulin superfamily, is widely expressed in human tissues and is developmentally regulated in human liver. Proc. Natl. Acad. Sci. U.S.A. 92 5496-500 PubMed GONUTS page

[PMID:7954395-7] Campbell, IG et al. (1994) Molecular cloning of the B-CAM cell surface glycoprotein of epithelial cancers: a novel member of the immunoglobulin superfamily. Cancer Res. 54 5761-5 PubMed GONUTS page

[PMID:9166867-8] Parsons, SF et al. (1997) Use of domain-deletion mutants to locate Lutheran blood group antigens to each of the five immunoglobulin superfamily domains of the Lutheran glycoprotein: elucidation of the molecular basis of the Lu(a)/Lu(b) and the Au(a)/Au(b) polymorphisms. Blood 89 4219-25 PubMed GONUTS page

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HUMAN:BCAM

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