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PMID:7954395

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Citation

Campbell, IG, Foulkes, WD, Senger, G, Trowsdale, J, Garin-Chesa, P and Rettig, WJ (1994) Molecular cloning of the B-CAM cell surface glycoprotein of epithelial cancers: a novel member of the immunoglobulin superfamily. Cancer Res. 54:5761-5

Abstract

The human F8/G253 antigen, B-CAM, is a cell surface glycoprotein that is expressed with restricted distribution pattern in normal fetal and adult tissues, and is up-regulated following malignant transformation in some cell types. We have isolated a complementary DNA for B-CAM using an expression cloning technique. The complementary DNA (EMBL accession number X80026) encodes a 588-amino acid protein which is a novel member of the immunoglobulin superfamily with a characteristic V-V-C2-C2-C2 immunoglobulin domain structure. This structure has been described previously for the human MUC18 melanoma antigen (31% amino acid identity) and chicken and rat versions of a neural adhesion molecule referred to as SC1/DM-GRASP/BEN or KG-CAM, respectively (26% amino acid identity). This homology is suggestive of a role for B-CAM in cell-cell or cell-matrix adhesion. The gene for B-CAM has been mapped by fluorescence in situ hybridization to chromosome 19q13.2-13.3.

Links

PubMed

Keywords

Activated-Leukocyte Cell Adhesion Molecule; Amino Acid Sequence; Antigens, CD; Antigens, CD146; Base Sequence; Blotting, Northern; Cell Adhesion Molecules/chemistry; Cell Adhesion Molecules/genetics; Chromosomes, Human, Pair 19/chemistry; Cloning, Molecular; Colonic Neoplasms/chemistry; DNA, Complementary/chemistry; DNA, Complementary/genetics; Extracellular Matrix Proteins/chemistry; Extracellular Matrix Proteins/genetics; Humans; In Situ Hybridization, Fluorescence; Lutheran Blood-Group System; Membrane Glycoproteins/analysis; Membrane Glycoproteins/chemistry; Membrane Glycoproteins/genetics; Molecular Sequence Data; Neoplasm Proteins/analysis; Neoplasm Proteins/chemistry; Neoplasm Proteins/genetics; Nerve Tissue Proteins/chemistry; Nerve Tissue Proteins/genetics; Neural Cell Adhesion Molecules; Tumor Cells, Cultured

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:BCAM

involved_in

GO:0007155: cell adhesion

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

See also

References

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