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HUMAN:B3A2

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) SLC4A2 (synonyms: AE2, EPB3L1, HKB3, MPB3L)
Protein Name(s) Anion exchange protein 2

AE 2 Anion exchanger 2 Non-erythroid band 3-like protein BND3L Solute carrier family 4 member 2

External Links
UniProt P04920
EMBL X62137
DQ149844
AK295767
AK312699
AC010973
CH471173
CH471173
BC009386
BC009434
X03918
CCDS CCDS56520.1
CCDS56521.1
CCDS5917.1
PIR S21086
RefSeq NP_001186621.1
NP_001186622.1
NP_001186623.1
NP_003031.3
UniGene Hs.647069
ProteinModelPortal P04920
SMR P04920
BioGrid 112413
IntAct P04920
STRING 9606.ENSP00000311402
TCDB 2.A.31.1.2
PhosphoSite P04920
DMDM 85687559
MaxQB P04920
PaxDb P04920
PeptideAtlas P04920
PRIDE P04920
DNASU 6522
Ensembl ENST00000392826
ENST00000413384
ENST00000461735
ENST00000485713
GeneID 6522
KEGG hsa:6522
UCSC uc003wit.4
uc003wiu.4
CTD 6522
GeneCards GC07P150754
HGNC HGNC:11028
HPA HPA019339
MIM 109280
neXtProt NX_P04920
PharmGKB PA35896
eggNOG NOG268067
GeneTree ENSGT00760000119021
HOVERGEN HBG004326
InParanoid P04920
KO K13855
OMA ALQGVIF
OrthoDB EOG7TMZR0
PhylomeDB P04920
TreeFam TF313630
Reactome REACT_19298
ChiTaRS SLC4A2
GeneWiki SLC4A2
GenomeRNAi 6522
NextBio 25371
PRO PR:P04920
Proteomes UP000005640
Bgee P04920
CleanEx HS_SLC4A2
ExpressionAtlas P04920
Genevestigator P04920
GO GO:0016323
GO:0005925
GO:0016021
GO:0016020
GO:0005886
GO:0008509
GO:0015108
GO:0005452
GO:0006820
GO:0015701
GO:0006811
GO:0055085
Gene3D 3.40.1100.10
InterPro IPR001717
IPR002978
IPR018241
IPR013769
IPR011531
IPR003020
IPR016152
PANTHER PTHR11453
PTHR11453:SF14
Pfam PF07565
PF00955
PRINTS PR00165
PR01188
PR01231
SUPFAM SSF55804
TIGRFAMs TIGR00834
PROSITE PS00219
PS00220

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0005925

focal adhesion

PMID:21423176[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000057)

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:19946888[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0051453

regulation of intracellular pH

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:109350
PANTHER:PTN000894242
RGD:3711

P

Seeded From UniProt

complete

involved_in

GO:0015701

bicarbonate transport

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0259111
MGI:MGI:1927555
PANTHER:PTN000894302
UniProtKB:P02730

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000894242
UniProtKB:P02730

C

Seeded From UniProt

complete

involved_in

GO:0015698

inorganic anion transport

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005452

P

Seeded From UniProt

complete

involved_in

GO:0055085

transmembrane transport

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0015297

P

Seeded From UniProt

complete

involved_in

GO:0098656

anion transmembrane transport

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0008509

P

Seeded From UniProt

complete

involved_in

GO:0098656

anion transmembrane transport

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0008509

P

Seeded From UniProt

complete

involved_in

GO:0098656

anion transmembrane transport

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0015301

P

Seeded From UniProt

complete

involved_in

GO:0051453

regulation of intracellular pH

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P23347
ensembl:ENSRNOP00000019666

P

Seeded From UniProt

complete

involved_in

GO:0048565

digestive tract development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P23347
ensembl:ENSRNOP00000019666

P

Seeded From UniProt

complete

enables

GO:0019899

enzyme binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P23347
ensembl:ENSRNOP00000019666

F

Seeded From UniProt

complete

part_of

GO:0016324

apical plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P23347
ensembl:ENSRNOP00000019666

C

Seeded From UniProt

complete

part_of

GO:0016323

basolateral plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P23347
ensembl:ENSRNOP00000019666

C

Seeded From UniProt

complete

involved_in

GO:0007283

spermatogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P23347
ensembl:ENSRNOP00000019666

P

Seeded From UniProt

complete

enables

GO:0005452

inorganic anion exchanger activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001717
InterPro:IPR002978
InterPro:IPR003020
InterPro:IPR018241

F

Seeded From UniProt

complete

involved_in

GO:0006820

anion transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001717
InterPro:IPR002978
InterPro:IPR003020
InterPro:IPR011531
InterPro:IPR013769
InterPro:IPR018241

P

Seeded From UniProt

complete

enables

GO:0008509

anion transmembrane transporter activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013769

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001717
InterPro:IPR002978
InterPro:IPR003020
InterPro:IPR018241

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011531
InterPro:IPR013769

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:3015590[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0008509

anion transmembrane transporter activity

PMID:3015590[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006820

anion transport

PMID:3015590[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0015701

bicarbonate transport

Reactome:R-HSA-425381

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-425482

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006811

ion transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0406

P

Seeded From UniProt

complete

enables

GO:0015297

antiporter activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0050

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472
UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

enables

GO:0015301

anion:anion antiporter activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0039

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page
  2. Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
  3. 3.0 3.1 3.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. 4.0 4.1 4.2 Demuth, DR et al. (1986) Cloning and structural characterization of a human non-erythroid band 3-like protein. EMBO J. 5 1205-14 PubMed GONUTS page