HUMAN:B3A2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	SLC4A2 (synonyms: AE2, EPB3L1, HKB3, MPB3L)
Protein Name(s)	Anion exchange protein 2 AE 2 Anion exchanger 2 Non-erythroid band 3-like protein BND3L Solute carrier family 4 member 2
External Links
UniProt	P04920
EMBL	X62137 DQ149844 AK295767 AK312699 AC010973 CH471173 CH471173 BC009386 BC009434 X03918
CCDS	CCDS56520.1 CCDS56521.1 CCDS5917.1
PIR	S21086
RefSeq	NP_001186621.1 NP_001186622.1 NP_001186623.1 NP_003031.3
UniGene	Hs.647069
ProteinModelPortal	P04920
SMR	P04920
BioGrid	112413
IntAct	P04920
STRING	9606.ENSP00000311402
TCDB	2.A.31.1.2
PhosphoSite	P04920
DMDM	85687559
MaxQB	P04920
PaxDb	P04920
PeptideAtlas	P04920
PRIDE	P04920
DNASU	6522
Ensembl	ENST00000392826 ENST00000413384 ENST00000461735 ENST00000485713
GeneID	6522
KEGG	hsa:6522
UCSC	uc003wit.4 uc003wiu.4
CTD	6522
GeneCards	GC07P150754
HGNC	HGNC:11028
HPA	HPA019339
MIM	109280
neXtProt	NX_P04920
PharmGKB	PA35896
eggNOG	NOG268067
GeneTree	ENSGT00760000119021
HOVERGEN	HBG004326
InParanoid	P04920
KO	K13855
OMA	ALQGVIF
OrthoDB	EOG7TMZR0
PhylomeDB	P04920
TreeFam	TF313630
Reactome	REACT_19298
ChiTaRS	SLC4A2
GeneWiki	SLC4A2
GenomeRNAi	6522
NextBio	25371
PRO	PR:P04920
Proteomes	UP000005640
Bgee	P04920
CleanEx	HS_SLC4A2
ExpressionAtlas	P04920
Genevestigator	P04920
GO	GO:0016323 GO:0005925 GO:0016021 GO:0016020 GO:0005886 GO:0008509 GO:0015108 GO:0005452 GO:0006820 GO:0015701 GO:0006811 GO:0055085
Gene3D	3.40.1100.10
InterPro	IPR001717 IPR002978 IPR018241 IPR013769 IPR011531 IPR003020 IPR016152
PANTHER	PTHR11453 PTHR11453:SF14
Pfam	PF07565 PF00955
PRINTS	PR00165 PR01188 PR01231
SUPFAM	SSF55804
TIGRFAMs	TIGR00834
PROSITE	PS00219 PS00220

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0005925	focal adhesion	PMID:21423176^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19946888^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051453	regulation of intracellular pH	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109350 PANTHER:PTN000894242 RGD:3711	P		Seeded From UniProt	complete
involved_in	GO:0015701	bicarbonate transport	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0259111 MGI:MGI:1927555 PANTHER:PTN000894302 UniProtKB:P02730	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000894242 UniProtKB:P02730	C		Seeded From UniProt	complete
involved_in	GO:0015698	inorganic anion transport	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005452	P		Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0015297	P		Seeded From UniProt	complete
involved_in	GO:0098656	anion transmembrane transport	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008509	P		Seeded From UniProt	complete
involved_in	GO:0098656	anion transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008509	P		Seeded From UniProt	complete
involved_in	GO:0098656	anion transmembrane transport	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0015301	P		Seeded From UniProt	complete
involved_in	GO:0051453	regulation of intracellular pH	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23347 ensembl:ENSRNOP00000019666	P		Seeded From UniProt	complete
involved_in	GO:0048565	digestive tract development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23347 ensembl:ENSRNOP00000019666	P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23347 ensembl:ENSRNOP00000019666	F		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23347 ensembl:ENSRNOP00000019666	C		Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23347 ensembl:ENSRNOP00000019666	C		Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23347 ensembl:ENSRNOP00000019666	P		Seeded From UniProt	complete
enables	GO:0005452	inorganic anion exchanger activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001717 InterPro:IPR002978 InterPro:IPR003020 InterPro:IPR018241	F		Seeded From UniProt	complete
involved_in	GO:0006820	anion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001717 InterPro:IPR002978 InterPro:IPR003020 InterPro:IPR011531 InterPro:IPR013769 InterPro:IPR018241	P		Seeded From UniProt	complete
enables	GO:0008509	anion transmembrane transporter activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013769	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001717 InterPro:IPR002978 InterPro:IPR003020 InterPro:IPR018241	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011531 InterPro:IPR013769	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:3015590^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008509	anion transmembrane transporter activity	PMID:3015590^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006820	anion transport	PMID:3015590^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0015701	bicarbonate transport	Reactome:R-HSA-425381	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-425482	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P		Seeded From UniProt	complete
enables	GO:0015297	antiporter activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0050	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
enables	GO:0015301	anion:anion antiporter activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0039	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page
↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Demuth, DR et al. (1986) Cloning and structural characterization of a human non-erythroid band 3-like protein. EMBO J. 5 1205-14 PubMed GONUTS page

[PMID:21423176-1] Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page

[PMID:19946888-2] Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:3015590-4] 4.0 ^4.1 ^4.2 Demuth, DR et al. (1986) Cloning and structural characterization of a human non-erythroid band 3-like protein. EMBO J. 5 1205-14 PubMed GONUTS page

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HUMAN:B3A2

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