GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

HUMAN:ATG7

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) ATG7 (synonyms: APG7L)
Protein Name(s) Ubiquitin-like modifier-activating enzyme ATG7

ATG12-activating enzyme E1 ATG7 Autophagy-related protein 7 APG7-like hAGP7 Ubiquitin-activating enzyme E1-like protein

External Links
UniProt O95352
EMBL AF094516
AK303694
AC020750
AC022001
AC026185
AC083855
BC000091
AL122075
CCDS CCDS2605.1
CCDS46752.1
CCDS46753.1
PIR T34556
RefSeq NP_001129503.2
NP_001138384.1
NP_006386.1
UniGene Hs.38032
ProteinModelPortal O95352
SMR O95352
BioGrid 115787
DIP DIP-29759N
IntAct O95352
STRING 9606.ENSP00000346437
BindingDB O95352
ChEMBL CHEMBL2321621
PhosphoSite O95352
MaxQB O95352
PaxDb O95352
PRIDE O95352
Ensembl ENST00000354449
ENST00000354956
ENST00000446450
GeneID 10533
KEGG hsa:10533
UCSC uc003bwc.3
uc003bwd.3
CTD 10533
GeneCards GC03P011313
HGNC HGNC:16935
HPA CAB018771
HPA007639
MIM 608760
neXtProt NX_O95352
PharmGKB PA134983397
eggNOG COG0476
GeneTree ENSGT00390000017509
HOGENOM HOG000162379
HOVERGEN HBG080877
InParanoid O95352
KO K08337
OMA EGYNMSI
OrthoDB EOG7X0VGG
PhylomeDB O95352
TreeFam TF105689
Reactome REACT_75842
ChiTaRS ATG7
GeneWiki ATG7
GenomeRNAi 10533
NextBio 39961
PRO PR:O95352
Proteomes UP000005640
Bgee O95352
CleanEx HS_ATG7
ExpressionAtlas O95352
Genevestigator O95352
GO GO:0005930
GO:0005737
GO:0005829
GO:0000407
GO:0019778
GO:0019779
GO:0042803
GO:0008134
GO:0004839
GO:0007628
GO:0006501
GO:0055013
GO:0006520
GO:0006464
GO:0071455
GO:0006995
GO:0009267
GO:0021955
GO:0021680
GO:0021987
GO:0044805
GO:0001889
GO:0061025
GO:0000422
GO:0007005
GO:0043066
GO:0039689
GO:0050877
GO:0034727
GO:0043065
GO:0010508
GO:0016239
GO:0045732
GO:0031401
GO:0009791
GO:0030163
GO:0006497
GO:0032446
GO:0015031
GO:0021860
GO:0031396
Gene3D 3.40.50.720
InterPro IPR006285
IPR009036
IPR016040
IPR000594
PANTHER PTHR10953:SF3
Pfam PF00899
SUPFAM SSF69572
TIGRFAMs TIGR01381

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0051607

defense response to virus

PMID:23290079[1]

ECO:0000315

P

Fig 5 shows that ATG7 inhibits spread of HPV16 infection in primary keratinocytes.

complete
CACAO 6505

GO:0039521

suppression by virus of host autophagy

PMID:23290079[1]

ECO:0000315

P

Fig 5 shows that the infection rate of HPV16 in primary keratinocytes is inhibited by ATG7 autophagy.

complete
CACAO 6815

GO:0006914

autophagy

PMID:24681637[2]

ECO:0000315

P

Figure 2 indicates that cells treated to knockout atg7 showed no presence of LC3-II when treated with MitoQ. Wildtype cells treated with MitoQ showed sufficient levels of LC3-II. The presence of LC3-II is used to indicate autophagy. Thus, atg7 is necessary for MitoQ-induced autophagy.

complete
CACAO 9771

involved_in

GO:0042752

regulation of circadian rhythm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9D906

P

Seeded From UniProt

complete

involved_in

GO:0006914

autophagy

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9D906

P

Seeded From UniProt

complete

involved_in

GO:0075044

positive regulation by symbiont of host autophagy

PMID:28389568[3]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q9H1Y0

P

Seeded From UniProt

complete

involved_in

GO:0051607

defense response to virus

PMID:23290079[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006914

autophagy

PMID:24681637[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000422

autophagy of mitochondrion

PMID:19279012[4]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q9BXM7

P

Seeded From UniProt

complete

involved_in

GO:0039521

suppression by virus of host autophagy

PMID:23290079[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016236

macroautophagy

PMID:22354037[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0071455

cellular response to hyperoxia

PMID:20543840[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045732

positive regulation of protein catabolic process

PMID:20543840[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043065

positive regulation of apoptotic process

PMID:20543840[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

PMID:11096062[7]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0019778

Atg12 activating enzyme activity

PMID:20723759[8]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9D906

F

Seeded From UniProt

complete

involved_in

GO:0006914

autophagy

PMID:20543840[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009267

cellular response to starvation

PMID:20543840[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

PMID:20543840[6]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q12778

F

Seeded From UniProt

complete

part_of

GO:0005930

axoneme

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9D906

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:20543840[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0044805

late nucleophagy

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000102341
SGD:S000001214

P

Seeded From UniProt

complete

involved_in

GO:0034727

piecemeal microautophagy of the nucleus

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000102341
SGD:S000001214

P

Seeded From UniProt

complete

involved_in

GO:0032446

protein modification by small protein conjugation

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0023143
FB:FBgn0029113
FB:FBgn0029512
FB:FBgn0032054
FB:FBgn0034366
FB:FBgn0261112
FB:FBgn0263697
MGI:MGI:1913894
MGI:MGI:1913913
MGI:MGI:1921494
MGI:MGI:98890
MGI:MGI:98891
PANTHER:PTN000102039
PomBase:SPAC4C5.04
PomBase:SPBC1604.21c
PomBase:SPBC16H5.03c
SGD:S000001153
SGD:S000001214
SGD:S000001693
SGD:S000002798
SGD:S000005924
SGD:S000006270
SGD:S000006384
TAIR:locus:2060854
TAIR:locus:2159727
TAIR:locus:2164270
TAIR:locus:2832477
UniProtKB:A0AVT1
UniProtKB:P22314
UniProtKB:P41226
UniProtKB:P42744
UniProtKB:Q13564
UniProtKB:Q5BAI0
UniProtKB:Q8I553
UniProtKB:Q8I5F9
UniProtKB:Q8IDZ6
UniProtKB:Q9GZZ9
UniProtKB:Q9SJT1
UniProtKB:Q9UBE0
UniProtKB:Q9UBT2
UniProtKB:Q9ZV69
WB:WBGene00000142
WB:WBGene00004341
WB:WBGene00006699
WB:WBGene00006700
ZFIN:ZDB-GENE-040625-21

P

Seeded From UniProt

complete

enables

GO:0019779

Atg8 activating enzyme activity

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0034366
MGI:MGI:1921494
PANTHER:PTN000102341
SGD:S000001214

F

Seeded From UniProt

complete

enables

GO:0019778

Atg12 activating enzyme activity

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1921494
PANTHER:PTN000102341
SGD:S000001214

F

Seeded From UniProt

complete

involved_in

GO:0006995

cellular response to nitrogen starvation

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000102341
dictyBase:DDB_G0271096

P

Seeded From UniProt

complete

involved_in

GO:0006501

C-terminal protein lipidation

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000102341
SGD:S000001214

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10154
EcoGene:EG11587
FB:FBgn0029113
FB:FBgn0032054
MGI:MGI:1921494
PANTHER:PTN000102040
PomBase:SPBC1604.21c
SGD:S000001214
SGD:S000001693
SGD:S000006384
TAIR:locus:2060854
TAIR:locus:2152375
TAIR:locus:2164270
TAIR:locus:2207185
UniProtKB:A0AVT1
UniProtKB:O95352
UniProtKB:O95396
UniProtKB:P42744
UniProtKB:Q8I5F9
UniProtKB:Q8ID54
UniProtKB:Q8IDZ6
UniProtKB:Q9GZZ9
UniProtKB:Q9SJT1
UniProtKB:Q9ZV69
WB:WBGene00004341
dictyBase:DDB_G0271096

C

Seeded From UniProt

complete

involved_in

GO:0000422

autophagy of mitochondrion

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1921494
PANTHER:PTN000102341
SGD:S000001214
UniProtKB:O95352

P

Seeded From UniProt

complete

part_of

GO:0000407

phagophore assembly site

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000102341
SGD:S000001214

C

Seeded From UniProt

complete

involved_in

GO:0000045

autophagosome assembly

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1921494
PANTHER:PTN000102341
UniProtKB:A0A0G2KPR3

P

Seeded From UniProt

complete

involved_in

GO:0031401

positive regulation of protein modification process

PMID:12890687[10]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006914

autophagy

PMID:25327288[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006497

protein lipidation

PMID:12890687[10]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004839

P

Seeded From UniProt

complete

involved_in

GO:1903204

negative regulation of oxidative stress-induced neuron death

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q641Y5
ensembl:ENSRNOP00000063617

P

Seeded From UniProt

complete

involved_in

GO:1902617

response to fluoride

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q641Y5
ensembl:ENSRNOP00000063617

P

Seeded From UniProt

complete

involved_in

GO:1901214

regulation of neuron death

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q641Y5
ensembl:ENSRNOP00000063617

P

Seeded From UniProt

complete

involved_in

GO:0090298

negative regulation of mitochondrial DNA replication

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q641Y5
ensembl:ENSRNOP00000063617

P

Seeded From UniProt

complete

involved_in

GO:0071315

cellular response to morphine

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q641Y5
ensembl:ENSRNOP00000063617

P

Seeded From UniProt

complete

involved_in

GO:0061684

chaperone-mediated autophagy

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q641Y5
ensembl:ENSRNOP00000063617

P

Seeded From UniProt

complete

involved_in

GO:0060548

negative regulation of cell death

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q641Y5
ensembl:ENSRNOP00000063617

P

Seeded From UniProt

complete

involved_in

GO:0031667

response to nutrient levels

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q641Y5
ensembl:ENSRNOP00000063617

P

Seeded From UniProt

complete

part_of

GO:0030424

axon

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q641Y5
ensembl:ENSRNOP00000063617

C

Seeded From UniProt

complete

involved_in

GO:0010508

positive regulation of autophagy

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q641Y5
ensembl:ENSRNOP00000063617

P

Seeded From UniProt

complete

involved_in

GO:0009749

response to glucose

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q641Y5
ensembl:ENSRNOP00000063617

P

Seeded From UniProt

complete

involved_in

GO:0007568

aging

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q641Y5
ensembl:ENSRNOP00000063617

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006285

C

Seeded From UniProt

complete

involved_in

GO:0006914

autophagy

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006285

P

Seeded From UniProt

complete

enables

GO:0008641

ubiquitin-like modifier activating enzyme activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000594
InterPro:IPR035985

F

Seeded From UniProt

complete

involved_in

GO:0061025

membrane fusion

PMID:10233149[12]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006464

cellular protein modification process

PMID:10233149[12]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:10233149[12]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004839

ubiquitin activating enzyme activity

PMID:10233149[12]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:1904813

ficolin-1-rich granule lumen

Reactome:R-HSA-6800434

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0043312

neutrophil degranulation

Reactome:R-HSA-6798695

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0034774

secretory granule lumen

Reactome:R-HSA-6798748

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0016236

macroautophagy

Reactome:R-HSA-1632852

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-9020616
Reactome:R-HSA-5683593
Reactome:R-HSA-5682896
Reactome:R-HSA-5682011
Reactome:R-HSA-5681981
Reactome:R-HSA-5681980

ECO:0000304

author statement supported by traceable reference used in manual assertion






C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-HSA-6800434
Reactome:R-HSA-6798748

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

involved_in

GO:0015031

protein transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0653

P

Seeded From UniProt

complete

involved_in

GO:0048511

rhythmic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0090

P

Seeded From UniProt

complete

involved_in

GO:0006914

autophagy

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0072

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0000407

phagophore assembly site

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0220

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 Griffin, LM et al. (2013) Human papillomavirus infection is inhibited by host autophagy in primary human keratinocytes. Virology 437 12-9 PubMed GONUTS page
  2. ↑ 2.0 2.1 Gonzalez, Y et al. (2014) Atg7- and Keap1-dependent autophagy protects breast cancer cell lines against mitoquinone-induced oxidative stress. Oncotarget 5 1526-37 PubMed GONUTS page
  3. ↑ Hansen, MD et al. (2017) Hepatitis C virus triggers Golgi fragmentation and autophagy through the immunity-related GTPase M. Proc. Natl. Acad. Sci. U.S.A. 114 E3462-E3471 PubMed GONUTS page
  4. ↑ Dagda, RK et al. (2009) Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission. J. Biol. Chem. 284 13843-55 PubMed GONUTS page
  5. ↑ McKnight, NC et al. (2012) Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC. EMBO J. 31 1931-46 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 Zhao, Y et al. (2010) Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity. Nat. Cell Biol. 12 665-75 PubMed GONUTS page
  7. ↑ Tanida, I et al. (2001) The human homolog of Saccharomyces cerevisiae Apg7p is a Protein-activating enzyme for multiple substrates including human Apg12p, GATE-16, GABARAP, and MAP-LC3. J. Biol. Chem. 276 1701-6 PubMed GONUTS page
  8. ↑ Radoshevich, L et al. (2010) ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death. Cell 142 590-600 PubMed GONUTS page
  9. ↑ 9.00 9.01 9.02 9.03 9.04 9.05 9.06 9.07 9.08 9.09 9.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  10. ↑ 10.0 10.1 Nemoto, T et al. (2003) The mouse APG10 homologue, an E2-like enzyme for Apg12p conjugation, facilitates MAP-LC3 modification. J. Biol. Chem. 278 39517-26 PubMed GONUTS page
  11. ↑ Dowdle, WE et al. (2014) Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo. Nat. Cell Biol. 16 1069-79 PubMed GONUTS page
  12. ↑ 12.0 12.1 12.2 12.3 Yuan, W et al. (1999) Glucose-induced autophagy of peroxisomes in Pichia pastoris requires a unique E1-like protein. Mol. Biol. Cell 10 1353-66 PubMed GONUTS page
Retrieved from "https://gowiki.tamu.edu/wiki/index.php?title=HUMAN:ATG7&oldid=5954329"