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HUMAN:ASPP2

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) TP53BP2 (synonyms: ASPP2, BBP)
Protein Name(s) Apoptosis-stimulating of p53 protein 2

Bcl2-binding protein Bbp Renal carcinoma antigen NY-REN-51 Tumor suppressor p53-binding protein 2 53BP2 p53-binding protein 2 p53BP2

External Links
UniProt Q13625
EMBL U58334
AJ318888
AK294432
AC096542
BC046150
BC058918
U09582
CCDS CCDS1538.1
CCDS44319.1
PIR I38607
RefSeq NP_001026855.2
NP_005417.1
XP_011542571.1
UniGene Hs.523968
PDB 1YCS
2UWQ
4A63
4IRV
PDBsum 1YCS
2UWQ
4A63
4IRV
ProteinModelPortal Q13625
SMR Q13625
BioGrid 113012
DIP DIP-426N
IntAct Q13625
MINT Q13625
STRING 9606.ENSP00000341957
iPTMnet Q13625
PhosphoSitePlus Q13625
BioMuta TP53BP2
DMDM 33860140
EPD Q13625
jPOST Q13625
MaxQB Q13625
PaxDb Q13625
PeptideAtlas Q13625
PRIDE Q13625
ProteomicsDB 59616
59617
59618
Ensembl ENST00000343537
ENST00000391878
GeneID 7159
KEGG hsa:7159
UCSC uc001hod.4
CTD 7159
DisGeNET 7159
EuPathDB HostDB:ENSG00000143514.16
GeneCards TP53BP2
HGNC HGNC:12000
HPA HPA021603
HPA050429
MIM 602143
neXtProt NX_Q13625
OpenTargets ENSG00000143514
PharmGKB PA36681
eggNOG KOG0515
ENOG410Y17W
GeneTree ENSGT00940000153463
HOGENOM HOG000034106
HOVERGEN HBG050596
InParanoid Q13625
KO K16823
OMA VQENHEN
OrthoDB 1041229at2759
PhylomeDB Q13625
TreeFam TF105545
Reactome R-HSA-139915
R-HSA-6803204
R-HSA-6803205
R-HSA-6803211
R-HSA-6804759
SIGNOR Q13625
ChiTaRS TP53BP2
EvolutionaryTrace Q13625
GeneWiki TP53BP2
GenomeRNAi 7159
PRO PR:Q13625
Proteomes UP000005640
Bgee ENSG00000143514
ExpressionAtlas Q13625
Genevisible Q13625
GO GO:0030054
GO:0005737
GO:0005829
GO:0005739
GO:0005654
GO:0005634
GO:0048471
GO:0042802
GO:0051059
GO:0002039
GO:0017124
GO:0005070
GO:0007049
GO:0072332
GO:0045786
GO:1900119
GO:1901216
GO:1900740
GO:0042981
GO:1901796
GO:0007165
CDD cd00204
Gene3D 1.25.40.20
InterPro IPR002110
IPR020683
IPR036770
IPR036028
IPR001452
IPR029071
Pfam PF12796
PF00018
SMART SM00248
SM00326
SUPFAM SSF48403
SSF50044
SSF54236
PROSITE PS50297
PS50088
PS50002

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0002039

p53 binding

PMID:14985081[1]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P04637

F

Seeded From UniProt

complete

part_of

GO:0048471

perinuclear region of cytoplasm

PMID:14985081[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:14985081[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:1900119

positive regulation of execution phase of apoptosis

PMID:14985081[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

colocalizes_with

GO:0048471

perinuclear region of cytoplasm

PMID:10646860[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:10646860[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0072332

intrinsic apoptotic signaling pathway by p53 class mediator

PMID:11684014[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0051059

NF-kappaB binding

PMID:10498867[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q04206

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:19377511[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:19377511[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001538228
RGD:1304651
RGD:1305461
UniProtKB:Q13625
UniProtKB:Q96KQ4

C

Seeded From UniProt

complete

enables

GO:0002039

p53 binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001538228
UniProtKB:Q13625
WB:WBGene00000146

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:18448430[7]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q13625

F

Seeded From UniProt

complete

part_of

GO:0030054

cell junction

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:1900740

C

Seeded From UniProt

complete

involved_in

GO:1901216

positive regulation of neuron death

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:F1M5H6
ensembl:ENSRNOP00000004330

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:F1M5H6
ensembl:ENSRNOP00000004330

C

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

PMID:9748285[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:9748285[8]
PMID:15782125[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

enables

GO:0005070

SH3/SH2 adaptor activity

PMID:8668206[10]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0045786

negative regulation of cell cycle

PMID:14729977[11]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1901796

regulation of signal transduction by p53 class mediator

Reactome:R-HSA-5633007

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1900740

positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway

Reactome:R-HSA-139915

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042981

regulation of apoptotic process

Reactome:R-HSA-5633008

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-6799815
Reactome:R-HSA-6799777
Reactome:R-HSA-6799462
Reactome:R-HSA-4331340
Reactome:R-HSA-3700981

ECO:0000304

author statement supported by traceable reference used in manual assertion





C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0053

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

enables

GO:0017124

SH3 domain binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0729

F

Seeded From UniProt

complete

part_of

GO:0048471

perinuclear region of cytoplasm

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0198

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 Cao, Y et al. (2004) Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis. Biochem. Biophys. Res. Commun. 315 788-95 PubMed GONUTS page
  2. ↑ 2.0 2.1 Nakagawa, H et al. (2000) APCL, a central nervous system-specific homologue of adenomatous polyposis coli tumor suppressor, binds to p53-binding protein 2 and translocates it to the perinucleus. Cancer Res. 60 101-5 PubMed GONUTS page
  3. ↑ Samuels-Lev, Y et al. (2001) ASPP proteins specifically stimulate the apoptotic function of p53. Mol. Cell 8 781-94 PubMed GONUTS page
  4. ↑ Yang, JP et al. (1999) NF-kappaB subunit p65 binds to 53BP2 and inhibits cell death induced by 53BP2. Oncogene 18 5177-86 PubMed GONUTS page
  5. ↑ 5.0 5.1 Uhlmann-Schiffler, H et al. (2009) The DEAD box protein Ddx42p modulates the function of ASPP2, a stimulator of apoptosis. Oncogene 28 2065-73 PubMed GONUTS page
  6. ↑ 6.0 6.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  7. ↑ Rotem, S et al. (2008) The structure and interactions of the proline-rich domain of ASPP2. J. Biol. Chem. 283 18990-9 PubMed GONUTS page
  8. ↑ 8.0 8.1 Iwabuchi, K et al. (1998) Stimulation of p53-mediated transcriptional activation by the p53-binding proteins, 53BP1 and 53BP2. J. Biol. Chem. 273 26061-8 PubMed GONUTS page
  9. ↑ Bergamaschi, D et al. (2005) Mdm2 and mdmX prevent ASPP1 and ASPP2 from stimulating p53 without targeting p53 for degradation. Oncogene 24 3836-41 PubMed GONUTS page
  10. ↑ Naumovski, L & Cleary, ML (1996) The p53-binding protein 53BP2 also interacts with Bc12 and impedes cell cycle progression at G2/M. Mol. Cell. Biol. 16 3884-92 PubMed GONUTS page
  11. ↑ Bergamaschi, D et al. (2004) ASPP1 and ASPP2: common activators of p53 family members. Mol. Cell. Biol. 24 1341-50 PubMed GONUTS page
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