GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

HUMAN:ARPC5

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) ARPC5 (synonyms: ARC16)
Protein Name(s) Actin-related protein 2/3 complex subunit 5

Arp2/3 complex 16 kDa subunit p16-ARC

External Links
UniProt O15511
EMBL AF006088
AF017807
AL137800
AL137800
CH471067
BC057237
CCDS CCDS1357.1
CCDS58050.1
RefSeq NP_001257368.1
NP_005708.1
UniGene Hs.518609
ProteinModelPortal O15511
SMR O15511
BioGrid 115399
DIP DIP-33144N
IntAct O15511
MINT MINT-2999073
STRING 9606.ENSP00000352918
PhosphoSite O15511
OGP O15511
SWISS-2DPAGE O15511
MaxQB O15511
PaxDb O15511
PRIDE O15511
DNASU 10092
Ensembl ENST00000294742
ENST00000359856
GeneID 10092
KEGG hsa:10092
UCSC uc001gql.4
uc021pgb.2
CTD 10092
GeneCards GC01M183592
HGNC HGNC:708
HPA HPA022013
MIM 604227
neXtProt NX_O15511
PharmGKB PA25003
eggNOG NOG259254
GeneTree ENSGT00390000014806
HOGENOM HOG000197215
HOVERGEN HBG050583
InParanoid O15511
KO K05754
OMA GHGAIMR
PhylomeDB O15511
TreeFam TF319716
Reactome REACT_160086
REACT_228085
ChiTaRS ARPC5
GeneWiki ARPC5
GenomeRNAi 10092
NextBio 38165
PRO PR:O15511
Proteomes UP000005640
Bgee O15511
CleanEx HS_ARPC5
ExpressionAtlas O15511
Genevestigator O15511
GO GO:0015629
GO:0005885
GO:0042995
GO:0005737
GO:0005829
GO:0070062
GO:0005925
GO:0005200
GO:0030036
GO:0034314
GO:0006928
GO:0038096
GO:0045087
Gene3D 1.25.40.190
InterPro IPR006789
PANTHER PTHR12644
Pfam PF04699
SUPFAM SSF69103

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0016477

cell migration

PMID:22378351[1]

ECO:0000315

P

figure 4B

complete
CACAO 8551

part_of

GO:0035861

site of double-strand break

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q6DE18

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q6DE18

C

Seeded From UniProt

complete

involved_in

GO:0016477

cell migration

PMID:22378351[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005925

focal adhesion

PMID:21423176[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000057)

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:19056867[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001088)

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:20458337[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000639)

Seeded From UniProt

complete

enables

GO:0051015

actin filament binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000291131
UniProtKB:O15511

F

Seeded From UniProt

complete

involved_in

GO:0034314

Arp2/3 complex-mediated actin nucleation

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000291131
PomBase:SPAC17G8.04c
UniProtKB:O15511
WB:WBGene00000205

P

Seeded From UniProt

complete

involved_in

GO:0016477

cell migration

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000974138
UniProtKB:O15511

P

Seeded From UniProt

complete

part_of

GO:0005885

Arp2/3 protein complex

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000291131
PomBase:SPAC17G8.04c
SGD:S000001324
UniProtKB:O15511
dictyBase:DDB_G0288319

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000291131
WB:WBGene00000205

C

Seeded From UniProt

complete

part_of

GO:0005885

Arp2/3 protein complex

PMID:11741539[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005200

structural constituent of cytoskeleton

PMID:11741539[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0034314

Arp2/3 complex-mediated actin nucleation

PMID:11741539[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

contributes_to

GO:0051015

actin filament binding

PMID:11741539[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0097581

lamellipodium organization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q4KLF8
ensembl:ENSRNOP00000061516

P

Seeded From UniProt

complete

involved_in

GO:0061842

microtubule organizing center localization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q4KLF8
ensembl:ENSRNOP00000061516

P

Seeded From UniProt

complete

involved_in

GO:0051639

actin filament network formation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q4KLF8
ensembl:ENSRNOP00000061516

P

Seeded From UniProt

complete

part_of

GO:0043005

neuron projection

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q4KLF8
ensembl:ENSRNOP00000061516

C

Seeded From UniProt

complete

part_of

GO:0030426

growth cone

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q4KLF8
ensembl:ENSRNOP00000061516

C

Seeded From UniProt

complete

involved_in

GO:0030011

maintenance of cell polarity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q4KLF8
ensembl:ENSRNOP00000061516

P

Seeded From UniProt

complete

involved_in

GO:0021769

orbitofrontal cortex development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q4KLF8
ensembl:ENSRNOP00000061516

P

Seeded From UniProt

complete

involved_in

GO:0014909

smooth muscle cell migration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q4KLF8
ensembl:ENSRNOP00000061516

P

Seeded From UniProt

complete

part_of

GO:0005768

endosome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q4KLF8
ensembl:ENSRNOP00000061516

C

Seeded From UniProt

complete

part_of

GO:0030027

lamellipodium

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9CPW4
ensembl:ENSMUSP00000076933

C

Seeded From UniProt

complete

part_of

GO:0005885

Arp2/3 protein complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006789
InterPro:IPR036743

C

Seeded From UniProt

complete

part_of

GO:0015629

actin cytoskeleton

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006789
InterPro:IPR036743

C

Seeded From UniProt

complete

involved_in

GO:0030833

regulation of actin filament polymerization

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006789
InterPro:IPR036743

P

Seeded From UniProt

complete

involved_in

GO:0034314

Arp2/3 complex-mediated actin nucleation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006789
InterPro:IPR036743

P

Seeded From UniProt

complete

involved_in

GO:0030036

actin cytoskeleton organization

PMID:9359840[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0015629

actin cytoskeleton

PMID:9230079[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005885

Arp2/3 protein complex

PMID:9230079[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:9359840[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005200

structural constituent of cytoskeleton

PMID:9230079[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:1904813

ficolin-1-rich granule lumen

Reactome:R-HSA-6800434

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0061024

membrane organization

Reactome:R-HSA-199991

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048013

ephrin receptor signaling pathway

Reactome:R-HSA-2682334

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043312

neutrophil degranulation

Reactome:R-HSA-6798695

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0038096

Fc-gamma receptor signaling pathway involved in phagocytosis

Reactome:R-HSA-2029480

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0034774

secretory granule lumen

Reactome:R-HSA-6798748

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-8871194
Reactome:R-HSA-8871193
Reactome:R-HSA-8869438
Reactome:R-HSA-8868661
Reactome:R-HSA-8868660
Reactome:R-HSA-8868659
Reactome:R-HSA-8868658
Reactome:R-HSA-8868651
Reactome:R-HSA-8868648
Reactome:R-HSA-8868236
Reactome:R-HSA-8868230
Reactome:R-HSA-3928595
Reactome:R-HSA-2197690
Reactome:R-HSA-2029476
Reactome:R-HSA-2029473
Reactome:R-HSA-2029466
Reactome:R-HSA-1861595

ECO:0000304

author statement supported by traceable reference used in manual assertion

















C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-HSA-6800434
Reactome:R-HSA-6798748

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

part_of

GO:0042995

cell projection

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0966
UniProtKB-SubCell:SL-0280

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206
UniProtKB-SubCell:SL-0090

C

Seeded From UniProt

complete

enables

GO:0003779

actin binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0009

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Kinoshita, T et al. (2012) Actin-related protein 2/3 complex subunit 5 (ARPC5) contributes to cell migration and invasion and is directly regulated by tumor-suppressive microRNA-133a in head and neck squamous cell carcinoma. Int. J. Oncol. 40 1770-8 PubMed GONUTS page
  2. ↑ Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page
  3. ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
  4. ↑ Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 5.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 Gournier, H et al. (2001) Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity. Mol. Cell 8 1041-52 PubMed GONUTS page
  7. ↑ 7.0 7.1 Machesky, LM et al. (1997) Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins. Biochem. J. 328 ( Pt 1) 105-12 PubMed GONUTS page
  8. ↑ 8.0 8.1 8.2 Welch, MD et al. (1997) The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. J. Cell Biol. 138 375-84 PubMed GONUTS page
Retrieved from "https://gowiki.tamu.edu/wiki/index.php?title=HUMAN:ARPC5&oldid=5941287"