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HUMAN:ARGI2
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | ARG2 | |
| Protein Name(s) | Arginase-2, mitochondrial
Kidney-type arginase Non-hepatic arginase Type II arginase | |
| External Links | ||
| UniProt | P78540 | |
| EMBL | D86724 U75667 U82256 AY074489 CR536550 AK312484 CH471061 BC001350 BC008464 BC029050 | |
| CCDS | CCDS9785.1 | |
| RefSeq | NP_001163.1 | |
| UniGene | Hs.226007 | |
| PDB | 1PQ3 4HZE 4I06 4IE2 4IE3 4IXU 4IXV | |
| PDBsum | 1PQ3 4HZE 4I06 4IE2 4IE3 4IXU 4IXV | |
| ProteinModelPortal | P78540 | |
| SMR | P78540 | |
| BioGrid | 106879 | |
| STRING | 9606.ENSP00000261783 | |
| BindingDB | P78540 | |
| ChEMBL | CHEMBL1795148 | |
| DrugBank | DB00125 DB00129 | |
| PhosphoSite | P78540 | |
| DMDM | 2492935 | |
| MaxQB | P78540 | |
| PaxDb | P78540 | |
| PeptideAtlas | P78540 | |
| PRIDE | P78540 | |
| DNASU | 384 | |
| Ensembl | ENST00000261783 | |
| GeneID | 384 | |
| KEGG | hsa:384 | |
| UCSC | uc001xjs.3 | |
| CTD | 384 | |
| GeneCards | GC14P068086 | |
| HGNC | HGNC:664 | |
| HPA | CAB009435 HPA000663 | |
| MIM | 107830 | |
| neXtProt | NX_P78540 | |
| PharmGKB | PA24948 | |
| eggNOG | COG0010 | |
| GeneTree | ENSGT00530000063082 | |
| HOGENOM | HOG000204319 | |
| HOVERGEN | HBG003030 | |
| InParanoid | P78540 | |
| KO | K01476 | |
| OMA | IATCFGQ | |
| OrthoDB | EOG747PJ5 | |
| PhylomeDB | P78540 | |
| TreeFam | TF300034 | |
| BioCyc | MetaCyc:HS01388-MONOMER | |
| Reactome | REACT_847 | |
| SABIO-RK | P78540 | |
| UniPathway | UPA00158 | |
| ChiTaRS | ARG2 | |
| EvolutionaryTrace | P78540 | |
| GenomeRNAi | 384 | |
| NextBio | 1607 | |
| PRO | PR:P78540 | |
| Proteomes | UP000005640 | |
| Bgee | P78540 | |
| CleanEx | HS_ARG2 | |
| ExpressionAtlas | P78540 | |
| Genevestigator | P78540 | |
| GO | GO:0005759 GO:0005739 GO:0004053 GO:0046872 GO:0006525 GO:0034641 GO:0006809 GO:0044281 GO:0006941 GO:0000050 GO:0001657 | |
| Gene3D | 3.40.800.10 | |
| InterPro | IPR014033 IPR006035 IPR023696 IPR020855 | |
| PANTHER | PTHR11358 | |
| Pfam | PF00491 | |
| PIRSF | PIRSF036979 | |
| PRINTS | PR00116 | |
| TIGRFAMs | TIGR01229 | |
| PROSITE | PS01053 PS51409 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0004053 |
arginase activity |
ECO:0000315 |
F |
figure 2 |
complete | |||||
|
involved_in |
GO:2000774 |
positive regulation of cellular senescence |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004053 |
arginase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032720 |
negative regulation of tumor necrosis factor production |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030145 |
manganese ion binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000144386 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0019547 |
arginine catabolic process to ornithine |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000144386 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1330806 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000144386 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:2000666 |
negative regulation of interleukin-13 secretion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08691 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:2000562 |
negative regulation of CD4-positive, alpha-beta T cell proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08691 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1905403 |
negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08691 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1905077 |
negative regulation of interleukin-17 secretion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08691 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1904468 |
negative regulation of tumor necrosis factor secretion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08691 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1903426 |
regulation of reactive oxygen species biosynthetic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08691 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1900425 |
negative regulation of defense response to bacterium |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08691 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071650 |
negative regulation of chemokine (C-C motif) ligand 5 production |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08691 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071644 |
negative regulation of chemokine (C-C motif) ligand 4 production |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08691 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071641 |
negative regulation of macrophage inflammatory protein 1 alpha production |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08691 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050706 |
regulation of interleukin-1 beta secretion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08691 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006941 |
striated muscle contraction |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08691 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08691 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0002829 |
negative regulation of type 2 immune response |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08691 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001657 |
ureteric bud development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08691 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004053 |
arginase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006525 |
arginine metabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016813 |
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004053 |
arginase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006809 |
nitric oxide biosynthetic process |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004053 |
arginase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005759 |
mitochondrial matrix |
Reactome:R-HSA-452036 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000050 |
urea cycle |
Reactome:R-HSA-70635 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0002250 |
adaptive immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006525 |
arginine metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002376 |
immune system process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000050 |
urea cycle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0835 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045087 |
innate immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 López, V et al. (2005) Insights into the interaction of human arginase II with substrate and manganese ions by site-directed mutagenesis and kinetic studies. Alteration of substrate specificity by replacement of Asn149 with Asp. FEBS J. 272 4540-8 PubMed GONUTS page
- ↑ Yepuri, G et al. (2012) Positive crosstalk between arginase-II and S6K1 in vascular endothelial inflammation and aging. Aging Cell 11 1005-16 PubMed GONUTS page
- ↑ McGovern, N et al. (2017) Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2. Nature 546 662-666 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 5.0 5.1 Gotoh, T et al. (1996) Molecular cloning of cDNA for nonhepatic mitochondrial arginase (arginase II) and comparison of its induction with nitric oxide synthase in a murine macrophage-like cell line. FEBS Lett. 395 119-22 PubMed GONUTS page
- ↑ Gotoh, T et al. (1997) Chromosomal localization of the human arginase II gene and tissue distribution of its mRNA. Biochem. Biophys. Res. Commun. 233 487-91 PubMed GONUTS page
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- GO:0071650 ! negative regulation of chemokine (C-C motif) ligand 5 production
- GO:0032720 ! negative regulation of tumor necrosis factor production
- GO:2000666 ! negative regulation of interleukin-13 secretion
- GO:2000562 ! negative regulation of CD4-positive, alpha-beta T cell proliferation
- GO:1905403 ! negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process
- GO:1904468 ! negative regulation of tumor necrosis factor secretion
- GO:1905077 ! negative regulation of interleukin-17 secretion
- GO:0071641 ! negative regulation of macrophage inflammatory protein 1 alpha production
- GO:0002829 ! negative regulation of type 2 immune response
- GO:1900425 ! negative regulation of defense response to bacterium
- GO:0071644 ! negative regulation of chemokine (C-C motif) ligand 4 production
- GO:0006809 ! nitric oxide biosynthetic process
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