PMID:28614294

Citation	McGovern, N, Shin, A, Low, G, Low, D, Duan, K, Yao, LJ, Msallam, R, Low, I, Shadan, NB, Sumatoh, HR, Soon, E, Lum, J, Mok, E, Hubert, S, See, P, Kunxiang, EH, Lee, YH, Janela, B, Choolani, M, Mattar, CNZ, Fan, Y, Lim, TKH, Chan, DKH, Tan, KK, Tam, JKC, Schuster, C, Elbe-Bürger, A, Wang, XN, Bigley, V, Collin, M, Haniffa, M, Schlitzer, A, Poidinger, M, Albani, S, Larbi, A, Newell, EW, Chan, JKY and Ginhoux, F (2017) Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2. Nature 546:662-666
Abstract	During gestation the developing human fetus is exposed to a diverse range of potentially immune-stimulatory molecules including semi-allogeneic antigens from maternal cells, substances from ingested amniotic fluid, food antigens, and microbes. Yet the capacity of the fetal immune system, including antigen-presenting cells, to detect and respond to such stimuli remains unclear. In particular, dendritic cells, which are crucial for effective immunity and tolerance, remain poorly characterized in the developing fetus. Here we show that subsets of antigen-presenting cells can be identified in fetal tissues and are related to adult populations of antigen-presenting cells. Similar to adult dendritic cells, fetal dendritic cells migrate to lymph nodes and respond to toll-like receptor ligation; however, they differ markedly in their response to allogeneic antigens, strongly promoting regulatory T-cell induction and inhibiting T-cell tumour-necrosis factor-α production through arginase-2 activity. Our results reveal a previously unappreciated role of dendritic cells within the developing fetus and indicate that they mediate homeostatic immune-suppressive responses during gestation.
Links	PubMed Online version:10.1038/nature22795
Keywords	Adult; Arginase/metabolism; Cell Movement; Cell Proliferation; Cytokines/biosynthesis; Cytokines/immunology; Dendritic Cells/enzymology; Dendritic Cells/immunology; Fetus/cytology; Fetus/enzymology; Fetus/immunology; Humans; Immune Tolerance; Lymph Nodes/cytology; Lymph Nodes/immunology; T-Lymphocytes/cytology; T-Lymphocytes/immunology; T-Lymphocytes, Regulatory/cytology; T-Lymphocytes, Regulatory/immunology; Toll-Like Receptors/immunology
edit table

Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
HUMAN:ARGI2	involved_in	GO:0032720: negative regulation of tumor necrosis factor production	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete

References

See Help:References for how to manage references in GONUTS.