GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

PMID:28614294

From GONUTS
Jump to: navigation, search
Citation

McGovern, N, Shin, A, Low, G, Low, D, Duan, K, Yao, LJ, Msallam, R, Low, I, Shadan, NB, Sumatoh, HR, Soon, E, Lum, J, Mok, E, Hubert, S, See, P, Kunxiang, EH, Lee, YH, Janela, B, Choolani, M, Mattar, CNZ, Fan, Y, Lim, TKH, Chan, DKH, Tan, KK, Tam, JKC, Schuster, C, Elbe-Bürger, A, Wang, XN, Bigley, V, Collin, M, Haniffa, M, Schlitzer, A, Poidinger, M, Albani, S, Larbi, A, Newell, EW, Chan, JKY and Ginhoux, F (2017) Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2. Nature 546:662-666

Abstract

During gestation the developing human fetus is exposed to a diverse range of potentially immune-stimulatory molecules including semi-allogeneic antigens from maternal cells, substances from ingested amniotic fluid, food antigens, and microbes. Yet the capacity of the fetal immune system, including antigen-presenting cells, to detect and respond to such stimuli remains unclear. In particular, dendritic cells, which are crucial for effective immunity and tolerance, remain poorly characterized in the developing fetus. Here we show that subsets of antigen-presenting cells can be identified in fetal tissues and are related to adult populations of antigen-presenting cells. Similar to adult dendritic cells, fetal dendritic cells migrate to lymph nodes and respond to toll-like receptor ligation; however, they differ markedly in their response to allogeneic antigens, strongly promoting regulatory T-cell induction and inhibiting T-cell tumour-necrosis factor-α production through arginase-2 activity. Our results reveal a previously unappreciated role of dendritic cells within the developing fetus and indicate that they mediate homeostatic immune-suppressive responses during gestation.

Links

PubMed Online version:10.1038/nature22795

Keywords

Adult; Arginase/metabolism; Cell Movement; Cell Proliferation; Cytokines/biosynthesis; Cytokines/immunology; Dendritic Cells/enzymology; Dendritic Cells/immunology; Fetus/cytology; Fetus/enzymology; Fetus/immunology; Humans; Immune Tolerance; Lymph Nodes/cytology; Lymph Nodes/immunology; T-Lymphocytes/cytology; T-Lymphocytes/immunology; T-Lymphocytes, Regulatory/cytology; T-Lymphocytes, Regulatory/immunology; Toll-Like Receptors/immunology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:ARGI2

involved_in

GO:0032720: negative regulation of tumor necrosis factor production

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

Notes

See also

References

See Help:References for how to manage references in GONUTS.