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HUMAN:ARGI1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) ARG1
Protein Name(s) Arginase-1

Liver-type arginase Type I arginase

External Links
UniProt P05089
EMBL M14502
X12662
X12663
X12664
X12665
X12666
X12667
X12668
X12669
AY074488
BT006741
AL121575
AL121575
AL121575
BC005321
BC020653
CCDS CCDS5145.1
CCDS59038.1
PIR S02132
RefSeq NP_000036.2
NP_001231367.1
UniGene Hs.440934
PDB 1WVA
1WVB
2AEB
2PHA
2PHO
2PLL
2ZAV
3DJ8
3E6K
3E6V
3F80
3GMZ
3GN0
3KV2
3LP4
3LP7
3MFV
3MFW
3MJL
3SJT
3SKK
3TF3
3TH7
3THE
3THH
3THJ
4FCI
4FCK
4GSM
4GSV
4GSZ
4GWC
4GWD
4HWW
4HXQ
4IE1
PDBsum 1WVA
1WVB
2AEB
2PHA
2PHO
2PLL
2ZAV
3DJ8
3E6K
3E6V
3F80
3GMZ
3GN0
3KV2
3LP4
3LP7
3MFV
3MFW
3MJL
3SJT
3SKK
3TF3
3TH7
3THE
3THH
3THJ
4FCI
4FCK
4GSM
4GSV
4GSZ
4GWC
4GWD
4HWW
4HXQ
4IE1
ProteinModelPortal P05089
SMR P05089
BioGrid 106878
IntAct P05089
MINT MINT-3974693
STRING 9606.ENSP00000357066
BindingDB P05089
ChEMBL CHEMBL1075097
DrugBank DB00129
PhosphoSite P05089
DMDM 12230985
MaxQB P05089
PaxDb P05089
PRIDE P05089
DNASU 383
Ensembl ENST00000356962
ENST00000368087
GeneID 383
KEGG hsa:383
UCSC uc003qco.2
uc010kfm.2
CTD 383
GeneCards GC06P131936
GeneReviews ARG1
HGNC HGNC:663
HPA CAB009434
CAB056159
HPA003595
HPA024006
MIM 207800
608313
neXtProt NX_P05089
Orphanet 90
PharmGKB PA24947
eggNOG COG0010
GeneTree ENSGT00530000063082
HOGENOM HOG000204319
HOVERGEN HBG003030
InParanoid P05089
KO K01476
OMA DYGDLPF
OrthoDB EOG747PJ5
PhylomeDB P05089
TreeFam TF300034
BioCyc MetaCyc:HS04231-MONOMER
Reactome REACT_847
SABIO-RK P05089
UniPathway UPA00158
EvolutionaryTrace P05089
GenomeRNAi 383
NextBio 1603
PRO PR:P05089
Proteomes UP000005640
Bgee P05089
CleanEx HS_ARG1
Genevestigator P05089
GO GO:0005737
GO:0005829
GO:0005615
GO:0070062
GO:0043005
GO:0043025
GO:0005634
GO:0004053
GO:0030145
GO:0006527
GO:0034641
GO:0071549
GO:0071377
GO:0070301
GO:0071353
GO:0071222
GO:0071560
GO:0032964
GO:0001889
GO:0030324
GO:0060056
GO:0060135
GO:0001938
GO:0070207
GO:0010963
GO:0014075
GO:0043200
GO:0048678
GO:0046686
GO:0042493
GO:0009635
GO:0010042
GO:0051597
GO:0010269
GO:0033189
GO:0033197
GO:0010043
GO:0044281
GO:0000050
Gene3D 3.40.800.10
InterPro IPR014033
IPR006035
IPR023696
IPR020855
PANTHER PTHR11358
Pfam PF00491
PIRSF PIRSF036979
PRINTS PR00116
TIGRFAMs TIGR01229
PROSITE PS01053
PS51409

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0004053

arginase activity

PMID:3540966[1]

ECO:0000247

PMID:3540966[1]


F

figure 4

complete
CACAO 4494

part_of

GO:0005615

extracellular space

PMID:16709924[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0042130

negative regulation of T cell proliferation

PMID:16709924[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060336

negative regulation of interferon-gamma-mediated signaling pathway

PMID:16709924[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070965

positive regulation of neutrophil mediated killing of fungus

PMID:15546957[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21630459[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000019)

Seeded From UniProt

complete

enables

GO:0030145

manganese ion binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000144386
RGD:2150
SGD:S000006032

F

Seeded From UniProt

complete

involved_in

GO:0019547

arginine catabolic process to ornithine

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000144386
PomBase:SPAC3H1.07
PomBase:SPBP26C9.02c
RGD:2150
RGD:2151
SGD:S000006032

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000144387
PomBase:SPBP26C9.02c
SGD:S000006032

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000144386
RGD:2150

C

Seeded From UniProt

complete

involved_in

GO:0071560

cellular response to transforming growth factor beta stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07824
ensembl:ENSRNOP00000017911

P

Seeded From UniProt

complete

involved_in

GO:0071549

cellular response to dexamethasone stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07824
ensembl:ENSRNOP00000017911

P

Seeded From UniProt

complete

involved_in

GO:0071377

cellular response to glucagon stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07824
ensembl:ENSRNOP00000017911

P

Seeded From UniProt

complete

involved_in

GO:0071353

cellular response to interleukin-4

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07824
ensembl:ENSRNOP00000017911

P

Seeded From UniProt

complete

involved_in

GO:0071222

cellular response to lipopolysaccharide

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07824
ensembl:ENSRNOP00000017911

P

Seeded From UniProt

complete

involved_in

GO:0070301

cellular response to hydrogen peroxide

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07824
ensembl:ENSRNOP00000017911

P

Seeded From UniProt

complete

involved_in

GO:0070207

protein homotrimerization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07824
ensembl:ENSRNOP00000017911

P

Seeded From UniProt

complete

involved_in

GO:0060135

maternal process involved in female pregnancy

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07824
ensembl:ENSRNOP00000017911

P

Seeded From UniProt

complete

involved_in

GO:0060056

mammary gland involution

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07824
ensembl:ENSRNOP00000017911

P

Seeded From UniProt

complete

involved_in

GO:0051597

response to methylmercury

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07824
ensembl:ENSRNOP00000017911

P

Seeded From UniProt

complete

involved_in

GO:0048678

response to axon injury

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07824
ensembl:ENSRNOP00000017911

P

Seeded From UniProt

complete

involved_in

GO:0048545

response to steroid hormone

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07824
ensembl:ENSRNOP00000017911

P

Seeded From UniProt

complete

involved_in

GO:0046686

response to cadmium ion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07824
ensembl:ENSRNOP00000017911

P

Seeded From UniProt

complete

involved_in

GO:0043434

response to peptide hormone

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07824
ensembl:ENSRNOP00000017911

P

Seeded From UniProt

complete

involved_in

GO:0043200

response to amino acid

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07824
ensembl:ENSRNOP00000017911

P

Seeded From UniProt

complete

part_of

GO:0043025

neuronal cell body

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07824
ensembl:ENSRNOP00000017911

C

Seeded From UniProt

complete

part_of

GO:0043005

neuron projection

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07824
ensembl:ENSRNOP00000017911

C

Seeded From UniProt

complete

involved_in

GO:0042493

response to drug

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07824
ensembl:ENSRNOP00000017911

P

Seeded From UniProt

complete

involved_in

GO:0033197

response to vitamin E

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07824
ensembl:ENSRNOP00000017911

P

Seeded From UniProt

complete

involved_in

GO:0033189

response to vitamin A

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07824
ensembl:ENSRNOP00000017911

P

Seeded From UniProt

complete

involved_in

GO:0032964

collagen biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07824
ensembl:ENSRNOP00000017911

P

Seeded From UniProt

complete

involved_in

GO:0032496

response to lipopolysaccharide

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07824
ensembl:ENSRNOP00000017911

P

Seeded From UniProt

complete

involved_in

GO:0030324

lung development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07824
ensembl:ENSRNOP00000017911

P

Seeded From UniProt

complete

enables

GO:0030145

manganese ion binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07824
ensembl:ENSRNOP00000017911

F

Seeded From UniProt

complete

involved_in

GO:0019547

arginine catabolic process to ornithine

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07824
ensembl:ENSRNOP00000017911

P

Seeded From UniProt

complete

involved_in

GO:0014075

response to amine

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07824
ensembl:ENSRNOP00000017911

P

Seeded From UniProt

complete

involved_in

GO:0010963

regulation of L-arginine import

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07824
ensembl:ENSRNOP00000017911

P

Seeded From UniProt

complete

involved_in

GO:0010269

response to selenium ion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07824
ensembl:ENSRNOP00000017911

P

Seeded From UniProt

complete

involved_in

GO:0010043

response to zinc ion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07824
ensembl:ENSRNOP00000017911

P

Seeded From UniProt

complete

involved_in

GO:0010042

response to manganese ion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07824
ensembl:ENSRNOP00000017911

P

Seeded From UniProt

complete

involved_in

GO:0009635

response to herbicide

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07824
ensembl:ENSRNOP00000017911

P

Seeded From UniProt

complete

involved_in

GO:0009611

response to wounding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07824
ensembl:ENSRNOP00000017911

P

Seeded From UniProt

complete

involved_in

GO:0007568

aging

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07824
ensembl:ENSRNOP00000017911

P

Seeded From UniProt

complete

involved_in

GO:0007565

female pregnancy

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07824
ensembl:ENSRNOP00000017911

P

Seeded From UniProt

complete

involved_in

GO:0006525

arginine metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07824
ensembl:ENSRNOP00000017911

P

Seeded From UniProt

complete

part_of

GO:0005741

mitochondrial outer membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07824
ensembl:ENSRNOP00000017911

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07824
ensembl:ENSRNOP00000017911

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07824
ensembl:ENSRNOP00000017911

C

Seeded From UniProt

complete

enables

GO:0004053

arginase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07824
ensembl:ENSRNOP00000017911

F

Seeded From UniProt

complete

involved_in

GO:0001938

positive regulation of endothelial cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07824
ensembl:ENSRNOP00000017911

P

Seeded From UniProt

complete

involved_in

GO:0001889

liver development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07824
ensembl:ENSRNOP00000017911

P

Seeded From UniProt

complete

involved_in

GO:0000050

urea cycle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07824
ensembl:ENSRNOP00000017911

P

Seeded From UniProt

complete

involved_in

GO:2000552

negative regulation of T-helper 2 cell cytokine production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61176
ensembl:ENSMUSP00000020161

P

Seeded From UniProt

complete

involved_in

GO:0046007

negative regulation of activated T cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61176
ensembl:ENSMUSP00000020161

P

Seeded From UniProt

complete

involved_in

GO:0042832

defense response to protozoan

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61176
ensembl:ENSMUSP00000020161

P

Seeded From UniProt

complete

enables

GO:0004053

arginase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61176
ensembl:ENSMUSP00000020161

F

Seeded From UniProt

complete

enables

GO:0004053

arginase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR014033

F

Seeded From UniProt

complete

involved_in

GO:0006525

arginine metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR014033

P

Seeded From UniProt

complete

enables

GO:0016813

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR020855

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006035
InterPro:IPR014033
InterPro:IPR020855

F

Seeded From UniProt

complete

enables

GO:0004053

arginase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.5.3.1

F

Seeded From UniProt

complete

involved_in

GO:0006527

arginine catabolic process

PMID:3540966[1]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:3540966[1]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004053

arginase activity

PMID:3540966[1]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0043312

neutrophil degranulation

Reactome:R-HSA-6798695

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0035580

specific granule lumen

Reactome:R-HSA-6798749

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0035578

azurophil granule lumen

Reactome:R-HSA-6798751

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-70569

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-HSA-6798751
Reactome:R-HSA-6798749

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

involved_in

GO:0000050

urea cycle

Reactome:R-HSA-70635

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

involved_in

GO:0006525

arginine metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0056

P

Seeded From UniProt

complete

involved_in

GO:0002250

adaptive immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1064

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

involved_in

GO:0000050

urea cycle

GO_REF:0000037
GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0835
UniPathway:UPA00158

P

Seeded From UniProt

complete

involved_in

GO:0045087

innate immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0399

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 Haraguchi, Y et al. (1987) Molecular cloning and nucleotide sequence of cDNA for human liver arginase. Proc. Natl. Acad. Sci. U.S.A. 84 412-5 PubMed GONUTS page
  2. 2.0 2.1 2.2 Munder, M et al. (2006) Suppression of T-cell functions by human granulocyte arginase. Blood 108 1627-34 PubMed GONUTS page
  3. Munder, M et al. (2005) Arginase I is constitutively expressed in human granulocytes and participates in fungicidal activity. Blood 105 2549-56 PubMed GONUTS page
  4. de Mateo, S et al. (2011) Proteomic characterization of the human sperm nucleus. Proteomics 11 2714-26 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page