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HUMAN:ARGI1
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | ARG1 | |
Protein Name(s) | Arginase-1
Liver-type arginase Type I arginase | |
External Links | ||
UniProt | P05089 | |
EMBL | M14502 X12662 X12663 X12664 X12665 X12666 X12667 X12668 X12669 AY074488 BT006741 AL121575 AL121575 AL121575 BC005321 BC020653 | |
CCDS | CCDS5145.1 CCDS59038.1 | |
PIR | S02132 | |
RefSeq | NP_000036.2 NP_001231367.1 | |
UniGene | Hs.440934 | |
PDB | 1WVA 1WVB 2AEB 2PHA 2PHO 2PLL 2ZAV 3DJ8 3E6K 3E6V 3F80 3GMZ 3GN0 3KV2 3LP4 3LP7 3MFV 3MFW 3MJL 3SJT 3SKK 3TF3 3TH7 3THE 3THH 3THJ 4FCI 4FCK 4GSM 4GSV 4GSZ 4GWC 4GWD 4HWW 4HXQ 4IE1 | |
PDBsum | 1WVA 1WVB 2AEB 2PHA 2PHO 2PLL 2ZAV 3DJ8 3E6K 3E6V 3F80 3GMZ 3GN0 3KV2 3LP4 3LP7 3MFV 3MFW 3MJL 3SJT 3SKK 3TF3 3TH7 3THE 3THH 3THJ 4FCI 4FCK 4GSM 4GSV 4GSZ 4GWC 4GWD 4HWW 4HXQ 4IE1 | |
ProteinModelPortal | P05089 | |
SMR | P05089 | |
BioGrid | 106878 | |
IntAct | P05089 | |
MINT | MINT-3974693 | |
STRING | 9606.ENSP00000357066 | |
BindingDB | P05089 | |
ChEMBL | CHEMBL1075097 | |
DrugBank | DB00129 | |
PhosphoSite | P05089 | |
DMDM | 12230985 | |
MaxQB | P05089 | |
PaxDb | P05089 | |
PRIDE | P05089 | |
DNASU | 383 | |
Ensembl | ENST00000356962 ENST00000368087 | |
GeneID | 383 | |
KEGG | hsa:383 | |
UCSC | uc003qco.2 uc010kfm.2 | |
CTD | 383 | |
GeneCards | GC06P131936 | |
GeneReviews | ARG1 | |
HGNC | HGNC:663 | |
HPA | CAB009434 CAB056159 HPA003595 HPA024006 | |
MIM | 207800 608313 | |
neXtProt | NX_P05089 | |
Orphanet | 90 | |
PharmGKB | PA24947 | |
eggNOG | COG0010 | |
GeneTree | ENSGT00530000063082 | |
HOGENOM | HOG000204319 | |
HOVERGEN | HBG003030 | |
InParanoid | P05089 | |
KO | K01476 | |
OMA | DYGDLPF | |
OrthoDB | EOG747PJ5 | |
PhylomeDB | P05089 | |
TreeFam | TF300034 | |
BioCyc | MetaCyc:HS04231-MONOMER | |
Reactome | REACT_847 | |
SABIO-RK | P05089 | |
UniPathway | UPA00158 | |
EvolutionaryTrace | P05089 | |
GenomeRNAi | 383 | |
NextBio | 1603 | |
PRO | PR:P05089 | |
Proteomes | UP000005640 | |
Bgee | P05089 | |
CleanEx | HS_ARG1 | |
Genevestigator | P05089 | |
GO | GO:0005737 GO:0005829 GO:0005615 GO:0070062 GO:0043005 GO:0043025 GO:0005634 GO:0004053 GO:0030145 GO:0006527 GO:0034641 GO:0071549 GO:0071377 GO:0070301 GO:0071353 GO:0071222 GO:0071560 GO:0032964 GO:0001889 GO:0030324 GO:0060056 GO:0060135 GO:0001938 GO:0070207 GO:0010963 GO:0014075 GO:0043200 GO:0048678 GO:0046686 GO:0042493 GO:0009635 GO:0010042 GO:0051597 GO:0010269 GO:0033189 GO:0033197 GO:0010043 GO:0044281 GO:0000050 | |
Gene3D | 3.40.800.10 | |
InterPro | IPR014033 IPR006035 IPR023696 IPR020855 | |
PANTHER | PTHR11358 | |
Pfam | PF00491 | |
PIRSF | PIRSF036979 | |
PRINTS | PR00116 | |
TIGRFAMs | TIGR01229 | |
PROSITE | PS01053 PS51409 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0004053 |
arginase activity |
ECO:0000247 |
|
F |
figure 4 |
complete | ||||
part_of |
GO:0005615 |
extracellular space |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0042130 |
negative regulation of T cell proliferation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060336 |
negative regulation of interferon-gamma-mediated signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0070965 |
positive regulation of neutrophil mediated killing of fungus |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(CL:0000019) |
Seeded From UniProt |
complete | ||
enables |
GO:0030145 |
manganese ion binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000144386 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0019547 |
arginine catabolic process to ornithine |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000144386 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005829 |
cytosol |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000144387 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000144386 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0071560 |
cellular response to transforming growth factor beta stimulus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07824 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0071549 |
cellular response to dexamethasone stimulus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07824 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0071377 |
cellular response to glucagon stimulus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07824 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0071353 |
cellular response to interleukin-4 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07824 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0071222 |
cellular response to lipopolysaccharide |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07824 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0070301 |
cellular response to hydrogen peroxide |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07824 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0070207 |
protein homotrimerization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07824 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060135 |
maternal process involved in female pregnancy |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07824 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060056 |
mammary gland involution |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07824 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0051597 |
response to methylmercury |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07824 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0048678 |
response to axon injury |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07824 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0048545 |
response to steroid hormone |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07824 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0046686 |
response to cadmium ion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07824 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043434 |
response to peptide hormone |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07824 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043200 |
response to amino acid |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07824 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0043025 |
neuronal cell body |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07824 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0043005 |
neuron projection |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07824 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0042493 |
response to drug |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07824 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0033197 |
response to vitamin E |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07824 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0033189 |
response to vitamin A |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07824 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032964 |
collagen biosynthetic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07824 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032496 |
response to lipopolysaccharide |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07824 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030324 |
lung development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07824 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0030145 |
manganese ion binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07824 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0019547 |
arginine catabolic process to ornithine |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07824 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0014075 |
response to amine |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07824 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010963 |
regulation of L-arginine import |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07824 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010269 |
response to selenium ion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07824 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010043 |
response to zinc ion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07824 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010042 |
response to manganese ion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07824 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0009635 |
response to herbicide |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07824 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0009611 |
response to wounding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07824 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007568 |
aging |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07824 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007565 |
female pregnancy |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07824 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006525 |
arginine metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07824 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005741 |
mitochondrial outer membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07824 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07824 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005615 |
extracellular space |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07824 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0004053 |
arginase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07824 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0001938 |
positive regulation of endothelial cell proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07824 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0001889 |
liver development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07824 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0000050 |
urea cycle |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07824 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:2000552 |
negative regulation of T-helper 2 cell cytokine production |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61176 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0046007 |
negative regulation of activated T cell proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61176 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0042832 |
defense response to protozoan |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61176 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0004053 |
arginase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61176 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0004053 |
arginase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006525 |
arginine metabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0016813 |
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0046872 |
metal ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004053 |
arginase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006527 |
arginine catabolic process |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0004053 |
arginase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043312 |
neutrophil degranulation |
Reactome:R-HSA-6798695 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0035580 |
specific granule lumen |
Reactome:R-HSA-6798749 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0035578 |
azurophil granule lumen |
Reactome:R-HSA-6798751 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-70569 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005576 |
extracellular region |
Reactome:R-HSA-6798751 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
involved_in |
GO:0000050 |
urea cycle |
Reactome:R-HSA-70635 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0002376 |
immune system process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006525 |
arginine metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0002250 |
adaptive immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0000050 |
urea cycle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0835 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045087 |
innate immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Haraguchi, Y et al. (1987) Molecular cloning and nucleotide sequence of cDNA for human liver arginase. Proc. Natl. Acad. Sci. U.S.A. 84 412-5 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Munder, M et al. (2006) Suppression of T-cell functions by human granulocyte arginase. Blood 108 1627-34 PubMed GONUTS page
- ↑ Munder, M et al. (2005) Arginase I is constitutively expressed in human granulocytes and participates in fungicidal activity. Blood 105 2549-56 PubMed GONUTS page
- ↑ de Mateo, S et al. (2011) Proteomic characterization of the human sperm nucleus. Proteomics 11 2714-26 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
a
c
- Catarrhini
- GO:0071377 ! cellular response to glucagon stimulus
- GO:0070301 ! cellular response to hydrogen peroxide
- GO:0071353 ! cellular response to interleukin-4
- GO:0071222 ! cellular response to lipopolysaccharide
- GO:0071549 ! cellular response to dexamethasone stimulus
- GO:0071560 ! cellular response to transforming growth factor beta stimulus
- Chordata
- GO:0032964 ! collagen biosynthetic process
- Craniata
- GO:0005737 ! cytoplasm
- GO:0005829 ! cytosol
e
h
m
n
- GO:0060336 ! negative regulation of type II interferon-mediated signaling pathway
- GO:0042130 ! negative regulation of T cell proliferation
- GO:2000552 ! negative regulation of T-helper 2 cell cytokine production
- GO:0046007 ! negative regulation of activated T cell proliferation
- GO:0043025 ! neuronal cell body
- GO:0043005 ! neuron projection
- GO:0043312 ! neutrophil degranulation
- GO:0005634 ! nucleus
p
r
- GO:0010963 ! regulation of L-arginine import
- GO:0051597 ! response to methylmercury
- GO:0048678 ! response to axon injury
- GO:0033189 ! response to vitamin A
- GO:0048545 ! response to steroid hormone
- GO:0046686 ! response to cadmium ion
- GO:0043434 ! response to peptide hormone
- GO:0032496 ! response to lipopolysaccharide
- GO:0043200 ! response to amino acid
- GO:0042493 ! response to drug
- GO:0009611 ! response to wounding
- GO:0033197 ! response to vitamin E
- GO:0010042 ! response to manganese ion
- GO:0010043 ! response to zinc ion
- GO:0010269 ! response to selenium ion
- GO:0014075 ! response to amine
- GO:0009635 ! response to herbicide