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HUMAN:APOM

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) APOM (synonyms: G3A, NG20)
Protein Name(s) Apolipoprotein M

Apo-M ApoM Protein G3a

External Links
UniProt O95445
EMBL AF118393
AJ245434
AF161454
AF129756
CN428415
BA000025
AL662801
AL670886
AL805934
AL805934
BX511262
BX511262
CR753842
CR753842
CR354443
CR354443
CR759761
CR759761
CH471081
CH471081
BC020683
CCDS CCDS4710.1
CCDS59004.1
RefSeq NP_001243098.1
NP_061974.2
UniGene Hs.534468
PDB 2WEW
2WEX
2YG2
PDBsum 2WEW
2WEX
2YG2
ProteinModelPortal O95445
SMR O95445
BioGrid 121006
IntAct O95445
MINT MINT-1379248
STRING 9606.ENSP00000365081
BioMuta APOM
MaxQB O95445
PaxDb O95445
PeptideAtlas O95445
PRIDE O95445
DNASU 55937
Ensembl ENST00000375916
ENST00000375920
ENST00000383438
ENST00000400157
ENST00000416324
ENST00000422771
ENST00000425177
ENST00000426800
ENST00000430282
ENST00000432598
ENST00000436931
ENST00000439902
ENST00000441436
ENST00000443975
GeneID 55937
KEGG hsa:55937
UCSC uc003nvk.4
CTD 55937
GeneCards GC06P031620
GC06Pj31607
GC06Pk31602
GC06Pl31659
GC06Pm31696
GC06Pn31610
GC06Po31610
HGNC HGNC:13916
HPA CAB034086
HPA051006
MIM 606907
neXtProt NX_O95445
PharmGKB PA38370
eggNOG NOG40194
GeneTree ENSGT00390000001026
HOGENOM HOG000034009
HOVERGEN HBG018735
InParanoid O95445
OMA WYFIAGA
PhylomeDB O95445
TreeFam TF330771
Reactome REACT_24968
EvolutionaryTrace O95445
GeneWiki APOM
GenomeRNAi 55937
NextBio 61349
PRO PR:O95445
Proteomes UP000005640
Bgee O95445
CleanEx HS_APOM
ExpressionAtlas O95445
Genevisible O95445
GO GO:0034365
GO:0070062
GO:0005576
GO:0034364
GO:0005887
GO:0034362
GO:0034366
GO:0034361
GO:0016209
GO:0005319
GO:0005543
GO:0033344
GO:0042632
GO:0034380
GO:0034384
GO:0034375
GO:0042157
GO:0034445
GO:0007603
GO:0009749
GO:0001523
GO:0043691
InterPro IPR022734
IPR011038
Pfam PF11032
SUPFAM SSF50814

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0005887

integral to plasma membrane

ECO:0000304

C

Source: ProtInc

Missing: reference

GO:0005319

lipid transporter activity

ECO:0000304

F

Source: ProtInc

Missing: reference

involved_in

GO:0043691

reverse cholesterol transport

PMID:15793583[1]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9Z1R3

P

Seeded From UniProt

complete

involved_in

GO:0042632

cholesterol homeostasis

PMID:15793583[1]

ECO:0000305

curator inference used in manual assertion

GO:0033344

P

Seeded From UniProt

complete

involved_in

GO:0034445

negative regulation of plasma lipoprotein oxidation

PMID:22204862[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034445

negative regulation of plasma lipoprotein oxidation

PMID:16682745[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034384

high-density lipoprotein particle clearance

PMID:15793583[1]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9Z1R3

P

Seeded From UniProt

complete

involved_in

GO:0034380

high-density lipoprotein particle assembly

PMID:15793583[1]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9Z1R3

P

Seeded From UniProt

complete

involved_in

GO:0034375

high-density lipoprotein particle remodeling

PMID:18006500[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0034366

spherical high-density lipoprotein particle

PMID:16682745[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0034365

discoidal high-density lipoprotein particle

PMID:15793583[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0034364

high-density lipoprotein particle

PMID:22204862[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0034362

low-density lipoprotein particle

PMID:16682745[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0034361

very-low-density lipoprotein particle

PMID:17154273[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0033344

cholesterol efflux

PMID:15793583[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0033344

cholesterol efflux

PMID:16682745[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0016209

antioxidant activity

PMID:22204862[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0005543

phospholipid binding

PMID:22204862[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0005319

lipid transporter activity

PMID:16682745[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0098869

cellular oxidant detoxification

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0016209

P

Seeded From UniProt

complete

involved_in

GO:0098869

cellular oxidant detoxification

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0016209

P

Seeded From UniProt

complete

involved_in

GO:0009749

response to glucose

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14630
ensembl:ENSRNOP00000001126

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14630
ensembl:ENSRNOP00000001126

C

Seeded From UniProt

complete

involved_in

GO:0043691

reverse cholesterol transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1R3
ensembl:ENSMUSP00000025249

P

Seeded From UniProt

complete

involved_in

GO:0042157

lipoprotein metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1R3
ensembl:ENSMUSP00000025249

P

Seeded From UniProt

complete

involved_in

GO:0034445

negative regulation of plasma lipoprotein oxidation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1R3
ensembl:ENSMUSP00000025249

P

Seeded From UniProt

complete

involved_in

GO:0034384

high-density lipoprotein particle clearance

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1R3
ensembl:ENSMUSP00000025249

P

Seeded From UniProt

complete

involved_in

GO:0034380

high-density lipoprotein particle assembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1R3
ensembl:ENSMUSP00000025249

P

Seeded From UniProt

complete

involved_in

GO:0034375

high-density lipoprotein particle remodeling

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1R3
ensembl:ENSMUSP00000025249

P

Seeded From UniProt

complete

part_of

GO:0034365

discoidal high-density lipoprotein particle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1R3
ensembl:ENSMUSP00000025249

C

Seeded From UniProt

complete

part_of

GO:0034364

high-density lipoprotein particle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1R3
ensembl:ENSMUSP00000025249

C

Seeded From UniProt

complete

involved_in

GO:0033344

cholesterol efflux

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1R3
ensembl:ENSMUSP00000025249

P

Seeded From UniProt

complete

enables

GO:0016209

antioxidant activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1R3
ensembl:ENSMUSP00000025249

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9Z1R3
ensembl:ENSMUSP00000025249

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-HSA-5246478

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0001523

retinoid metabolic process

Reactome:R-HSA-975634

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0034364

high-density lipoprotein particle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0345

C

Seeded From UniProt

complete

involved_in

GO:0006869

lipid transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0445

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Wolfrum, C et al. (2005) Apolipoprotein M is required for prebeta-HDL formation and cholesterol efflux to HDL and protects against atherosclerosis. Nat. Med. 11 418-22 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 Elsøe, S et al. (2012) Apolipoprotein M binds oxidized phospholipids and increases the antioxidant effect of HDL. Atherosclerosis 221 91-7 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 Christoffersen, C et al. (2006) Isolation and characterization of human apolipoprotein M-containing lipoproteins. J. Lipid Res. 47 1833-43 PubMed GONUTS page
  4. ↑ Christoffersen, C et al. (2008) Effect of apolipoprotein M on high density lipoprotein metabolism and atherosclerosis in low density lipoprotein receptor knock-out mice. J. Biol. Chem. 283 1839-47 PubMed GONUTS page
  5. ↑ Mancone, C et al. (2007) Proteomic analysis of human very low-density lipoprotein by two-dimensional gel electrophoresis and MALDI-TOF/TOF. Proteomics 7 143-54 PubMed GONUTS page
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