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PMID:22204862

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Citation

Elsøe, S, Ahnström, J, Christoffersen, C, Hoofnagle, AN, Plomgaard, P, Heinecke, JW, Binder, CJ, Björkbacka, H, Dahlbäck, B and Nielsen, LB (2012) Apolipoprotein M binds oxidized phospholipids and increases the antioxidant effect of HDL. Atherosclerosis 221:91-7

Abstract

Oxidation of LDL plays a key role in the development of atherosclerosis. HDL may, in part, protect against atherosclerosis by inhibiting LDL oxidation. Overexpression of HDL-associated apolipoprotein M (apoM) protects mice against atherosclerosis through a not yet clarified mechanism. Being a lipocalin, apoM contains a binding pocket for small lipophilic molecules. Here, we report that apoM likely serves as an antioxidant in HDL by binding oxidized phospholipids, thus enhancing the antioxidant potential of HDL.

Links

PubMed Online version:10.1016/j.atherosclerosis.2011.11.031

Keywords

Amidines/chemistry; Animals; Antioxidants/chemistry; Antioxidants/metabolism; Apolipoproteins/blood; Apolipoproteins/chemistry; Apolipoproteins/genetics; Atherosclerosis/blood; Atherosclerosis/etiology; Atherosclerosis/genetics; Binding Sites; Cholesterol, Dietary; Disease Models, Animal; Humans; Lipocalins/blood; Lipocalins/chemistry; Lipocalins/genetics; Lipoproteins, HDL/blood; Lipoproteins, HDL/chemistry; Lipoproteins, LDL/blood; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Myristic Acid/chemistry; Oxidants/chemistry; Oxidation-Reduction; Phospholipids/blood; Phospholipids/chemistry; Receptors, LDL/deficiency; Receptors, LDL/genetics; Recombinant Proteins/metabolism; Thiobarbituric Acid Reactive Substances/metabolism; Time Factors

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:APOM

enables

GO:0016209: antioxidant activity

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

MOUSE:APOM

enables

GO:0005543: phospholipid binding

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:O95445

F

Seeded From UniProt

complete

MOUSE:APOM

involved_in

GO:0034445: negative regulation of plasma lipoprotein oxidation

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:APOM

part_of

GO:0034364: high-density lipoprotein particle

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:APOM

involved_in

GO:0034445: negative regulation of plasma lipoprotein oxidation

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:APOM

part_of

GO:0034364: high-density lipoprotein particle

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:APOM

enables

GO:0005543: phospholipid binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

HUMAN:APOM

enables

GO:0016209: antioxidant activity

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete


See also

References

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