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HUMAN:APOC2
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | APOC2 (synonyms: APC2) | |
| Protein Name(s) | Apolipoprotein C-II
Apo-CII ApoC-II Apolipoprotein C2 Proapolipoprotein C-II ProapoC-II | |
| External Links | ||
| UniProt | P02655 | |
| EMBL | X05151 X00568 J02698 AY422955 BT006708 FJ525875 CH471126 BC005348 M29844 M10612 AF113884 | |
| CCDS | CCDS12650.1 | |
| PIR | A24238 | |
| RefSeq | NP_000474.2 | |
| UniGene | Hs.75615 | |
| PDB | 1BY6 1I5J 1O8T 1SOH | |
| PDBsum | 1BY6 1I5J 1O8T 1SOH | |
| ProteinModelPortal | P02655 | |
| SMR | P02655 | |
| BioGrid | 106841 | |
| IntAct | P02655 | |
| STRING | 9606.ENSP00000466775 | |
| PhosphoSite | P02655 | |
| BioMuta | APOC2 | |
| DMDM | 114022 | |
| DOSAC-COBS-2DPAGE | P02655 | |
| SWISS-2DPAGE | P02655 | |
| MaxQB | P02655 | |
| PaxDb | P02655 | |
| PeptideAtlas | P02655 | |
| PRIDE | P02655 | |
| DNASU | 344 | |
| Ensembl | ENST00000590360 | |
| GeneID | 344 | |
| KEGG | hsa:344 | |
| CTD | 344 | |
| GeneCards | GC19P045449 | |
| HGNC | HGNC:609 | |
| HPA | HPA055877 | |
| MIM | 207750 608083 | |
| neXtProt | NX_P02655 | |
| Orphanet | 309020 | |
| PharmGKB | PA52 | |
| eggNOG | NOG25045 | |
| GeneTree | ENSGT00390000007913 | |
| HOGENOM | HOG000034002 | |
| HOVERGEN | HBG050548 | |
| InParanoid | P02655 | |
| PhylomeDB | P02655 | |
| Reactome | REACT_13621 REACT_24968 REACT_6841 | |
| EvolutionaryTrace | P02655 | |
| GeneWiki | Apolipoprotein_C2 | |
| GenomeRNAi | 344 | |
| NextBio | 1419 | |
| PMAP-CutDB | P02655 | |
| PRO | PR:P02655 | |
| Proteomes | UP000005640 | |
| Bgee | P02655 | |
| CleanEx | HS_APC2 HS_APOC2 | |
| ExpressionAtlas | P02655 | |
| Genevisible | P02655 | |
| GO | GO:0042627 GO:0005769 GO:0070062 GO:0005576 GO:0005615 GO:0034363 GO:0034362 GO:0034366 GO:0034361 GO:0055102 GO:0008289 GO:0060230 GO:0016004 GO:0043274 GO:0042803 GO:0033344 GO:0042632 GO:0034382 GO:0034371 GO:0034384 GO:0016042 GO:0042157 GO:0043086 GO:0032375 GO:0045833 GO:0048261 GO:0010916 GO:0033700 GO:0007603 GO:0045723 GO:0051006 GO:0010518 GO:0060697 GO:0010898 GO:0010902 GO:0001523 GO:0043691 GO:0044281 GO:0070328 GO:0034370 GO:0034372 | |
| Gene3D | 1.10.1440.10 | |
| InterPro | IPR008019 IPR023121 | |
| PANTHER | PTHR16566 | |
| Pfam | PF05355 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0060230 |
lipoprotein lipase activator activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070328 |
triglyceride homeostasis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060697 |
positive regulation of phospholipid catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0060230 |
lipoprotein lipase activator activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0055102 |
lipase inhibitor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051006 |
positive regulation of lipoprotein lipase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051006 |
positive regulation of lipoprotein lipase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048261 |
negative regulation of receptor-mediated endocytosis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045833 |
negative regulation of lipid metabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045723 |
positive regulation of fatty acid biosynthetic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043691 |
reverse cholesterol transport |
ECO:0000305 |
curator inference used in manual assertion |
GO:0034384 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0043274 |
phospholipase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042632 |
cholesterol homeostasis |
ECO:0000305 |
curator inference used in manual assertion |
GO:0032375 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0042627 |
chylomicron |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0034384 |
high-density lipoprotein particle clearance |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0034382 |
chylomicron remnant clearance |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0034371 |
chylomicron remodeling |
ECO:0000305 |
curator inference used in manual assertion |
GO:0051006 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0034366 |
spherical high-density lipoprotein particle |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
| GO:0060230 |
lipoprotein lipase activator activity |
ECO:0000314 |
F |
Based on figure 4 and figure 5 activity of Lipoprotein Lipase (LPL) was enhanced by Apolipoprotein C-II (apoC-II) |
complete | |||||
|
part_of |
GO:0034363 |
intermediate-density lipoprotein particle |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0034362 |
low-density lipoprotein particle |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0034361 |
very-low-density lipoprotein particle |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0033700 |
phospholipid efflux |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0033344 |
cholesterol efflux |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032375 |
negative regulation of cholesterol transport |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016004 |
phospholipase activator activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010916 |
negative regulation of very-low-density lipoprotein particle clearance |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010902 |
positive regulation of very-low-density lipoprotein particle remodeling |
ECO:0000305 |
curator inference used in manual assertion |
GO:0051006 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010898 |
positive regulation of triglyceride catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010518 |
positive regulation of phospholipase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008289 |
lipid binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000303 |
author statement without traceable support used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060697 |
positive regulation of phospholipid catabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000421988 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0060230 |
lipoprotein lipase activator activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000421988 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051006 |
positive regulation of lipoprotein lipase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000421988 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0043274 |
phospholipase binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000421988 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0042627 |
chylomicron |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000421988 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0034384 |
high-density lipoprotein particle clearance |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000421988 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0034382 |
chylomicron remnant clearance |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000421988 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0034366 |
spherical high-density lipoprotein particle |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000421988 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0034363 |
intermediate-density lipoprotein particle |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000421988 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0034362 |
low-density lipoprotein particle |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000421988 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0034361 |
very-low-density lipoprotein particle |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000421988 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016004 |
phospholipase activator activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000421988 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010916 |
negative regulation of very-low-density lipoprotein particle clearance |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000421988 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010518 |
positive regulation of phospholipase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000421988 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008289 |
lipid binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000421988 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043086 |
negative regulation of catalytic activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0055102 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042953 |
lipoprotein transport |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:G3V8D4 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042493 |
response to drug |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:G3V8D4 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006629 |
lipid metabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006869 |
lipid transport |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008047 |
enzyme activator activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042627 |
chylomicron |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0034372 |
very-low-density lipoprotein particle remodeling |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0034370 |
triglyceride-rich lipoprotein particle remodeling |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0034378 |
chylomicron assembly |
Reactome:R-HSA-8963888 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0034375 |
high-density lipoprotein particle remodeling |
Reactome:R-HSA-8964058 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0034371 |
chylomicron remodeling |
Reactome:R-HSA-8963901 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005769 |
early endosome |
Reactome:R-HSA-2429643 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005576 |
extracellular region |
Reactome:R-HSA-266303 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0001523 |
retinoid metabolic process |
Reactome:R-HSA-975634 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006869 |
lipid transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006629 |
lipid metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016042 |
lipid catabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042627 |
chylomicron |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0034361 |
very-low-density lipoprotein particle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0034364 |
high-density lipoprotein particle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0034362 |
low-density lipoprotein particle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Kinnunen, PK et al. (1977) Activation of lipoprotein lipase by native and synthetic fragments of human plasma apolipoprotein C-II. Proc. Natl. Acad. Sci. U.S.A. 74 4848-51 PubMed GONUTS page
- ↑ 2.0 2.1 Pulawa, LK et al. (2007) Reduction of plasma triglycerides in apolipoprotein C-II transgenic mice overexpressing lipoprotein lipase in muscle. J. Lipid Res. 48 145-51 PubMed GONUTS page
- ↑ 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 MacPhee, CE et al. (2000) Apolipoprotein C-II39-62 activates lipoprotein lipase by direct lipid-independent binding. Biochemistry 39 3433-40 PubMed GONUTS page
- ↑ 4.0 4.1 Kinnunen, PK & Ehnolm, C (1976) Effect of serum and C-apoproteins from very low density lipoproteins on human postheparin plasma hepatic lipase. FEBS Lett. 65 354-7 PubMed GONUTS page
- ↑ Lookene, A et al. (2005) Apolipoprotein A-V-heparin interactions: implications for plasma lipoprotein metabolism. J. Biol. Chem. 280 25383-7 PubMed GONUTS page
- ↑ 6.0 6.1 Sehayek, E & Eisenberg, S (1991) Mechanisms of inhibition by apolipoprotein C of apolipoprotein E-dependent cellular metabolism of human triglyceride-rich lipoproteins through the low density lipoprotein receptor pathway. J. Biol. Chem. 266 18259-67 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 7.4 Huard, K et al. (2005) Apolipoproteins C-II and C-III inhibit selective uptake of low- and high-density lipoprotein cholesteryl esters in HepG2 cells. Int. J. Biochem. Cell Biol. 37 1308-18 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 Connelly, PW et al. (1993) Identification of disulfide-linked apolipoprotein species in human lipoproteins. J. Lipid Res. 34 1717-27 PubMed GONUTS page
- ↑ Windler, E & Havel, RJ (1985) Inhibitory effects of C apolipoproteins from rats and humans on the uptake of triglyceride-rich lipoproteins and their remnants by the perfused rat liver. J. Lipid Res. 26 556-65 PubMed GONUTS page
- ↑ Christoffersen, C et al. (2006) Isolation and characterization of human apolipoprotein M-containing lipoproteins. J. Lipid Res. 47 1833-43 PubMed GONUTS page
- ↑ Meyer, BJ et al. (2007) Fractionation of cholesteryl ester rich intermediate density lipoprotein subpopulations by chondroitin sulphate. Atherosclerosis 195 e28-34 PubMed GONUTS page
- ↑ 12.0 12.1 Remaley, AT et al. (2001) Apolipoprotein specificity for lipid efflux by the human ABCAI transporter. Biochem. Biophys. Res. Commun. 280 818-23 PubMed GONUTS page
- ↑ Anderson, NL et al. (2004) The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol. Cell Proteomics 3 311-26 PubMed GONUTS page
- ↑ 14.00 14.01 14.02 14.03 14.04 14.05 14.06 14.07 14.08 14.09 14.10 14.11 14.12 14.13 14.14 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
c
e
h
l
- GO:0055102 ! lipase inhibitor activity
- GO:0008289 ! lipid binding
- GO:0016042 ! lipid catabolic process
- GO:0006629 ! lipid metabolic process
- GO:0006869 ! lipid transport
- GO:0060230 ! lipoprotein lipase activator activity
- GO:0042953 ! lipoprotein transport
- GO:0034362 ! low-density lipoprotein particle
n
- GO:0048261 ! negative regulation of receptor-mediated endocytosis
- GO:0045833 ! negative regulation of lipid metabolic process
- GO:0010916 ! negative regulation of very-low-density lipoprotein particle clearance
- GO:0032375 ! negative regulation of cholesterol transport
- GO:0043086 ! negative regulation of catalytic activity
p
- GO:0043274 ! phospholipase binding
- GO:0016004 ! phospholipase activator activity
- GO:0033700 ! phospholipid efflux
- GO:0010518 ! positive regulation of phospholipase activity
- GO:0045723 ! positive regulation of fatty acid biosynthetic process
- GO:0010902 ! positive regulation of very-low-density lipoprotein particle remodeling
- GO:0010898 ! positive regulation of triglyceride catabolic process
- GO:0060697 ! positive regulation of phospholipid catabolic process
- GO:0051006 ! positive regulation of lipoprotein lipase activity
- Primates
- GO:0042803 ! protein homodimerization activity
r
t
