HUMAN:APOA1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	APOA1
Protein Name(s)	Apolipoprotein A-I Apo-AI ApoA-I Apolipoprotein A1 Proapolipoprotein A-I ProapoA-I Truncated apolipoprotein A-I Apolipoprotein A-I(1-242)
External Links
UniProt	P02647
EMBL	J00098 X01038 X02162 X00566 M11791 X07496 M27875 M29068 AY422952 AY555191 A14829 AK292231 EF444948 EF444948 EF444948 EF444948 EF444948 CH471065 BC005380 BC110286
CCDS	CCDS8378.1
PIR	A90947
RefSeq	NP_000030.1 XP_005271596.1 XP_005271597.1
UniGene	Hs.93194
PDB	1AV1 1GW3 1GW4 1ODP 1ODQ 1ODR 2A01 2MSC 2MSD 2MSE 3K2S 3R2P 4V6M
PDBsum	1AV1 1GW3 1GW4 1ODP 1ODQ 1ODR 2A01 2MSC 2MSD 2MSE 3K2S 3R2P 4V6M
DisProt	DP00386
ProteinModelPortal	P02647
SMR	P02647
BioGrid	106832
DIP	DIP-29619N
IntAct	P02647
MINT	MINT-5000866
STRING	9606.ENSP00000236850
ChEMBL	CHEMBL5984
PhosphoSite	P02647
BioMuta	APOA1
DMDM	113992
DOSAC-COBS-2DPAGE	P02647
OGP	P02647
REPRODUCTION-2DPAGE	IPI00021841 P02647
SWISS-2DPAGE	P02647
UCD-2DPAGE	P02647
MaxQB	P02647
PaxDb	P02647
PeptideAtlas	P02647
PRIDE	P02647
DNASU	335
Ensembl	ENST00000236850 ENST00000359492 ENST00000375320 ENST00000375323
GeneID	335
KEGG	hsa:335
UCSC	uc001ppv.1
CTD	335
GeneCards	GC11M116706
HGNC	HGNC:600
HPA	CAB016778 HPA046715
MIM	105200 107680 205400 604091
neXtProt	NX_P02647
Orphanet	425 93560 314701
PharmGKB	PA49
eggNOG	NOG39720
GeneTree	ENSGT00530000063081
HOGENOM	HOG000033998
HOVERGEN	HBG105708
InParanoid	P02647
KO	K08757
OMA	YRQKVAP
OrthoDB	EOG7TBC3N
PhylomeDB	P02647
TreeFam	TF334458
Reactome	REACT_111158 REACT_116145 REACT_13621 REACT_160163 REACT_163679 REACT_163699 REACT_24968 REACT_318 REACT_6841 REACT_75925
ChiTaRS	APOA1
EvolutionaryTrace	P02647
GeneWiki	Apolipoprotein_A1
GenomeRNAi	335
NextBio	1387
PMAP-CutDB	P02647
PRO	PR:P02647
Proteomes	UP000005640
Bgee	P02647
CleanEx	HS_APOA1
ExpressionAtlas	P02647
Genevisible	P02647
GO	GO:0072562 GO:0009986 GO:0042627 GO:0031410 GO:0005829 GO:0034365 GO:0005769 GO:0030139 GO:0071682 GO:0005788 GO:0070062 GO:0005576 GO:0005615 GO:1903561 GO:0034364 GO:0005634 GO:0005886 GO:0034774 GO:0034366 GO:0034361 GO:0034191 GO:0034190 GO:0001540 GO:0045499 GO:0015485 GO:0017127 GO:0019899 GO:0008035 GO:0070653 GO:0042802 GO:0055102 GO:0031210 GO:0060228 GO:0005543 GO:0005548 GO:0030325 GO:0007596 GO:0043534 GO:0044255 GO:0006695 GO:0033344 GO:0042632 GO:0070508 GO:0008203 GO:0030301 GO:0001935 GO:0007186 GO:0008211 GO:0034380 GO:0034384 GO:0034375 GO:0007229 GO:0019915 GO:0042158 GO:0042157 GO:0050919 GO:0060354 GO:0002740 GO:0034115 GO:0050728 GO:0050713 GO:0060192 GO:0060761 GO:0010804 GO:0010903 GO:0031102 GO:0031100 GO:0018206 GO:0014012 GO:0006656 GO:0033700 GO:0055091 GO:0007603 GO:0030168 GO:0002576 GO:0010873 GO:0045723 GO:0051345 GO:0051006 GO:0035025 GO:0051496 GO:1900026 GO:0051347 GO:0010898 GO:0018158 GO:0050821 GO:0006898 GO:0032489 GO:0030300 GO:0001932 GO:0042493 GO:0043627 GO:0007584 GO:0001523 GO:0043691 GO:0044281 GO:0055085 GO:0019433 GO:0070328 GO:0034372 GO:0051180
InterPro	IPR000074
Pfam	PF01442

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0050821	protein stabilization	PMID:20495215^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902995	positive regulation of phospholipid efflux	PMID:27472885^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010875	positive regulation of cholesterol efflux	PMID:27472885^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:27477018^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9NZC2	F	happens_during:(GO:0006497)	Seeded From UniProt	complete
involved_in	GO:0050766	positive regulation of phagocytosis	PMID:20495215^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:27068509^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0007318)	Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	PMID:9211985^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000093	F	occurs_in:(GO:0034364)	Seeded From UniProt	complete
enables	GO:0031072	heat shock protein binding	PMID:11027668^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P10809	F		Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:27559042^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0006618) part_of:(UBERON:0002302)	Seeded From UniProt	complete
involved_in	GO:0034375	high-density lipoprotein particle remodeling	PMID:21481393^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002476)	Seeded From UniProt	complete
involved_in	GO:0033344	cholesterol efflux	PMID:21481393^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002476)	Seeded From UniProt	complete
part_of	GO:0034364	high-density lipoprotein particle	PMID:9211985^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051180	vitamin transport	PMID:15140193^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0000201)	Seeded From UniProt	complete
involved_in	GO:0033344	cholesterol efflux	PMID:12202492^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0000201)	Seeded From UniProt	complete
involved_in	GO:0007229	integrin-mediated signaling pathway	PMID:23726972^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000192) has_input:(UniProtKB:P06756) has_input:(UniProtKB:P05106)	Seeded From UniProt	complete
involved_in	GO:0035025	positive regulation of Rho protein signal transduction	PMID:23726972^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000192) has_input:(UniProtKB:P61586)	Seeded From UniProt	complete
involved_in	GO:0051496	positive regulation of stress fiber assembly	PMID:23726972^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000192)	Seeded From UniProt	complete
involved_in	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	PMID:23726972^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000192)	Seeded From UniProt	complete
NOT\|involved_in	GO:0070371	ERK1 and ERK2 cascade	PMID:23726972^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
NOT\|involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:23726972^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050919	negative chemotaxis	PMID:23726972^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0045499	chemorepellent activity	PMID:23726972^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[12]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:1903561	extracellular vesicle	PMID:24769233^[13]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001359)	Seeded From UniProt	complete
part_of	GO:0072562	blood microparticle	PMID:22516433^[14]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19199708^[15]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001831)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[16]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:16502470^[17]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001914)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:22664934^[18]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001827)	Seeded From UniProt	complete
enables	GO:0070653	high-density lipoprotein particle receptor binding	PMID:10764676^[19]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8WTV0	F		Seeded From UniProt	complete
enables	GO:0070653	high-density lipoprotein particle receptor binding	PMID:12651854^[20]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8WTV0	F		Seeded From UniProt	complete
involved_in	GO:0070508	cholesterol import	PMID:14718538^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070328	triglyceride homeostasis	PMID:21571275^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060761	negative regulation of response to cytokine stimulus	PMID:21571275^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060354	negative regulation of cell adhesion molecule production	PMID:21571275^[22]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:P05362)\|has_input:(UniProtKB:P19320)	Seeded From UniProt	complete
enables	GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity	PMID:4335615^[23]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0055091	phospholipid homeostasis	PMID:21571275^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051345	positive regulation of hydrolase activity	PMID:7638166^[24]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	PMID:17655203^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	PMID:21571275^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050713	negative regulation of interleukin-1 beta secretion	PMID:12458630^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043691	reverse cholesterol transport	PMID:15464323^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:8049247^[28]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P02647	F		Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	PMID:15464323^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	PMID:21571275^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034384	high-density lipoprotein particle clearance	PMID:12651854^[20]	ECO:0000305	curator inference used in manual assertion	GO:0070653	P		Seeded From UniProt	complete
involved_in	GO:0034380	high-density lipoprotein particle assembly	PMID:190223^[29]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034375	high-density lipoprotein particle remodeling	PMID:4335615^[23]	ECO:0000305	curator inference used in manual assertion	GO:0060228	P		Seeded From UniProt	complete
part_of	GO:0034366	spherical high-density lipoprotein particle	PMID:16682745^[30]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0034364	high-density lipoprotein particle	PMID:21571275^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0034364	high-density lipoprotein particle	PMID:210174^[31]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0034364	high-density lipoprotein particle	PMID:3104518^[32]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0034364	high-density lipoprotein particle	PMID:15464323^[27]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0034361	very-low-density lipoprotein particle	PMID:17154273^[33]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0034191	apolipoprotein A-I receptor binding	PMID:16443932^[34]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O95477	F		Seeded From UniProt	complete
enables	GO:0034190	apolipoprotein receptor binding	PMID:11162594^[35]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O95477	F		Seeded From UniProt	complete
involved_in	GO:0034115	negative regulation of heterotypic cell-cell adhesion	PMID:21571275^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033700	phospholipid efflux	PMID:11162594^[35]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033700	phospholipid efflux	PMID:14703508^[36]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033344	cholesterol efflux	PMID:15358760^[37]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033344	cholesterol efflux	PMID:11162594^[35]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033344	cholesterol efflux	PMID:14703508^[36]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033344	cholesterol efflux	PMID:16443932^[34]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032489	regulation of Cdc42 protein signal transduction	PMID:16443932^[34]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	PMID:14703508^[36]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030139	endocytic vesicle	PMID:14747463^[38]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:1587806^[39]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04180	F		Seeded From UniProt	complete
enables	GO:0017127	cholesterol transporter activity	PMID:15464323^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
contributes_to	GO:0017127	cholesterol transporter activity	PMID:9651324^[40]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0015485	cholesterol binding	PMID:15464323^[27]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0010903	negative regulation of very-low-density lipoprotein particle remodeling	PMID:14967812^[41]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010873	positive regulation of cholesterol esterification	PMID:4335615^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway	PMID:21571275^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008203	cholesterol metabolic process	PMID:15464323^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	PMID:16443932^[34]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006656	phosphatidylcholine biosynthetic process	PMID:4335615^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:20551380^[42]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001496)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:22261194^[43]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P18648	C	part_of:(UBERON:0002084)	Seeded From UniProt	complete
enables	GO:0005543	phospholipid binding	PMID:12810715^[44]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0002740	negative regulation of cytokine secretion involved in immune response	PMID:12458630^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	PMID:11297421^[45]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0018206	peptidyl-methionine modification	PMID:12576517^[46]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018158	protein oxidation	PMID:12576517^[46]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0070653	high-density lipoprotein particle receptor binding	PMID:21873635^[47]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000439036 UniProtKB:P02647	F		Seeded From UniProt	complete
enables	GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity	PMID:21873635^[47]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88057 PANTHER:PTN000439006 UniProtKB:P02647 UniProtKB:P02649 UniProtKB:P06727	F		Seeded From UniProt	complete
involved_in	GO:0046889	positive regulation of lipid biosynthetic process	PMID:21873635^[47]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000439006 UniProtKB:P02649	P		Seeded From UniProt	complete
involved_in	GO:0043691	reverse cholesterol transport	PMID:21873635^[47]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000439006 UniProtKB:P02647 UniProtKB:P02649 UniProtKB:P06727	P		Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	PMID:21873635^[47]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88057 PANTHER:PTN000439006 UniProtKB:P02647 UniProtKB:P02649 UniProtKB:P06727 UniProtKB:Q6Q788	P		Seeded From UniProt	complete
part_of	GO:0042627	chylomicron	PMID:21873635^[47]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000439006 RGD:2132 RGD:2138 UniProtKB:P02649 UniProtKB:P06727 UniProtKB:Q6Q788	C		Seeded From UniProt	complete
involved_in	GO:0042157	lipoprotein metabolic process	PMID:21873635^[47]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88057 PANTHER:PTN000439006 RGD:2138	P		Seeded From UniProt	complete
involved_in	GO:0034380	high-density lipoprotein particle assembly	PMID:21873635^[47]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000439006 UniProtKB:P02647 UniProtKB:P02649	P		Seeded From UniProt	complete
involved_in	GO:0034372	very-low-density lipoprotein particle remodeling	PMID:21873635^[47]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88057 PANTHER:PTN000439006 UniProtKB:P02649 UniProtKB:P06727	P		Seeded From UniProt	complete
part_of	GO:0034364	high-density lipoprotein particle	PMID:21873635^[47]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000439006 RGD:2130 RGD:2138 UniProtKB:P02647 UniProtKB:P02649 UniProtKB:P06727 UniProtKB:Q6Q788	C		Seeded From UniProt	complete
involved_in	GO:0033700	phospholipid efflux	PMID:21873635^[47]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000439006 UniProtKB:P02647 UniProtKB:P02649 UniProtKB:P06727	P		Seeded From UniProt	complete
involved_in	GO:0033344	cholesterol efflux	PMID:21873635^[47]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88049 MGI:MGI:88057 PANTHER:PTN000439006 UniProtKB:P02647 UniProtKB:P02649 UniProtKB:P06727	P		Seeded From UniProt	complete
involved_in	GO:0032374	regulation of cholesterol transport	PMID:21873635^[47]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000439006 UniProtKB:P06727	P		Seeded From UniProt	complete
involved_in	GO:0019433	triglyceride catabolic process	PMID:21873635^[47]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000439006 UniProtKB:Q6Q788	P		Seeded From UniProt	complete
enables	GO:0017127	cholesterol transporter activity	PMID:21873635^[47]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88049 MGI:MGI:88057 PANTHER:PTN000439006 RGD:2130 UniProtKB:P02647 UniProtKB:P06727	F		Seeded From UniProt	complete
enables	GO:0015485	cholesterol binding	PMID:21873635^[47]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000439006 UniProtKB:P02647	F		Seeded From UniProt	complete
involved_in	GO:0010873	positive regulation of cholesterol esterification	PMID:21873635^[47]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88057 PANTHER:PTN000439006 UniProtKB:P02647 UniProtKB:P02649 UniProtKB:P06727	P		Seeded From UniProt	complete
involved_in	GO:0006695	cholesterol biosynthetic process	PMID:21873635^[47]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88049 PANTHER:PTN000439006	P		Seeded From UniProt	complete
enables	GO:0005543	phospholipid binding	PMID:21873635^[47]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000439006 RGD:2138 UniProtKB:P02647 UniProtKB:P02649 UniProtKB:Q6Q788	F		Seeded From UniProt	complete
involved_in	GO:0030301	cholesterol transport	PMID:10559507^[48]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:19433579^[49]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:24702826^[50]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P02647	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:24316228^[51]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P02647	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:22609356^[52]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P02647	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:20133843^[53]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P02647	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:18719128^[54]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P02647	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:17676061^[55]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P02647	F		Seeded From UniProt	complete
involved_in	GO:0060192	negative regulation of lipase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04639 ensembl:ENSRNOP00000065206	P		Seeded From UniProt	complete
enables	GO:0055102	lipase inhibitor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04639 ensembl:ENSRNOP00000065206	F		Seeded From UniProt	complete
involved_in	GO:0043627	response to estrogen	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04639 ensembl:ENSRNOP00000065206	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04639 ensembl:ENSRNOP00000065206	P		Seeded From UniProt	complete
part_of	GO:0034365	discoidal high-density lipoprotein particle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04639 ensembl:ENSRNOP00000065206	C		Seeded From UniProt	complete
part_of	GO:0034364	high-density lipoprotein particle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04639 ensembl:ENSRNOP00000065206	C		Seeded From UniProt	complete
part_of	GO:0034363	intermediate-density lipoprotein particle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04639 ensembl:ENSRNOP00000065206	C		Seeded From UniProt	complete
part_of	GO:0034362	low-density lipoprotein particle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04639 ensembl:ENSRNOP00000065206	C		Seeded From UniProt	complete
involved_in	GO:0031100	animal organ regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04639 ensembl:ENSRNOP00000065206	P		Seeded From UniProt	complete
involved_in	GO:0030301	cholesterol transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04639 ensembl:ENSRNOP00000065206	P		Seeded From UniProt	complete
enables	GO:0017127	cholesterol transporter activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04639 ensembl:ENSRNOP00000065206	F		Seeded From UniProt	complete
involved_in	GO:0015914	phospholipid transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04639 ensembl:ENSRNOP00000065206	P		Seeded From UniProt	complete
involved_in	GO:0014012	peripheral nervous system axon regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04639 ensembl:ENSRNOP00000065206	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04639 ensembl:ENSRNOP00000065206	C		Seeded From UniProt	complete
involved_in	GO:0007584	response to nutrient	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04639 ensembl:ENSRNOP00000065206	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04639 ensembl:ENSRNOP00000065206	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04639 ensembl:ENSRNOP00000065206	C		Seeded From UniProt	complete
enables	GO:0005548	phospholipid transporter activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04639 ensembl:ENSRNOP00000065206	F		Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04639 ensembl:ENSRNOP00000065206	F		Seeded From UniProt	complete
enables	GO:0071813	lipoprotein particle binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00623 ensembl:ENSMUSP00000034588	F		Seeded From UniProt	complete
involved_in	GO:0051346	negative regulation of hydrolase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00623 ensembl:ENSMUSP00000034588	P		Seeded From UniProt	complete
involved_in	GO:0043534	blood vessel endothelial cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00623 ensembl:ENSMUSP00000034588	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00623 ensembl:ENSMUSP00000034588	F		Seeded From UniProt	complete
involved_in	GO:0042158	lipoprotein biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00623 ensembl:ENSMUSP00000034588	P		Seeded From UniProt	complete
involved_in	GO:0033344	cholesterol efflux	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00623 ensembl:ENSMUSP00000034588	P		Seeded From UniProt	complete
involved_in	GO:0030325	adrenal gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00623 ensembl:ENSMUSP00000034588	P		Seeded From UniProt	complete
involved_in	GO:0030301	cholesterol transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00623 ensembl:ENSMUSP00000034588	P		Seeded From UniProt	complete
involved_in	GO:0030300	regulation of intestinal cholesterol absorption	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00623 ensembl:ENSMUSP00000034588	P		Seeded From UniProt	complete
involved_in	GO:0019915	lipid storage	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00623 ensembl:ENSMUSP00000034588	P		Seeded From UniProt	complete
enables	GO:0017127	cholesterol transporter activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00623 ensembl:ENSMUSP00000034588	F		Seeded From UniProt	complete
enables	GO:0008289	lipid binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00623 ensembl:ENSMUSP00000034588	F		Seeded From UniProt	complete
involved_in	GO:0008211	glucocorticoid metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00623 ensembl:ENSMUSP00000034588	P		Seeded From UniProt	complete
involved_in	GO:0008203	cholesterol metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00623 ensembl:ENSMUSP00000034588	P		Seeded From UniProt	complete
enables	GO:0008035	high-density lipoprotein particle binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00623 ensembl:ENSMUSP00000034588	F		Seeded From UniProt	complete
involved_in	GO:0006695	cholesterol biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00623 ensembl:ENSMUSP00000034588	P		Seeded From UniProt	complete
involved_in	GO:0006644	phospholipid metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00623 ensembl:ENSMUSP00000034588	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00623 ensembl:ENSMUSP00000034588	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00623 ensembl:ENSMUSP00000034588	C		Seeded From UniProt	complete
enables	GO:0005319	lipid transporter activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00623 ensembl:ENSMUSP00000034588	F		Seeded From UniProt	complete
involved_in	GO:0001935	endothelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00623 ensembl:ENSMUSP00000034588	P		Seeded From UniProt	complete
involved_in	GO:0001932	regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00623 ensembl:ENSMUSP00000034588	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000074	C		Seeded From UniProt	complete
involved_in	GO:0006869	lipid transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000074	P		Seeded From UniProt	complete
enables	GO:0008289	lipid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000074	F		Seeded From UniProt	complete
involved_in	GO:0042157	lipoprotein metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000074	P		Seeded From UniProt	complete
part_of	GO:0034364	high-density lipoprotein particle	PMID:27477018^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0071682	endocytic vesicle lumen	Reactome:R-HSA-2247512	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	Reactome:R-HSA-382556	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0044267	cellular protein metabolic process	Reactome:R-HSA-392499	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043687	post-translational protein modification	Reactome:R-HSA-597592	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0034774	secretory granule lumen	Reactome:R-HSA-482770	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0034384	high-density lipoprotein particle clearance	Reactome:R-HSA-8964011	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034380	high-density lipoprotein particle assembly	Reactome:R-HSA-8963896	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034378	chylomicron assembly	Reactome:R-HSA-8963888	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034375	high-density lipoprotein particle remodeling	Reactome:R-HSA-8964058	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034371	chylomicron remodeling	Reactome:R-HSA-8963901	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019216	regulation of lipid metabolic process	Reactome:R-HSA-400206	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006898	receptor-mediated endocytosis	Reactome:R-HSA-3000480 Reactome:R-HSA-3000471 Reactome:R-HSA-2173782	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-382553 Reactome:R-HSA-349638 Reactome:R-HSA-349637 Reactome:R-HSA-264848 Reactome:R-HSA-264834 Reactome:R-HSA-216757 Reactome:R-HSA-216727 Reactome:R-HSA-216723	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-2395764 Reactome:R-HSA-2187332	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	Reactome:R-HSA-8952289 Reactome:R-HSA-174741 Reactome:R-HSA-174587	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	Reactome:R-HSA-2429643 Reactome:R-HSA-2404140 Reactome:R-HSA-2404131	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-977136 Reactome:R-HSA-976734 Reactome:R-HSA-8858252 Reactome:R-HSA-482770 Reactome:R-HSA-349657 Reactome:R-HSA-349638 Reactome:R-HSA-349637 Reactome:R-HSA-349404 Reactome:R-HSA-266328 Reactome:R-HSA-266315 Reactome:R-HSA-266310 Reactome:R-HSA-266303 Reactome:R-HSA-266299 Reactome:R-HSA-266089 Reactome:R-HSA-264848 Reactome:R-HSA-264758 Reactome:R-HSA-264689 Reactome:R-HSA-264678 Reactome:R-HSA-2507854 Reactome:R-HSA-2423785 Reactome:R-HSA-2404131 Reactome:R-HSA-2395784 Reactome:R-HSA-2395768 Reactome:R-HSA-2247512 Reactome:R-HSA-2197646 Reactome:R-HSA-2187332 Reactome:R-HSA-2168889 Reactome:R-HSA-216756 Reactome:R-HSA-216727 Reactome:R-HSA-1989754 Reactome:R-HSA-174757 Reactome:R-HSA-174690 Reactome:R-HSA-174660 Reactome:R-HSA-174587	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0002576	platelet degranulation	Reactome:R-HSA-114608	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001523	retinoid metabolic process	Reactome:R-HSA-975634	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0443	P		Seeded From UniProt	complete
involved_in	GO:0006869	lipid transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0445	P		Seeded From UniProt	complete
involved_in	GO:0008202	steroid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0753	P		Seeded From UniProt	complete
part_of	GO:0034364	high-density lipoprotein particle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0345	C		Seeded From UniProt	complete
involved_in	GO:0008203	cholesterol metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0153	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Tanaka, N et al. (2010) Helical apolipoproteins of high-density lipoprotein enhance phagocytosis by stabilizing ATP-binding cassette transporter A7. J. Lipid Res. 51 2591-9 PubMed GONUTS page
↑ ^2.0 ^2.1 Fu, Y et al. (2016) ABCA7 Mediates Phagocytic Clearance of Amyloid-β in the Brain. J. Alzheimers Dis. 54 569-84 PubMed GONUTS page
↑ ^3.0 ^3.1 Yeh, FL et al. (2016) TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia. Neuron 91 328-40 PubMed GONUTS page
↑ Barallobre-Barreiro, J et al. (2016) Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc. Res. 110 419-30 PubMed GONUTS page
↑ ^5.0 ^5.1 LaDu, MJ et al. (1997) Association of human, rat, and rabbit apolipoprotein E with beta-amyloid. J. Neurosci. Res. 49 9-18 PubMed GONUTS page
↑ Bocharov, AV et al. (2000) Heat shock protein 60 is a high-affinity high-density lipoprotein binding protein. Biochem. Biophys. Res. Commun. 277 228-35 PubMed GONUTS page
↑ Barallobre-Barreiro, J et al. (2016) Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation. Circulation 134 817-32 PubMed GONUTS page
↑ ^8.0 ^8.1 Ji, A et al. (2011) Scavenger receptor SR-BI in macrophage lipid metabolism. Atherosclerosis 217 106-12 PubMed GONUTS page
↑ Balazs, Z et al. (2004) Uptake and transport of high-density lipoprotein (HDL) and HDL-associated alpha-tocopherol by an in vitro blood-brain barrier model. J. Neurochem. 89 939-50 PubMed GONUTS page
↑ Panzenboeck, U et al. (2002) ABCA1 and scavenger receptor class B, type I, are modulators of reverse sterol transport at an in vitro blood-brain barrier constituted of porcine brain capillary endothelial cells. J. Biol. Chem. 277 42781-9 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 ^11.7 Riches, K et al. (2013) Apolipoprotein(a) acts as a chemorepellent to human vascular smooth muscle cells via integrin αVβ3 and RhoA/ROCK-mediated mechanisms. Int. J. Biochem. Cell Biol. 45 1776-83 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ Chiasserini, D et al. (2014) Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset. J Proteomics 106 191-204 PubMed GONUTS page
↑ Bastos-Amador, P et al. (2012) Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. J Proteomics 75 3574-84 PubMed GONUTS page
↑ Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page
↑ Böhm, D et al. (2012) Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Oncol. Rep. 28 429-38 PubMed GONUTS page
↑ Pilon, A et al. (2000) Apolipoprotein AII enrichment of HDL enhances their affinity for class B type I scavenger receptor but inhibits specific cholesteryl ester uptake. Arterioscler. Thromb. Vasc. Biol. 20 1074-81 PubMed GONUTS page
↑ ^20.0 ^20.1 Vishnyakova, TG et al. (2003) Binding and internalization of lipopolysaccharide by Cla-1, a human orthologue of rodent scavenger receptor B1. J. Biol. Chem. 278 22771-80 PubMed GONUTS page
↑ Thuahnai, ST et al. (2004) Scavenger receptor class B type I-mediated cholesteryl ester-selective uptake and efflux of unesterified cholesterol. Influence of high density lipoprotein size and structure. J. Biol. Chem. 279 12448-55 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 ^22.3 ^22.4 ^22.5 ^22.6 ^22.7 ^22.8 Di Bartolo, BA et al. (2011) The apolipoprotein A-I mimetic peptide ETC-642 exhibits anti-inflammatory properties that are comparable to high density lipoproteins. Atherosclerosis 217 395-400 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 ^23.3 Fielding, CJ et al. (1972) A protein cofactor of lecithin:cholesterol acyltransferase. Biochem. Biophys. Res. Commun. 46 1493-8 PubMed GONUTS page
↑ Sorenson, RC et al. (1995) Reconsideration of the catalytic center and mechanism of mammalian paraoxonase/arylesterase. Proc. Natl. Acad. Sci. U.S.A. 92 7187-91 PubMed GONUTS page
↑ Mukhamedova, N et al. (2007) The role of different regions of ATP-binding cassette transporter A1 in cholesterol efflux. Biochemistry 46 9388-98 PubMed GONUTS page
↑ ^26.0 ^26.1 Furlaneto, CJ et al. (2002) Apolipoproteins A-I and A-II downregulate neutrophil functions. Lipids 37 925-8 PubMed GONUTS page
↑ ^27.0 ^27.1 ^27.2 ^27.3 ^27.4 ^27.5 Hovingh, GK et al. (2004) A novel apoA-I mutation (L178P) leads to endothelial dysfunction, increased arterial wall thickness, and premature coronary artery disease. J. Am. Coll. Cardiol. 44 1429-35 PubMed GONUTS page
↑ Gong, EL et al. (1994) Structural and functional properties of human and mouse apolipoprotein A-I. Biochim. Biophys. Acta 1213 335-42 PubMed GONUTS page
↑ Ritter, MC & Scanus, AM (1977) Role of apolipoprotein A-I in the structure of human serum high density lipoproteins. Reconstitution studies. J. Biol. Chem. 252 1208-16 PubMed GONUTS page
↑ Christoffersen, C et al. (2006) Isolation and characterization of human apolipoprotein M-containing lipoproteins. J. Lipid Res. 47 1833-43 PubMed GONUTS page
↑ Weisgraber, KH & Mahley, RW (1978) Apoprotein (E--A-II) complex of human plasma lipoproteins. I. Characterization of this mixed disulfide and its identification in a high density lipoprotein subfraction. J. Biol. Chem. 253 6281-8 PubMed GONUTS page
↑ Cheung, MC et al. (1986) Distribution and localization of lecithin:cholesterol acyltransferase and cholesteryl ester transfer activity in A-I-containing lipoproteins. J. Lipid Res. 27 1135-44 PubMed GONUTS page
↑ Mancone, C et al. (2007) Proteomic analysis of human very low-density lipoprotein by two-dimensional gel electrophoresis and MALDI-TOF/TOF. Proteomics 7 143-54 PubMed GONUTS page
↑ ^34.0 ^34.1 ^34.2 ^34.3 Nofer, JR et al. (2006) Apolipoprotein A-I activates Cdc42 signaling through the ABCA1 transporter. J. Lipid Res. 47 794-803 PubMed GONUTS page
↑ ^35.0 ^35.1 ^35.2 Remaley, AT et al. (2001) Apolipoprotein specificity for lipid efflux by the human ABCAI transporter. Biochem. Biophys. Res. Commun. 280 818-23 PubMed GONUTS page
↑ ^36.0 ^36.1 ^36.2 Smith, JD et al. (2004) ABCA1 mediates concurrent cholesterol and phospholipid efflux to apolipoprotein A-I. J. Lipid Res. 45 635-44 PubMed GONUTS page
↑ Zeng, L et al. (2004) Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism. J. Biol. Chem. 279 48801-7 PubMed GONUTS page
↑ Neufeld, EB et al. (2004) The ABCA1 transporter modulates late endocytic trafficking: insights from the correction of the genetic defect in Tangier disease. J. Biol. Chem. 279 15571-8 PubMed GONUTS page
↑ Furukawa, Y et al. (1992) Interaction of rat lecithin-cholesterol acyltransferase with rat apolipoprotein A-I and with lecithin-cholesterol vesicles. J. Biochem. 111 413-8 PubMed GONUTS page
↑ Wang, WQ et al. (1998) Enhanced cholesterol efflux by tyrosyl radical-oxidized high density lipoprotein is mediated by apolipoprotein AI-AII heterodimers. J. Biol. Chem. 273 17391-8 PubMed GONUTS page
↑ Boucher, J et al. (2004) Apolipoprotein A-II regulates HDL stability and affects hepatic lipase association and activity. J. Lipid Res. 45 849-58 PubMed GONUTS page
↑ Didangelos, A et al. (2010) Proteomics characterization of extracellular space components in the human aorta. Mol. Cell Proteomics 9 2048-62 PubMed GONUTS page
↑ Barallobre-Barreiro, J et al. (2012) Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury. Circulation 125 789-802 PubMed GONUTS page
↑ Weinberg, RB et al. (2003) Structure and interfacial properties of human apolipoprotein A-V. J. Biol. Chem. 278 34438-44 PubMed GONUTS page
↑ Koldamova, RP et al. (2001) Apolipoprotein A-I directly interacts with amyloid precursor protein and inhibits A beta aggregation and toxicity. Biochemistry 40 3553-60 PubMed GONUTS page
↑ ^46.0 ^46.1 Pankhurst, G et al. (2003) Characterization of specifically oxidized apolipoproteins in mildly oxidized high density lipoprotein. J. Lipid Res. 44 349-55 PubMed GONUTS page
↑ ^47.00 ^47.01 ^47.02 ^47.03 ^47.04 ^47.05 ^47.06 ^47.07 ^47.08 ^47.09 ^47.10 ^47.11 ^47.12 ^47.13 ^47.14 ^47.15 ^47.16 ^47.17 ^47.18 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Fournier, N et al. (1999) Fractional efflux and net change in cellular cholesterol content mediated by sera from mice expressing both human apolipoprotein AI and human lecithin:cholesterol acyltransferase genes. Atherosclerosis 147 227-35 PubMed GONUTS page
↑ Watanabe, J et al. (2009) Hemoglobin and its scavenger protein haptoglobin associate with apoA-1-containing particles and influence the inflammatory properties and function of high density lipoprotein. J. Biol. Chem. 284 18292-301 PubMed GONUTS page
↑ Das, M et al. (2014) Amyloidogenic mutations in human apolipoprotein A-I are not necessarily destabilizing - a common mechanism of apolipoprotein A-I misfolding in familial amyloidosis and atherosclerosis. FEBS J. 281 2525-42 PubMed GONUTS page
↑ Adachi, E et al. (2014) The extreme N-terminal region of human apolipoprotein A-I has a strong propensity to form amyloid fibrils. FEBS Lett. 588 389-94 PubMed GONUTS page
↑ Wong, YQ et al. (2012) Identification of an amyloid fibril forming peptide comprising residues 46-59 of apolipoprotein A-I. FEBS Lett. 586 1754-8 PubMed GONUTS page
↑ Wong, YQ et al. (2010) Methionine oxidation induces amyloid fibril formation by full-length apolipoprotein A-I. Proc. Natl. Acad. Sci. U.S.A. 107 1977-82 PubMed GONUTS page
↑ Silva, RA et al. (2008) Structure of apolipoprotein A-I in spherical high density lipoproteins of different sizes. Proc. Natl. Acad. Sci. U.S.A. 105 12176-81 PubMed GONUTS page
↑ Wu, Z et al. (2007) The refined structure of nascent HDL reveals a key functional domain for particle maturation and dysfunction. Nat. Struct. Mol. Biol. 14 861-8 PubMed GONUTS page

[PMID:20495215-1] 1.0 ^1.1 Tanaka, N et al. (2010) Helical apolipoproteins of high-density lipoprotein enhance phagocytosis by stabilizing ATP-binding cassette transporter A7. J. Lipid Res. 51 2591-9 PubMed GONUTS page

[PMID:27472885-2] 2.0 ^2.1 Fu, Y et al. (2016) ABCA7 Mediates Phagocytic Clearance of Amyloid-β in the Brain. J. Alzheimers Dis. 54 569-84 PubMed GONUTS page

[PMID:27477018-3] 3.0 ^3.1 Yeh, FL et al. (2016) TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia. Neuron 91 328-40 PubMed GONUTS page

[PMID:27068509-4] Barallobre-Barreiro, J et al. (2016) Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc. Res. 110 419-30 PubMed GONUTS page

[PMID:9211985-5] 5.0 ^5.1 LaDu, MJ et al. (1997) Association of human, rat, and rabbit apolipoprotein E with beta-amyloid. J. Neurosci. Res. 49 9-18 PubMed GONUTS page

[PMID:11027668-6] Bocharov, AV et al. (2000) Heat shock protein 60 is a high-affinity high-density lipoprotein binding protein. Biochem. Biophys. Res. Commun. 277 228-35 PubMed GONUTS page

[PMID:27559042-7] Barallobre-Barreiro, J et al. (2016) Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation. Circulation 134 817-32 PubMed GONUTS page

[PMID:21481393-8] 8.0 ^8.1 Ji, A et al. (2011) Scavenger receptor SR-BI in macrophage lipid metabolism. Atherosclerosis 217 106-12 PubMed GONUTS page

[PMID:15140193-9] Balazs, Z et al. (2004) Uptake and transport of high-density lipoprotein (HDL) and HDL-associated alpha-tocopherol by an in vitro blood-brain barrier model. J. Neurochem. 89 939-50 PubMed GONUTS page

[PMID:12202492-10] Panzenboeck, U et al. (2002) ABCA1 and scavenger receptor class B, type I, are modulators of reverse sterol transport at an in vitro blood-brain barrier constituted of porcine brain capillary endothelial cells. J. Biol. Chem. 277 42781-9 PubMed GONUTS page

[PMID:23726972-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 ^11.7 Riches, K et al. (2013) Apolipoprotein(a) acts as a chemorepellent to human vascular smooth muscle cells via integrin αVβ3 and RhoA/ROCK-mediated mechanisms. Int. J. Biochem. Cell Biol. 45 1776-83 PubMed GONUTS page

[PMID:23533145-12] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:24769233-13] Chiasserini, D et al. (2014) Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset. J Proteomics 106 191-204 PubMed GONUTS page

[PMID:22516433-14] Bastos-Amador, P et al. (2012) Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. J Proteomics 75 3574-84 PubMed GONUTS page

[PMID:19199708-15] Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page

[PMID:19056867-16] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:16502470-17] Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page

[PMID:22664934-18] Böhm, D et al. (2012) Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Oncol. Rep. 28 429-38 PubMed GONUTS page

[PMID:10764676-19] Pilon, A et al. (2000) Apolipoprotein AII enrichment of HDL enhances their affinity for class B type I scavenger receptor but inhibits specific cholesteryl ester uptake. Arterioscler. Thromb. Vasc. Biol. 20 1074-81 PubMed GONUTS page

[PMID:12651854-20] 20.0 ^20.1 Vishnyakova, TG et al. (2003) Binding and internalization of lipopolysaccharide by Cla-1, a human orthologue of rodent scavenger receptor B1. J. Biol. Chem. 278 22771-80 PubMed GONUTS page

[PMID:14718538-21] Thuahnai, ST et al. (2004) Scavenger receptor class B type I-mediated cholesteryl ester-selective uptake and efflux of unesterified cholesterol. Influence of high density lipoprotein size and structure. J. Biol. Chem. 279 12448-55 PubMed GONUTS page

[PMID:21571275-22] 22.0 ^22.1 ^22.2 ^22.3 ^22.4 ^22.5 ^22.6 ^22.7 ^22.8 Di Bartolo, BA et al. (2011) The apolipoprotein A-I mimetic peptide ETC-642 exhibits anti-inflammatory properties that are comparable to high density lipoproteins. Atherosclerosis 217 395-400 PubMed GONUTS page

[PMID:4335615-23] 23.0 ^23.1 ^23.2 ^23.3 Fielding, CJ et al. (1972) A protein cofactor of lecithin:cholesterol acyltransferase. Biochem. Biophys. Res. Commun. 46 1493-8 PubMed GONUTS page

[PMID:7638166-24] Sorenson, RC et al. (1995) Reconsideration of the catalytic center and mechanism of mammalian paraoxonase/arylesterase. Proc. Natl. Acad. Sci. U.S.A. 92 7187-91 PubMed GONUTS page

[PMID:17655203-25] Mukhamedova, N et al. (2007) The role of different regions of ATP-binding cassette transporter A1 in cholesterol efflux. Biochemistry 46 9388-98 PubMed GONUTS page

[PMID:12458630-26] 26.0 ^26.1 Furlaneto, CJ et al. (2002) Apolipoproteins A-I and A-II downregulate neutrophil functions. Lipids 37 925-8 PubMed GONUTS page

[PMID:15464323-27] 27.0 ^27.1 ^27.2 ^27.3 ^27.4 ^27.5 Hovingh, GK et al. (2004) A novel apoA-I mutation (L178P) leads to endothelial dysfunction, increased arterial wall thickness, and premature coronary artery disease. J. Am. Coll. Cardiol. 44 1429-35 PubMed GONUTS page

[PMID:8049247-28] Gong, EL et al. (1994) Structural and functional properties of human and mouse apolipoprotein A-I. Biochim. Biophys. Acta 1213 335-42 PubMed GONUTS page

[PMID:190223-29] Ritter, MC & Scanus, AM (1977) Role of apolipoprotein A-I in the structure of human serum high density lipoproteins. Reconstitution studies. J. Biol. Chem. 252 1208-16 PubMed GONUTS page

[PMID:16682745-30] Christoffersen, C et al. (2006) Isolation and characterization of human apolipoprotein M-containing lipoproteins. J. Lipid Res. 47 1833-43 PubMed GONUTS page

[PMID:210174-31] Weisgraber, KH & Mahley, RW (1978) Apoprotein (E--A-II) complex of human plasma lipoproteins. I. Characterization of this mixed disulfide and its identification in a high density lipoprotein subfraction. J. Biol. Chem. 253 6281-8 PubMed GONUTS page

[PMID:3104518-32] Cheung, MC et al. (1986) Distribution and localization of lecithin:cholesterol acyltransferase and cholesteryl ester transfer activity in A-I-containing lipoproteins. J. Lipid Res. 27 1135-44 PubMed GONUTS page

[PMID:17154273-33] Mancone, C et al. (2007) Proteomic analysis of human very low-density lipoprotein by two-dimensional gel electrophoresis and MALDI-TOF/TOF. Proteomics 7 143-54 PubMed GONUTS page

[PMID:16443932-34] 34.0 ^34.1 ^34.2 ^34.3 Nofer, JR et al. (2006) Apolipoprotein A-I activates Cdc42 signaling through the ABCA1 transporter. J. Lipid Res. 47 794-803 PubMed GONUTS page

[PMID:11162594-35] 35.0 ^35.1 ^35.2 Remaley, AT et al. (2001) Apolipoprotein specificity for lipid efflux by the human ABCAI transporter. Biochem. Biophys. Res. Commun. 280 818-23 PubMed GONUTS page

[PMID:14703508-36] 36.0 ^36.1 ^36.2 Smith, JD et al. (2004) ABCA1 mediates concurrent cholesterol and phospholipid efflux to apolipoprotein A-I. J. Lipid Res. 45 635-44 PubMed GONUTS page

[PMID:15358760-37] Zeng, L et al. (2004) Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism. J. Biol. Chem. 279 48801-7 PubMed GONUTS page

[PMID:14747463-38] Neufeld, EB et al. (2004) The ABCA1 transporter modulates late endocytic trafficking: insights from the correction of the genetic defect in Tangier disease. J. Biol. Chem. 279 15571-8 PubMed GONUTS page

[PMID:1587806-39] Furukawa, Y et al. (1992) Interaction of rat lecithin-cholesterol acyltransferase with rat apolipoprotein A-I and with lecithin-cholesterol vesicles. J. Biochem. 111 413-8 PubMed GONUTS page

[PMID:9651324-40] Wang, WQ et al. (1998) Enhanced cholesterol efflux by tyrosyl radical-oxidized high density lipoprotein is mediated by apolipoprotein AI-AII heterodimers. J. Biol. Chem. 273 17391-8 PubMed GONUTS page

[PMID:14967812-41] Boucher, J et al. (2004) Apolipoprotein A-II regulates HDL stability and affects hepatic lipase association and activity. J. Lipid Res. 45 849-58 PubMed GONUTS page

[PMID:20551380-42] Didangelos, A et al. (2010) Proteomics characterization of extracellular space components in the human aorta. Mol. Cell Proteomics 9 2048-62 PubMed GONUTS page

[PMID:22261194-43] Barallobre-Barreiro, J et al. (2012) Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury. Circulation 125 789-802 PubMed GONUTS page

[PMID:12810715-44] Weinberg, RB et al. (2003) Structure and interfacial properties of human apolipoprotein A-V. J. Biol. Chem. 278 34438-44 PubMed GONUTS page

[PMID:11297421-45] Koldamova, RP et al. (2001) Apolipoprotein A-I directly interacts with amyloid precursor protein and inhibits A beta aggregation and toxicity. Biochemistry 40 3553-60 PubMed GONUTS page

[PMID:12576517-46] 46.0 ^46.1 Pankhurst, G et al. (2003) Characterization of specifically oxidized apolipoproteins in mildly oxidized high density lipoprotein. J. Lipid Res. 44 349-55 PubMed GONUTS page

[PMID:21873635-47] 47.00 ^47.01 ^47.02 ^47.03 ^47.04 ^47.05 ^47.06 ^47.07 ^47.08 ^47.09 ^47.10 ^47.11 ^47.12 ^47.13 ^47.14 ^47.15 ^47.16 ^47.17 ^47.18 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:10559507-48] Fournier, N et al. (1999) Fractional efflux and net change in cellular cholesterol content mediated by sera from mice expressing both human apolipoprotein AI and human lecithin:cholesterol acyltransferase genes. Atherosclerosis 147 227-35 PubMed GONUTS page

[PMID:19433579-49] Watanabe, J et al. (2009) Hemoglobin and its scavenger protein haptoglobin associate with apoA-1-containing particles and influence the inflammatory properties and function of high density lipoprotein. J. Biol. Chem. 284 18292-301 PubMed GONUTS page

[PMID:24702826-50] Das, M et al. (2014) Amyloidogenic mutations in human apolipoprotein A-I are not necessarily destabilizing - a common mechanism of apolipoprotein A-I misfolding in familial amyloidosis and atherosclerosis. FEBS J. 281 2525-42 PubMed GONUTS page

[PMID:24316228-51] Adachi, E et al. (2014) The extreme N-terminal region of human apolipoprotein A-I has a strong propensity to form amyloid fibrils. FEBS Lett. 588 389-94 PubMed GONUTS page

[PMID:22609356-52] Wong, YQ et al. (2012) Identification of an amyloid fibril forming peptide comprising residues 46-59 of apolipoprotein A-I. FEBS Lett. 586 1754-8 PubMed GONUTS page

[PMID:20133843-53] Wong, YQ et al. (2010) Methionine oxidation induces amyloid fibril formation by full-length apolipoprotein A-I. Proc. Natl. Acad. Sci. U.S.A. 107 1977-82 PubMed GONUTS page

[PMID:18719128-54] Silva, RA et al. (2008) Structure of apolipoprotein A-I in spherical high density lipoproteins of different sizes. Proc. Natl. Acad. Sci. U.S.A. 105 12176-81 PubMed GONUTS page

[PMID:17676061-55] Wu, Z et al. (2007) The refined structure of nascent HDL reveals a key functional domain for particle maturation and dysfunction. Nat. Struct. Mol. Biol. 14 861-8 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

[21]

[22]

[23]

[24]

[25]

[26]

[27]

[28]

[29]

[30]

[31]

[32]

[33]

[34]

[35]

[36]

[37]

[38]

[39]

[40]

[41]

[42]

[43]

[44]

[45]

[46]

[47]

[48]

[49]

[50]

[51]

[52]

[53]

[54]

[55]

HUMAN:APOA1

Contents

Annotations

Notes

References

a

b

c

d

e

g

h

i

l

m

n

o

p

r

s

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools