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HUMAN:APBB2

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) APBB2 (synonyms: FE65L, FE65L1)
Protein Name(s) Amyloid beta A4 precursor protein-binding family B member 2

Protein Fe65-like 1

External Links
UniProt Q92870
EMBL AK299800
AK226179
AC093804
AC096712
AC108937
AC131953
BC027946
U62325
CCDS CCDS43224.1
CCDS54760.1
CCDS54761.1
CCDS54762.1
RefSeq NP_001159522.1
NP_001159523.1
NP_001159524.1
NP_001159525.1
NP_001159526.1
NP_775098.2
UniGene Hs.479602
ProteinModelPortal Q92870
SMR Q92870
BioGrid 106820
IntAct Q92870
MINT MINT-1493142
STRING 9606.ENSP00000295974
PhosphoSite Q92870
DMDM 317373476
MaxQB Q92870
PaxDb Q92870
PRIDE Q92870
DNASU 323
Ensembl ENST00000295974
ENST00000502841
ENST00000504305
ENST00000508593
ENST00000513140
ENST00000543538
GeneID 323
KEGG hsa:323
UCSC uc003gvk.3
uc003gvl.3
uc003gvm.3
CTD 323
GeneCards GC04M040812
HGNC HGNC:582
HPA HPA023542
MIM 602710
neXtProt NX_Q92870
PharmGKB PA24874
eggNOG NOG76544
GeneTree ENSGT00390000000002
HOGENOM HOG000033983
HOVERGEN HBG050524
InParanoid Q92870
KO K04530
OMA TKNSTPP
OrthoDB EOG79W94P
PhylomeDB Q92870
TreeFam TF314331
SignaLink Q92870
ChiTaRS APBB2
GeneWiki APBB2
GenomeRNAi 323
NextBio 1325
PRO PR:Q92870
Proteomes UP000005640
Bgee Q92870
CleanEx HS_APBB2
ExpressionAtlas Q92870
Genevestigator Q92870
GO GO:0005737
GO:0030426
GO:0030027
GO:0016020
GO:0005634
GO:0045202
GO:0001540
GO:0008134
GO:0007411
GO:0007050
GO:0030198
GO:0035556
GO:0043066
GO:0030308
GO:0001764
GO:0043065
GO:0006355
Gene3D 2.30.29.30
InterPro IPR011993
IPR006020
IPR001202
Pfam PF00640
PF00397
SMART SM00462
SM00456
SUPFAM SSF51045
PROSITE PS01179
PS01159
PS50020

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0031175

neuron projection development

PMID:21298006[1]

ECO:0000314

P

sAPP-Beta induces axon elongation. Fig.2

complete
CACAO 3573

part_of

GO:0045202

synapse

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O00213

C

Seeded From UniProt

complete

involved_in

GO:0035556

intracellular signal transduction

PMID:8855266[2]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0030426

growth cone

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O00213

C

Seeded From UniProt

complete

involved_in

GO:0030308

negative regulation of cell growth

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9QXJ1

P

Seeded From UniProt

complete

part_of

GO:0030027

lamellipodium

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O00213

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:8855266[2]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9QXJ1

F

Seeded From UniProt

complete

involved_in

GO:0007050

cell cycle arrest

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9QXJ1

P

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9QXJ1

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9QXJ1

C

Seeded From UniProt

complete

enables

GO:0001540

amyloid-beta binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9QXJ1

F

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107765
MGI:MGI:108405
PANTHER:PTN000362318

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107765
MGI:MGI:108405
PANTHER:PTN000362318

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107765
MGI:MGI:108405
PANTHER:PTN000362318
RGD:2122
UniProtKB:O00213

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107765
MGI:MGI:108405
PANTHER:PTN000362318
RGD:2122
UniProtKB:O00213

C

Seeded From UniProt

complete

enables

GO:0001540

amyloid-beta binding

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107765
PANTHER:PTN000362318
RGD:2122
RGD:620853
UniProtKB:O00213
WB:WBGene00001410

F

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9DBR4
ensembl:ENSMUSP00000123752

P

Seeded From UniProt

complete

involved_in

GO:0043065

positive regulation of apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9DBR4
ensembl:ENSMUSP00000123752

P

Seeded From UniProt

complete

involved_in

GO:0030308

negative regulation of cell growth

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9DBR4
ensembl:ENSMUSP00000123752

P

Seeded From UniProt

complete

involved_in

GO:0030198

extracellular matrix organization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9DBR4
ensembl:ENSMUSP00000123752

P

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9DBR4
ensembl:ENSMUSP00000123752

F

Seeded From UniProt

complete

involved_in

GO:0007411

axon guidance

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9DBR4
ensembl:ENSMUSP00000123752

P

Seeded From UniProt

complete

involved_in

GO:0007050

cell cycle arrest

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9DBR4
ensembl:ENSMUSP00000123752

P

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9DBR4
ensembl:ENSMUSP00000123752

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9DBR4
ensembl:ENSMUSP00000123752

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9DBR4
ensembl:ENSMUSP00000123752

C

Seeded From UniProt

complete

involved_in

GO:0001764

neuron migration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9DBR4
ensembl:ENSMUSP00000123752

P

Seeded From UniProt

complete

enables

GO:0001540

amyloid-beta binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR039576

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Chasseigneaux, S et al. (2011) Secreted amyloid precursor protein β and secreted amyloid precursor protein α induce axon outgrowth in vitro through Egr1 signaling pathway. PLoS ONE 6 e16301 PubMed GONUTS page
  2. ↑ 2.0 2.1 Guénette, SY et al. (1996) Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein. Proc. Natl. Acad. Sci. U.S.A. 93 10832-7 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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