GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:21298006
| Citation |
Chasseigneaux, S, Dinc, L, Rose, C, Chabret, C, Coulpier, F, Topilko, P, Mauger, G and Allinquant, B (2011) Secreted amyloid precursor protein β and secreted amyloid precursor protein α induce axon outgrowth in vitro through Egr1 signaling pathway. PLoS ONE 6:e16301 |
|---|---|
| Abstract |
sAPPα released after α secretase cleavage of Amyloid Precursor Protein (APP) has several functions including the stimulation of neurite outgrowth although detailed morphometric analysis has not been done. Two domains involved in this function have been described and are present in sAPPβ released at the first step of amyloid peptide cleavage, raising the possibility that sAPPβ could also stimulate neurite outgrowth. We investigated the morphological effects of sAPPα and sAPPβ on primary neurons and identified a key signaling event required for the changes observed. |
| Links |
PubMed PMC3029320 Online version:10.1371/journal.pone.0016301 |
| Keywords |
Amyloid beta-Protein Precursor/pharmacology; Amyloid beta-Protein Precursor/secretion; Animals; Axons/drug effects; Axons/metabolism; Brain/cytology; Cell Adhesion; Cells, Cultured; Dose-Response Relationship, Drug; Early Growth Response Protein 1/metabolism; Mice; Mice, Knockout; Neurons/ultrastructure; Signal Transduction/physiology |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0031175: neuron projection development |
ECO:0000314: |
P |
sAPP-Beta induces axon elongation. Fig.2 |
complete | ||||
See also
References
See Help:References for how to manage references in GONUTS.
