HUMAN:ANFB

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	NPPB
Protein Name(s)	Natriuretic peptides B Gamma-brain natriuretic peptide Brain natriuretic peptide 32 BNP(1-32) BNP-32 BNP(1-30) BNP(1-29) BNP(1-28) BNP(2-31) BNP(3-32) BNP(3-30) BNP(3-29) BNP(4-32) BNP(4-31) BNP(4-30) BNP(4-29) BNP(4-27) BNP(5-32) BNP(5-31) BNP(5-29)
External Links
UniProt	P16860
EMBL	M31776 M25296 AB037521 CR541976 CR542003 EU326309 AL021155 CH471130 BC025785
CCDS	CCDS140.1
PIR	A36736
RefSeq	NP_002512.1
UniGene	Hs.219140
PDB	1YK1 3N56
PDBsum	1YK1 3N56
DisProt	DP00551
ProteinModelPortal	P16860
SMR	P16860
BioGrid	110939
IntAct	P16860
MINT	MINT-1434895
STRING	9606.ENSP00000365651
DrugBank	DB01136
PhosphoSite	P16860
DMDM	113836
PaxDb	P16860
PRIDE	P16860
DNASU	4879
Ensembl	ENST00000376468
GeneID	4879
KEGG	hsa:4879
UCSC	uc001atj.3
CTD	4879
GeneCards	GC01M011918
HGNC	HGNC:7940
MIM	600295
neXtProt	NX_P16860
PharmGKB	PA31734
eggNOG	NOG67899
GeneTree	ENSGT00510000049822
HOGENOM	HOG000206568
HOVERGEN	HBG004227
InParanoid	P16860
KO	K12335
OMA	SGCFGRK
OrthoDB	EOG7P2XV4
PhylomeDB	P16860
TreeFam	TF106304
EvolutionaryTrace	P16860
GeneWiki	Brain_natriuretic_peptide
GenomeRNAi	4879
NextBio	18780
PMAP-CutDB	P16860
PRO	PR:P16860
Proteomes	UP000005640
Bgee	P16860
CleanEx	HS_NPPB
Genevestigator	P16860
GO	GO:0005576 GO:0005615 GO:0043234 GO:0008613 GO:0005179 GO:0005102 GO:0007589 GO:0007166 GO:0006182 GO:0016525 GO:0030308 GO:0035815 GO:0035810 GO:0007168 GO:0008217 GO:0050880 GO:0043114 GO:0042312
InterPro	IPR000663 IPR002408
Pfam	PF00212
PRINTS	PR00712
SMART	SM00183
PROSITE	PS00263

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0006457	protein folding	PMID:16870210^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:16870210^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:16870210^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P17342	F	Seeded From UniProt	complete
involved_in	GO:0097746	regulation of blood vessel diameter	PMID:7601467^[2]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	PMID:12727915^[3]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008217	regulation of blood pressure	PMID:12727915^[3]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007168	receptor guanylyl cyclase signaling pathway	PMID:1672777^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007166	cell surface receptor signaling pathway	PMID:12727915^[3]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of	GO:0006182	cGMP biosynthetic process	PMID:1672777^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:7601467^[2]	ECO:0000303	author statement without traceable support used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005179	hormone activity	PMID:7601467^[2]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0051427	hormone receptor binding	PMID:1660465^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P17342	F	Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:12727915^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P16066	F	Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:1672777^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0051427	hormone receptor binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002679372 UniProtKB:P01160 UniProtKB:P16860	F	Seeded From UniProt	complete
involved_in	GO:0019934	cGMP-mediated signaling	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002679372 RGD:3193	P	Seeded From UniProt	complete
involved_in	GO:0007218	neuropeptide signaling pathway	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002679372 UniProtKB:P01160	P	Seeded From UniProt	complete
involved_in	GO:0007168	receptor guanylyl cyclase signaling pathway	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002679372 RGD:3193 UniProtKB:P01160 UniProtKB:P16860	P	Seeded From UniProt	complete
involved_in	GO:0006182	cGMP biosynthetic process	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002679372 UniProtKB:P01160 UniProtKB:P16860	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97367 PANTHER:PTN002679372 RGD:3193 RGD:3194	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002679372 RGD:3193 RGD:3194	C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97367 PANTHER:PTN002679372 RGD:3194	C	Seeded From UniProt	complete
enables	GO:0005179	hormone activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002679372 RGD:3193 RGD:3194 UniProtKB:P01160	F	Seeded From UniProt	complete
involved_in	GO:0003085	negative regulation of systemic arterial blood pressure	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002679372 RGD:3193 RGD:3194	P	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:23382219^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005179	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005179	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008613	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005179	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005179	P	Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000663 InterPro:IPR002408	F	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000663 InterPro:IPR002408	C	Seeded From UniProt	complete
involved_in	GO:0031640	killing of cells of other organism	PMID:11410403^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031640	killing of cells of other organism	PMID:11410403^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031640	killing of cells of other organism	PMID:11410403^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031640	killing of cells of other organism	PMID:11410403^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031640	killing of cells of other organism	PMID:11410403^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031640	killing of cells of other organism	PMID:11410403^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	PMID:11410403^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043114	regulation of vascular permeability	PMID:14737067^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035815	positive regulation of renal sodium excretion	PMID:14960748^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035810	positive regulation of urine volume	PMID:14737067^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0016525	negative regulation of angiogenesis	PMID:14737067^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0008613	diuretic hormone activity	PMID:14960748^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0007589	body fluid secretion	PMID:14960748^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:14960748^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0372	F	Seeded From UniProt	complete
involved_in	GO:0050880	regulation of blood vessel size	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0838	P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 He, XL et al. (2006) Structural determinants of natriuretic peptide receptor specificity and degeneracy. J. Mol. Biol. 361 698-714 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Arden, KC et al. (1995) Localization of the human B-type natriuretic peptide precursor (NPPB) gene to chromosome 1p36. Genomics 26 385-9 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Molkentin, JD (2003) A friend within the heart: natriuretic peptide receptor signaling. J. Clin. Invest. 111 1275-7 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Koller, KJ et al. (1991) Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP). Science 252 120-3 PubMed GONUTS page
↑ Bennett, BD et al. (1991) Extracellular domain-IgG fusion proteins for three human natriuretic peptide receptors. Hormone pharmacology and application to solid phase screening of synthetic peptide antisera. J. Biol. Chem. 266 23060-7 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 ^6.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Ghai, R et al. (2013) Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc. Natl. Acad. Sci. U.S.A. 110 E643-52 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 Krause, A et al. (2001) Human natriuretic peptides exhibit antimicrobial activity. Eur. J. Med. Res. 6 215-8 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Rollín, R et al. (2004) Natriuretic peptide system in the human retina. Mol. Vis. 10 15-22 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Mark, DB & Felker, GM (2004) B-type natriuretic peptide - a biomarker for all seasons? N. Engl. J. Med. 350 718-20 PubMed GONUTS page

[PMID:16870210-1] 1.0 ^1.1 ^1.2 He, XL et al. (2006) Structural determinants of natriuretic peptide receptor specificity and degeneracy. J. Mol. Biol. 361 698-714 PubMed GONUTS page

[PMID:7601467-2] 2.0 ^2.1 ^2.2 Arden, KC et al. (1995) Localization of the human B-type natriuretic peptide precursor (NPPB) gene to chromosome 1p36. Genomics 26 385-9 PubMed GONUTS page

[PMID:12727915-3] 3.0 ^3.1 ^3.2 ^3.3 Molkentin, JD (2003) A friend within the heart: natriuretic peptide receptor signaling. J. Clin. Invest. 111 1275-7 PubMed GONUTS page

[PMID:1672777-4] 4.0 ^4.1 ^4.2 Koller, KJ et al. (1991) Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP). Science 252 120-3 PubMed GONUTS page

[PMID:1660465-5] Bennett, BD et al. (1991) Extracellular domain-IgG fusion proteins for three human natriuretic peptide receptors. Hormone pharmacology and application to solid phase screening of synthetic peptide antisera. J. Biol. Chem. 266 23060-7 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 ^6.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23382219-7] Ghai, R et al. (2013) Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc. Natl. Acad. Sci. U.S.A. 110 E643-52 PubMed GONUTS page

[PMID:11410403-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 Krause, A et al. (2001) Human natriuretic peptides exhibit antimicrobial activity. Eur. J. Med. Res. 6 215-8 PubMed GONUTS page

[PMID:14737067-9] 9.0 ^9.1 ^9.2 Rollín, R et al. (2004) Natriuretic peptide system in the human retina. Mol. Vis. 10 15-22 PubMed GONUTS page

[PMID:14960748-10] 10.0 ^10.1 ^10.2 ^10.3 Mark, DB & Felker, GM (2004) B-type natriuretic peptide - a biomarker for all seasons? N. Engl. J. Med. 350 718-20 PubMed GONUTS page

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HUMAN:ANFB

Contents

Annotations

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