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HUMAN:AKAP8

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) AKAP8 (synonyms: AKAP95)
Protein Name(s) A-kinase anchor protein 8

AKAP-8 A-kinase anchor protein 95 kDa AKAP 95

External Links
UniProt O43823
EMBL Y11997
AC005785
CCDS CCDS12329.1
PIR T13161
RefSeq NP_005849.1
UniGene Hs.594496
ProteinModelPortal O43823
BioGrid 115561
DIP DIP-38194N
IntAct O43823
MINT MINT-2796393
STRING 9606.ENSP00000269701
iPTMnet O43823
PhosphoSite O43823
BioMuta AKAP8
EPD O43823
MaxQB O43823
PaxDb O43823
PeptideAtlas O43823
PRIDE O43823
Ensembl ENST00000269701
GeneID 10270
KEGG hsa:10270
UCSC uc002nav.4
CTD 10270
GeneCards AKAP8
HGNC HGNC:378
HPA HPA004776
MIM 604692
neXtProt NX_O43823
PharmGKB PA24672
eggNOG ENOG410IFNG
ENOG410YE5A
GeneTree ENSGT00530000063777
HOGENOM HOG000033876
HOVERGEN HBG053198
InParanoid O43823
KO K16525
OMA GCGRSQT
OrthoDB EOG741Z1X
PhylomeDB O43823
TreeFam TF105407
ChiTaRS AKAP8
GeneWiki AKAP8
GenomeRNAi 10270
NextBio 38910
PRO PR:O43823
Proteomes UP000005640
Bgee O43823
CleanEx HS_AKAP8
ExpressionAtlas O43823
Genevisible O43823
GO GO:0001939
GO:0005794
GO:0016020
GO:0005739
GO:0016363
GO:0005654
GO:0005634
GO:0003690
GO:0044822
GO:0034237
GO:0008270
GO:0007067
GO:0007165
InterPro IPR007071
IPR015880
PANTHER PTHR12190
Pfam PF04988
SMART SM00355

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0042826

histone deacetylase binding

PMID:16980585[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0044839

cell cycle G2/M phase transition

PMID:16980585[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0033127

regulation of histone phosphorylation

PMID:16980585[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031065

positive regulation of histone deacetylation

PMID:16980585[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

GO:0005730

nucleolus

PMID:26683827[2]

ECO:0000314

C

Figure 1. shows the intra-nuclear localization of AKAP95 is dependent on both RNA polymerase I and RNA polymerase II.

complete
CACAO 12042

enables

GO:0034237

protein kinase A regulatory subunit binding

PMID:17911601[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P13861

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:19946888[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22681889[5]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22658674[6]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0016363

nuclear matrix

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9DBR0

C

Seeded From UniProt

complete

enables

GO:0034237

protein kinase A regulatory subunit binding

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000257171
RGD:620832
UniProtKB:O43823

F

Seeded From UniProt

complete

part_of

GO:0016363

nuclear matrix

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1860606
MGI:MGI:1928488
PANTHER:PTN000257171
RGD:620832
UniProtKB:Q9ULX6

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0034237

protein kinase A regulatory subunit binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q63014
ensembl:ENSRNOP00000008827

F

Seeded From UniProt

complete

part_of

GO:0016363

nuclear matrix

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q63014
ensembl:ENSRNOP00000008827

C

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q63014
ensembl:ENSRNOP00000008827

F

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q63014
ensembl:ENSRNOP00000008827

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q63014
ensembl:ENSRNOP00000008827

C

Seeded From UniProt

complete

enables

GO:0003690

double-stranded DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q63014
ensembl:ENSRNOP00000008827

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q63014
ensembl:ENSRNOP00000008827

F

Seeded From UniProt

complete

involved_in

GO:0071380

cellular response to prostaglandin E stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9DBR0
ensembl:ENSMUSP00000002699

P

Seeded From UniProt

complete

involved_in

GO:0071222

cellular response to lipopolysaccharide

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9DBR0
ensembl:ENSMUSP00000002699

P

Seeded From UniProt

complete

enables

GO:0051059

NF-kappaB binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9DBR0
ensembl:ENSMUSP00000002699

F

Seeded From UniProt

complete

involved_in

GO:0032720

negative regulation of tumor necrosis factor production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9DBR0
ensembl:ENSMUSP00000002699

P

Seeded From UniProt

complete

part_of

GO:0016363

nuclear matrix

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9DBR0
ensembl:ENSMUSP00000002699

C

Seeded From UniProt

complete

involved_in

GO:0007076

mitotic chromosome condensation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9DBR0
ensembl:ENSMUSP00000002699

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9DBR0
ensembl:ENSMUSP00000002699

C

Seeded From UniProt

complete

part_of

GO:0001939

female pronucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9DBR0
ensembl:ENSMUSP00000002699

C

Seeded From UniProt

complete

part_of

GO:0000793

condensed chromosome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9DBR0
ensembl:ENSMUSP00000002699

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR007071

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR007071

C

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

PMID:9473338[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000278

mitotic cell cycle

PMID:9473338[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:9473338[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0045087

innate immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0399

P

Seeded From UniProt

complete

involved_in

GO:0015031

protein transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0653

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0188

C

Seeded From UniProt

complete

part_of

GO:0016363

nuclear matrix

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0181

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 Li, Y et al. (2006) A novel histone deacetylase pathway regulates mitosis by modulating Aurora B kinase activity. Genes Dev. 20 2566-79 PubMed GONUTS page
  2. ↑ Marstad, A et al. (2016) A-kinase anchoring protein AKAP95 is a novel regulator of ribosomal RNA synthesis. FEBS J. 283 757-70 PubMed GONUTS page
  3. ↑ Ruppelt, A et al. (2007) Inhibition of T cell activation by cyclic adenosine 5'-monophosphate requires lipid raft targeting of protein kinase A type I by the A-kinase anchoring protein ezrin. J. Immunol. 179 5159-68 PubMed GONUTS page
  4. ↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
  5. ↑ Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
  6. ↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
  7. ↑ 7.0 7.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  8. ↑ 8.0 8.1 8.2 Eide, T et al. (1998) Molecular cloning, chromosomal localization, and cell cycle-dependent subcellular distribution of the A-kinase anchoring protein, AKAP95. Exp. Cell Res. 238 305-16 PubMed GONUTS page
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