HUMAN:AK1C3

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	AKR1C3 (synonyms: DDH1, HSD17B5, KIAA0119, PGFS)
Protein Name(s)	Aldo-keto reductase family 1 member C3 17-beta-hydroxysteroid dehydrogenase type 5 17-beta-HSD 5 3-alpha-HSD type II, brain 3-alpha-hydroxysteroid dehydrogenase type 2 3-alpha-HSD type 2 Chlordecone reductase homolog HAKRb Dihydrodiol dehydrogenase 3 DD-3 DD3 Dihydrodiol dehydrogenase type I HA1753 Indanol dehydrogenase Prostaglandin F synthase PGFS Testosterone 17-beta-dehydrogenase 5 Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
External Links
UniProt	P42330
EMBL	S68288 L43839 L43831 L43832 L43833 L43834 L43835 L43836 L43837 L43838 AB018580 AB028065 AF149416 AB032157 D17793 BT007286 AK290365 AK296829 AL391427 CH471072 BC001479 BC019230
CCDS	CCDS7063.1
PIR	B57407 I73674
RefSeq	NP_001240837.1 NP_003730.4
UniGene	Hs.78183
PDB	1RY0 1RY8 1S1P 1S1R 1S2A 1S2C 1XF0 1ZQ5 2F38 2FGB 3R43 3R58 3R6I 3R7M 3R8G 3R8H 3R94 3UFY 3UG8 3UGR 3UWE 4DBS 4DBU 4DBW 4DZ5 4FA3 4FAL 4FAM 4H7C 4HMN 4WRH
PDBsum	1RY0 1RY8 1S1P 1S1R 1S2A 1S2C 1XF0 1ZQ5 2F38 2FGB 3R43 3R58 3R6I 3R7M 3R8G 3R8H 3R94 3UFY 3UG8 3UGR 3UWE 4DBS 4DBU 4DBW 4DZ5 4FA3 4FAL 4FAM 4H7C 4HMN 4WRH
ProteinModelPortal	P42330
SMR	P42330
BioGrid	114196
IntAct	P42330
MINT	MINT-1379107
BindingDB	P42330
ChEMBL	CHEMBL4681
DrugBank	DB00905 DB00997
PhosphoSite	P42330
DMDM	308153646
DOSAC-COBS-2DPAGE	P42330
MaxQB	P42330
PaxDb	P42330
PRIDE	P42330
DNASU	8644
Ensembl	ENST00000380554
GeneID	8644
KEGG	hsa:8644
UCSC	uc001ihr.3
CTD	8644
GeneCards	GC10P005077
HGNC	HGNC:386
HPA	CAB010874
MIM	603966
neXtProt	NX_P42330
PharmGKB	PA24679
eggNOG	COG0656
GeneTree	ENSGT00760000119041
HOVERGEN	HBG000020
InParanoid	P42330
KO	K04119
OMA	IPWCEAH
PhylomeDB	P42330
TreeFam	TF106492
Reactome	REACT_11041 REACT_11048 REACT_11053 REACT_150149 REACT_24968
SABIO-RK	P42330
ChiTaRS	AKR1C3
EvolutionaryTrace	P42330
GeneWiki	AKR1C3
GenomeRNAi	8644
NextBio	32407
PRO	PR:P42330
Proteomes	UP000005640
Bgee	P42330
CleanEx	HS_AKR1C3
ExpressionAtlas	P42330
Genevestigator	P42330
GO	GO:0005737 GO:0005829 GO:0070062 GO:0005622 GO:0005634 GO:0047020 GO:0004032 GO:0004033 GO:0047023 GO:0047787 GO:0035410 GO:0045550 GO:0047718 GO:0045703 GO:0047086 GO:0016655 GO:0018636 GO:0036131 GO:0004958 GO:0047017 GO:0001758 GO:0004745 GO:0047045 GO:0047035 GO:0047115 GO:0019369 GO:0071276 GO:0071277 GO:0071384 GO:0071395 GO:0071379 GO:0034614 GO:0009267 GO:0019371 GO:0044597 GO:0044598 GO:0016488 GO:0007186 GO:0030216 GO:0008584 GO:0044259 GO:1900053 GO:0055114 GO:0007603 GO:0010942 GO:0008284 GO:2000353 GO:0051897 GO:2000379 GO:0042448 GO:0006693 GO:0000060 GO:0048385 GO:2000224 GO:0070293 GO:0007584 GO:0034694 GO:0042574 GO:0001523 GO:0044281 GO:0008202 GO:0061370
Gene3D	3.20.20.100
InterPro	IPR001395 IPR018170 IPR020471 IPR023210
PANTHER	PTHR11732
Pfam	PF00248
PIRSF	PIRSF000097
PRINTS	PR00069
SUPFAM	SSF51430
PROSITE	PS00798 PS00062 PS00063

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0004033	aldo-keto reductase activity	PMID:9792917^[1]	ECO:0000270			F		See Table 2.	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005622	intracellular	GO_REF:0000054	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000379	positive regulation of reactive oxygen species metabolic process	PMID:19442656^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000353	positive regulation of endothelial cell apoptotic process	PMID:19442656^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000224	regulation of testosterone biosynthetic process	PMID:19336506^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0002055)	Seeded From UniProt	complete
involved_in	GO:1900053	negative regulation of retinoic acid biosynthetic process	PMID:21851338^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071395	cellular response to jasmonic acid stimulus	PMID:19487289^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071384	cellular response to corticosteroid stimulus	PMID:19336506^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0002055)	Seeded From UniProt	complete
involved_in	GO:0071379	cellular response to prostaglandin stimulus	PMID:22170488^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071277	cellular response to calcium ion	PMID:22170488^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071276	cellular response to cadmium ion	PMID:21787718^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070293	renal absorption	PMID:16157291^[9]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061370	testosterone biosynthetic process	PMID:16983398^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	PMID:19442656^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	PMID:16983398^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	PMID:21232532^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	PMID:18508192^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	happens_during:(GO:0071799)	Seeded From UniProt	complete
involved_in	GO:0048385	regulation of retinoic acid receptor signaling pathway	PMID:21851338^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0047787	delta4-3-oxosteroid 5beta-reductase activity	PMID:16983398^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0047086	ketosteroid monooxygenase activity	PMID:21232532^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0047023	androsterone dehydrogenase activity	PMID:16983398^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0047020	15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity	PMID:22170488^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0045703	ketoreductase activity	PMID:19487289^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(CHEBI:57406)	Seeded From UniProt	complete
enables	GO:0045550	geranylgeranyl reductase activity	PMID:21187079^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0044598	doxorubicin metabolic process	PMID:20837989^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0044597	daunorubicin metabolic process	PMID:20837989^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043170	macromolecule metabolic process	PMID:18641923^[15]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042574	retinal metabolic process	PMID:21851338^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042448	progesterone metabolic process	PMID:21232532^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0035410	dihydrotestosterone 17-beta-dehydrogenase activity	PMID:16983398^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0071799	cellular response to prostaglandin D stimulus	PMID:18508192^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002231)	Seeded From UniProt	complete
involved_in	GO:0034614	cellular response to reactive oxygen species	PMID:21787718^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030216	keratinocyte differentiation	PMID:22170488^[7]	ECO:0000270	expression pattern evidence used in manual assertion		P	happens_during:(GO:0071277)	Seeded From UniProt	complete
enables	GO:0018636	phenanthrene 9,10-monooxygenase activity	PMID:21851338^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	PMID:19442656^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(CHEBI:37454)	Seeded From UniProt	complete
enables	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	PMID:20837989^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0016488	farnesol catabolic process	PMID:21187079^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010942	positive regulation of cell death	PMID:21787718^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009267	cellular response to starvation	PMID:18641923^[15]	ECO:0000270	expression pattern evidence used in manual assertion		P	occurs_in:(UBERON:0001013)	Seeded From UniProt	complete
involved_in	GO:0008584	male gonad development	PMID:19942269^[16]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:21851338^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:20036328^[17]	ECO:0000314	direct assay evidence used in manual assertion		P	happens_during:(GO:0043627)\|happens_during:(GO:0034694)	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:18508192^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	happens_during:(GO:0071799) occurs_in:(CL:0002231)	Seeded From UniProt	complete
involved_in	GO:0008202	steroid metabolic process	PMID:20036328^[17]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007584	response to nutrient	PMID:19007764^[18]	ECO:0000270	expression pattern evidence used in manual assertion		P	has_input:(CHEBI:24698)	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	PMID:18508192^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006693	prostaglandin metabolic process	PMID:20036328^[17]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:22170488^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0002026) part_of:(CL:0000312)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:18574251^[19]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002188)\|part_of:(CL:0000178)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19942269^[16]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000178)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19336506^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0002055)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18574251^[19]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002341)\|part_of:(CL:0002622)\|part_of:(UBERON:0001230)\|part_of:(CL:1000742)\|part_of:(CL:1000838)\|part_of:(UBERON:0005211)\|part_of:(UBERON:0005270)\|part_of:(UBERON:0005249)\|part_of:(CL:0002188)\|part_of:(CL:0000066)\|part_of:(CL:0000178)\|part_of:(UBERON:0006645) part_of:(CL:0000115) part_of:(CL:0000499)	Seeded From UniProt	complete
enables	GO:0004745	retinol dehydrogenase activity	PMID:21851338^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004032	alditol:NADP+ 1-oxidoreductase activity	PMID:21232532^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001758	retinal dehydrogenase activity	PMID:21851338^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0047086	ketosteroid monooxygenase activity	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000199026 UniProtKB:P42330 UniProtKB:P52895 UniProtKB:Q04828	F		Seeded From UniProt	complete
enables	GO:0047023	androsterone dehydrogenase activity	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2145458 PANTHER:PTN002482509 UniProtKB:P17516 UniProtKB:P42330	F		Seeded From UniProt	complete
enables	GO:0047023	androsterone dehydrogenase activity	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2145458 PANTHER:PTN000199031 UniProtKB:P17516 UniProtKB:P42330	F		Seeded From UniProt	complete
involved_in	GO:0044598	doxorubicin metabolic process	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000199031 UniProtKB:P17516 UniProtKB:P42330	P		Seeded From UniProt	complete
involved_in	GO:0044597	daunorubicin metabolic process	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000199031 UniProtKB:P17516 UniProtKB:P42330	P		Seeded From UniProt	complete
involved_in	GO:0042448	progesterone metabolic process	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000199031 RGD:708428 UniProtKB:P42330	P		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000198921 SGD:S000005646 UniProtKB:Q96JD6	F		Seeded From UniProt	complete
enables	GO:0016229	steroid dehydrogenase activity	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000199026 RGD:708361	F		Seeded From UniProt	complete
involved_in	GO:0008202	steroid metabolic process	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1933427 PANTHER:PTN000199026 UniProtKB:P42330 UniProtKB:P52895	P		Seeded From UniProt	complete
enables	GO:0008106	alcohol dehydrogenase (NADP+) activity	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG13015 PANTHER:PTN000198921 TAIR:locus:2040646 UniProtKB:Q90W83	F		Seeded From UniProt	complete
involved_in	GO:0006693	prostaglandin metabolic process	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000199031 UniProtKB:P42330	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG13015 MGI:MGI:1929955 PANTHER:PTN000198921 RGD:2092 RGD:708428 RGD:708475 SGD:S000000353 TAIR:locus:2025936 TAIR:locus:2040751 TAIR:locus:2065639 TAIR:locus:2084505 UniProtKB:C9JRZ8 UniProtKB:P15121 UniProtKB:P51857 UniProtKB:Q04828 UniProtKB:Q96JD6 UniProtKB:Q9SJV2 dictyBase:DDB_G0293850	C		Seeded From UniProt	complete
enables	GO:0004032	alditol:NADP+ 1-oxidoreductase activity	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1353494 MGI:MGI:1929955 PANTHER:PTN000198921 RGD:2092 RGD:708428 SGD:S000001146 SGD:S000002282 SGD:S000002776 SGD:S000003857 SGD:S000005646 UniProtKB:P15121 UniProtKB:P42330 UniProtKB:P52895 UniProtKB:Q04828 dictyBase:DDB_G0293850	F		Seeded From UniProt	complete
involved_in	GO:0042572	retinol metabolic process	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0052650	P		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018170 InterPro:IPR020471	F		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018170 InterPro:IPR020471	P		Seeded From UniProt	complete
enables	GO:0047718	indanol dehydrogenase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.1.1.112	F		Seeded From UniProt	complete
enables	GO:0047035	testosterone dehydrogenase (NAD+) activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.1.1.239	F		Seeded From UniProt	complete
enables	GO:0036131	prostaglandin D2 11-ketoreductase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.1.1.188	F		Seeded From UniProt	complete
enables	GO:0047017	prostaglandin-F synthase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.1.1.188	F		Seeded From UniProt	complete
enables	GO:0047115	trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.3.1.20	F		Seeded From UniProt	complete
enables	GO:0047045	testosterone 17-beta-dehydrogenase (NADP+) activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.1.1.64	F		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	PMID:9792917^[1]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006693	prostaglandin metabolic process	PMID:9792917^[1]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004033	aldo-keto reductase (NADP) activity	PMID:9792917^[1]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0052650	NADP-retinol dehydrogenase activity	Reactome:R-HSA-5615668	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0036131	prostaglandin D2 11-ketoreductase activity	Reactome:R-HSA-2161614	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0036130	prostaglandin H2 endoperoxidase reductase activity	Reactome:R-HSA-2161549	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0019371	cyclooxygenase pathway	Reactome:R-HSA-2162123	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-5615668 Reactome:R-HSA-2855252 Reactome:R-HSA-2161614 Reactome:R-HSA-2161549	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0001523	retinoid metabolic process	Reactome:R-HSA-975634	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Matsuura, K et al. (1998) Identification of a principal mRNA species for human 3alpha-hydroxysteroid dehydrogenase isoform (AKR1C3) that exhibits high prostaglandin D2 11-ketoreductase activity. J. Biochem. 124 940-6 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Matsunaga, T et al. (2009) Involvement of an aldo-keto reductase (AKR1C3) in redox cycling of 9,10-phenanthrenequinone leading to apoptosis in human endothelial cells. Chem. Biol. Interact. 181 52-60 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Nakamura, Y et al. (2009) Type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3) contributes to testosterone production in the adrenal reticularis. J. Clin. Endocrinol. Metab. 94 2192-8 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 Ruiz, FX et al. (2011) Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily. Biochem. J. 440 335-44 PubMed GONUTS page
↑ ^6.0 ^6.1 Davies, NJ et al. (2009) AKR1C isoforms represent a novel cellular target for jasmonates alongside their mitochondrial-mediated effects. Cancer Res. 69 4769-75 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Mantel, A et al. (2012) Aldo-keto reductase 1C3 is expressed in differentiated human epidermis, affects keratinocyte differentiation, and is upregulated in atopic dermatitis. J. Invest. Dermatol. 132 1103-10 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Lee, YJ et al. (2011) Cadmium-induced up-regulation of aldo-keto reductase 1C3 expression in human nasal septum carcinoma RPMI-2650 cells: Involvement of reactive oxygen species and phosphatidylinositol 3-kinase/Akt. Environ. Toxicol. Pharmacol. 31 469-78 PubMed GONUTS page
↑ Sakurai, M et al. (2005) Localization of cyclooxygenases-1 and -2, and prostaglandin F synthase in human kidney and renal cell carcinoma. Biochem. Biophys. Res. Commun. 338 82-6 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 Jakobsson, J et al. (2007) A novel polymorphism in the 17beta-hydroxysteroid dehydrogenase type 5 (aldo-keto reductase 1C3) gene is associated with lower serum testosterone levels in caucasian men. Pharmacogenomics J. 7 282-9 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Hevir, N et al. (2011) Aldo-keto reductases AKR1C1, AKR1C2 and AKR1C3 may enhance progesterone metabolism in ovarian endometriosis. Chem. Biol. Interact. 191 217-26 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Wang, S et al. (2008) AKR1C2 and AKR1C3 mediated prostaglandin D2 metabolism augments the PI3K/Akt proliferative signaling pathway in human prostate cancer cells. Mol. Cell. Endocrinol. 289 60-6 PubMed GONUTS page
↑ ^13.0 ^13.1 Endo, S et al. (2011) Roles of rat and human aldo-keto reductases in metabolism of farnesol and geranylgeraniol. Chem. Biol. Interact. 191 261-8 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Bains, OS et al. (2010) Naturally occurring variants of human aldo-keto reductases with reduced in vitro metabolism of daunorubicin and doxorubicin. J. Pharmacol. Exp. Ther. 335 533-45 PubMed GONUTS page
↑ ^15.0 ^15.1 Svensson, PA et al. (2008) Regulation of human aldoketoreductase 1C3 (AKR1C3) gene expression in the adipose tissue. Cell. Mol. Biol. Lett. 13 599-613 PubMed GONUTS page
↑ ^16.0 ^16.1 Ashley, RA et al. (2010) Developmental evaluation of aldo-keto reductase 1C3 expression in the cryptorchid testis. Urology 76 67-72 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 Byrns, MC et al. (2010) Aldo-keto reductase 1C3 expression in MCF-7 cells reveals roles in steroid hormone and prostaglandin metabolism that may explain its over-expression in breast cancer. J. Steroid Biochem. Mol. Biol. 118 177-87 PubMed GONUTS page
↑ Skarydová, L et al. (2009) AKR1C3 as a potential target for the inhibitory effect of dietary flavonoids. Chem. Biol. Interact. 178 138-44 PubMed GONUTS page
↑ ^19.0 ^19.1 Azzarello, J et al. (2008) Tissue distribution of human AKR1C3 and rat homolog in the adult genitourinary system. J. Histochem. Cytochem. 56 853-61 PubMed GONUTS page
↑ ^20.00 ^20.01 ^20.02 ^20.03 ^20.04 ^20.05 ^20.06 ^20.07 ^20.08 ^20.09 ^20.10 ^20.11 ^20.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9792917-1] 1.0 ^1.1 ^1.2 ^1.3 Matsuura, K et al. (1998) Identification of a principal mRNA species for human 3alpha-hydroxysteroid dehydrogenase isoform (AKR1C3) that exhibits high prostaglandin D2 11-ketoreductase activity. J. Biochem. 124 940-6 PubMed GONUTS page

[PMID:23533145-2] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:19442656-3] 3.0 ^3.1 ^3.2 ^3.3 Matsunaga, T et al. (2009) Involvement of an aldo-keto reductase (AKR1C3) in redox cycling of 9,10-phenanthrenequinone leading to apoptosis in human endothelial cells. Chem. Biol. Interact. 181 52-60 PubMed GONUTS page

[PMID:19336506-4] 4.0 ^4.1 ^4.2 Nakamura, Y et al. (2009) Type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3) contributes to testosterone production in the adrenal reticularis. J. Clin. Endocrinol. Metab. 94 2192-8 PubMed GONUTS page

[PMID:21851338-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 Ruiz, FX et al. (2011) Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily. Biochem. J. 440 335-44 PubMed GONUTS page

[PMID:19487289-6] 6.0 ^6.1 Davies, NJ et al. (2009) AKR1C isoforms represent a novel cellular target for jasmonates alongside their mitochondrial-mediated effects. Cancer Res. 69 4769-75 PubMed GONUTS page

[PMID:22170488-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Mantel, A et al. (2012) Aldo-keto reductase 1C3 is expressed in differentiated human epidermis, affects keratinocyte differentiation, and is upregulated in atopic dermatitis. J. Invest. Dermatol. 132 1103-10 PubMed GONUTS page

[PMID:21787718-8] 8.0 ^8.1 ^8.2 Lee, YJ et al. (2011) Cadmium-induced up-regulation of aldo-keto reductase 1C3 expression in human nasal septum carcinoma RPMI-2650 cells: Involvement of reactive oxygen species and phosphatidylinositol 3-kinase/Akt. Environ. Toxicol. Pharmacol. 31 469-78 PubMed GONUTS page

[PMID:16157291-9] Sakurai, M et al. (2005) Localization of cyclooxygenases-1 and -2, and prostaglandin F synthase in human kidney and renal cell carcinoma. Biochem. Biophys. Res. Commun. 338 82-6 PubMed GONUTS page

[PMID:16983398-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 Jakobsson, J et al. (2007) A novel polymorphism in the 17beta-hydroxysteroid dehydrogenase type 5 (aldo-keto reductase 1C3) gene is associated with lower serum testosterone levels in caucasian men. Pharmacogenomics J. 7 282-9 PubMed GONUTS page

[PMID:21232532-11] 11.0 ^11.1 ^11.2 ^11.3 Hevir, N et al. (2011) Aldo-keto reductases AKR1C1, AKR1C2 and AKR1C3 may enhance progesterone metabolism in ovarian endometriosis. Chem. Biol. Interact. 191 217-26 PubMed GONUTS page

[PMID:18508192-12] 12.0 ^12.1 ^12.2 ^12.3 Wang, S et al. (2008) AKR1C2 and AKR1C3 mediated prostaglandin D2 metabolism augments the PI3K/Akt proliferative signaling pathway in human prostate cancer cells. Mol. Cell. Endocrinol. 289 60-6 PubMed GONUTS page

[PMID:21187079-13] 13.0 ^13.1 Endo, S et al. (2011) Roles of rat and human aldo-keto reductases in metabolism of farnesol and geranylgeraniol. Chem. Biol. Interact. 191 261-8 PubMed GONUTS page

[PMID:20837989-14] 14.0 ^14.1 ^14.2 Bains, OS et al. (2010) Naturally occurring variants of human aldo-keto reductases with reduced in vitro metabolism of daunorubicin and doxorubicin. J. Pharmacol. Exp. Ther. 335 533-45 PubMed GONUTS page

[PMID:18641923-15] 15.0 ^15.1 Svensson, PA et al. (2008) Regulation of human aldoketoreductase 1C3 (AKR1C3) gene expression in the adipose tissue. Cell. Mol. Biol. Lett. 13 599-613 PubMed GONUTS page

[PMID:19942269-16] 16.0 ^16.1 Ashley, RA et al. (2010) Developmental evaluation of aldo-keto reductase 1C3 expression in the cryptorchid testis. Urology 76 67-72 PubMed GONUTS page

[PMID:20036328-17] 17.0 ^17.1 ^17.2 Byrns, MC et al. (2010) Aldo-keto reductase 1C3 expression in MCF-7 cells reveals roles in steroid hormone and prostaglandin metabolism that may explain its over-expression in breast cancer. J. Steroid Biochem. Mol. Biol. 118 177-87 PubMed GONUTS page

[PMID:19007764-18] Skarydová, L et al. (2009) AKR1C3 as a potential target for the inhibitory effect of dietary flavonoids. Chem. Biol. Interact. 178 138-44 PubMed GONUTS page

[PMID:18574251-19] 19.0 ^19.1 Azzarello, J et al. (2008) Tissue distribution of human AKR1C3 and rat homolog in the adult genitourinary system. J. Histochem. Cytochem. 56 853-61 PubMed GONUTS page

[PMID:21873635-20] 20.00 ^20.01 ^20.02 ^20.03 ^20.04 ^20.05 ^20.06 ^20.07 ^20.08 ^20.09 ^20.10 ^20.11 ^20.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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