Category:GO:0047787 ! Delta4-3-oxosteroid 5beta-reductase activity

name: Delta4-3-oxosteroid 5beta-reductase activity
namespace: molecular_function
alt_id: GO:0047752
def: "Catalysis of the reaction: a 3-oxo-5beta-steroid + NADP+ = a 3-oxo-Delta(4)-steroid + H+ + NADPH. The enzyme from human efficiently catalyzes the reduction of progesterone, androstenedione, 17alpha-hydroxyprogesterone and testosterone to 5beta-reduced metabolites; it can also act on aldosterone, corticosterone and cortisol, but to a lesser extent. The bile acid intermediates 7alpha,12alpha-dihydroxy-4-cholesten-3- one and 7alpha-hydroxy-4-cholesten-3-one can also act as substrates." [EC:1.3.1.3]
synonym: "3-oxo-5beta-steroid:NADP+ delta4-oxidoreductase activity" EXACT [EC:1.3.1.3]
synonym: "3-oxo-Delta(4)-steroid 5-beta-reductase activity" EXACT [EC:1.3.1.3]
synonym: "3-oxo-Delta4-steroid 5beta-reductase activity" EXACT [EC:1.3.1.3]
synonym: "4,5beta-dihydrocortisone:NADP+ delta4-oxidoreductase activity" NARROW [EC:1.3.1.3]
synonym: "5-beta-reductase activity" BROAD [EC:1.3.1.3]
synonym: "5beta-cholestan-3-one:NADP+ 4,5-oxidoreductase activity" NARROW [EC:1.3.1.3]
synonym: "5beta-reductase activity" RELATED [EC:1.3.1.3]
synonym: "androstenedione 5-beta-reductase activity" NARROW [EC:1.3.1.3]
synonym: "androstenedione 5beta-reductase activity" NARROW [EC:1.3.1.3]
synonym: "cholestenone 5-beta-reductase activity" NARROW []
synonym: "cholestenone 5b-reductase activity" NARROW []
synonym: "cholestenone 5beta-reductase activity" NARROW [EC:1.3.1.3]
synonym: "cortisone 5-beta-reductase activity" NARROW [EC:1.3.1.3]
synonym: "cortisone 5beta-reductase activity" NARROW [EC:1.3.1.3]
synonym: "cortisone b-reductase activity" NARROW []
synonym: "cortisone beta-reductase activity" NARROW []
synonym: "cortisone delta(4)-5-beta-reductase activity" NARROW [EC:1.3.1.3]
synonym: "cortisone delta4-5beta-reductase activity" RELATED [EC:1.3.1.3]
synonym: "Delta(4)-3-ketosteroid 5-beta-reductase activity" RELATED [EC:1.3.1.3]
synonym: "Delta(4)-5-beta-reductase activity" RELATED [EC:1.3.1.3]
synonym: "Delta(4)-hydrogenase activity" RELATED [EC:1.3.1.3]
synonym: "Delta4-3-ketosteroid 5beta-reductase activity" RELATED [EC:1.3.1.3]
synonym: "Delta4-3-oxosteroid 5-beta-reductase activity" EXACT []
synonym: "Delta4-5beta-reductase activity" RELATED [EC:1.3.1.3]
synonym: "Delta4-hydrogenase activity" RELATED [EC:1.3.1.3]
synonym: "steroid 5-beta-reductase activity" RELATED [EC:1.3.1.3]
synonym: "steroid 5beta-reductase activity" RELATED [EC:1.3.1.3]
synonym: "testosterone 5-beta-reductase activity" NARROW [EC:1.3.1.3]
synonym: "testosterone 5beta-reductase activity" NARROW [EC:1.3.1.3]
xref: EC:1.3.1.3
xref: MetaCyc:RXN-23672
xref: RHEA:54412
is_a: GO:0035671 ! enone reductase activity

AmiGO <GOterm>GO:0047787</GOterm>
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