HUMAN:ADIPO

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	ADIPOQ (synonyms: ACDC, ACRP30, APM1, GBP28)
Protein Name(s)	Adiponectin 30 kDa adipocyte complement-related protein Adipocyte complement-related 30 kDa protein ACRP30 Adipocyte, C1q and collagen domain-containing protein Adipose most abundant gene transcript 1 protein apM-1 Gelatin-binding protein
External Links
UniProt	Q15848
EMBL	D45371 AB012165 AJ131460 AJ131461 BC054496 BC096308 BC096309 BC096310 BC096311
CCDS	CCDS3284.1
PIR	JC4708
RefSeq	NP_001171271.1 NP_004788.1
UniGene	Hs.80485
PDB	4DOU
PDBsum	4DOU
ProteinModelPortal	Q15848
SMR	Q15848
BioGrid	114771
STRING	9606.ENSP00000320709
DMDM	2493789
PaxDb	Q15848
PeptideAtlas	Q15848
PRIDE	Q15848
Ensembl	ENST00000320741 ENST00000444204
GeneID	9370
KEGG	hsa:9370
UCSC	uc003fra.3
CTD	9370
GeneCards	GC03P186560
HGNC	HGNC:13633
HPA	CAB046467
MIM	125853 605441 612556
neXtProt	NX_Q15848
PharmGKB	PA134933118
eggNOG	NOG136972
GeneTree	ENSGT00760000118830
HOGENOM	HOG000085653
HOVERGEN	HBG108220
InParanoid	Q15848
KO	K07296
OMA	LFTYDQY
OrthoDB	EOG70ZZPW
PhylomeDB	Q15848
TreeFam	TF329591
Reactome	REACT_27161
ChiTaRS	ADIPOQ
GeneWiki	Adiponectin
GenomeRNAi	9370
NextBio	35094
PRO	PR:Q15848
Proteomes	UP000005640
Bgee	Q15848
CleanEx	HS_ADIPOQ
ExpressionAtlas	Q15848
Genevestigator	Q15848
GO	GO:0009986 GO:0005581 GO:0005783 GO:0005576 GO:0005615 GO:0070062 GO:0005125 GO:0005179 GO:0042802 GO:0042803 GO:0005102 GO:0033691 GO:0033211 GO:0050873 GO:0071320 GO:0035690 GO:0071872 GO:0032869 GO:0007623 GO:0070994 GO:0006635 GO:0019395 GO:0006091 GO:0042593 GO:0006006 GO:0034383 GO:0051899 GO:0060081 GO:0045776 GO:0030336 GO:2000279 GO:0070373 GO:0045599 GO:0045721 GO:0030853 GO:0034115 GO:0046888 GO:0043124 GO:0050728 GO:0090317 GO:0045715 GO:0010745 GO:0045650 GO:0043407 GO:2000590 GO:0050765 GO:0010642 GO:2000584 GO:0031953 GO:1900121 GO:0014912 GO:0048662 GO:0050805 GO:0045892 GO:0032720 GO:0010804 GO:0045777 GO:2000481 GO:0032270 GO:0010875 GO:0045923 GO:0046326 GO:2000467 GO:0043123 GO:0032757 GO:2000478 GO:0071639 GO:0033034 GO:0050731 GO:0010739 GO:0001934 GO:2000534 GO:0009967 GO:0070208 GO:0051260 GO:0072659 GO:0010906 GO:0014823 GO:0045471 GO:0051384 GO:0009749 GO:0001666 GO:0070543 GO:0007584 GO:0009744 GO:0034612
Gene3D	2.60.120.40
InterPro	IPR028572 IPR001073 IPR008160 IPR008983
PANTHER	PTHR24022:SF81
Pfam	PF00386 PF01391
PRINTS	PR00007
SMART	SM00110
SUPFAM	SSF49842
PROSITE	PS50871

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:28675934^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0003688)	Seeded From UniProt	complete
enables	GO:0005201	extracellular matrix structural constituent	PMID:28675934^[1]	ECO:0007666	automatically integrated combinatorial computational and experimental evidence used in manual assertion		F	occurs_in:(UBERON:0003688)	Seeded From UniProt	complete
involved_in	GO:0120163	negative regulation of cold-induced thermogenesis	PMID:26166748^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60994	P		Seeded From UniProt	complete
involved_in	GO:0120163	negative regulation of cold-induced thermogenesis	PMID:24531262^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60994	P		Seeded From UniProt	complete
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	PMID:26166748^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60994	P		Seeded From UniProt	complete
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	PMID:24531262^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60994	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:27068509^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0007318)	Seeded From UniProt	complete
involved_in	GO:0050765	negative regulation of phagocytosis	PMID:10961870^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	PMID:12611609^[6]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046326	positive regulation of glucose import	PMID:12368907^[7]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60994	P		Seeded From UniProt	complete
involved_in	GO:0045923	positive regulation of fatty acid metabolic process	PMID:12368907^[7]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60994	P		Seeded From UniProt	complete
involved_in	GO:0045721	negative regulation of gluconeogenesis	PMID:12368907^[7]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60994	P		Seeded From UniProt	complete
involved_in	GO:0045715	negative regulation of low-density lipoprotein particle receptor biosynthetic process	PMID:11222466^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045650	negative regulation of macrophage differentiation	PMID:10961870^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045599	negative regulation of fat cell differentiation	PMID:12021245^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	PMID:10982546^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:12021245^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q15848	F		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	PMID:12368907^[7]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60994	P		Seeded From UniProt	complete
involved_in	GO:0034612	response to tumor necrosis factor	PMID:10604883^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034383	low-density lipoprotein particle clearance	PMID:11222466^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034115	negative regulation of heterotypic cell-cell adhesion	PMID:10604883^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033034	positive regulation of myeloid cell apoptotic process	PMID:10961870^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032720	negative regulation of tumor necrosis factor production	PMID:10961870^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032270	positive regulation of cellular protein metabolic process	PMID:18703020^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000235) has_output:(UniProtKB:O95477)	Seeded From UniProt	complete
involved_in	GO:0030853	negative regulation of granulocyte differentiation	PMID:10961870^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010875	positive regulation of cholesterol efflux	PMID:18703020^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000235)	Seeded From UniProt	complete
involved_in	GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway	PMID:10604883^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010745	negative regulation of macrophage derived foam cell differentiation	PMID:11222466^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010739	positive regulation of protein kinase A signaling	PMID:10982546^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:10982546^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0009967	positive regulation of signal transduction	PMID:12368907^[7]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60994	P		Seeded From UniProt	complete
involved_in	GO:0009749	response to glucose	PMID:12368907^[7]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60994	P		Seeded From UniProt	complete
involved_in	GO:0006635	fatty acid beta-oxidation	PMID:12368907^[7]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60994	P		Seeded From UniProt	complete
involved_in	GO:0006006	glucose metabolic process	PMID:12368907^[7]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60994	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:10403784^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005179	hormone activity	PMID:11222466^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:12611609^[6]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:12368907^[7]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60994	F		Seeded From UniProt	complete
involved_in	GO:2000590	negative regulation of metanephric mesenchymal cell migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60994	P		Seeded From UniProt	complete
involved_in	GO:2000584	negative regulation of platelet-derived growth factor receptor-alpha signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60994	P		Seeded From UniProt	complete
involved_in	GO:2000534	positive regulation of renal albumin absorption	PMID:18431508^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000481	positive regulation of cAMP-dependent protein kinase activity	PMID:19524870^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000481	positive regulation of cAMP-dependent protein kinase activity	PMID:18431508^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000478	positive regulation of metanephric glomerular visceral epithelial cell development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60994	P		Seeded From UniProt	complete
involved_in	GO:2000467	positive regulation of glycogen (starch) synthase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8K3R4	P		Seeded From UniProt	complete
involved_in	GO:2000279	negative regulation of DNA biosynthetic process	PMID:12070119^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900121	negative regulation of receptor binding	PMID:12070119^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090317	negative regulation of intracellular protein transport	PMID:18431508^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072659	protein localization to plasma membrane	PMID:18431508^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071639	positive regulation of monocyte chemotactic protein-1 production	PMID:19524870^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070994	detection of oxidative stress	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60994	P		Seeded From UniProt	complete
involved_in	GO:0070373	negative regulation of ERK1 and ERK2 cascade	PMID:12070119^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60994	P		Seeded From UniProt	complete
involved_in	GO:0050873	brown fat cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60994	P		Seeded From UniProt	complete
involved_in	GO:0050805	negative regulation of synaptic transmission	PMID:17327472^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60994	P		Seeded From UniProt	complete
involved_in	GO:1904706	negative regulation of vascular smooth muscle cell proliferation	PMID:12070119^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:18431508^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045776	negative regulation of blood pressure	PMID:17327472^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043407	negative regulation of MAP kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60994	P		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60994	P		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60994	P		Seeded From UniProt	complete
involved_in	GO:0035690	cellular response to drug	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60994	P		Seeded From UniProt	complete
enables	GO:0033691	sialic acid binding	PMID:19855092^[18]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032869	cellular response to insulin stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60994	P		Seeded From UniProt	complete
involved_in	GO:0032757	positive regulation of interleukin-8 production	PMID:19524870^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031953	negative regulation of protein autophosphorylation	PMID:12070119^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030336	negative regulation of cell migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60994	P		Seeded From UniProt	complete
involved_in	GO:0019395	fatty acid oxidation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60994	P		Seeded From UniProt	complete
involved_in	GO:1904753	negative regulation of vascular associated smooth muscle cell migration	PMID:12070119^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010906	regulation of glucose metabolic process	PMID:17327472^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway	PMID:12070119^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006635	fatty acid beta-oxidation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60994	P		Seeded From UniProt	complete
involved_in	GO:0006006	glucose metabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60994	P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60994	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:15585515^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:17327472^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60994	F		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	PMID:18431508^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005179	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005179	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005179	P		Seeded From UniProt	complete
involved_in	GO:2000590	negative regulation of metanephric mesenchymal cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60994 ensembl:ENSMUSP00000023593	P		Seeded From UniProt	complete
involved_in	GO:2000584	negative regulation of platelet-derived growth factor receptor-alpha signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60994 ensembl:ENSMUSP00000023593	P		Seeded From UniProt	complete
involved_in	GO:2000534	positive regulation of renal albumin absorption	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60994 ensembl:ENSMUSP00000023593	P		Seeded From UniProt	complete
involved_in	GO:2000481	positive regulation of cAMP-dependent protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60994 ensembl:ENSMUSP00000023593	P		Seeded From UniProt	complete
involved_in	GO:2000478	positive regulation of metanephric glomerular visceral epithelial cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60994 ensembl:ENSMUSP00000023593	P		Seeded From UniProt	complete
involved_in	GO:0120163	negative regulation of cold-induced thermogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60994 ensembl:ENSMUSP00000023593	P		Seeded From UniProt	complete
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60994 ensembl:ENSMUSP00000023593	P		Seeded From UniProt	complete
involved_in	GO:0070994	detection of oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60994 ensembl:ENSMUSP00000023593	P		Seeded From UniProt	complete
involved_in	GO:0070208	protein heterotrimerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60994 ensembl:ENSMUSP00000023593	P		Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60994 ensembl:ENSMUSP00000023593	P		Seeded From UniProt	complete
involved_in	GO:0050873	brown fat cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60994 ensembl:ENSMUSP00000023593	P		Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60994 ensembl:ENSMUSP00000023593	P		Seeded From UniProt	complete
involved_in	GO:0046326	positive regulation of glucose import	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60994 ensembl:ENSMUSP00000023593	P		Seeded From UniProt	complete
involved_in	GO:0045923	positive regulation of fatty acid metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60994 ensembl:ENSMUSP00000023593	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60994 ensembl:ENSMUSP00000023593	P		Seeded From UniProt	complete
involved_in	GO:0045721	negative regulation of gluconeogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60994 ensembl:ENSMUSP00000023593	P		Seeded From UniProt	complete
involved_in	GO:0045599	negative regulation of fat cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60994 ensembl:ENSMUSP00000023593	P		Seeded From UniProt	complete
involved_in	GO:0043407	negative regulation of MAP kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60994 ensembl:ENSMUSP00000023593	P		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60994 ensembl:ENSMUSP00000023593	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60994 ensembl:ENSMUSP00000023593	F		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60994 ensembl:ENSMUSP00000023593	P		Seeded From UniProt	complete
involved_in	GO:0035690	cellular response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60994 ensembl:ENSMUSP00000023593	P		Seeded From UniProt	complete
involved_in	GO:0032869	cellular response to insulin stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60994 ensembl:ENSMUSP00000023593	P		Seeded From UniProt	complete
involved_in	GO:0030336	negative regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60994 ensembl:ENSMUSP00000023593	P		Seeded From UniProt	complete
involved_in	GO:0019395	fatty acid oxidation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60994 ensembl:ENSMUSP00000023593	P		Seeded From UniProt	complete
involved_in	GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60994 ensembl:ENSMUSP00000023593	P		Seeded From UniProt	complete
involved_in	GO:0009967	positive regulation of signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60994 ensembl:ENSMUSP00000023593	P		Seeded From UniProt	complete
involved_in	GO:0009749	response to glucose	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60994 ensembl:ENSMUSP00000023593	P		Seeded From UniProt	complete
involved_in	GO:0009617	response to bacterium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60994 ensembl:ENSMUSP00000023593	P		Seeded From UniProt	complete
involved_in	GO:0006635	fatty acid beta-oxidation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60994 ensembl:ENSMUSP00000023593	P		Seeded From UniProt	complete
involved_in	GO:0006006	glucose metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60994 ensembl:ENSMUSP00000023593	P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60994 ensembl:ENSMUSP00000023593	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60994 ensembl:ENSMUSP00000023593	C		Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60994 ensembl:ENSMUSP00000023593	F		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60994 ensembl:ENSMUSP00000023593	F		Seeded From UniProt	complete
involved_in	GO:2000467	positive regulation of glycogen (starch) synthase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8K3R4 ensembl:ENSRNOP00000002492	P		Seeded From UniProt	complete
involved_in	GO:0071872	cellular response to epinephrine stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8K3R4 ensembl:ENSRNOP00000002492	P		Seeded From UniProt	complete
involved_in	GO:0071320	cellular response to cAMP	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8K3R4 ensembl:ENSRNOP00000002492	P		Seeded From UniProt	complete
involved_in	GO:0070543	response to linoleic acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8K3R4 ensembl:ENSRNOP00000002492	P		Seeded From UniProt	complete
involved_in	GO:0051384	response to glucocorticoid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8K3R4 ensembl:ENSRNOP00000002492	P		Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8K3R4 ensembl:ENSRNOP00000002492	P		Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8K3R4 ensembl:ENSRNOP00000002492	P		Seeded From UniProt	complete
involved_in	GO:0046888	negative regulation of hormone secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8K3R4 ensembl:ENSRNOP00000002492	P		Seeded From UniProt	complete
involved_in	GO:0045860	positive regulation of protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8K3R4 ensembl:ENSRNOP00000002492	P		Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8K3R4 ensembl:ENSRNOP00000002492	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8K3R4 ensembl:ENSRNOP00000002492	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8K3R4 ensembl:ENSRNOP00000002492	C		Seeded From UniProt	complete
involved_in	GO:0032869	cellular response to insulin stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8K3R4 ensembl:ENSRNOP00000002492	P		Seeded From UniProt	complete
involved_in	GO:0031667	response to nutrient levels	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8K3R4 ensembl:ENSRNOP00000002492	P		Seeded From UniProt	complete
involved_in	GO:0014823	response to activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8K3R4 ensembl:ENSRNOP00000002492	P		Seeded From UniProt	complete
involved_in	GO:0009744	response to sucrose	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8K3R4 ensembl:ENSRNOP00000002492	P		Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8K3R4 ensembl:ENSRNOP00000002492	P		Seeded From UniProt	complete
involved_in	GO:0007584	response to nutrient	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8K3R4 ensembl:ENSRNOP00000002492	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8K3R4 ensembl:ENSRNOP00000002492	C		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8K3R4 ensembl:ENSRNOP00000002492	P		Seeded From UniProt	complete
involved_in	GO:0006091	generation of precursor metabolites and energy	PMID:10095105^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:10961870^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0042304	regulation of fatty acid biosynthetic process	Reactome:R-HSA-163680	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-8848663 Reactome:R-HSA-1183058	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005581	collagen trimer	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0176	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0372	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Naba, A et al. (2017) Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics. J. Proteome Res. 16 3083-3091 PubMed GONUTS page
↑ ^2.0 ^2.1 Hui, X et al. (2015) Adiponectin Enhances Cold-Induced Browning of Subcutaneous Adipose Tissue via Promoting M2 Macrophage Proliferation. Cell Metab. 22 279-90 PubMed GONUTS page
↑ ^3.0 ^3.1 Qiao, L et al. (2014) Adiponectin reduces thermogenesis by inhibiting brown adipose tissue activation in mice. Diabetologia 57 1027-36 PubMed GONUTS page
↑ Barallobre-Barreiro, J et al. (2016) Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc. Res. 110 419-30 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Yokota, T et al. (2000) Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages. Blood 96 1723-32 PubMed GONUTS page
↑ ^6.0 ^6.1 Díez, JJ & Iglesias, P (2003) The role of the novel adipocyte-derived hormone adiponectin in human disease. Eur. J. Endocrinol. 148 293-300 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 Yamauchi, T et al. (2002) Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat. Med. 8 1288-95 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Ouchi, N et al. (2001) Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages. Circulation 103 1057-63 PubMed GONUTS page
↑ ^9.0 ^9.1 Yokota, T et al. (2002) Paracrine regulation of fat cell formation in bone marrow cultures via adiponectin and prostaglandins. J. Clin. Invest. 109 1303-10 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Ouchi, N et al. (2000) Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway. Circulation 102 1296-301 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Ouchi, N et al. () Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin. Circulation 100 2473-6 PubMed GONUTS page
↑ ^12.0 ^12.1 Tsubakio-Yamamoto, K et al. (2008) Adiponectin prevents atherosclerosis by increasing cholesterol efflux from macrophages. Biochem. Biophys. Res. Commun. 375 390-4 PubMed GONUTS page
↑ Schäffler, A et al. (1999) The human apM-1, an adipocyte-specific gene linked to the family of TNF's and to genes expressed in activated T cells, is mapped to chromosome 1q21.3-q23, a susceptibility locus identified for familial combined hyperlipidaemia (FCH). Biochem. Biophys. Res. Commun. 260 416-25 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 Sharma, K et al. (2008) Adiponectin regulates albuminuria and podocyte function in mice. J. Clin. Invest. 118 1645-56 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Song, H et al. (2009) Induction of chemokine expression by adiponectin in vitro is isoform dependent. Transl Res 154 18-26 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 ^16.6 Arita, Y et al. (2002) Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell. Circulation 105 2893-8 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 Tanida, M et al. (2007) Effects of adiponectin on the renal sympathetic nerve activity and blood pressure in rats. Exp. Biol. Med. (Maywood) 232 390-7 PubMed GONUTS page
↑ Richards, AA et al. (2010) Sialic acid modification of adiponectin is not required for multimerization or secretion but determines half-life in circulation. Mol. Endocrinol. 24 229-39 PubMed GONUTS page
↑ Guebre-Egziabher, F et al. (2005) Adiponectin in chronic kidney disease is related more to metabolic disturbances than to decline in renal function. Nephrol. Dial. Transplant. 20 129-34 PubMed GONUTS page
↑ Saito, K et al. (1999) Organization of the gene for gelatin-binding protein (GBP28). Gene 229 67-73 PubMed GONUTS page

[PMID:28675934-1] 1.0 ^1.1 Naba, A et al. (2017) Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics. J. Proteome Res. 16 3083-3091 PubMed GONUTS page

[PMID:26166748-2] 2.0 ^2.1 Hui, X et al. (2015) Adiponectin Enhances Cold-Induced Browning of Subcutaneous Adipose Tissue via Promoting M2 Macrophage Proliferation. Cell Metab. 22 279-90 PubMed GONUTS page

[PMID:24531262-3] 3.0 ^3.1 Qiao, L et al. (2014) Adiponectin reduces thermogenesis by inhibiting brown adipose tissue activation in mice. Diabetologia 57 1027-36 PubMed GONUTS page

[PMID:27068509-4] Barallobre-Barreiro, J et al. (2016) Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc. Res. 110 419-30 PubMed GONUTS page

[PMID:10961870-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Yokota, T et al. (2000) Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages. Blood 96 1723-32 PubMed GONUTS page

[PMID:12611609-6] 6.0 ^6.1 Díez, JJ & Iglesias, P (2003) The role of the novel adipocyte-derived hormone adiponectin in human disease. Eur. J. Endocrinol. 148 293-300 PubMed GONUTS page

[PMID:12368907-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 Yamauchi, T et al. (2002) Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat. Med. 8 1288-95 PubMed GONUTS page

[PMID:11222466-8] 8.0 ^8.1 ^8.2 ^8.3 Ouchi, N et al. (2001) Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages. Circulation 103 1057-63 PubMed GONUTS page

[PMID:12021245-9] 9.0 ^9.1 Yokota, T et al. (2002) Paracrine regulation of fat cell formation in bone marrow cultures via adiponectin and prostaglandins. J. Clin. Invest. 109 1303-10 PubMed GONUTS page

[PMID:10982546-10] 10.0 ^10.1 ^10.2 Ouchi, N et al. (2000) Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway. Circulation 102 1296-301 PubMed GONUTS page

[PMID:10604883-11] 11.0 ^11.1 ^11.2 Ouchi, N et al. () Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin. Circulation 100 2473-6 PubMed GONUTS page

[PMID:18703020-12] 12.0 ^12.1 Tsubakio-Yamamoto, K et al. (2008) Adiponectin prevents atherosclerosis by increasing cholesterol efflux from macrophages. Biochem. Biophys. Res. Commun. 375 390-4 PubMed GONUTS page

[PMID:10403784-13] Schäffler, A et al. (1999) The human apM-1, an adipocyte-specific gene linked to the family of TNF's and to genes expressed in activated T cells, is mapped to chromosome 1q21.3-q23, a susceptibility locus identified for familial combined hyperlipidaemia (FCH). Biochem. Biophys. Res. Commun. 260 416-25 PubMed GONUTS page

[PMID:18431508-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 Sharma, K et al. (2008) Adiponectin regulates albuminuria and podocyte function in mice. J. Clin. Invest. 118 1645-56 PubMed GONUTS page

[PMID:19524870-15] 15.0 ^15.1 ^15.2 Song, H et al. (2009) Induction of chemokine expression by adiponectin in vitro is isoform dependent. Transl Res 154 18-26 PubMed GONUTS page

[PMID:12070119-16] 16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 ^16.6 Arita, Y et al. (2002) Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell. Circulation 105 2893-8 PubMed GONUTS page

[PMID:17327472-17] 17.0 ^17.1 ^17.2 ^17.3 Tanida, M et al. (2007) Effects of adiponectin on the renal sympathetic nerve activity and blood pressure in rats. Exp. Biol. Med. (Maywood) 232 390-7 PubMed GONUTS page

[PMID:19855092-18] Richards, AA et al. (2010) Sialic acid modification of adiponectin is not required for multimerization or secretion but determines half-life in circulation. Mol. Endocrinol. 24 229-39 PubMed GONUTS page

[PMID:15585515-19] Guebre-Egziabher, F et al. (2005) Adiponectin in chronic kidney disease is related more to metabolic disturbances than to decline in renal function. Nephrol. Dial. Transplant. 20 129-34 PubMed GONUTS page

[PMID:10095105-20] Saito, K et al. (1999) Organization of the gene for gelatin-binding protein (GBP28). Gene 229 67-73 PubMed GONUTS page

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