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PMID:10982546

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Citation

Ouchi, N, Kihara, S, Arita, Y, Okamoto, Y, Maeda, K, Kuriyama, H, Hotta, K, Nishida, M, Takahashi, M, Muraguchi, M, Ohmoto, Y, Nakamura, T, Yamashita, S, Funahashi, T and Matsuzawa, Y (2000) Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway. Circulation 102:1296-301

Abstract

Among the many adipocyte-derived endocrine factors, we found an adipocyte-derived plasma protein, adiponectin, that was decreased in obesity. We recently demonstrated that adiponectin inhibited tumor necrosis factor-alpha (TNF-alpha)-induced expression of endothelial adhesion molecules and that plasma adiponectin level was reduced in patients with coronary artery disease (CIRCULATION: 1999;100:2473-2476). However, the intracellular signal by which adiponectin suppressed adhesion molecule expression was not elucidated. The present study investigated the mechanism of modulation for endothelial function by adiponectin.

Links

PubMed

Keywords

Adenylyl Cyclase Inhibitors; Adiponectin; Adipose Tissue/metabolism; Aorta/cytology; Biotinylation; Cell Adhesion Molecules/genetics; Cell Adhesion Molecules/metabolism; Cyclic AMP/biosynthesis; Cyclic AMP/physiology; Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors; DNA-Binding Proteins/metabolism; Electrophoresis/methods; Endothelium, Vascular/cytology; Endothelium, Vascular/metabolism; Enzyme Inhibitors/pharmacology; Enzyme-Linked Immunosorbent Assay; Humans; I-kappa B Proteins; Immunoblotting; In Vitro Techniques; Intercellular Signaling Peptides and Proteins; Monocytes/metabolism; NF-kappa B/metabolism; NF-kappa B/physiology; Phosphorylation; Protein Binding; Proteins/metabolism; Proteins/physiology; RNA, Messenger/metabolism; Tumor Necrosis Factor-alpha/pharmacology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:ADIPO

located_in

GO:0009986: cell surface

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:ADIPO

part_of

GO:0009986: cell surface

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:ADIPO

involved_in

GO:0010739: positive regulation of protein kinase A signaling

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:ADIPO

involved_in

GO:0043124: negative regulation of I-kappaB kinase/NF-kappaB signaling

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

Notes

See also

References

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