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HUMAN:ACTG

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) ACTG1 (synonyms: ACTG)
Protein Name(s) Actin, cytoplasmic 2

Gamma-actin Actin, cytoplasmic 2, N-terminally processed

External Links
UniProt P63261
EMBL X04098
M19283
AK291937
BT019856
BC000292
BC001920
BC007442
BC009848
BC010999
BC012050
BC015005
BC015695
BC015779
BC018774
BC053572
M16247
CCDS CCDS11782.1
PIR A28098
JC5818
RefSeq NP_001186883.1
NP_001605.1
UniGene Hs.514581
Hs.713764
ProteinModelPortal P63261
SMR P63261
BioGrid 106586
IntAct P63261
MINT MINT-4998686
STRING 9606.ENSP00000331514
PhosphoSite P63261
DMDM 54036678
DOSAC-COBS-2DPAGE P60709_OR_P63261
P63261
OGP P63261
REPRODUCTION-2DPAGE P63261
SWISS-2DPAGE P63261
MaxQB P63261
PRIDE P63261
DNASU 71
Ensembl ENST00000331925
ENST00000573283
ENST00000575087
ENST00000575842
ENST00000576544
ENST00000615544
GeneID 71
KEGG hsa:71
UCSC uc002kak.2
CTD 71
GeneCards GC17M079476
GeneReviews ACTG1
H-InvDB HIX0001479
HIX0199868
HGNC HGNC:144
HPA CAB013531
HPA041264
HPA041271
MIM 102560
604717
614583
neXtProt NX_P63261
Orphanet 90635
2995
PharmGKB PA24468
GeneTree ENSGT00760000118957
HOVERGEN HBG003771
InParanoid P63261
KO K05692
OMA ANGIHET
PhylomeDB P63261
TreeFam TF354237
Reactome REACT_11035
REACT_11049
REACT_147867
REACT_160086
REACT_19195
REACT_20649
REACT_22266
REACT_22365
REACT_228085
REACT_228166
REACT_228189
SignaLink P63261
ChiTaRS ACTG1
GeneWiki ACTG1
GenomeRNAi 71
NextBio 279
PMAP-CutDB P63261
PRO PR:P63261
Proteomes UP000005640
Bgee P63261
CleanEx HS_ACTB
HS_ACTG1
ExpressionAtlas P63261
Genevestigator P63261
GO GO:0072562
GO:0005856
GO:0005829
GO:0005615
GO:0070062
GO:0031941
GO:0016020
GO:0030016
GO:0005634
GO:0005524
GO:0042802
GO:0005200
GO:0031625
GO:0034332
GO:0007411
GO:0034329
GO:0045216
GO:0006928
GO:0038096
GO:0045087
GO:0061024
GO:0070527
GO:0001895
GO:0045214
InterPro IPR004000
IPR020902
IPR004001
PANTHER PTHR11937
Pfam PF00022
PRINTS PR00190
SMART SM00268
PROSITE PS00406
PS00432
PS01132

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0005884

actin filament

PMID:28493397[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005522

profilin binding

PMID:28493397[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P60706

C

Seeded From UniProt

complete

part_of

GO:0097433

dense body

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P60706

C

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P60706

C

Seeded From UniProt

complete

part_of

GO:0005925

focal adhesion

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P60706

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:G1NS52

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q58J72

C

Seeded From UniProt

complete

enables

GO:0031625

ubiquitin protein ligase binding

PMID:21753002[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O60260

F

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:23533145[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0070527

platelet aggregation

PMID:23382103[4]

ECO:0007001

high throughput mutant phenotypic evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:19946888[5]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0072562

blood microparticle

PMID:22516433[6]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:20458337[7]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000639)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21630459[8]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000019)

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:16502470[9]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001914)

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:23580065[10]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001827)

Seeded From UniProt

complete

involved_in

GO:0001895

retina homeostasis

PMID:23580065[10]

ECO:0007007

high throughput expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:21557262[11]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(UBERON:0001088)

Seeded From UniProt

complete

enables

GO:0005200

structural constituent of cytoskeleton

PMID:16130169[12]

ECO:0000305

curator inference used in manual assertion

GO:0005856

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:25910212[13]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P63261

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:25416956[14]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P63261

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:21516116[15]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P63261

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:16189514[16]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P63261

F

Seeded From UniProt

complete

involved_in

GO:0098974

postsynaptic actin cytoskeleton organization

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0098973

P

Seeded From UniProt

complete

part_of

GO:0099143

presynaptic actin cytoskeleton

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P63259
ensembl:ENSRNOP00000051859

C

Seeded From UniProt

complete

enables

GO:0098973

structural constituent of postsynaptic actin cytoskeleton

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P63259
ensembl:ENSRNOP00000051859

F

Seeded From UniProt

complete

part_of

GO:0098871

postsynaptic actin cytoskeleton

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P63259
ensembl:ENSRNOP00000051859

C

Seeded From UniProt

complete

involved_in

GO:0051592

response to calcium ion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P63259
ensembl:ENSRNOP00000051859

P

Seeded From UniProt

complete

involved_in

GO:0009612

response to mechanical stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P63259
ensembl:ENSRNOP00000051859

P

Seeded From UniProt

complete

part_of

GO:0098685

Schaffer collateral - CA1 synapse

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P63260
ensembl:ENSMUSP00000071486

C

Seeded From UniProt

complete

involved_in

GO:0071346

cellular response to interferon-gamma

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P63260
ensembl:ENSMUSP00000071486

P

Seeded From UniProt

complete

involved_in

GO:0048488

synaptic vesicle endocytosis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P63260
ensembl:ENSMUSP00000071486

P

Seeded From UniProt

complete

part_of

GO:0045335

phagocytic vesicle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P63260
ensembl:ENSMUSP00000071486

C

Seeded From UniProt

complete

involved_in

GO:0045214

sarcomere organization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P63260
ensembl:ENSMUSP00000071486

P

Seeded From UniProt

complete

part_of

GO:0044305

calyx of Held

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P63260
ensembl:ENSMUSP00000071486

C

Seeded From UniProt

complete

part_of

GO:0031941

filamentous actin

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P63260
ensembl:ENSMUSP00000071486

C

Seeded From UniProt

complete

part_of

GO:0030016

myofibril

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P63260
ensembl:ENSMUSP00000071486

C

Seeded From UniProt

complete

part_of

GO:0015629

actin cytoskeleton

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P63260
ensembl:ENSMUSP00000071486

C

Seeded From UniProt

complete

enables

GO:0005200

structural constituent of cytoskeleton

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P63260
ensembl:ENSMUSP00000071486

F

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

PMID:16130169[12]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0061024

membrane organization

Reactome:R-HSA-199991

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048013

ephrin receptor signaling pathway

Reactome:R-HSA-2682334

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0038096

Fc-gamma receptor signaling pathway involved in phagocytosis

Reactome:R-HSA-2029480

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034329

cell junction assembly

Reactome:R-HSA-446728

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-8871194
Reactome:R-HSA-8871193
Reactome:R-HSA-8869438
Reactome:R-HSA-8868661
Reactome:R-HSA-8868660
Reactome:R-HSA-8868659
Reactome:R-HSA-8868658
Reactome:R-HSA-8868651
Reactome:R-HSA-8868648
Reactome:R-HSA-8868236
Reactome:R-HSA-8868230
Reactome:R-HSA-3928654

ECO:0000304

author statement supported by traceable reference used in manual assertion












C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-5666001
Reactome:R-HSA-5665982
Reactome:R-HSA-5665809
Reactome:R-HSA-5665802
Reactome:R-HSA-5665767
Reactome:R-HSA-5665751
Reactome:R-HSA-5626507
Reactome:R-HSA-5218916
Reactome:R-HSA-445089
Reactome:R-HSA-443779
Reactome:R-HSA-430347
Reactome:R-HSA-3928595
Reactome:R-HSA-392751
Reactome:R-HSA-2197690
Reactome:R-HSA-203070
Reactome:R-HSA-2029476
Reactome:R-HSA-2029473
Reactome:R-HSA-2029466
Reactome:R-HSA-1861595

ECO:0000304

author statement supported by traceable reference used in manual assertion



















C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206
UniProtKB-SubCell:SL-0090

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Rainger, J et al. (2017) A recurrent de novo mutation in ACTG1 causes isolated ocular coloboma. Hum. Mutat. 38 942-946 PubMed GONUTS page
  2. Van Humbeeck, C et al. (2011) Parkin interacts with Ambra1 to induce mitophagy. J. Neurosci. 31 10249-61 PubMed GONUTS page
  3. Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
  4. Fröbel, J et al. (2013) Platelet proteome analysis reveals integrin-dependent aggregation defects in patients with myelodysplastic syndromes. Mol. Cell Proteomics 12 1272-80 PubMed GONUTS page
  5. Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
  6. Bastos-Amador, P et al. (2012) Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. J Proteomics 75 3574-84 PubMed GONUTS page
  7. Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
  8. de Mateo, S et al. (2011) Proteomic characterization of the human sperm nucleus. Proteomics 11 2714-26 PubMed GONUTS page
  9. Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page
  10. 10.0 10.1 Pieragostino, D et al. (2013) Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy. Mol Biosyst 9 1108-16 PubMed GONUTS page
  11. Li, Y et al. (2011) Proteomic identification of exosomal LRG1: a potential urinary biomarker for detecting NSCLC. Electrophoresis 32 1976-83 PubMed GONUTS page
  12. 12.0 12.1 Bruneel, A et al. (2005) Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis. Proteomics 5 3876-84 PubMed GONUTS page
  13. Sahni, N et al. (2015) Widespread macromolecular interaction perturbations in human genetic disorders. Cell 161 647-660 PubMed GONUTS page
  14. Rolland, T et al. (2014) A proteome-scale map of the human interactome network. Cell 159 1212-26 PubMed GONUTS page
  15. Yu, H et al. (2011) Next-generation sequencing to generate interactome datasets. Nat. Methods 8 478-80 PubMed GONUTS page
  16. Rual, JF et al. (2005) Towards a proteome-scale map of the human protein-protein interaction network. Nature 437 1173-8 PubMed GONUTS page