HUMAN:ACTG

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	ACTG1 (synonyms: ACTG)
Protein Name(s)	Actin, cytoplasmic 2 Gamma-actin Actin, cytoplasmic 2, N-terminally processed
External Links
UniProt	P63261
EMBL	X04098 M19283 AK291937 BT019856 BC000292 BC001920 BC007442 BC009848 BC010999 BC012050 BC015005 BC015695 BC015779 BC018774 BC053572 M16247
CCDS	CCDS11782.1
PIR	A28098 JC5818
RefSeq	NP_001186883.1 NP_001605.1
UniGene	Hs.514581 Hs.713764
ProteinModelPortal	P63261
SMR	P63261
BioGrid	106586
IntAct	P63261
MINT	MINT-4998686
STRING	9606.ENSP00000331514
PhosphoSite	P63261
DMDM	54036678
DOSAC-COBS-2DPAGE	P60709_OR_P63261 P63261
OGP	P63261
REPRODUCTION-2DPAGE	P63261
SWISS-2DPAGE	P63261
MaxQB	P63261
PRIDE	P63261
DNASU	71
Ensembl	ENST00000331925 ENST00000573283 ENST00000575087 ENST00000575842 ENST00000576544 ENST00000615544
GeneID	71
KEGG	hsa:71
UCSC	uc002kak.2
CTD	71
GeneCards	GC17M079476
GeneReviews	ACTG1
H-InvDB	HIX0001479 HIX0199868
HGNC	HGNC:144
HPA	CAB013531 HPA041264 HPA041271
MIM	102560 604717 614583
neXtProt	NX_P63261
Orphanet	90635 2995
PharmGKB	PA24468
GeneTree	ENSGT00760000118957
HOVERGEN	HBG003771
InParanoid	P63261
KO	K05692
OMA	ANGIHET
PhylomeDB	P63261
TreeFam	TF354237
Reactome	REACT_11035 REACT_11049 REACT_147867 REACT_160086 REACT_19195 REACT_20649 REACT_22266 REACT_22365 REACT_228085 REACT_228166 REACT_228189
SignaLink	P63261
ChiTaRS	ACTG1
GeneWiki	ACTG1
GenomeRNAi	71
NextBio	279
PMAP-CutDB	P63261
PRO	PR:P63261
Proteomes	UP000005640
Bgee	P63261
CleanEx	HS_ACTB HS_ACTG1
ExpressionAtlas	P63261
Genevestigator	P63261
GO	GO:0072562 GO:0005856 GO:0005829 GO:0005615 GO:0070062 GO:0031941 GO:0016020 GO:0030016 GO:0005634 GO:0005524 GO:0042802 GO:0005200 GO:0031625 GO:0034332 GO:0007411 GO:0034329 GO:0045216 GO:0006928 GO:0038096 GO:0045087 GO:0061024 GO:0070527 GO:0001895 GO:0045214
InterPro	IPR004000 IPR020902 IPR004001
PANTHER	PTHR11937
Pfam	PF00022
PRINTS	PR00190
SMART	SM00268
PROSITE	PS00406 PS00432 PS01132

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0005884	actin filament	PMID:28493397^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005522	profilin binding	PMID:28493397^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60706	C		Seeded From UniProt	complete
part_of	GO:0097433	dense body	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60706	C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60706	C		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60706	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:G1NS52	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q58J72	C		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:21753002^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O60260	F		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0070527	platelet aggregation	PMID:23382103^[4]	ECO:0007001	high throughput mutant phenotypic evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19946888^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0072562	blood microparticle	PMID:22516433^[6]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:20458337^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000639)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21630459^[8]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000019)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:16502470^[9]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001914)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:23580065^[10]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001827)	Seeded From UniProt	complete
involved_in	GO:0001895	retina homeostasis	PMID:23580065^[10]	ECO:0007007	high throughput expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:21557262^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
enables	GO:0005200	structural constituent of cytoskeleton	PMID:16130169^[12]	ECO:0000305	curator inference used in manual assertion	GO:0005856	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:25910212^[13]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P63261	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:25416956^[14]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P63261	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:21516116^[15]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P63261	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:16189514^[16]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P63261	F		Seeded From UniProt	complete
involved_in	GO:0098974	postsynaptic actin cytoskeleton organization	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0098973	P		Seeded From UniProt	complete
part_of	GO:0099143	presynaptic actin cytoskeleton	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63259 ensembl:ENSRNOP00000051859	C		Seeded From UniProt	complete
enables	GO:0098973	structural constituent of postsynaptic actin cytoskeleton	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63259 ensembl:ENSRNOP00000051859	F		Seeded From UniProt	complete
part_of	GO:0098871	postsynaptic actin cytoskeleton	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63259 ensembl:ENSRNOP00000051859	C		Seeded From UniProt	complete
involved_in	GO:0051592	response to calcium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63259 ensembl:ENSRNOP00000051859	P		Seeded From UniProt	complete
involved_in	GO:0009612	response to mechanical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63259 ensembl:ENSRNOP00000051859	P		Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63260 ensembl:ENSMUSP00000071486	C		Seeded From UniProt	complete
involved_in	GO:0071346	cellular response to interferon-gamma	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63260 ensembl:ENSMUSP00000071486	P		Seeded From UniProt	complete
involved_in	GO:0048488	synaptic vesicle endocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63260 ensembl:ENSMUSP00000071486	P		Seeded From UniProt	complete
part_of	GO:0045335	phagocytic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63260 ensembl:ENSMUSP00000071486	C		Seeded From UniProt	complete
involved_in	GO:0045214	sarcomere organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63260 ensembl:ENSMUSP00000071486	P		Seeded From UniProt	complete
part_of	GO:0044305	calyx of Held	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63260 ensembl:ENSMUSP00000071486	C		Seeded From UniProt	complete
part_of	GO:0031941	filamentous actin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63260 ensembl:ENSMUSP00000071486	C		Seeded From UniProt	complete
part_of	GO:0030016	myofibril	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63260 ensembl:ENSMUSP00000071486	C		Seeded From UniProt	complete
part_of	GO:0015629	actin cytoskeleton	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63260 ensembl:ENSMUSP00000071486	C		Seeded From UniProt	complete
enables	GO:0005200	structural constituent of cytoskeleton	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63260 ensembl:ENSMUSP00000071486	F		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	PMID:16130169^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0061024	membrane organization	Reactome:R-HSA-199991	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048013	ephrin receptor signaling pathway	Reactome:R-HSA-2682334	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	Reactome:R-HSA-2029480	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034329	cell junction assembly	Reactome:R-HSA-446728	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-8871194 Reactome:R-HSA-8871193 Reactome:R-HSA-8869438 Reactome:R-HSA-8868661 Reactome:R-HSA-8868660 Reactome:R-HSA-8868659 Reactome:R-HSA-8868658 Reactome:R-HSA-8868651 Reactome:R-HSA-8868648 Reactome:R-HSA-8868236 Reactome:R-HSA-8868230 Reactome:R-HSA-3928654	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-5666001 Reactome:R-HSA-5665982 Reactome:R-HSA-5665809 Reactome:R-HSA-5665802 Reactome:R-HSA-5665767 Reactome:R-HSA-5665751 Reactome:R-HSA-5626507 Reactome:R-HSA-5218916 Reactome:R-HSA-445089 Reactome:R-HSA-443779 Reactome:R-HSA-430347 Reactome:R-HSA-3928595 Reactome:R-HSA-392751 Reactome:R-HSA-2197690 Reactome:R-HSA-203070 Reactome:R-HSA-2029476 Reactome:R-HSA-2029473 Reactome:R-HSA-2029466 Reactome:R-HSA-1861595	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Rainger, J et al. (2017) A recurrent de novo mutation in ACTG1 causes isolated ocular coloboma. Hum. Mutat. 38 942-946 PubMed GONUTS page
↑ Van Humbeeck, C et al. (2011) Parkin interacts with Ambra1 to induce mitophagy. J. Neurosci. 31 10249-61 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ Fröbel, J et al. (2013) Platelet proteome analysis reveals integrin-dependent aggregation defects in patients with myelodysplastic syndromes. Mol. Cell Proteomics 12 1272-80 PubMed GONUTS page
↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
↑ Bastos-Amador, P et al. (2012) Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. J Proteomics 75 3574-84 PubMed GONUTS page
↑ Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
↑ de Mateo, S et al. (2011) Proteomic characterization of the human sperm nucleus. Proteomics 11 2714-26 PubMed GONUTS page
↑ Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page
↑ ^10.0 ^10.1 Pieragostino, D et al. (2013) Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy. Mol Biosyst 9 1108-16 PubMed GONUTS page
↑ Li, Y et al. (2011) Proteomic identification of exosomal LRG1: a potential urinary biomarker for detecting NSCLC. Electrophoresis 32 1976-83 PubMed GONUTS page
↑ ^12.0 ^12.1 Bruneel, A et al. (2005) Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis. Proteomics 5 3876-84 PubMed GONUTS page
↑ Sahni, N et al. (2015) Widespread macromolecular interaction perturbations in human genetic disorders. Cell 161 647-660 PubMed GONUTS page
↑ Rolland, T et al. (2014) A proteome-scale map of the human interactome network. Cell 159 1212-26 PubMed GONUTS page
↑ Yu, H et al. (2011) Next-generation sequencing to generate interactome datasets. Nat. Methods 8 478-80 PubMed GONUTS page
↑ Rual, JF et al. (2005) Towards a proteome-scale map of the human protein-protein interaction network. Nature 437 1173-8 PubMed GONUTS page

[PMID:28493397-1] 1.0 ^1.1 Rainger, J et al. (2017) A recurrent de novo mutation in ACTG1 causes isolated ocular coloboma. Hum. Mutat. 38 942-946 PubMed GONUTS page

[PMID:21753002-2] Van Humbeeck, C et al. (2011) Parkin interacts with Ambra1 to induce mitophagy. J. Neurosci. 31 10249-61 PubMed GONUTS page

[PMID:23533145-3] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:23382103-4] Fröbel, J et al. (2013) Platelet proteome analysis reveals integrin-dependent aggregation defects in patients with myelodysplastic syndromes. Mol. Cell Proteomics 12 1272-80 PubMed GONUTS page

[PMID:19946888-5] Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page

[PMID:22516433-6] Bastos-Amador, P et al. (2012) Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. J Proteomics 75 3574-84 PubMed GONUTS page

[PMID:20458337-7] Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page

[PMID:21630459-8] Mateo, S et al. (2011) Proteomic characterization of the human sperm nucleus. Proteomics 11 2714-26 PubMed GONUTS page

[PMID:16502470-9] Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page

[PMID:23580065-10] 10.0 ^10.1 Pieragostino, D et al. (2013) Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy. Mol Biosyst 9 1108-16 PubMed GONUTS page

[PMID:21557262-11] Li, Y et al. (2011) Proteomic identification of exosomal LRG1: a potential urinary biomarker for detecting NSCLC. Electrophoresis 32 1976-83 PubMed GONUTS page

[PMID:16130169-12] 12.0 ^12.1 Bruneel, A et al. (2005) Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis. Proteomics 5 3876-84 PubMed GONUTS page

[PMID:25910212-13] Sahni, N et al. (2015) Widespread macromolecular interaction perturbations in human genetic disorders. Cell 161 647-660 PubMed GONUTS page

[PMID:25416956-14] Rolland, T et al. (2014) A proteome-scale map of the human interactome network. Cell 159 1212-26 PubMed GONUTS page

[PMID:21516116-15] Yu, H et al. (2011) Next-generation sequencing to generate interactome datasets. Nat. Methods 8 478-80 PubMed GONUTS page

[PMID:16189514-16] Rual, JF et al. (2005) Towards a proteome-scale map of the human protein-protein interaction network. Nature 437 1173-8 PubMed GONUTS page

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HUMAN:ACTG

Contents

Annotations

Notes

References

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