HUMAN:ACSL1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	ACSL1 (synonyms: FACL1, FACL2, LACS, LACS1, LACS2)
Protein Name(s)	Long-chain-fatty-acid--CoA ligase 1 Acyl-CoA synthetase 1 ACS1 Long-chain acyl-CoA synthetase 1 LACS 1 Long-chain acyl-CoA synthetase 2 LACS 2 Long-chain fatty acid-CoA ligase 2 Palmitoyl-CoA ligase 1 Palmitoyl-CoA ligase 2
External Links
UniProt	P33121
EMBL	D10040 L09229 AK096117 AK296826 AC079257 AC084871 CH471056 CH471056 CH471056 BC026290 BC050073
CCDS	CCDS3839.1 CCDS68826.1
PIR	JX0202
RefSeq	NP_001273637.1 NP_001273639.1 NP_001273640.1 NP_001273641.1 NP_001986.2 XP_005262885.1 XP_005262886.1 XP_005262888.1
UniGene	Hs.406678
ProteinModelPortal	P33121
SMR	P33121
BioGrid	108476
IntAct	P33121
STRING	9606.ENSP00000281455
DrugBank	DB00131 DB00171
PhosphoSite	P33121
DMDM	417241
MaxQB	P33121
PaxDb	P33121
PRIDE	P33121
Ensembl	ENST00000281455 ENST00000504342 ENST00000513317 ENST00000515030
GeneID	2180
KEGG	hsa:2180
UCSC	uc003iwt.1
CTD	2180
GeneCards	GC04M185676
HGNC	HGNC:3569
HPA	HPA011316 HPA011964
MIM	152425
neXtProt	NX_P33121
PharmGKB	PA27966
eggNOG	COG1022
GeneTree	ENSGT00690000101725
HOGENOM	HOG000159459
HOVERGEN	HBG050452
InParanoid	P33121
KO	K01897
OMA	TMTLIYT
OrthoDB	EOG71CFKN
PhylomeDB	P33121
TreeFam	TF313877
BioCyc	MetaCyc:HS07766-MONOMER
BRENDA	6.2.1.3
Reactome	REACT_116145 REACT_121100 REACT_121147 REACT_380
ChiTaRS	ACSL1
GeneWiki	ACSL1
GenomeRNAi	2180
NextBio	35479388
PRO	PR:P33121
Proteomes	UP000005640
Bgee	P33121
CleanEx	HS_ACSL1
ExpressionAtlas	P33121
Genevestigator	P33121
GO	GO:0005789 GO:0016021 GO:0016020 GO:0005741 GO:0005739 GO:0005778 GO:0005886 GO:0005524 GO:0004467 GO:0033211 GO:0036109 GO:0044255 GO:0043651 GO:0008610 GO:0044539 GO:0001676 GO:0035338 GO:0071902 GO:0042493 GO:0007584 GO:0034201 GO:0014070 GO:0044281 GO:0019432 GO:0033559 GO:0042178
InterPro	IPR020845 IPR000873
Pfam	PF00501
PROSITE	PS00455

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	PMID:20620995^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41216	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19946888^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0044539	long-chain fatty acid import into cell	PMID:22022213^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008610	lipid biosynthetic process	PMID:21242590^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:22022213^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004467	long-chain fatty acid-CoA ligase activity	PMID:22022213^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004467	long-chain fatty acid-CoA ligase activity	PMID:21242590^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(CHEBI:15525)\|has_direct_input:(CHEBI:15534)	Seeded From UniProt	complete
involved_in	GO:0001676	long-chain fatty acid metabolic process	PMID:22022213^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18163 ensembl:ENSRNOP00000014235	P		Seeded From UniProt	complete
involved_in	GO:0042178	xenobiotic catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18163 ensembl:ENSRNOP00000014235	P		Seeded From UniProt	complete
involved_in	GO:0035338	long-chain fatty-acyl-CoA biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18163 ensembl:ENSRNOP00000014235	P		Seeded From UniProt	complete
involved_in	GO:0034201	response to oleic acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18163 ensembl:ENSRNOP00000014235	P		Seeded From UniProt	complete
involved_in	GO:0019432	triglyceride biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18163 ensembl:ENSRNOP00000014235	P		Seeded From UniProt	complete
involved_in	GO:0015908	fatty acid transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18163 ensembl:ENSRNOP00000014235	P		Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18163 ensembl:ENSRNOP00000014235	P		Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18163 ensembl:ENSRNOP00000014235	P		Seeded From UniProt	complete
involved_in	GO:0007584	response to nutrient	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18163 ensembl:ENSRNOP00000014235	P		Seeded From UniProt	complete
involved_in	GO:0006631	fatty acid metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18163 ensembl:ENSRNOP00000014235	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18163 ensembl:ENSRNOP00000014235	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18163 ensembl:ENSRNOP00000014235	C		Seeded From UniProt	complete
part_of	GO:0005778	peroxisomal membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18163 ensembl:ENSRNOP00000014235	C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18163 ensembl:ENSRNOP00000014235	C		Seeded From UniProt	complete
enables	GO:0004467	long-chain fatty acid-CoA ligase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18163 ensembl:ENSRNOP00000014235	F		Seeded From UniProt	complete
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41216 ensembl:ENSMUSP00000034046	P		Seeded From UniProt	complete
involved_in	GO:0071902	positive regulation of protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41216 ensembl:ENSMUSP00000034046	P		Seeded From UniProt	complete
involved_in	GO:0033211	adiponectin-activated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41216 ensembl:ENSMUSP00000034046	P		Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000873	F		Seeded From UniProt	complete
enables	GO:0004467	long-chain fatty acid-CoA ligase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:6.2.1.3	F		Seeded From UniProt	complete
enables	GO:0003996	acyl-CoA ligase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:6.2.1.3	F		Seeded From UniProt	complete
enables	GO:0102391	decanoate-CoA ligase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:6.2.1.3	F		Seeded From UniProt	complete
involved_in	GO:0043651	linoleic acid metabolic process	Reactome:R-HSA-2046105	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0036109	alpha-linolenic acid metabolic process	Reactome:R-HSA-2046106	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035338	long-chain fatty-acyl-CoA biosynthetic process	Reactome:R-HSA-75876	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019216	regulation of lipid metabolic process	Reactome:R-HSA-400206	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	Reactome:R-HSA-2046098 Reactome:R-HSA-2046085 Reactome:R-HSA-201035	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	Reactome:R-HSA-1989778	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0016874	ligase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0436	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005777	peroxisome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0576	C		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0443	P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1000 UniProtKB-SubCell:SL-0172	C		Seeded From UniProt	complete
involved_in	GO:0006631	fatty acid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0276	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0492	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
part_of	GO:0031090	organelle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0165	C		Seeded From UniProt	complete
part_of	GO:0005778	peroxisomal membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0203	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Ellis, JM et al. (2010) Adipose acyl-CoA synthetase-1 directs fatty acids toward beta-oxidation and is required for cold thermogenesis. Cell Metab. 12 53-64 PubMed GONUTS page
↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Krammer, J et al. (2011) Overexpression of CD36 and acyl-CoA synthetases FATP2, FATP4 and ACSL1 increases fatty acid uptake in human hepatoma cells. Int J Med Sci 8 599-614 PubMed GONUTS page
↑ ^4.0 ^4.1 Golej, DL et al. (2011) Long-chain acyl-CoA synthetase 4 modulates prostaglandin E₂ release from human arterial smooth muscle cells. J. Lipid Res. 52 782-93 PubMed GONUTS page

[PMID:20620995-1] Ellis, JM et al. (2010) Adipose acyl-CoA synthetase-1 directs fatty acids toward beta-oxidation and is required for cold thermogenesis. Cell Metab. 12 53-64 PubMed GONUTS page

[PMID:19946888-2] Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page

[PMID:22022213-3] 3.0 ^3.1 ^3.2 ^3.3 Krammer, J et al. (2011) Overexpression of CD36 and acyl-CoA synthetases FATP2, FATP4 and ACSL1 increases fatty acid uptake in human hepatoma cells. Int J Med Sci 8 599-614 PubMed GONUTS page

[PMID:21242590-4] 4.0 ^4.1 Golej, DL et al. (2011) Long-chain acyl-CoA synthetase 4 modulates prostaglandin E₂ release from human arterial smooth muscle cells. J. Lipid Res. 52 782-93 PubMed GONUTS page

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HUMAN:ACSL1

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