HUMAN:ACHA7

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	CHRNA7 (synonyms: NACHRA7)
Protein Name(s)	Neuronal acetylcholine receptor subunit alpha-7
External Links
UniProt	P36544
EMBL	X70297 U40583 U62436 Y08420 AF385585 AK292069 AK294229 AC004460 AC009562 AC012236 AC021316 AC026150 AC026951 AC058803 AC068448 AC079969 AC087481 AC090829 AC091057 AC104266 AC104759 BC037571 BC101345 L25827 Z23141 AF332758
CCDS	CCDS10027.1 CCDS53924.1
PIR	G02259 I37185
RefSeq	NP_000737.1 NP_001177384.1 NP_683709.1 XP_005254807.1
UniGene	Hs.510853 Hs.511772 Hs.713151
PDB	2MAW
PDBsum	2MAW
ProteinModelPortal	P36544
SMR	P36544
BioGrid	107561
IntAct	P36544
STRING	9606.ENSP00000303727
BindingDB	P36544
ChEMBL	CHEMBL2492
DrugBank	DB01351 DB01352 DB00237 DB00241 DB01353 DB00514 DB00674 DB01354 DB01355 DB00849 DB00184 DB00312 DB01174 DB00794 DB00418 DB00306 DB00599 DB01273
GuidetoPHARMACOLOGY	468
TCDB	1.A.9.1.7
PhosphoSite	P36544
DMDM	2506127
PaxDb	P36544
PRIDE	P36544
Ensembl	ENST00000306901 ENST00000454250 ENST00000455693
GeneID	1139 89832
KEGG	hsa:1139 hsa:89832
UCSC	uc001zft.4 uc021sic.2
CTD	1139 89832
GeneCards	GC15P032322
HGNC	HGNC:1960
HPA	CAB033624 HPA029422
MIM	118511
neXtProt	NX_P36544
Orphanet	199318
PharmGKB	PA114 PA26483
eggNOG	NOG235631
GeneTree	ENSGT00760000118930
HOGENOM	HOG000006756
HOVERGEN	HBG003756
InParanoid	P36544
KO	K04809
OMA	HRCASAT
OrthoDB	EOG72JWGV
PhylomeDB	P36544
TreeFam	TF315605
Reactome	REACT_22303
SignaLink	P36544
ChiTaRS	CHRNA7
GeneWiki	CHRFAM7A CHRNA7
NextBio	4738
PRO	PR:P36544
Proteomes	UP000005640 UP000005640
Bgee	P36544
CleanEx	HS_CHRNA7
ExpressionAtlas	P36544
Genevestigator	P36544
GO	GO:0005892 GO:0030054 GO:0016021 GO:0005886 GO:0045211 GO:0042166 GO:0015464 GO:0004889 GO:0022848 GO:0001540 GO:0017081 GO:0042803 GO:0015643 GO:0000187 GO:0006816 GO:0098655 GO:0006874 GO:0050890 GO:0034220 GO:0006811 GO:0007613 GO:0032720 GO:0045766 GO:0008284 GO:0001666 GO:0035094 GO:0007165 GO:0007268
Gene3D	1.20.120.370 2.70.170.10
InterPro	IPR027361 IPR006202 IPR006201 IPR006029 IPR018000 IPR002394
PANTHER	PTHR18945
Pfam	PF02931 PF02932
PRINTS	PR00254 PR00252
SUPFAM	SSF63712 SSF90112
TIGRFAMs	TIGR00860
PROSITE	PS00236

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:1905144	response to acetylcholine	PMID:17898229^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	PMID:17898229^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	part_of:(GO:1905144)	Seeded From UniProt	complete
enables	GO:0022848	acetylcholine-gated cation-selective channel activity	PMID:18387948^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0044853	plasma membrane raft	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q05941	C		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q05941	P	occurs_in:(UBERON:0002421) part_of:(GO:0035094) has_regulation_target:(UniProtKB:P28482)	Seeded From UniProt	complete
involved_in	GO:0035094	response to nicotine	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q05941	P	occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49582	P	occurs_in:(UBERON:0002421) part_of:(GO:0035094) has_regulation_target:(UniProtKB:P28482)	Seeded From UniProt	complete
involved_in	GO:0035094	response to nicotine	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49582	P	occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0097061	dendritic spine organization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49582	P	occurs_in:(UBERON:0003881) occurs_in:(CL:0002608) occurs_in:(GO:0098794)	Seeded From UniProt	complete
involved_in	GO:0140059	dendrite arborization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49582	P	occurs_in:(UBERON:0035874)	Seeded From UniProt	complete
involved_in	GO:1902991	regulation of amyloid precursor protein catabolic process	PMID:20708605^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067	P		Seeded From UniProt	complete
involved_in	GO:1902430	negative regulation of amyloid-beta formation	PMID:20708605^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067	P		Seeded From UniProt	complete
involved_in	GO:1900273	positive regulation of long-term synaptic potentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49582	P	occurs_in:(UBERON:0003881) happens_during:(UBERON:0018241)	Seeded From UniProt	complete
involved_in	GO:0098815	modulation of excitatory postsynaptic potential	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49582	P	occurs_in:(UBERON:0003881) happens_during:(UBERON:0018241)	Seeded From UniProt	complete
involved_in	GO:1900273	positive regulation of long-term synaptic potentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49582	P		Seeded From UniProt	complete
involved_in	GO:0098815	modulation of excitatory postsynaptic potential	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49582	P		Seeded From UniProt	complete
involved_in	GO:0050808	synapse organization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49582	P	occurs_in:(UBERON:0001870) happens_during:(UBERON:0007222)\|occurs_in(UBERON:0002421) happens_during:(UBERON:0007222)	Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49582	P	happens_during:(UBERON:0007222)	Seeded From UniProt	complete
involved_in	GO:1905906	regulation of amyloid fibril formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49582	P	happens_during:(UBERON:0018241) occurs_in:(UBERON:0002421) has_regulation_target:(UniProtKB:P05067)	Seeded From UniProt	complete
involved_in	GO:1902004	positive regulation of amyloid-beta formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49582	P	has_output:(UniProtKB:P05067:PRO_0000000093) happens_during:(UBERON:0018241) occurs_in:(UBERON:0002421) has_input:(UniProtKB:P12023) has_regulation_target:(UniProtKB:P05067)\|has_output(UniProtKB:P05067:PRO_0000000093) happens_during:(UBERON:0007222) occurs_in:(UBERON:0002421) has_input:(UniProtKB:P12023) has_regulation_target:(UniProtKB:P05067)\|has_output(UniProtKB:P05067:PRO_0000000092) happens_during:(UBERON:0018241) occurs_in:(UBERON:0002421) has_input:(UniProtKB:P12023) has_regulation_target:(UniProtKB:P05067)\|has_output(UniProtKB:P05067:PRO_0000000092) happens_during:(UBERON:0007222) occurs_in:(UBERON:0002421) has_input:(UniProtKB:P12023) has_regulation_target:(UniProtKB:P05067)	Seeded From UniProt	complete
involved_in	GO:1901214	regulation of neuron death	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49582	P	has_input:(UniProtKB:P12023) happens_during:(UBERON:0018241) regulates_o_occurs_in:(CL:1001571)\|has_input(UniProtKB:P12023) happens_during:(UBERON:0018241) regulates_o_occurs_in:(CL:0001033)	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49582	P	happens_during:(UBERON:0018241) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0051247	positive regulation of protein metabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49582	P	happens_during:(UBERON:0018241) occurs_in:(UBERON:0002421) has_regulation_target:(UniProtKB:P11137)	Seeded From UniProt	complete
involved_in	GO:0051247	positive regulation of protein metabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49582	P	happens_during:(UBERON:0018241) occurs_in:(UBERON:0002421) has_regulation_target:(UniProtKB:P28329)\|happens_during(UBERON:0018241) occurs_in:(UBERON:0002743) has_regulation_target:(UniProtKB:P28329)	Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49582	P	happens_during:(UBERON:0018241)	Seeded From UniProt	complete
involved_in	GO:1905920	positive regulation of CoA-transferase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49582	P	happens_during:(UBERON:0018241) occurs_in:(UBERON:0002421) has_regulation_target:(UniProtKB:Q03059)\|happens_during(UBERON:0018241) occurs_in:(UBERON:0002743) has_regulation_target:(UniProtKB:Q03059)	Seeded From UniProt	complete
enables	GO:0022848	acetylcholine-gated cation-selective channel activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q05941	F	occurs_in:(CL:0002608) occurs_at:(GO:0044853)	Seeded From UniProt	complete
involved_in	GO:1905144	response to acetylcholine	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q05941	P	occurs_in:(CL:0002608) occurs_in:(GO:0044853)	Seeded From UniProt	complete
involved_in	GO:0095500	acetylcholine receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q05941	P	occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:2000463	positive regulation of excitatory postsynaptic potential	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49582	P	occurs_in:(UBERON:0002421) part_of:(GO:1904645)	Seeded From UniProt	complete
involved_in	GO:1904645	response to amyloid-beta	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49582	P	occurs_in:(UBERON:0002421) regulates:(GO:0060291)\|occurs_in(UBERON:0002421) regulates:(GO:0007611)	Seeded From UniProt	complete
involved_in	GO:1900273	positive regulation of long-term synaptic potentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49582	P	occurs_in:(UBERON:0002421) part_of:(GO:1904645)	Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49582	P	occurs_in:(UBERON:0002421) part_of:(GO:1904645)	Seeded From UniProt	complete
involved_in	GO:0007614	short-term memory	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q866A2	P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49582	P	occurs_in:(UBERON:0003027) regulates_o_occurs_in:(GO:0043005)\|occurs_in(UBERON:0001885) regulates_o_occurs_in:(GO:0043005)	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q05941	P		Seeded From UniProt	complete
involved_in	GO:0050893	sensory processing	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q05941	P		Seeded From UniProt	complete
involved_in	GO:0007613	memory	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q05941	P		Seeded From UniProt	complete
involved_in	GO:0050893	sensory processing	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49582	P		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49582	P	occurs_in:(UBERON:0003027)	Seeded From UniProt	complete
involved_in	GO:0034220	ion transmembrane transport	PMID:21718690^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0022848	acetylcholine-gated cation-selective channel activity	PMID:21718690^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21718690^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0050890	cognition	PMID:16754836^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050890	cognition	PMID:10681545^[6]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:16280133^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:12189247^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:8145738^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042166	acetylcholine binding	PMID:8145738^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0035094	response to nicotine	PMID:12189247^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035094	response to nicotine	PMID:8145738^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032720	negative regulation of tumor necrosis factor production	PMID:12508119^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0017081	chloride channel regulator activity	PMID:8145738^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:8145738^[9]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:8906617^[11]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0015643	toxic substance binding	PMID:12508119^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0015464	acetylcholine receptor activity	PMID:8906617^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:17498763^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:16280133^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007613	memory	PMID:10681545^[6]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:8906617^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006874	cellular calcium ion homeostasis	PMID:16280133^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	PMID:10771023^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	PMID:8145738^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	PMID:8906617^[11]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005892	acetylcholine-gated channel complex	PMID:8906617^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:16280133^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000071)	Seeded From UniProt	complete
enables	GO:0022848	acetylcholine-gated cation-selective channel activity	PMID:8145738^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0022848	acetylcholine-gated cation-selective channel activity	PMID:8906617^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	PMID:12189247^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	PMID:10681545^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000092	F		Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	PMID:10771023^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050877	nervous system process	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87888 PANTHER:PTN000434994 UniProtKB:P11230 UniProtKB:P17787 UniProtKB:P43681	P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95747 PANTHER:PTN000434994 UniProtKB:G5EDF1 UniProtKB:P11230 WB:WBGene00006765 WB:WBGene00006774	C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95747 PANTHER:PTN000434994 RGD:2351 RGD:621544 WB:WBGene00000042 WB:WBGene00002974 WB:WBGene00006765 WB:WBGene00006774	C		Seeded From UniProt	complete
involved_in	GO:0042391	regulation of membrane potential	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87885 MGI:MGI:87887 MGI:MGI:87888 MGI:MGI:87890 MGI:MGI:87891 MGI:MGI:87892 MGI:MGI:87893 MGI:MGI:87894 MGI:MGI:87895 MGI:MGI:95747 MGI:MGI:95751 MGI:MGI:99779 PANTHER:PTN000434994 RGD:2348 UniProtKB:P02708 UniProtKB:P23415	P		Seeded From UniProt	complete
enables	GO:0042166	acetylcholine binding	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001450553 RGD:2348 UniProtKB:P36544	F		Seeded From UniProt	complete
involved_in	GO:0034220	ion transmembrane transport	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95613 PANTHER:PTN000434994 UniProtKB:P23416 UniProtKB:P36544 UniProtKB:Q401N2 WB:WBGene00000055 WB:WBGene00002974 WB:WBGene00006797	P		Seeded From UniProt	complete
contributes_to	GO:0015464	acetylcholine receptor activity	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001450553 UniProtKB:P36544	F		Seeded From UniProt	complete
involved_in	GO:0007271	synaptic transmission, cholinergic	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99779 PANTHER:PTN001450553 RGD:2348	P		Seeded From UniProt	complete
involved_in	GO:0007268	chemical synaptic transmission	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003011 FB:FBgn0086778 MGI:MGI:103156 MGI:MGI:95613 MGI:MGI:95623 MGI:MGI:95747 PANTHER:PTN000434994 RGD:2648 RGD:61859 RGD:61901 UniProtKB:P48167 WB:WBGene00000050 WB:WBGene00000054	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000434994 UniProtKB:P11230 UniProtKB:P17787 UniProtKB:P30926 UniProtKB:P32297 UniProtKB:P36544 UniProtKB:P43681 UniProtKB:Q15822	P		Seeded From UniProt	complete
part_of	GO:0005892	acetylcholine-gated channel complex	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001450553 RGD:2348 UniProtKB:P36544	C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1861899 MGI:MGI:95623 MGI:MGI:95750 PANTHER:PTN000434994 RGD:2649 RGD:2650 RGD:61855 RGD:61861 RGD:621229 UniProtKB:O75311 UniProtKB:P23415 UniProtKB:P23416 UniProtKB:P28472 UniProtKB:P48167 UniProtKB:Q9UGM1 WB:WBGene00000955 WB:WBGene00001133 WB:WBGene00001591 WB:WBGene00001592	C		Seeded From UniProt	complete
contributes_to	GO:0005230	extracellular ligand-gated ion channel activity	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000434994 WB:WBGene00000043 WB:WBGene00001512 WB:WBGene00003386 WB:WBGene00006774 WB:WBGene00012857 WB:WBGene00017375	F		Seeded From UniProt	complete
involved_in	GO:0032720	negative regulation of tumor necrosis factor production	PMID:12508119^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0022848	acetylcholine-gated cation-selective channel activity	PMID:12508119^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:12508119^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0060078	regulation of postsynaptic membrane potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0022848	P		Seeded From UniProt	complete
involved_in	GO:0060078	regulation of postsynaptic membrane potential	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0022848	P		Seeded From UniProt	complete
involved_in	GO:0060078	regulation of postsynaptic membrane potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0022848	P		Seeded From UniProt	complete
involved_in	GO:0060078	regulation of postsynaptic membrane potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0022848	P		Seeded From UniProt	complete
involved_in	GO:0060078	regulation of postsynaptic membrane potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0022848	P		Seeded From UniProt	complete
involved_in	GO:0060078	regulation of postsynaptic membrane potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0022848	P		Seeded From UniProt	complete
involved_in	GO:0060078	regulation of postsynaptic membrane potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0022848	P		Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0022848	P		Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0022848	P		Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0022848	P		Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0022848	P		Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0022848	P		Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0022848	P		Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0022848	P		Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005262	P		Seeded From UniProt	complete
enables	GO:0004888	transmembrane signaling receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006201	F		Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002394 InterPro:IPR006201	F		Seeded From UniProt	complete
enables	GO:0005230	extracellular ligand-gated ion channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006202 InterPro:IPR036734	F		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002394 InterPro:IPR006029 InterPro:IPR006202 InterPro:IPR036719 InterPro:IPR036734	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002394 InterPro:IPR006029 InterPro:IPR006201 InterPro:IPR006202 InterPro:IPR036719 InterPro:IPR036734	C		Seeded From UniProt	complete
enables	GO:0022848	acetylcholine-gated cation-selective channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002394	F		Seeded From UniProt	complete
involved_in	GO:0034220	ion transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006201	P		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002394	C		Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	PMID:26224839^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	PMID:11404397^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-629596 Reactome:R-HSA-629595	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770	C		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0628 UniProtKB-SubCell:SL-0219	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Bitner, RS et al. (2007) Broad-spectrum efficacy across cognitive domains by alpha7 nicotinic acetylcholine receptor agonism correlates with activation of ERK1/2 and CREB phosphorylation pathways. J. Neurosci. 27 10578-87 PubMed GONUTS page
↑ Levitin, F et al. (2008) PATE gene clusters code for multiple, secreted TFP/Ly-6/uPAR proteins that are expressed in reproductive and neuron-rich tissues and possess neuromodulatory activity. J. Biol. Chem. 283 16928-39 PubMed GONUTS page
↑ ^3.0 ^3.1 Nie, HZ et al. (2010) Activation of α7 nicotinic receptor affects APP processing by regulating secretase activity in SH-EP1-α7 nAChR-hAPP695 cells. Brain Res. 1356 112-20 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Araud, T et al. (2011) The chimeric gene CHRFAM7A, a partial duplication of the CHRNA7 gene, is a dominant negative regulator of α7*nAChR function. Biochem. Pharmacol. 82 904-14 PubMed GONUTS page
↑ Olincy, A et al. (2006) Proof-of-concept trial of an alpha7 nicotinic agonist in schizophrenia. Arch. Gen. Psychiatry 63 630-8 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Wang, HY et al. (2000) beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology. J. Biol. Chem. 275 5626-32 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Li, XW & Wang, H (2006) Non-neuronal nicotinic alpha 7 receptor, a new endothelial target for revascularization. Life Sci. 78 1863-70 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Heeschen, C et al. (2002) A novel angiogenic pathway mediated by non-neuronal nicotinic acetylcholine receptors. J. Clin. Invest. 110 527-36 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 Peng, X et al. (1994) Human alpha 7 acetylcholine receptor: cloning of the alpha 7 subunit from the SH-SY5Y cell line and determination of pharmacological properties of native receptors and functional alpha 7 homomers expressed in Xenopus oocytes. Mol. Pharmacol. 45 546-54 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 Wang, H et al. (2003) Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation. Nature 421 384-8 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 Elliott, KJ et al. (1996) Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits. J. Mol. Neurosci. 7 217-28 PubMed GONUTS page
↑ Wong, HP et al. (2007) Nicotine promotes cell proliferation via alpha7-nicotinic acetylcholine receptor and catecholamine-synthesizing enzymes-mediated pathway in human colon adenocarcinoma HT-29 cells. Toxicol. Appl. Pharmacol. 221 261-7 PubMed GONUTS page
↑ ^13.0 ^13.1 Schuller, HM et al. (2000) Interaction of tobacco-specific toxicants with the neuronal alpha(7) nicotinic acetylcholine receptor and its associated mitogenic signal transduction pathway: potential role in lung carcinogenesis and pediatric lung disorders. Eur. J. Pharmacol. 393 265-77 PubMed GONUTS page
↑ ^14.00 ^14.01 ^14.02 ^14.03 ^14.04 ^14.05 ^14.06 ^14.07 ^14.08 ^14.09 ^14.10 ^14.11 ^14.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Ohnishi, T et al. (2015) Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly. Proc. Natl. Acad. Sci. U.S.A. 112 E4465-74 PubMed GONUTS page
↑ Dineley, KT et al. (2001) Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease. J. Neurosci. 21 4125-33 PubMed GONUTS page

[PMID:17898229-1] 1.0 ^1.1 Bitner, RS et al. (2007) Broad-spectrum efficacy across cognitive domains by alpha7 nicotinic acetylcholine receptor agonism correlates with activation of ERK1/2 and CREB phosphorylation pathways. J. Neurosci. 27 10578-87 PubMed GONUTS page

[PMID:18387948-2] Levitin, F et al. (2008) PATE gene clusters code for multiple, secreted TFP/Ly-6/uPAR proteins that are expressed in reproductive and neuron-rich tissues and possess neuromodulatory activity. J. Biol. Chem. 283 16928-39 PubMed GONUTS page

[PMID:20708605-3] 3.0 ^3.1 Nie, HZ et al. (2010) Activation of α7 nicotinic receptor affects APP processing by regulating secretase activity in SH-EP1-α7 nAChR-hAPP695 cells. Brain Res. 1356 112-20 PubMed GONUTS page

[PMID:21718690-4] 4.0 ^4.1 ^4.2 Araud, T et al. (2011) The chimeric gene CHRFAM7A, a partial duplication of the CHRNA7 gene, is a dominant negative regulator of α7*nAChR function. Biochem. Pharmacol. 82 904-14 PubMed GONUTS page

[PMID:16754836-5] Olincy, A et al. (2006) Proof-of-concept trial of an alpha7 nicotinic agonist in schizophrenia. Arch. Gen. Psychiatry 63 630-8 PubMed GONUTS page

[PMID:10681545-6] 6.0 ^6.1 ^6.2 Wang, HY et al. (2000) beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology. J. Biol. Chem. 275 5626-32 PubMed GONUTS page

[PMID:16280133-7] 7.0 ^7.1 ^7.2 ^7.3 Li, XW & Wang, H (2006) Non-neuronal nicotinic alpha 7 receptor, a new endothelial target for revascularization. Life Sci. 78 1863-70 PubMed GONUTS page

[PMID:12189247-8] 8.0 ^8.1 ^8.2 Heeschen, C et al. (2002) A novel angiogenic pathway mediated by non-neuronal nicotinic acetylcholine receptors. J. Clin. Invest. 110 527-36 PubMed GONUTS page

[PMID:8145738-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 Peng, X et al. (1994) Human alpha 7 acetylcholine receptor: cloning of the alpha 7 subunit from the SH-SY5Y cell line and determination of pharmacological properties of native receptors and functional alpha 7 homomers expressed in Xenopus oocytes. Mol. Pharmacol. 45 546-54 PubMed GONUTS page

[PMID:12508119-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 Wang, H et al. (2003) Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation. Nature 421 384-8 PubMed GONUTS page

[PMID:8906617-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 Elliott, KJ et al. (1996) Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits. J. Mol. Neurosci. 7 217-28 PubMed GONUTS page

[PMID:17498763-12] Wong, HP et al. (2007) Nicotine promotes cell proliferation via alpha7-nicotinic acetylcholine receptor and catecholamine-synthesizing enzymes-mediated pathway in human colon adenocarcinoma HT-29 cells. Toxicol. Appl. Pharmacol. 221 261-7 PubMed GONUTS page

[PMID:10771023-13] 13.0 ^13.1 Schuller, HM et al. (2000) Interaction of tobacco-specific toxicants with the neuronal alpha(7) nicotinic acetylcholine receptor and its associated mitogenic signal transduction pathway: potential role in lung carcinogenesis and pediatric lung disorders. Eur. J. Pharmacol. 393 265-77 PubMed GONUTS page

[PMID:21873635-14] 14.00 ^14.01 ^14.02 ^14.03 ^14.04 ^14.05 ^14.06 ^14.07 ^14.08 ^14.09 ^14.10 ^14.11 ^14.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:26224839-15] Ohnishi, T et al. (2015) Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly. Proc. Natl. Acad. Sci. U.S.A. 112 E4465-74 PubMed GONUTS page

[PMID:11404397-16] Dineley, KT et al. (2001) Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease. J. Neurosci. 21 4125-33 PubMed GONUTS page

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